Electric fields in tumors exposed to external voltage sources: Implication for electric field-mediated drug and gene delivery

Annals of Biomedical Engineering

Volumn 34, Issue 10, 2006, Pages 1564-1572

  Mossop, Brian J ^a   Barr, Roger C ^a   Henshaw, Joshua W ^a   Zaharoff, David A ^a   Yuan, Fan ^a  

^a Duke University   (United States)

Author keywords

Drug and gene delivery; Electrochemotherapy; Electrogenetherapy; Electroporation

Indexed keywords

AGAROSE GEL; APPLIED FIELD; ELECTRIC STIMULI; ELECTROCHEMOTHERAPY; ELECTRODE-TISSUE INTERFACE; ELECTROGENETHERAPY; ELECTROPORATION; EX-VIVO; EXTERNAL VOLTAGES; FIELD STRENGTHS; GENE DELIVERY; IN-VIVO; MOUSE SKIN; MOUSE TUMORS; PARALLEL-PLATE ELECTRODES; PULSED ELECTRIC FIELD; SOLID TUMORS; TISSUE PHANTOM; TOTAL RESISTANCE; TUMOR MODELS; TUMOR TISSUES;

ELECTRODES; GENE TRANSFER; TUMORS;

ELECTRIC FIELDS;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOMEDICAL ENGINEERING; C57BL MOUSE; DRUG DELIVERY SYSTEM; ELECTROCHEMOTHERAPY; ELECTROPORATION; ELECTROSTIMULATION; EXPERIMENTAL MELANOMA; EXPERIMENTAL NEOPLASM; FEMALE; GENE THERAPY; IMAGE QUALITY; IMPEDANCE; IN VITRO STUDY; MOUSE; PATHOPHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; BIOMEDICAL ENGINEERING; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; ELECTRIC IMPEDANCE; ELECTRIC STIMULATION; ELECTROCHEMOTHERAPY; ELECTROPORATION; FEMALE; GENE THERAPY; MAMMARY NEOPLASMS, EXPERIMENTAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PHANTOMS, IMAGING;

EID: 34250726267     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-006-9151-3     Document Type: Article

References (31)

1. Brummer, S. B., and M. J. Turner. Electrical stimulation with Pt electrodes: II-estimation of maximum surface redox (theoretical non-gassing) limits. IEEE Trans. Biomed. Eng. 24:440-443, 1977.
2. Brummer, S. B., and M. J. Turner. Electrochemical considerations for safe electrical stimulation of the nervous system with platinum electrodes. IEEE Trans. Biomed. Eng. 24:59-63, 1977.
3. Bureau, M. F., J. Gehl, V. Deleuze, L. M. Mir, and D. Scherman. Importance of association between permeabilization and electrophoretic forces for intramuscular DNA electrotransfer. Biochim. Biophys. Acta 1474:353-359, 2000.
4. Canatella, P. J., M. M. Black, D. M. Bonnichsen, C. McKenna, and M. R. Prausnitz. Tissue electroporation: quantification and analysis of heterogeneous transport in multicellular environments. Biophys. J. 86:3260-3268, 2004.
5. Canatella, P. J., J. F. Karr, J. A. Petros, and M. R. Prausnitz. Quantitative study of electroporation-mediated molecular uptake and cell viability. Biophys. J. 80:755-764, 2001.
6. Cemazar, M., I. Wilson, G. U. Dachs, G. M. Tozer, and G. Sersa. Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy-spatial and time dependent distribution. BMC Cancer. 4:81, 2004.
7. DeBruin, K. A., and W. Krassowska. Modeling electroporation in a single cell. I. Effects Of field strength and rest potential. Biophys. J. 77:1213-1224, 1999.
8. Dorgan, S. J., and R. B. Reilly. A model for human skin impedance during surface functional neuromuscular stimulation. IEEE Trans. Rehabil. Eng. 7:341-348, 1999.
9. Gu, W. Y., and M. A. Justiz. Apparatus for measuring the swelling dependent electrical conductivity of charged hydrated soft tissues. J. Biomech. Eng. 124:790-793, 2002.
10. Gu, W. Y., W. M. Lai, and V. C. Mow. Transport of fluid and ions through a porous-permeable charged-hydrated tissue, and streaming potential data on normal bovine articular cartilage. J. Biomech. 26:709-723, 1993.
11. Heller, L.,M. J. Jaroszeski, D. Coppola, C. Pottinger, R. Gilbert, and R. Heller. Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo. Gene. Ther. 7:826-829, 2000.
12. Heller, R., R. Gilbert, and M. J. Jaroszeski. Electrochemotherapy: An emerging drug delivery method for the treatment of cancer. Adv. Drug Deliv. Rev. 26:185-197, 1997.
13. Jadoul, A., J. Bouwstra, and V. V. Preat. Effects of iontophoresis and electroporation on the stratum corneum. Review of the biophysical studies. Adv. Drug Deliv. Rev. 35:89-105, 1999.
14. Kotnik, T., and D. Miklavcic. Analytical description of transmembrane voltage induced by electric fields on spheroidal cells. Biophys. J. 79:670-679, 2000.
15. Krol, A., M. W. Dewhirst, and F. Yuan. Effects of cell damage and glycosaminoglycan degradation on available extravascular space of different dextrans in a rat fibrosarcoma. Int. J. Hyperthermia. 19:154-164, 2003.
16. Krol, A., J. Maresca, M. W. Dewhirst, and F. Yuan. Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: Implications for drug delivery. Cancer Res. 59:4136-4141, 1999.
17. Lohr, F., D. Y. Lo, D. A. Zaharoff, K. Hu, X. Zhang, Y. Li, Y. Zhao, M. W. Dewhirst, F. Yuan, and C. Y. Li. Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. Cancer Res. 61:3281-3214, 2001.
18. Lucas, M. L., L.Heller, D. Coppola, andR. Heller. IL-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16.F10 melanoma. Mol. Ther. 5:668-675, 2002.
19. Mir, L. M. Therapeurtic perspectives on in vivo cell electropermeabilization. Bioelectrochemistry 53:1-10, 2000.
20. Mossop, B. J., R. C. Barr, D. A. Zaharoff, and F. Yuan. Electric fields within cells as a function ofmembrane resistivity-a model study. IEEE Trans. Nanobioscience 3:225-231, 2004.
21. Neumann, E., S. Kakorin, and K. Toensing. Fundamentals of electroporative delivery of drugs and genes. Bioelectrochem. Bioenerg. 48:3-16, 1999.
22. Niidome, T., and L. Huang. Gene therapy progress and prospects: nonviral vectors. Gene. Ther. 9:1647-1652, 2002.
23. Nishikawa, M., and L. Huang. Nonviral vectors in the new millennium: Delivery barriers in gene transfer. Hum. Gene Ther. 12:861-870, 2001.
24. Panescu, D., J. G. Webster, and R. A. Stratbucker. A nonlinear finite element model of the electrode-electrolyte-skin system. IEEE Trans. Biomed. Eng. 41:681-687, 1994.
25. Pavlin, M., and D. Miklavcic. Effective conductivity of a suspension of permeabilized cells: a theoretical analysis. Biophys. J. 85:719-729, 2003.
26. Pavselj, N., Z. Bregar, D. Cukjati, D. Batiuskaite, L.M.Mir, and D. Miklavcic. The course of tissue permeabilization studied on a mathematical model of a subcutaneous tumor in small animals. IEEE Trans. Biomed. Eng. 52:1373-1381, 2005.
27. Prausnitz, M. R., V. G. Bose, R. Langer, and J. C. Weaver. Electroporation of mammalian skin: A mechanism to enhance transdermal drug delivery. Proc.Natl. Acad. Sci. USA 90:10504-10508, 1993.
28. Sel, D., D. Cukjati, D. Batiuskaite, T. Slivnik, L. M. Mir, and D. Miklavcic. Sequential finite element model of tissue electropermeabilization. IEEE Trans. Biomed. Eng. 52:816-827, 2005.
29. Sersa, G., M. Cemazar, and D. Miklavcic. Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum( II) in mice. Cancer Res. 55:3450-3455, 1995.
30. Zaharoff, D. A., R. C. Barr, C. Y. Li, and F. Yuan. Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. Gene Ther. 9:1286-1290, 2002.
31. Zaharoff, D. A., and F. Yuan. Effects of pulse strength and pulse duration on in vitro DNA electromobility. Bioelectrochemistry 62:37-45, 2004.