Validated HPLC method for the determination of gabapentin in human plasma using pre-column derivatization with 1-fluoro-2,4-dinitrobenzene and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 854, Issue 1-2, 2007, Pages 43-47

  Jalalizadeh, Hassan ^a   Souri, Effat ^a   Tehrani, Maliheh Barazandeh ^a   Jahangiri, Alireza ^b  

^a Tehran University of Medical Science   (Iran)

^b AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1 Fluoro 2,4 dinitrobenzene; Epilepsy; Gabapentin; HPLC; UV detection

Indexed keywords

DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MAMMALS; PLASMAS; PRECIPITATION (CHEMICAL); PROTEINS; ULTRAVIOLET DETECTORS;

GABAPENTIN; UV-DETECTION;

PHARMACOKINETICS;

1 FLUORO 2,4 DINITROBENZENE; ACETONITRILE; AMLODIPINE; GABAPENTIN;

ACCURACY; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DERIVATIZATION; DRUG DETERMINATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEPARATION TECHNIQUE; ULTRAVIOLET RADIATION;

ADULT; AMINES; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYCLOHEXANECARBOXYLIC ACIDS; DINITROFLUOROBENZENE; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 34250732928     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.03.039     Document Type: Article

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