Effect of a standardized meal on the bioavailability of a single oral dose of tibolone 2.5 mg in healthy postmenopausal women

Pharmacotherapy

Volumn 22, Issue 3 II, 2002, Pages 310-315

  Timmer, Cees J ^a   Huisman, Johannes A M ^a  

^a NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXYTIBOLONE; 3BETA HYDROXYTIBOLONE; DRUG METABOLITE; TIBOLONE; TIBOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DISPOSITION; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; FOOD INTAKE; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIPID DIET; MASS SPECTROMETRY; NORMAL HUMAN; PHARMACOKINETICS; POSTMENOPAUSE; RANDOMIZED CONTROLLED TRIAL; TABLET;

EID: 0036194774     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.22.5.310.33186     Document Type: Article

References (8)

1. Livial: A review of clinical studies
2. The in vivo human metabolism of tibolone
3. Human endometrial 3β-hydroxysteroid dehydrogenase/isomerase can locally reduce intrinsic estrogenic/progestagenic activity ratios of a steroidal drug (Org OD 14)
4. Tibolone: Dose-response analysis of uterine bleedings in a multicentre, placebo-controlled study
5. Prevention of bone loss with tibolone in postmenopausal women: Results of two randomized, double-blind, placebo-controlled, dose finding studies