The human amygdala and orbital prefrontal cortex in behavioural regulation

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 362, Issue 1481, 2007, Pages 787-799

  Dolan, R J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Amygdala: orbital prefrontal cortex; Decision making; Emotion; fMRI; Reward

Indexed keywords

BRAIN; DECISION MAKING; EXPERIMENTAL STUDY; INFORMATION;

AMYGDALOID NUCLEUS; BEHAVIOR; DECISION MAKING; EMOTION; HUMAN; LEARNING; PHYSIOLOGY; PREFRONTAL CORTEX; REVIEW; REWARD;

AMYGDALA; BEHAVIOR; DECISION MAKING; EMOTIONS; HUMANS; LEARNING; PREFRONTAL CORTEX; REWARD;

EID: 34250359894     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2007.2088     Document Type: Conference Paper

References (110)

1. Anderson, A. K. & Sobel, N. 2003 Dissociating intensity from valence as sensory inputs to emotion. Neuron 39, 581-583. (doi:10.1016/S0896-6273(03)00504-X)
2. Arana, F. S., Parkinson, J. A., Hinton, E., Holland, A. J., Owen, A. M. & Roberts, A. C. 2003 Dissociable contributions of the human amygdala and orbitofrontal cortex to incentive motivation and goal selection. J. Neurosci. 23, 9632-9638.
3. Balleine, B. W. & Killcross, S. 2006 Parallel incentive processing: an integrated view of amygdala function. Trends Neurosci. 29, 272-279. (doi:10.1016/j.tins.2006.03.002)
4. Baxter, M. G. & Murray, E. A. 2002 The amygdala and reward. Nat. Rev. Neurosci. 3, 563-573. (doi:10.1038/nrn875)
5. Baxter, M. G., Parker, A., Lindner, C. C., Izquierdo, A. D. & Murray, E. A. 2000 Control of response selection by reinforcer value requires interaction of amygdala and orbital prefrontal cortex. J. Neurosci. 20, 4311-4319.
6. Bechara, A., Damasio, A. R., Damasio, H. & Anderson, S. W. 1994 Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7-15. (doi:10.1016/0010-0277(94)90018-3)
7. Bell, D. 1982 Regret and decision making under uncertainty. Oper. Res. 30, 961-981.
8. Bell, D. E. 1985 Disappointment in decision making under uncertainty. Oper. Res. 33, 1-27.
9. Bensafi, M., Rouby, C., Farget, V., Bertrand, B., Vigouroux, M. & Holley, A. 2002 Autonomic nervous system responses to odours: the role of pleasantness and arousal. Chem. Senses 27, 703-709. (doi:10.1093/chemse/27.8.703)
10. Botvinick, M. M., Braver, T. S., Barch, D. M., Carter, C. S. & Cohen, J. D. 2001 Conflict monitoring and cognitive control. Psychol. Rev. 108, 624-652. (doi:10.1037/0033-295X.108.3.624)
11. Bouton, M. E. 1993 Context, time, and memory retrieval in the interference paradigms of Pavlovian learning. Psychol. Bull. 114, 80-99. (doi:10.1037/0033-2909.114.1.80)
12. Bouton, M. E. 2004 Context and behavioral processes in extinction. Learn. Mem. 11, 485-494. (doi:10.1101/ lm.78804)
13. Braver, T. S. & Bongiolatti, S. R. 2002 The role of frontopolar cortex in subgoal processing during working memory. Neuroimage 15, 523-536. (doi:10.1006/nimg.2001.1019)
14. Burgess, P. W., Gilbert, S. J. & Dumontheil, I. 2007 Function and localization within rostral prefrontal cortex (area 10). Phil. Trans. R. Soc. B 362, 887-899. (doi:10.1098/rstb. 2007.2095)
15. Cahill, L. & McGaugh, J. L. 1998 Mechanisms of emotional arousal and lasting declarative memory. Trends Neurosci. 21, 294-299. (doi:10.1016/S0166-2236(97)01214-9)
16. Cahill, L., Prins, B., Weber, M. & McGaugh, J. L. 1994 Beta-adrenergic activation and memory for emotional events. Nature 371, 702-704. (doi:10.1038/371702a0)
17. Cahill, L., Babinsky, R., Markowitsch, H. J. & McGaugh, J. L. 1995 The amygdala and emotional memory. Nature 377, 295-296. (doi:10.1038/377295a0)
18. Cahill, L., Haier, R. J., Fallon, J., Alkire, M. T., Tang, C., Keator, D., Wu, J. & McGaugh, J. L. 1996 Amygdala activity at encoding correlated with long-term, free recall of emotional information. Proc. Natl Acad. Sci. USA 93, 8016-8021. (doi:10.1073/pnas.93.15.8016)
19. Camerer, C. F. 2003 Behavioral gain theory. New Jersey, NJ: Princeton University Press.
20. Camille, N., Coricelli, G., Sallet, J., Pradat-Diehl, P., Duhamel, J. R. & Sirigu, A. 2004 The involvement of the orbitofrontal cortex in the experience of regret. Science 304, 1167-1170. (doi:10.1126/ science.1094550)
21. Cohen, J., McLure, S. M. & Yu, A. 2007 Should I stay or should I go? How the human brain manages the tradeoff between exploration and exploitation. Phil. Trans. R. Soc. B 362, 933-942. (doi:10.1098/rstb.2007.2098)
22. Coricelli, G., Critchley, H. D., Joffily, M., O'Doherty, J. P., Sirigu, A. & Dolan, R. J. 2005 Regret and its avoidance: a neuroimaging study of choice behavior. Nat. Neurosci. 8, 1255-1262. (doi:10.1038/nn1514)
23. Craig, A. D. 2003 A new view of pain as a homeostatic emotion. Trends Neurosci. 26, 303-307. (doi:10.1016/ S0166-2236(03)00123-1)
24. Critchley, H. D., Mathias, C. J. & Dolan, R. J. 2002 Fear conditioning in humans: the influence of awareness and autonomic arousal on functional neuroanatomy. Neuron 33, 653-663. (doi:10.1016/S0896- 6273(02)00588-3)
25. Damasio, H., Grabowski, T., Frank, R., Galaburda, A. M. & Damasio, A. R. 1994 The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science 264, 1102-1105. (doi:10.1126/science. 8178168) [Erratum in Science 1994 265, 1159.]
26. Daw, N. D., O'Doherty, J. P., Dayan, P., Seymour, B. & Dolan, R. J. 2006 Cortical substrates for exploratory decisions in humans. Nature 441, 876-879. (doi:10.1038/ nature04766)
27. Dayan, P. & Balleine, B. W. 2002 Reward, motivation, and reinforcement learning. Neuron 36, 285-298. (doi:10. 1016/S0896-6273(02)00963-7)
28. De Martino, B., Kumaran, D., Seymour, B. & Dolan, R. J. 2006 Frames, biases, and rational decision-making in the human brain. Science 313, 684-687. (doi:10.1126/science. 1128356)
29. Delamater, A. R. 2004 Experimental extinction in Pavlovian conditioning: behavioural and neuroscience perspectives. Q. J. Exp. Psychol. B 57, 97-132. (doi:10.1080/02724 990344000097)
30. Falls, W. A., Miserendino, M. J. & Davis, M. 1992 Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala. J. Neurosci. 12, 854-863.
31. Gallagher, M., McMahan, R. W. & Schoenbaum, G. 1999 Orbitofrontal cortex and representation of incentive value in associative learning. J. Neurosci. 19, 6610-6614.
32. Gallistel, C. R. & Gibbon, J. 2000 Time, rate, and conditioning. Psychol. Rev. 107, 289-344. (doi:10.1037/ 0033-295X.107.2.289)
33. Garcia, R. 2002 Postextinction of conditioned fear: between two CS-related memories. Learn. Mem. 9, 361-363. (doi:10.1101/lm. 56402)
34. Gilovich, T., Griffin, D. W. & Kahneman, D. 2002 Heuristics and biases: the psychology of intuitive judgment. New York, NY: Cambridge University Press.
35. Glimcher, P. W. & Rustichini, A. 2004 Neuroeconomics: the consilience of brain and decision. Science 306, 447-452. (doi:10.1126/ science.1102566)
36. Gottfried, J. A. & Dolan, R. J. 2004 Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value. Nat. Neurosci. 7, 1144-1152. (doi:10.1038/nn1314)
37. Gottfried, J. A., O'Doherty, J. & Dolan, R. J. 2002 Appetitive and aversive olfactory learning in humans studied using event-related functional magnetic resonance imaging. J. Neurosci. 22, 10 829-10 837.
38. Gottfried, J. A., O'Doherty, J. & Dolan, R. J. 2003 Encoding predictive reward value in human amygdala and orbitofrontal cortex. Science 301, 1104-1107. (doi:10.1126/ science.1087919)
39. Greene, J. & Haidt, J. 2002 How (and where) does moral judgment work? Trends Cogn. Sci. 6, 517-523. (doi:10. 1016/S1364-6613(02)02011- 9)
40. Hamann, S. 2003 Nosing in on the emotional brain. Nat. Neurosci. 6, 106-108. (doi:10.1038/nn0203-106)
41. Hatfield, T., Han, J. S., Conley, M., Gallagher, M. & Holland, P. 1996 Neurotoxic lesions of basolateral, but not central, amygdala interfere with Pavlovian second-order conditioning and reinforcer devaluation effects. J. Neurosci. 16, 5256-5265.
42. Herry, C. & Garcia, R. 2002 Prefrontal cortex long-term potentiation, but not long-term depression, is associated with the maintenance of extinction of learned fear in mice. J. Neurosci. 22, 577-583.
43. Hobin, J. A., Goosens, K. A. & Maren, S. 2003 Context-dependent neuronal activity in the lateral amygdala represents fear memories after extinction. J. Neurosci. 23, 8410-8416.
44. Hsu, M., Bhatt, M., Adolphs, R., Tranel, D. & Camerer, C. F. 2005 Neural systems responding to degrees of uncertainty in human decision-making. Science 310, 1680-1683. (doi:10.1126/science.1115327)
45. Ikeda, M., Brown, J., Holland, A. J., Fukuhara, R. & Hodges, J. R. 2002 Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 73, 371-376. (doi:10.1136/jnnp.73.4.371)
46. Kahneman, D. & Tversky, A. 1979 Prospect theory: an analysis of decision under risk. Econometrica 47, 263-291. (doi:10.2307/1914185)
47. Kahneman, D. & Tversky, A. 2000 Choices, values, and frames. New York, NY: Cambridge University Press.
48. Kalisch, R., Korenfeld, E., Stephan, K. E., Weiskopf, N., Seymour, B. & Dolan, R. J. 2006 Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network. J. Neurosci. 26, 9503-9511. (doi:10.1523/JNEUROSCI.2021-06.2006)
49. Kim, H., Somerville, L. H., Johnstone, T., Polis, S., Alexander, A. L., Shin, L. M. & Whalen, P. J. 2004 Contextual modulation of amygdala responsivity to surprised faces. J. Cogn. Neurosci. 16, 1730-1745. (doi:10.1162/0898929042947865)
50. LaBar, K. S. & Phelps, E. A. 2005 Reinstatement of conditioned fear in humans is context dependent and impaired in amnesia. Behav. Neurosci. 119, 677-686. (doi:10.1037/0735-7044.119.3.677)
51. Lang, P. J. 1995 The emotion probe. Studies of motivation and attention. Am. J. Psychol. 50, 372-385. (doi:10.1037/ 0003-066X.50.5.372)
52. LeDoux, J. E. 1996 The emotional brain. New York, NY: Simon and Schuster.
53. Loewenstein, G. F., Weber, E. U., Hsee, C. K. & Welch, N. 2001 Risk as feelings. Psychol. Bull. 127, 267-286. (doi:10. 1037/0033-2909.127.2.267)
54. Loomes, G. 1988 Further evidence of the impact of regret and disappointment in choice under uncertainty. Econometrica 55, 47-62.
55. Loomes, G. & Sugden, R. 1983 A rationale for preference reversal. Am. Econ. Rev. 73, 428-432.
56. Loomes, G. & Sugden, R. 1986 Disappointment and dynamic consistency in choice under uncertainty. Rev. Econ. Stud. 53, 272-282.
57. Mai, J. K., Assheuer, J. & Paxinos, G. 1997 Atlas of the human brain. San Dieto, CA: Academie Press.
58. Malkova, L., Gaffan, D. & Murray, E. A. 1997 Excitotoxic lesions of the amygdala fail to produce impairment in visual iearning for auditory secondary reinforcement but interfere with reinforcer devaluation effects in rhesus monkeys. J. Neurosci. 17, 6011-6020.
59. McGaugh, J. L. & Roozendaal, B. 2002 Role of adrenal stress hormones in forming lasting memories in the brain. Curr. Opin. Neurobiol. 12, 205-210. (doi:10.1016/S0959-4388 (02)00306-9)
60. McGaugh, J. L., Cahill, L. & Roozendaal, B. 1996 Involvement of the amygdala in memory storage: interaction with other brain systems. Proc. Natl Acad. Sci. USA 93, 13 508-13 514. (doi:10.1073/pnas.93.24.13508)
61. McNeil, B. J., Pauker, S. G., Sox, H. C. & Tversky, A. 1982 On the elicitation of preferences for alternative therapies. N. Engl. J. Med. 306, 1259-1262.
62. Mellers, B., Ritov, I. & Schwartz, A. 1999 Emotion-based Choice. J. Exp. Psychol. General 128, 332-345. (doi:10. 1037/0096-3445.128.3.332)
63. Milad, M. R. & Quirk, G. J. 2002 Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420, 70-74. (doi:10.1038/nature01138)
64. Milad, M. R., Quinn, B. T., Pitman, R. K., Orr, S. P., Fischl, B. & Rauch, S. L. 2005 Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory. Proc. Natl Acad. Sci. USA 102, 10 706-10 711. (doi:10.1073/pnas.0502441102)
65. Morgan, M. A. & LeDoux, J. E. 1995 Differential contribution of dorsal and ventral medial prefrontal cortex to the acquisition and extinction of conditioned fear in rats. Behav. Neurosci. 109, 681-688. (doi:10.1037/0735-7044.109.4.681)
66. Morgan, M. A., Romanski, L. M. & LeDoux, J. E. 1993 Extinction of emotional learning: contribution of medial prefrontal cortex. Neurosci. Lett. 163, 109-113. (doi:10. 1016/0304-3940(93)90241-C)
67. Morris, J. S. & Dolan, R. J. 2004 Dissociable amygdala and orbitofrontal responses during reversal fear conditioning. Neuroimage 22, 372-380. (doi:10.1016/j.neuroimage. 2004.01.012)
68. Myers, K. M. & Davis, M. 2002 Behavioral and neural analysis of extinction. Neuron 36, 567-584. (doi:10.1016/ S0896-6273(02)01064- 4)
69. O'Doherty, J. P. 2004 Reward representations and reward-related learning in the human brain: insights from neuroimaging. Curr. Opin. Neurobiol. 14, 769-776. (doi:10.1016/j.conb.2004.10.016)
70. O'Doherty, J., Kringelbach, M. L., Hornak, J., Andrews, C. & Rolls, E. T. 2001 Abstract reward and punishment representations in the human orbitofrontal cortex. Nat. Neurosci. 4, 95-102. (doi:10.1038/82959)
71. O'Doherty, J. P., Deichmann, R., Critchley, H. D. & Dolan, R. J. 2002 Neural responses during anticipation of a primary taste reward. Neuron 33, 815-826. (doi:10.1016/ S0896-6273(02)00603-7)
72. O'Doherty, J., Critchley, H., Deichmann, R. & Dolan, R. J. 2003 Dissociating valence of outcome from behavioral control in human orbital and ventral prefrontal cortices. J. Neurosci. 23, 7931-7939.
73. Paton, J. J., Belova, M. A., Morrison, S. E. & Salzman, C. D. 2006 The primate amygdala represents the positive and negative value of visual stimuli during learning. Nature 439, 865-870. (doi:10.1038/ nature04490)
74. Payne, J. W., Bettman, J. R. & Johnson, E. J. 1992 Behavioral decision research: a constructive processing pespective. Annu. Rev. Psychol. 43, 87-131. (doi:10.1146/annurev.ps. 43.020192.000511)
75. Pearce, J. M. & Hall, G. 1980 A model for Pavlovian learning: variations in the effectiveness of conditioned but not of unconditioned stimuli. Psychol. Rev. 87, 532-552. (doi:10. 1037/0033-295X.87.6.532)
76. Phelps, E. A., LaBar, K. S., Anderson, A. K., O'Connor, K. J., Fulbright, R. K. & Spencer, D. D. 1998 Specifying the contributions of the human amygdala to emotional memory: a case study. Neurocase 4, 527-540. (doi:10. 1093/neucas/4.6.527)
77. Phelps, E. A., Delgado, M. R., Nearing, K. I. & LeDoux, J. E. 2004 Extinction learning in humans: role of the amygdala and vmPFC. Neuron 43, 897-905. (doi:10.1016/j.neuron. 2004.08.042)
78. Pickens, C. L., Saddoris, M. P., Setlow, B., Gallagher, M., Holland, P. C. & Schoenbaum, G. 2003 Different roles for orbitofrontal cortex and basolateral amygdala in a reinforcer devaluation task. J. Neurosci. 23, 11 078-11 084.
79. Price, D. D. 1999 Psychological mechanisms of pain and analgesia. Seattle, WA: IASP.
80. Quirk, G. J. & Gehlert, D. R. 2003 Inhibition of the amygdala: key to pathological states? Ann. NY Acad. Sci. 985, 263-272.
81. Quirk, G. J., Likhtik, E., Pelletier, J. G. & Pare, D. 2003 Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. J. Neurosci. 23, 8800-8807.
82. Ramnani, N. & Owen, A. M. 2004 Anterior prefrontal cortex: insights into function from anatomy and neuroimaging. Nat Rev. Neurosci. 5, 184-194. (doi:10.1038/nrn1343)
83. Repa, J. C., Muller, J., Apergis, J., Desrochers, T. M., Zhou, Y. & LeDoux, J. E. 2001 Two different lateral amygdala cell populations contribute to the initiation and storage of memory. Nat. Neurosci. 4, 724-731. (doi:10. 1038/89512)
84. Rescorla, R. A. 1972 "Configural" conditioning in discrete-trial bar pressing. Q. J. Exp. Psychol. B 79, 307-317.
85. Rescorla, R. A. 2001 Experimental extinction. In Handbook of contemporary learning theories (eds R. R. Mowrer & S. Klein), pp. 119-154. Mahwah, NJ: Lawrence Erlbaum.
86. Rolls, B. J., Rolls, E. T., Rowe, E. A. & Sweeney, K. 1981 Sensory specific satiety in man. Physiol. Behav. 27, 137-142. (doi:10.1016/0031-9384(81)90310-3)
87. Rolls, E. T., Hornak, J., Wade, D. & McGrath, J. 1994 Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. J. Neurol. Neurosurg. Psychiatry 57, 1518-1524.
88. Rosenkranz, J. A., Moore, H. & Grace, A. A. 2003 The prefrontal cortex regulates lateral amygdala neuronal plasticity and responses to previously conditioned stimuli. J. Neurosci. 23, 11 054-11 064.
89. Russell, J. 1980 A circumplex model of affect. J. Pers. Soc. Psychol. 39, 1161-1178. (doi:10.1037/h0077714)
90. Schiffman, S. S. 1974 Physicochemical correlates of olfactory quality. Science 185, 112-117. (doi:10.1126/science.185. 4146.112)
91. Schoenbaum, G., Setlow, B., Saddoris, M. P. & Gallagher, M. 2003 Encoding predicted outcome and acquired value in orbitofrontal cortex during cue sampling depends upon input from basolateral amygdala. Neuron 39, 855-867. (doi:10.1016/S0896-6273(03)00474-4)
92. Schoenbaum, G., Roesch, M. R. & Stalnaker, T. A. 2006 Orbitofrontal cortex, decision-making and drug addiction. Trends Neurosci. 29, 116-124. (doi:10.1016/j.tins.2005.12. 006)
93. Seymour, B., O'Doherty, J. P., Koltzenburg, M., Wiech, K., Frackowiak, R., Friston, K. & Dolan, R. 2005 Opponent appetitive-aversive neural processes underlie predictive learning of pain relief. Nat. Neurosci. 8, 1234-1240. (doi:10.1038/nn1527)
94. Slovic, P., Finucane, M., Perers, E. & MacGregor, D. 2002 The affect heuristic. In Heuristics and biases: the psychology of intuitive judgment (eds T. Gilovich, D. W. Griffin & D. Kahneman), pp. 397-421. New York, NY: Cambridge University Press.
95. Small, D. M., Zatorre, R. J., Dagher, A., Evans, A. C. & Jones-Gotman, M. 2001 Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain 124, 1720-1733. (doi:10.1093/brain/124.9.1720)
96. Small, D. M., Gregory, M. D., Mak, Y. E., Gitelman, D., Mesulam, M. M. & Parrish, T. 2003 Dissociation of neural representation of intensity and affective valuation in human gustation. Neuron 39, 701-711. (doi:10.1016/ S0896-6273(03)00467-7)
97. Strange, B. A. & Dolan, R. J. 2004 Beta-adrenergic modulation of emotional memory-evoked human amygdala and hippocampal responses. Proc. Natl Acad. Sci. USA 101, 11 454-11 458. (doi:10.1073/pnas.0404282101)
98. Strange, B. A., Hurlemann, R. & Dolan, R. J. 2003 An emotion-induced retrograde amnesia in humans is amygdala- and β-adrenergic-dependent. Proc. Natl Acad. Sci. USA 100, 13 626-13 631. (doi:10.1073/pnas. 1635116100)
99. Sutton, R. S. & Barto, A. G. 1981 Toward a modern theory of adaptive networks: expectation and prediction. Psychol. Rev. 88, 135-170. (doi:10.1037/0033-295X.88.2.135)
100. Tanaka, S. C., Doya, K., Okada, G., Ueda, K., Okamoto, Y. & Yamawaki, S. 2004 Prediction of immediate and future rewards differentially recruits cortico-basal ganglia loops. Nat. Neurosci. 7, 887-893. (doi:10.1038/nn1279)
101. Terzian, H. & Ore, G. D. 1955 Syndrome of Kluver and Bucy; reproduced in man by bilateral removal of the temporal lobes. Neurology 5, 373-380.
102. Tremblay, L. & Schultz, W. 1999 Relative reward preference in primate orbitofrontal cortex. Nature 398, 704-708. (doi:10.1038/19525)
103. Tversky, A. & Kahneman, D. 1981 The framing of decisions and the psychology of choice. Science 211, 453-458. (doi:10.1126/science. 7455683)
104. Tversky, A. & Kahneman, D. 1986 Rational choice and the framing of decisions. Business 59, 251-278. (doi:10.1086/ 296365)
105. van Stegeren, A. H., Everaerd, W., Cahill, L., McGaugh, J. L. & Gooren, L. J. 1998 Memory for emotional events: differential effects of centrally versus peripherally acting beta-blocking agents. Psychopharmacology (Berlin) 138, 305-310. (doi:10.1007/s002130050675)
106. Wasserman, E. A. & Miller, R. R. 1997 What's elementary about associative learning? Annu. Rev. Psychol. 48, 573-607. (doi:10.1146/annurev.psych.48.1.573)
107. Whalen, P. J. et al. 2004 Human amygdala responsivity to masked fearful eye whites. Science 306, 2061. (doi:10. 1126/science.1103617)
108. White, K. & Davey, G. C. 1989 Sensory preconditioning and UCS inflation in human 'fear' conditioning. Behav. Res. Ther. 27, 161-166. (doi:10.1016/0005-7967(89)90074-0)
109. Winstanley, C. A., Theobald, D. E., Cardinal, R. N. & Robbins, T. W. 2004 Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice. J. Neurosci. 24, 4718-4722. (doi:10.1523/ JNEUROSCI. 5606-03.2004)
110. Winston, J. S., Gottfried, J. A., Kilner, J. M. & Dolan, R. J. 2005 Integrated neural representations of odor intensity and affective valence in human amygdala. J. Neurosci. 25, 8903-8907. (doi:10.1523/ JNEUROSCI.1569-05.2005)