L-Arginine plus atorvastatin for prevention of atheroma formation in genetically hypercolesterolaemic rabbits

British Journal of Nutrition

Volumn 97, Issue 6, 2007, Pages 1083-1089

  Rasmusen, Carole ^a   Moinard, Christophe ^a   Martin, Chantal ^a   Tricottet, Viviane ^a,b   Cynober, Luc ^a,c   Couderc, Rémy ^a,d  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HÔPITAL PAUL BROUSSE   (France)

^c HÔTEL DIEU   (France)

^d ARMAND TROUSSEAU HOSPITAL   (France)

Author keywords

Atherosclerosis; L Arginine; Nitric oxide; Statins

Indexed keywords

ARGININE; ATORVASTATIN; NITRATE; NITRITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROMA; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; MACRONUTRIENT; MALE; NONHUMAN; RABBIT; TRANSGENIC ANIMAL; TREATMENT RESPONSE;

ANIMALS; ARGININE; ATHEROSCLEROSIS; CHOLESTEROL; COMBINED MODALITY THERAPY; DIETARY SUPPLEMENTS; EATING; FEMALE; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; MALE; NITRIC OXIDE; PYRROLES; RABBITS;

ORYCTOLAGUS CUNICULUS;

EID: 34250307095     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507659066     Document Type: Article

References (49)

1. Adams MR, McCredie R, Jessup W, Robinson J, Sullivan D & Celermajer DS (1997) Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease. Atherosclerosis 129, 261-269.
2. Aliev G & Burnstock G (1998) Watanabe rabbits with heritable hypercholesterolaemia: A model of atherosclerosis. Histol Histopathol 13, 797-817.
3. Allain CC, Poon LS, Chan CS, Richmond W & Fu PC (1974) Enzymatic determination of total serum cholesterol. Clin Chem 20, 470-475.
4. Boger RH, Bode-Boger SM, Brandes RP, Phivthong-ngam L, Bohme M, Nafe R, Mugge A & Frolich JC (1997) Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: Comparison with lovastatin. Circulation 96, 1282-1290.
5. Boger RH, Bode-Boger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF & Cooke JP (1998) Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction: Its role in hypercholesterolemia. Circulation 98, 1842-1847.
6. Brandes RP, Brandes S, Boger RH, Bode-Boger SM & Mugge A (2000) L-Arginine supplementation in hypercholesterolemic rabbits normalizes leukocyte adhesion to non-endothelial matrix. Life Sci 66, 1519-1524.
7. Clubb FJ, Cerny JL, Deferrari DA, Butler-Aucoin MM, Willerson JT & Buja LM (2001) Development of atherosclerotic plaque with endothelial disruption in Watanabe heritable hyperlipidemic rabbit aortas. Cardiovasc Pathol 10, 1-11.
8. Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA & Billingham ME (1992) Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest 90, 1168-1172.
9. Cynober L, Le Boucher J & Vasson MP (1995) Arginine metabolism in mammals. J Nutr Biochem 6, 402-413.
10. Dejam A, Hunter CJ, Schechter AN & Gladwin MT (2004) Emerging role of nitrite in human biology. Blood Cells Mol Dis 32, 423-429.
11. Dichtl W, Dulak J, Frick M, Alber HF, Schwarzacher SP, Ares MP, Nilsson J, Pachinger O & Weidinger F (2003) HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 23 58-63.
12. Dowell FJ, Hamilton CA, Lindop GB & Reid JL (1995) Development and progression of atherosclerosis in aorta from heterozygous and homozygous WHHL rabbits. Effects of simvastatin treatment. Arterioscler Thromb Vasc Biol 15, 1152-1160.
13. Dujovne CA (1997) New lipid lowering drugs and new effocts of old drugs. Curr Opin Lipidol 8, 362-369.
14. Endres M (2006) Statins: Potential new indications in inflammatory conditions. Atheroscler Suppl 7, 31-35.
15. Feron O, Dessy C, Desager JP & Balligand JL (2001) Hydroxymethylglutaryl-coenzyme A reductase inhibition promotes endothelial nitric oxide synthase activation through a decrease in caveolin abundance. Circulation 103, 113-118.
16. Gornik HL & Creager MA (2004) Arginine and endothelial and vascular health. J Nutr 134, 2880S-2887S.
17. Gresser U & Gathof BS (2004) Atorvastatin: Gold standard for prophylaxis of myocardial ischemia and stroke - comparison of the clinical benefit of statins on the basis of randomized controlled endpoint studies. Eur J Med Res 9, 1-17.
18. Hayashi T, Esaki T, Sumi D, Mukherjee T, Iguchi A & Chaudhuri G (2006 a) Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism. Proc Natl Acad Sci U S A 103, 10485-10490.
19. Hayashi T, Juliet PA, Matsui-Hirai H, Miyazaki A, Fukatsu A, Funami J, Iguchi A & Ignarro LJ (2005) L-Citrulline and L-arginine supplementation retards the progression of high-cholesterol-diet-induced atherosclerosis in rabbits. Proc Natl Acad Sci U S A 102, 13681-13686.
20. Hayashi T, Matsui-Hirai H, Fukatsu A, Sumi D, Kano-Hayashi H, Rani PJ & Iguchi A (2006b) Selective iNOS inhibitor, ONO1714 successfully retards the development of high-cholesterol diet induced atherosclerosis by novel mechanism 1. Atherosclerosis 187, 316-324.
21. Kalinowski L, Dobrucki LW, Brovkovych V & Malinski T (2002) Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin. Circulation 105, 933-938.
22. Kleinbongard P, Dejam A, Lauer T, et al. (2003) Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med 35, 790-796.
23. Kroon AA, Stalenhoef AF, Buikema H, Demacker PN, de Wilde PC, Leijten PA & van Gilst WH (1993) The effect of cholesterol reduction on the endothelial function and progression of atherosclerosis in WHHL rabbits. Atherosclerosis 103, 221-230.
24. Laufs U, La Fata V, Plutzky J & Liao JK (1998) Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 97, 1129-1135.
25. Leong HX, Simkevich C, Lesieur-Brooks A, Lau BW, Fugere C, Sabo E & Thompson NL (2006) Short-term arginine deprivation results in large-scale modulation of hepatic gene expression in both normal and tumor cells: Microarray bioinformatic analysis. Nutr Metab 3 37-50.
26. Loscalzo J (2003) Adverse effects of supplemental L-arginine in atherosclerosis: Consequences of methylation stress in a complex catabolism? Arterioscler Thromb Vasc Biol 23, 3-5.
27. Maeso R, Aragoncillo P, Navarro-Cid J, Ruilope LM, Diaz C, Hernandez G, Lahera V & Cachofeiro V (2000) Effect of atorvastatin on endothelium-dependent constrictor factors in dyslipidemic rabbits. Gen Pharmacol 34, 263-272.
28. Matthys KE & Bult H (1997) Nitric oxide function in atherosclerosis. Mediators Inflammation 6, 3-21.
29. Ming XF, Barandier C, Viswambharan H, et al. (2004) Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: Implications for atherosclerotic endothelial dysfunction. Circulation 110, 3708-3714.
30. Miyoshi T, Li Y. Shih DM, Wang X, Laubach VE, Matsumoto AH, Helm GA, Lusis AJ & Shi W (2006) Deficiency of inducible No synthase reduces advanced but not early atherosclerosis in apolipo-protein E-deficient mice. Life Sci 79, 525-531.
31. Napoli C, De Nigris F, Williams-Ignarro S, Pignalosa O, Sica V & Ignarro LJ (2006) Nitric oxide and atherosclerosis: An update. Nitric Oxide 15, 265-279.
32. Neveux N, David P & Cynober L (2004) Measurement of amino acid concentrations in biological fluids using ion exchange chromatography. In Metabolic and Therapeutic Aspects of Amino Acids in Clinical Nutrition, 2nd edition, pp. 17-28 [L Cynober, editor]. Boca Raton, FL: CRC Press.
33. Nieuw Amerongen GP, Vermeer MA, Negre-Aminou P, Lankelma J, Emeis JJ & van Hinsbergh VW (2000) Simvastatin improves disturbed endothelial barrier function. Circulation 102, 2803-2809.
34. Ochoa JB, Bernard AC, Mistry SK, Morris SM Jr, Figert PL, Maley ME, Tsuei BJ, Boulanger BR & Kearney PA (2000) Trauma increases extrahepatic arginase activity. Surgery 127, 419-426.
35. Ozaki M, Kawashima S, Yamashita T, Hirase T, Namiki M, Inoue N, Hirata K, Yasui H, Sakurai H, Yoshida Y, Masada M & Yokoyama M (2002) Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. J Clin Invest 110, 331-340.
36. Pereira EC, Bertolami MC, Faludi AA, Salem M, Bersch D & Abdalla DS (2003) Effects of simvastatin and 1-arginine on vasodilation, nitric oxide metabolites and endogenous NOS inhibitors in hypercholesterolemic subjects. Free Radic Res 37, 529-536.
37. Preli RB, Klein KP & Herrington DM (2002) Vascular effects of dietary L-arginine supplementation. Atherosclerosis 162, 1-15.
38. Ricart-Jane D, Llobera M & Lopez-Tejero MD (2002) Anticoagulants and other preanalytical factors interfere in plasma nitrite/nitrite quantification by the Griess method. Nitric Oxide 6, 178-185.
39. Schulman SP, Becker LC, Kass DA, et al. (2006) L-Arginine therapy in acute myocardial infarction: The Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 295, 58-64.
40. Siasos G, Tousoulis D, Antoniades C, Stefanadi E & Stefanadis C (2007) L-Arginine, the substrate for NO synthesis: An alternative treatment for premature atherosclerosis? Int J Cardiol 116, 300-308.
41. Singer AH, Tsao PS, Wang BY, Bloch DA & Cooke JP (1995) Discordant effects of dietary 1-arginine on vascular structure and reactivity in hypercholesterolemic rabbits. J Cardiovasc Pharmacol 25, 710-716.
42. Soeters PB, Hallemeesch MM, Bruins MJ, van Eijk HM & Deutz NE (2002) Quantitative in vivo assessment of arginine utilization and nitric oxide production in endotoxemia. Am J Surg 183, 480-488.
43. Takemoto M & Liao JK (2001) Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 21, 1712-1719.
44. Tedgui A & Mallat Z (1999) Atherosclerotic plaque formation (article in French). Rev Prat 49, 2081-2086.
45. Thakur NK, Hayashi T, Sumi D, Kano H, Tsunekawa T & Iguchi A (2001) HMG-CoA reductase inhibitor stabilizes rabbit atheroma by increasing basal NO and decreasing superoxide. Am J Physiol 281, H75-H83.
46. Vaughan CJ, Murphy MB & Buckley BM (1996) Statins do more than just lower cholesterol. Lancet 348, 1079-1082.
47. Weber C. Erl W, Weber KS & Weber PC (1999) Effects of oxidized low-density lipoprotein, lipid mediators and statins on vascular cell interactions. Clin Chem Lab Med 37, 243-251.
48. Wu G & Meininger CJ (2000) Arginine nutrition and cardiovascular function. J Nutr 130, 2626-2629.
49. Yang Z & Ming XF (2006) Recent advances in understanding endothelial dysfunction in atherosclerosis. Clin Med Res 4, 53-65.