Design and synthesis of complementing ligands for mutant thyroid hormone receptor TRβ(R320H): A tailor-made approach toward the treatment of resistance to thyroid hormone

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 11, 2005, Pages 3627-3639

  Hashimoto, Atsushi ^a   Shi, Youheng ^a   Drake, Katherine ^a   Koh, John T ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

Molecular complementation; Molecular rescue; Resistance to thyroid hormone; RTH; Thyroid hormone receptor

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 4 [2,6 DIMETHYL 4 (1H TETRAZOL 5 YL)BENZYL] 2 ISOPROPYLPHENOL; 4 [2,6 DIMETHYL 4 (1H TETRAZOL 5 YLMETHOXY)BENZYL] 2 ISOPROPYLPHENOL; 4 [2,6 DIMETHYL 4 (1H TETRAZOL 5 YLMETHY)BENZYL] 2 ISOPROPYLPHENOL; 5 [4 (4 HYDROXY 3 ISOPROPYLBENZYL) 3,5 DIMETHYLBENZYLIDENE]THIAZOLIDINE 2,4 DIONE; 5 [4 (4 HYDROXY 3 ISOPROPYLBENZYL) 3,5 DIMETHYLBENZYL] 3 METHYLTHIAZOLIDINE 2,4 DIONE; 5 [4 (4 HYDROXY 3 ISOPROPYLBENZYL) 3,5 DIMETHYLBENZYL]THIAZOLIDINE 2,4 DIONE; LIGAND; MUTANT PROTEIN; TETRAZOLE DERIVATIVE; THYROID HORMONE; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR BETA; THYROMIMETIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HOMEOSTASIS; HORMONE ACTION; HUMAN; HUMAN CELL; THYROID HORMONE RESISTANCE; WILD TYPE;

EID: 18144428778     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.03.040     Document Type: Article

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