7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: Synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 14, 2007, Pages 3840-3844

  Larsen, Scott D ^a   Zhang, Zhijun ^a   DiPaolo, Brian A ^a   Manninen, Peter R ^a   Rohrer, Douglas C ^a   Hageman, Michael J ^a   Hopkins, Todd A ^a   Knechtel, Mary L ^a   Oien, Nancee L ^a   Rush, Bob D ^a   Schwende, Francis J ^a   Stefanski, Kevin J ^a   Wieber, Janet L ^a   Wilkinson, Karen F ^a   Zamora, Kathyrn M ^a   Wathen, Michael W ^a   Brideau, Roger J ^a  

^a PFIZER INC   (United States)

Author keywords

Antiviral; Conformational restriction; Cytomegalovirus; HCMV; Herpes; Herpesvirus; HSV; Non nucleoside; VZV

Indexed keywords

7 OXO 4,7 DIHYDROTHIENO[3,2 B]PYRIDINE 6 CARBOXAMIDE DERIVATIVE; ANTIVIRUS AGENT; DNA POLYMERASE INHIBITOR; ENZYME INHIBITOR; THIENO[2,3 B]PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN CYTOMEGALOVIRUS; NONHUMAN;

CYTOMEGALOVIRUS; DNA-DIRECTED DNA POLYMERASE; ENZYME INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

CYTOMEGALOVIRUS; HERPES; HERPESVIRIDAE; HUMAN HERPESVIRUS 3; HUMAN HERPESVIRUS 5; SIMPLEXVIRUS;

EID: 34250341207     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.05.010     Document Type: Article

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