The Crystal Structure of Human Cytosolic β-Glucosidase Unravels the Substrate Aglycone Specificity of a Family 1 Glycoside Hydrolase

Journal of Molecular Biology

Volumn 370, Issue 5, 2007, Pages 964-975

  Tribolo, Sandra ^a   Berrin, Jean Guy ^b   Kroon, Paul A ^a   Czjzek, Mirjam ^c   Juge, Nathalie ^a,b  

^a NORWICH RESEARCH PARK   (United Kingdom)

^b AIX MARSEILLE UNIVERSITY   (France)

^c CNRS   (France)

Author keywords

aglycone specificity; crystal structure; flavonoid glycosides; human glucosidase; site directed mutagenesis

Indexed keywords

ACID; AGLYCONE; BASE; BETA GLUCOSIDASE; GLYCOSIDASE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOSOL; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STRUCTURE; HYDROPHOBICITY; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

EID: 34250210786     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.05.034     Document Type: Article

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