메뉴 건너뛰기




Volumn 37, Issue 1, 1998, Pages 17-28

Penciclovir and pathogenesis phenotypes of drug-resistant Herpes simplex virus mutants

Author keywords

DNA polymerase; Latency; Neurovirulence; Thymidine kinase

Indexed keywords

ACICLOVIR; FOSCARNET; PENCICLOVIR; THYMIDINE KINASE;

EID: 0031984781     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(97)00054-5     Document Type: Article
Times cited : (45)

References (60)
  • 1
    • 0027131363 scopus 로고
    • Penciclovir: A review of its spectrum of activity, selectivity, and cross-resistance pattern
    • Boyd, M.R., Safrin, S., Kern, E.R., 1993. Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chem. Chemother. 4 (Suppl. 1), 3-11.
    • (1993) Antiviral Chem. Chemother. , vol.4 , Issue.SUPPL. 1 , pp. 3-11
    • Boyd, M.R.1    Safrin, S.2    Kern, E.R.3
  • 2
    • 0010711387 scopus 로고
    • PhD thesis, Harvard University
    • Chiou, H., 1988. PhD thesis, Harvard University.
    • (1988)
    • Chiou, H.1
  • 3
    • 0022256207 scopus 로고
    • Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors
    • Chiou, H., Weller, S.K., Coen, D.M., 1985. Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors. Virology 145, 213-226.
    • (1985) Virology , vol.145 , pp. 213-226
    • Chiou, H.1    Weller, S.K.2    Coen, D.M.3
  • 4
    • 0022519449 scopus 로고
    • Mutations within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)-guanine
    • Chiou, H.C., Kerns, K.M., Coen, D.M., 1986. Mutations within the herpes simplex virus DNA polymerase gene conferring resistance to (R)-9-(3,4-dihydroxybutyl)-guanine. Antimicrob. Agents Chemother. 30, 502-504.
    • (1986) Antimicrob. Agents Chemother. , vol.30 , pp. 502-504
    • Chiou, H.C.1    Kerns, K.M.2    Coen, D.M.3
  • 5
    • 0029151329 scopus 로고
    • Penciclovir-resistance mutations in the herpes simplex virus DNA polymerase gene
    • Chiou, H.C., Kumura, K., Hu, A., Kerns, K.M., Coen, D.M., 1995. Penciclovir-resistance mutations in the herpes simplex virus DNA polymerase gene. Antiviral Chem. Chemother. 6, 281-288.
    • (1995) Antiviral Chem. Chemother. , vol.6 , pp. 281-288
    • Chiou, H.C.1    Kumura, K.2    Hu, A.3    Kerns, K.M.4    Coen, D.M.5
  • 6
    • 0024337663 scopus 로고
    • Characterization of encephalitis in adult mice induced by intracerebral inoculation of herpes simplex virus type 1 (KOS) and comparison with mutants showing decreased virulence
    • Chrisp, C.E., Sunstrum, J.C., Averill, D.R. Jr., Levine, M., Glorioso, J.C., 1989. Characterization of encephalitis in adult mice induced by intracerebral inoculation of herpes simplex virus type 1 (KOS) and comparison with mutants showing decreased virulence. Lab. Invest. 60, 822-830.
    • (1989) Lab. Invest. , vol.60 , pp. 822-830
    • Chrisp, C.E.1    Sunstrum, J.C.2    Averill D.R., Jr.3    Levine, M.4    Glorioso, J.C.5
  • 7
    • 0002827405 scopus 로고
    • Molecular aspects of anti-herpesvirus drugs
    • Coen, D.M., 1992. Molecular aspects of anti-herpesvirus drugs. Sem. Virol. 3, 3-12.
    • (1992) Sem. Virol. , vol.3 , pp. 3-12
    • Coen, D.M.1
  • 8
    • 0027985004 scopus 로고
    • Acyclovir-resistant, pathogenic herpesviruses
    • Coen, D.M., 1994. Acyclovir-resistant, pathogenic herpesviruses. Trends Microbiol. 2, 481-485.
    • (1994) Trends Microbiol. , vol.2 , pp. 481-485
    • Coen, D.M.1
  • 9
    • 0029916636 scopus 로고    scopus 로고
    • Antiviral drug resistance in herpes simplex virus
    • Mills, J.S., Corey, L. (Eds)
    • Coen, D.M., 1996a. Antiviral drug resistance in herpes simplex virus. In: Mills, J.S., Corey, L. (Eds), Proc. Conf. Antiviral Chemotherapy, New Directions, pp. 49-57.
    • (1996) Proc. Conf. Antiviral Chemotherapy, New Directions , pp. 49-57
    • Coen, D.M.1
  • 10
    • 0002985866 scopus 로고    scopus 로고
    • Herpes simplex virus and varicella zoster virus: Nucleosides and foscarnet. Mechanisms
    • Richman, D. (Ed), Wiley, Chichester
    • Coen, D.M., 1996b. Herpes simplex virus and varicella zoster virus: nucleosides and foscarnet. Mechanisms. In: Richman, D. (Ed), Antiviral Drug Resistance, Wiley, Chichester, pp. 81-102.
    • (1996) Antiviral Drug Resistance , pp. 81-102
    • Coen, D.M.1
  • 11
    • 0018827818 scopus 로고
    • Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1
    • Coen, D.M., Schaffer, P.A., 1980. Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1. Proc. Natl. Acad. Sci. USA 77, 2265-2269.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 2265-2269
    • Coen, D.M.1    Schaffer, P.A.2
  • 12
    • 0010718089 scopus 로고
    • Genetics of acycloguanosine resistance and the thymidine kinase gene in HSV-1
    • Fields, B., Jaenisch, R., Fox, C.F. (Eds.), Academic Press, New York
    • Coen, D.M., Dixon, R.A.F., Rub, S.W., Schaffe, P.A., 1980. Genetics of acycloguanosine resistance and the thymidine kinase gene in HSV-1. In: Fields, B., Jaenisch, R., Fox, C.F. (Eds.), Animal Virus Genetics, Academic Press, New York, pp. 581-590.
    • (1980) Animal Virus Genetics , pp. 581-590
    • Coen, D.M.1    Dixon, R.A.F.2    Rub, S.W.3    Schaffe, P.A.4
  • 13
    • 0020073036 scopus 로고
    • Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine
    • Coen, D.M., Furman, P.A., Gelep, P.T., Schaffer, P.A., 1982. Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine. J. Virol. 41, 909-918.
    • (1982) J. Virol. , vol.41 , pp. 909-918
    • Coen, D.M.1    Furman, P.A.2    Gelep, P.T.3    Schaffer, P.A.4
  • 14
    • 0021969586 scopus 로고
    • Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus
    • Coen, D.M., Fleming, H.E. Jr., Leslie, L.K., Retondo, M.J., 1985. Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus. J. Virol. 53, 477-488.
    • (1985) J. Virol. , vol.53 , pp. 477-488
    • Coen, D.M.1    Fleming H.E., Jr.2    Leslie, L.K.3    Retondo, M.J.4
  • 15
    • 0022995745 scopus 로고
    • A genetic approach to promoter recognition during trans induction of viral gene expression
    • Coen, D.M., Weinheimer, S.P., McKnight, S.L., 1986. A genetic approach to promoter recognition during trans induction of viral gene expression. Science 234, 53-59.
    • (1986) Science , vol.234 , pp. 53-59
    • Coen, D.M.1    Weinheimer, S.P.2    McKnight, S.L.3
  • 16
    • 0024385506 scopus 로고
    • Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir
    • Coen, D.M., Goldstein, D.J., Weller, S.K., 1989a. Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir. Antimicrob. Agents Chemother. 33, 1395-1399.
    • (1989) Antimicrob. Agents Chemother. , vol.33 , pp. 1395-1399
    • Coen, D.M.1    Goldstein, D.J.2    Weller, S.K.3
  • 17
    • 0024603574 scopus 로고
    • Low levels of herpes simplex virus thymidine-thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model
    • Coen, D.M., Irmiere, A.F., Jacobson, J.G., Kerns, K.M., 1989b. Low levels of herpes simplex virus thymidine-thymidylate kinase are not limiting for sensitivity to certain antiviral drugs or for latency in a mouse model. Virology 168, 221-231.
    • (1989) Virology , vol.168 , pp. 221-231
    • Coen, D.M.1    Irmiere, A.F.2    Jacobson, J.G.3    Kerns, K.M.4
  • 19
    • 0024520120 scopus 로고
    • Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir
    • Collins, P., Larder, B.A., Oliver, N.M., Kemp, S., Mith, I.W., DArby, G., 1989. Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir. J. Gen. Virol. 70, 375-382.
    • (1989) J. Gen. Virol. , vol.70 , pp. 375-382
    • Collins, P.1    Larder, B.A.2    Oliver, N.M.3    Kemp, S.4    Mith, I.W.5    Darby, G.6
  • 20
    • 0021278114 scopus 로고
    • Cooperative effects between two acyclovir resistance loci in herpes simplex virus
    • Darby, G., Churcher, M.J., Larder, B.A., 1984. Cooperative effects between two acyclovir resistance loci in herpes simplex virus. J. Virol. 50, 838-846.
    • (1984) J. Virol. , vol.50 , pp. 838-846
    • Darby, G.1    Churcher, M.J.2    Larder, B.A.3
  • 21
    • 0019350295 scopus 로고
    • Altered substrate-specificity of herpes simplex virus thymidine kinase confers acyclovir resistance
    • Darby, G., Field, H.J., Salisbury, S.A., 1981. Altered substrate-specificity of herpes simplex virus thymidine kinase confers acyclovir resistance. Nature (Lond.) 289, 81-83.
    • (1981) Nature (Lond.) , vol.289 , pp. 81-83
    • Darby, G.1    Field, H.J.2    Salisbury, S.A.3
  • 22
    • 0023860849 scopus 로고
    • Evidence that the gene for herpes simplex virus type 1 DNA polymerase accounts for the capacity of an intertypic recombinant to spread from eye to central nervous system
    • Day, S.P., Lausch, R.N., Oakes, J.E., 1988. Evidence that the gene for herpes simplex virus type 1 DNA polymerase accounts for the capacity of an intertypic recombinant to spread from eye to central nervous system. Virology 163, 166-173.
    • (1988) Virology , vol.163 , pp. 166-173
    • Day, S.P.1    Lausch, R.N.2    Oakes, J.E.3
  • 23
    • 0020360826 scopus 로고
    • Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid
    • Derse, D., Bastow, K.F., Cheng, Y., 1982. Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid. J. Biol. Chem. 257, 10251-10260.
    • (1982) J. Biol. Chem. , vol.257 , pp. 10251-10260
    • Derse, D.1    Bastow, K.F.2    Cheng, Y.3
  • 24
    • 0024598849 scopus 로고
    • The role of herpes simplex virus type 1 thymidine kinase in pathogenesis
    • Efstathiou, S., Kemp, S., Darby, G., Minson, A.C., 1989. The role of herpes simplex virus type 1 thymidine kinase in pathogenesis. J. Gen. Virol. 70, 869-879.
    • (1989) J. Gen. Virol. , vol.70 , pp. 869-879
    • Efstathiou, S.1    Kemp, S.2    Darby, G.3    Minson, A.C.4
  • 26
    • 0028905944 scopus 로고
    • A comparative study of the in vitro and in vivo antiviral activities of aciclovir and penciclovir
    • Ertl, P., Snowden, W., Lowe, D., Miller, W., Littler, E., 1995. A comparative study of the in vitro and in vivo antiviral activities of aciclovir and penciclovir. Antiviral Chem. Chemother. 6, 89-97.
    • (1995) Antiviral Chem. Chemother. , vol.6 , pp. 89-97
    • Ertl, P.1    Snowden, W.2    Lowe, D.3    Miller, W.4    Littler, E.5
  • 27
    • 0022533838 scopus 로고
    • Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene
    • Field, H.J., Coen, D.M., 1986. Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene. J. Virol. 60, 286-288.
    • (1986) J. Virol. , vol.60 , pp. 286-288
    • Field, H.J.1    Coen, D.M.2
  • 28
    • 0018834367 scopus 로고
    • Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo
    • Field, H.J., Darby, G., 1980. Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo. Antimicrob. Agents Chemother. 17, 209-216.
    • (1980) Antimicrob. Agents Chemother. , vol.17 , pp. 209-216
    • Field, H.J.1    Darby, G.2
  • 29
    • 0018141515 scopus 로고
    • The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice
    • Field, H.J., Wildy, P., 1978. The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice. J. Hyg. 81, 267-277.
    • (1978) J. Hyg. , vol.81 , pp. 267-277
    • Field, H.J.1    Wildy, P.2
  • 30
    • 0003115412 scopus 로고
    • Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition
    • Gibbs, J.S., Chiou, H.C., Bastow, K.F., Cheng, Y.C., Coen, D.M., 1988. Identification of amino acids in herpes simplex virus DNA polymerase involved in substrate and drug recognition. Proc. Natl. Acad. Sci. USA 85, 6672-6676.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 6672-6676
    • Gibbs, J.S.1    Chiou, H.C.2    Bastow, K.F.3    Cheng, Y.C.4    Coen, D.M.5
  • 31
    • 0022379386 scopus 로고
    • Utilization of internal AUG codons for initiation of protein synthesis directed by mRNAs from normal and mutant genes encoding herpes simplex virus-specified thymidine kinase
    • Haarr, L., Marsden, H.S., Preston, C.M., Smiley, J.R., Summers, W.C., Summers, W.P., 1985. Utilization of internal AUG codons for initiation of protein synthesis directed by mRNAs from normal and mutant genes encoding herpes simplex virus-specified thymidine kinase. J. Virol. 56, 512-519.
    • (1985) J. Virol. , vol.56 , pp. 512-519
    • Haarr, L.1    Marsden, H.S.2    Preston, C.M.3    Smiley, J.R.4    Summers, W.C.5    Summers, W.P.6
  • 33
    • 0024551693 scopus 로고
    • Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability
    • Irmiere, A.F., Manos, M.M., Jacobson, J.G., Gibbs, J.S., Coen, D.M., 1989. Effect of an amber mutation in the herpes simplex virus thymidine kinase gene on polypeptide synthesis and stability. Virology 168, 210-220.
    • (1989) Virology , vol.168 , pp. 210-220
    • Irmiere, A.F.1    Manos, M.M.2    Jacobson, J.G.3    Gibbs, J.S.4    Coen, D.M.5
  • 34
    • 0028814472 scopus 로고
    • Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase
    • Jacobson, J., Kramer, M., Rozenberg, F., Hu, A., Coen, D.M., 1995. Synergistic effects on ganglionic herpes simplex virus infections by mutations or drugs that inhibit the viral polymerase and thymidine kinase. Virology 206, 263-268.
    • (1995) Virology , vol.206 , pp. 263-268
    • Jacobson, J.1    Kramer, M.2    Rozenberg, F.3    Hu, A.4    Coen, D.M.5
  • 36
    • 0016800481 scopus 로고
    • Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice
    • Klein, R.J., Friedman-Kien, A.E., 1975. Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice. Antimicrob. Agents Chemother. 7, 289-293.
    • (1975) Antimicrob. Agents Chemother. , vol.7 , pp. 289-293
    • Klein, R.J.1    Friedman-Kien, A.E.2
  • 37
    • 0019802360 scopus 로고
    • Pathogenesis of experimental skin infections induced by drug resistant herpes simplex virus mutants
    • Klein, R.J., Friedman-Kien, A.E., DeStefano, E., 1981. Pathogenesis of experimental skin infections induced by drug resistant herpes simplex virus mutants. Infect. Immun. 34, 693-701.
    • (1981) Infect. Immun. , vol.34 , pp. 693-701
    • Klein, R.J.1    Friedman-Kien, A.E.2    DeStefano, E.3
  • 38
    • 0027362888 scopus 로고
    • Brief report: Recurrent acyclovir-resistant genital herpes in an immunocompetent patient
    • Kost, R.G., Hill, E.G., Tigges, M., Straus, S.E., 1993. Brief report: recurrent acyclovir-resistant genital herpes in an immunocompetent patient. N. Engl. J. Med. 329, 1777-1782.
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1777-1782
    • Kost, R.G.1    Hill, E.G.2    Tigges, M.3    Straus, S.E.4
  • 39
    • 0021223581 scopus 로고
    • Virus drug-resistance: Mechanisms and consequences
    • Larder, B.A., Darby, G., 1984. Virus drug-resistance: mechanisms and consequences. Antiviral Res. 4, 1-42.
    • (1984) Antiviral Res. , vol.4 , pp. 1-42
    • Larder, B.A.1    Darby, G.2
  • 40
    • 0022271262 scopus 로고
    • Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities
    • Larder, B.A., Darby, G., 1985. Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities. Virology 146, 262-271.
    • (1985) Virology , vol.146 , pp. 262-271
    • Larder, B.A.1    Darby, G.2
  • 41
    • 0023081808 scopus 로고
    • Related functional domains in virus DNA polymerases
    • Larder, B.A., Kemp, S.D., Darby, G., 1987. Related functional domains in virus DNA polymerases. EMBO J. 6, 169-175.
    • (1987) EMBO J. , vol.6 , pp. 169-175
    • Larder, B.A.1    Kemp, S.D.2    Darby, G.3
  • 42
    • 0023007492 scopus 로고
    • Restoration of wild-type pathogenicity to an attenuated DNA polymerase mutant of herpes simplex virus type 1
    • Larder, B.A., Lisle, J.J., Darby, G., 1986. Restoration of wild-type pathogenicity to an attenuated DNA polymerase mutant of herpes simplex virus type 1. J. Gen. Virol. 67, 2501-2506.
    • (1986) J. Gen. Virol. , vol.67 , pp. 2501-2506
    • Larder, B.A.1    Lisle, J.J.2    Darby, G.3
  • 43
    • 0025287194 scopus 로고
    • Nucleotide sequences responsible for the inability of a herpes simplex virus type 2 strain to grow in human lymphocytes are identical to those responsible for its inability to grow in mouse tissues following ocular infection
    • Lausch, R.N., Yeung, K.C., Miller, J.Z., Oakes, J.E., 1990. Nucleotide sequences responsible for the inability of a herpes simplex virus type 2 strain to grow in human lymphocytes are identical to those responsible for its inability to grow in mouse tissues following ocular infection. Virology 176, 319-328.
    • (1990) Virology , vol.176 , pp. 319-328
    • Lausch, R.N.1    Yeung, K.C.2    Miller, J.Z.3    Oakes, J.E.4
  • 44
    • 0024537137 scopus 로고
    • Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency
    • Leib, D.A., Coen, D.M., Bogard, C.L., Hicks, K.A., Yager, D.R., Knipe, D.M., Tyler, K.L., Schaffer, P.A., 1989. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. J. Virol. 63, 759-768.
    • (1989) J. Virol. , vol.63 , pp. 759-768
    • Leib, D.A.1    Coen, D.M.2    Bogard, C.L.3    Hicks, K.A.4    Yager, D.R.5    Knipe, D.M.6    Tyler, K.L.7    Schaffer, P.A.8
  • 45
    • 0026074395 scopus 로고
    • The promoter of the latency-associated transcripts of the herpes simplex virus type 1 contains a functional cAMP-raponse element: Role of the latency-associated transcripts and cAMP in reactivation of viral latency
    • Leib, D.A., Nadeau, K.C., Rundle, S.A., Schaffer, P.A., 1991. The promoter of the latency-associated transcripts of the herpes simplex virus type 1 contains a functional cAMP-raponse element: role of the latency-associated transcripts and cAMP in reactivation of viral latency. Proc. Natl. Acad. Sci. USA 88, 48-52.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 48-52
    • Leib, D.A.1    Nadeau, K.C.2    Rundle, S.A.3    Schaffer, P.A.4
  • 47
    • 0025241595 scopus 로고
    • Engineered herpes simplex virus DNA polymerase point mutants: The most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition
    • Marcy, A.I., Hwang, C.B., Ruffner, K.L., Coen, D.M., 1990. Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition. J. Virol. 64, 5883-5890.
    • (1990) J. Virol. , vol.64 , pp. 5883-5890
    • Marcy, A.I.1    Hwang, C.B.2    Ruffner, K.L.3    Coen, D.M.4
  • 48
    • 0025864440 scopus 로고
    • Experimental therapy of human glioma by means of a genetically engineered virus mutant
    • Martuza, R.L., Malick, A., Markert, J.M., Ruffner, K.L., Coen, D.M., 1991. Experimental therapy of human glioma by means of a genetically engineered virus mutant. Science 252, 854-856.
    • (1991) Science , vol.252 , pp. 854-856
    • Martuza, R.L.1    Malick, A.2    Markert, J.M.3    Ruffner, K.L.4    Coen, D.M.5
  • 49
    • 0026329741 scopus 로고
    • Herpes simplex virus isolates from an immunocompromised patient who failed to respond to acyclovir treatment express thymidine kinase with altered substrate specificity
    • Nugier, F., Collins, P., Larder, B.A., Langlois, M., Aymard, M., Darby, G., 1991. Herpes simplex virus isolates from an immunocompromised patient who failed to respond to acyclovir treatment express thymidine kinase with altered substrate specificity. Antiviral Chem. Chemother. 2, 295-302.
    • (1991) Antiviral Chem. Chemother. , vol.2 , pp. 295-302
    • Nugier, F.1    Collins, P.2    Larder, B.A.3    Langlois, M.4    Aymard, M.5    Darby, G.6
  • 50
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • Reed, J.H., Muench, H., 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27, 493-497.
    • (1938) Am. J. Hyg. , vol.27 , pp. 493-497
    • Reed, J.H.1    Muench, H.2
  • 51
    • 0002609154 scopus 로고    scopus 로고
    • Herpes simplex virus and varicella zoster virus: Nucleosides and foscarnet. Clinical aspects
    • Richman, D.D. (Ed), Wiley, Chichester
    • Safrin, S., 1996. Herpes simplex virus and varicella zoster virus: nucleosides and foscarnet. Clinical aspects. In: Richman, D.D. (Ed), Antiviral Drug Resistance, Wiley, Chichester, pp. 103-122.
    • (1996) Antiviral Drug Resistance , pp. 103-122
    • Safrin, S.1
  • 52
    • 0028214014 scopus 로고
    • Correlation between response to acyclovir and foscarnet therapy and in vitro susceptibility result for isolates of herpes simplex virus from human immunodeficiency virus-infected patients
    • Safrin, S., Elbeik, T., Phan, L., Robinson, D., Rush, J., Elbaggari, A., Mills, J., 1994a. Correlation between response to acyclovir and foscarnet therapy and in vitro susceptibility result for isolates of herpes simplex virus from human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 38, 1246-1250.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 1246-1250
    • Safrin, S.1    Elbeik, T.2    Phan, L.3    Robinson, D.4    Rush, J.5    Elbaggari, A.6    Mills, J.7
  • 55
    • 0000337275 scopus 로고
    • Relationships between the envelope and the infectivity of herpes simplex virus
    • Smith, K.O., 1964. Relationships between the envelope and the infectivity of herpes simplex virus. Proc. Soc. Exp. Biol. Med. 115, 814-816.
    • (1964) Proc. Soc. Exp. Biol. Med. , vol.115 , pp. 814-816
    • Smith, K.O.1
  • 56
    • 0024470257 scopus 로고
    • Human herpesviruses: A consideration of the latent state
    • Stevens, J.G., 1989. Human herpesviruses: a consideration of the latent state. Microbiol. Rev. 53, 318-332.
    • (1989) Microbiol. Rev. , vol.53 , pp. 318-332
    • Stevens, J.G.1
  • 57
    • 0020638764 scopus 로고
    • Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes
    • Summers, W.P., Summers, W.C., Laski, F.A., RajBhandary, U.L., Sharp, P.A., 1983. Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes. J. Virol. 47, 376-379.
    • (1983) J. Virol. , vol.47 , pp. 376-379
    • Summers, W.P.1    Summers, W.C.2    Laski, F.A.3    RajBhandary, U.L.4    Sharp, P.A.5
  • 58
    • 0028822213 scopus 로고
    • Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2
    • Suzutani, T., Koyano, S., Takada, M., Yoshida, I., Azuma, M., 1995. Analysis of the relationship between cellular thymidine kinase activity and virulence of thymidine kinase-negative herpes simplex virus types 1 and 2. Microbiol. Immunol. 39, 787-794.
    • (1995) Microbiol. Immunol. , vol.39 , pp. 787-794
    • Suzutani, T.1    Koyano, S.2    Takada, M.3    Yoshida, I.4    Azuma, M.5
  • 59
    • 0020625176 scopus 로고
    • Intracerebral inoculation of newborn and adult mice with thymidine kinase-deficient mutants of herpes simplex virus type 1
    • Tenser, R.B., 1983. Intracerebral inoculation of newborn and adult mice with thymidine kinase-deficient mutants of herpes simplex virus type 1. J. Infect. Dis. 147, 956.
    • (1983) J. Infect. Dis. , vol.147 , pp. 956
    • Tenser, R.B.1
  • 60
    • 0021038440 scopus 로고
    • Genetic analysis of temperature-sensitive mutants of HSV-1: The combined use of complementation and physical mapping for cistron assignment
    • Weller, S.K., Aschman, D.P., Sacks, W.R., Coen, D.M., Schaffer, P.A., 1983. Genetic analysis of temperature-sensitive mutants of HSV-1: the combined use of complementation and physical mapping for cistron assignment. Virology 130, 290-305.
    • (1983) Virology , vol.130 , pp. 290-305
    • Weller, S.K.1    Aschman, D.P.2    Sacks, W.R.3    Coen, D.M.4    Schaffer, P.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.