메뉴 건너뛰기




Volumn 17, Issue 14, 2007, Pages 3992-3996

Novel heterocyclic thyromimetics. Part 2

Author keywords

Benzofuranes; Thiazinane 2,4 dione; Thyromimetics

Indexed keywords

3,5 DIBROMO 3' (2,3 DIHYDRO 3 OXO 6 PYRIDAZINYLMETHYL)THYRONINE; BENZOFURAN DERIVATIVE; HETEROCYCLIC COMPOUND; KB 141; THYROID HORMONE RECEPTOR; THYROMIMETIC AGENT; UNCLASSIFIED DRUG;

EID: 34250311979     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.085     Document Type: Article
Times cited : (7)

References (28)
  • 23
    • 34250336181 scopus 로고    scopus 로고
    • Li, Y. L.; Liu, Y.; Hedfors, A.; Malm, J.; Mellin, C.; Zhang, M., WO9900353; Chem. Abstr. 1999, 130, 110054.
  • 27
    • 34250314181 scopus 로고    scopus 로고
    • note
    • NMRI mice (8-10 animals per group) were orally treated once daily by gavage (vehicle: solutol/ethanol/water 10:10:80) with doses of 0.1, 0.3, 1.0 and 3.0 mg/kg with the ethyl ester of compound 21 over a period of 7 days. At the end of the study blood was retroorbitally collected and serum cholesterol and triglyceride concentration levels were enzymatically determined using commercially available test kits (Boehringer Mannheim, Germany) and an autoanalyzer (EPOS 5060, Eppendorf Gerätebau, Hamburg, Germany). Serum cholesterol reductions of 32%, 34%, 39% and 41% versus control were determined.
  • 28
    • 34250323164 scopus 로고    scopus 로고
    • note
    • C57BL/6J mice (10-12 animals per group) were orally treated once daily by gavage (vehicle: solutol/ethanol/water 10:10:80) with doses of 0.1, 0.3 and 3.0 mg/kg with the ethyl ester of compound 21 over a period of 11 days. At the end of the study heart rate was determined using a computerized non-invasive tail cuff system (TSE Systems GmbH, Bad Homburg, Germany). Animals were sacrificed and heart weight was determined. Increases in heart weight of 12%, 17% and 27% were determined, respectively.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.