Application of the intramolecular yamamoto vinylogous aldol reaction to the synthesis of macrolides

Organic Letters

Volumn 9, Issue 11, 2007, Pages 2103-2106

  Abramite, Joseph A ^a   Sammakia, Tarek ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MACROLIDE;

ARTICLE; CHEMICAL STRUCTURE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; MACROLIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 34250648473     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0704901     Document Type: Article

References (48)

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40. See the Supporting Information for details.
41. 3Al (1 equiv) with 2,6diphenylphenol (3 equiv). See Supporting Information or ref 6a for details.
42. Varying amounts of starting material and unidentified side products were observed in these reactions.
43. For details, see the general cyclization procedure in the Supporting Information.
44. Crystallographic data for the 3,5-dinitrobenzoates 14 and 15 can be found in the Supporting Information. The stereochemistry of compound 5 was assigned by analogy.
45. Crystallographic data for the 3,5-dinitrobenzoate 16 can be found in the Supporting Information. The stereochemistry of compound 8 was assigned by analogy.
46. The stereochemistry of compound 11 was assigned by analogy.
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