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note
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NMRI mice (8-10 animals per group) were orally treated once daily by gavage (vehicle: solutol/ethanol/water 10:10:80) with doses of 0.1, 0.3, 1.0 and 3.0 mg/kg with the ethyl ester of compound 21 over a period of 7 days. At the end of the study blood was retroorbitally collected and serum cholesterol and triglyceride concentration levels were enzymatically determined using commercially available test kits (Boehringer Mannheim, Germany) and an autoanalyzer (EPOS 5060, Eppendorf Gerätebau, Hamburg, Germany). Serum cholesterol reductions of 32%, 34%, 39% and 41% versus control were determined.
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C57BL/6J mice (10-12 animals per group) were orally treated once daily by gavage (vehicle: solutol/ethanol/water 10:10:80) with doses of 0.1, 0.3 and 3.0 mg/kg with the ethyl ester of compound 21 over a period of 11 days. At the end of the study heart rate was determined using a computerized non-invasive tail cuff system (TSE Systems GmbH, Bad Homburg, Germany). Animals were sacrificed and heart weight was determined. Increases in heart weight of 12%, 17% and 27% were determined, respectively.
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