Gene therapy in peripheral nerve reconstruction approaches

Current Gene Therapy

Volumn 7, Issue 3, 2007, Pages 221-228

  Haastert, Kirsten ^a,b   Grothe, Claudia ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

Cell transplantation; Gene transfer; Neurotrophic growth factor therapy; Peripheral nerve regeneration across long gaps; Tissue engineering

Indexed keywords

ADENOVIRUS VECTOR; BETA GALACTOSIDASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; COMPLEMENTARY DNA; FIBROBLAST GROWTH FACTOR 2; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LUCIFERASE; NEUROTROPHIC FACTOR; PARVOVIRUS VECTOR; PLASMID DNA; RETROVIRUS VECTOR; SIALYLTRANSFERASE; SIALYLTRANSFERASE X; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA2; UNCLASSIFIED DRUG;

CELL ISOLATION; CELL TRANSPLANTATION; DISEASE SEVERITY; DNA MODIFICATION; DNA VECTOR; EX VIVO STUDY; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MONOCYTE; MOTONEURON; NERVE DEGENERATION; NERVE FIBER REGENERATION; NERVE GRAFT; NERVE REGENERATION; NERVE TRANSPLANTATION; NEUROSURGERY; NONVIRAL GENE DELIVERY SYSTEM; PERIPHERAL NERVE INJURY; REVIEW; SCHWANN CELL; SENSORY NERVE CELL; SOMATIC GENE THERAPY; TISSUE ENGINEERING; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; GENE THERAPY; GENETIC VECTORS; HUMANS; NERVE GROWTH FACTORS; NERVE REGENERATION; PERIPHERAL NERVES; TISSUE ENGINEERING;

EID: 34250192241     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652307780859035     Document Type: Review

References (47)

1. Aebischer, P., Salessiotis, A.N. and Winn S.R. (1989) Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps. J. Neurosci. Res., 23: 282-289.
2. Araki, K., Shiotani, A., Watabe, K., Saito, K., Moro, K. and Ogawa, K. (2006) Adenoviral GDNF gene transfer enhances neurofunctional recovery after recurrent laryngeal nerve injury. Gene Ther., 13: 296-303.
3. Barati, S., Hurtado, P.R., Zhang, SH., Tinsley, R., Ferguson, I.A. and Rush, R.A. (2006) GDNF gene delivery via the p75(NTR) receptor rescues injured motor neurons. Exp. Neurol., 202: 179-188.
4. Blomer, U., Gruh, I., Witschel, H., Haverich, A. and Martin, U. (2005) Shuttle of lentiviral vectors via transplanted cells in vivo. Gene Ther., 12: 67-74.
5. Bunge, R.P. (1993) Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration. Curr. Opin. Neurobiol., 3: 805-809.
6. Evans, G.R. (2001) Peripheral nerve injury: a review and approach to tissue engineered constructs. Anat. Rec., 263: 396-404.
7. Fine, E.G., Decosterd, I., Papaloizos, M., Zurn, A.D. and Aebischer, P. (2002) GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap. Eur. J. Neurosci., 15: 589-601.
8. Fink, D.J., DeLuca, N.A., Goins, W.F. and Glorioso, J.C. (1996) Gene transfer to neurons using herpes simplex virus-based vectors. Annu. Rev., Neurosc., 19: 265-287.
9. Flores, A.J., Lavernia, C.J. and Owens, P.W. (2000) Anatomy and physiology of peripheral nerve injury and repair. Am. J. Orthop., 29: 167-173.
10. Frostick, S.P., Yin, Q. and Kemp, G.J. (1998) Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurgery, 18: 397-405.
11. Fu, S.Y. and Gordon, T. (1997) The cellular and molecular basis of peripheral nerve regeneration. Mol. Neurobiol., 14: 67-116.
12. Fujimoto, E., Mizoguchi, A., Hanada, K., Yajima, M. and Ide, C. (1997) Basic fibroblast growth factor promotes extension of regenerating axons of peripheral nerve. In vivo experiments using a Schwann cell basal lamina tube model. J. Neurocytol., 26: 511-528.
13. Gardlik, R., Palffy, R., Hodosy, J., Lukacs, J., Turna, J. and Celec, P. (2005) Vectors and delivery systems in gene therapy. Med. Sci. Monit., 11: RA110-121.
14. Glatzel, M., Flechsig, E., Navarro, B., Klein, M.A., Paterna, J.C., Bueler, H. and Aguzzi, A. (2000) Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system. Proc. Natl. Acad. Sci., U S A, 97: 442-447.
15. Gravvanis, A.I., Lavdas, A., Papalois, A.E., Franceschini, I., Tsoutsos, D.A., Dubois-Dalcq, M., Matsas, R. and Ioannovich, J.D. (2005) Effect of genetically modified Schwann cells with increased motility in end-to-side nerve grafting. Microsurgery, 25: 423-432.
16. Grothe, C., Haastert, K. and Jungnickel, J. (2006) Physiological function and putative therapeutic impact of the FGF-2 system in peripheral nerve regeneration-Lessons from in vivo studies in mice and rats. Brain Res. Brain Res. Rev., 51: 293-299.
17. Haastert, K., Lipokatic, E., Fischer, M., Timmer, M. and Grothe, C. (2006a) Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms. Neurobiol. Dis., 21: 138-153.
18. Haastert, K., Mauritz, C., Chaturvedi, S. and Grothe, C. (2007) Human and Rat adult Schwann cell cultures - fast and efficient enrichment plus highly effective non-viral transfection protocol. Nat. Protoc., 2: 99-104.
19. Haastert, K., Mauritz, C., Matthies, C. and Grothe, C. (2006b) Autologous adult human Schwann cells genetically modified to provide alternative cellular transplants in peripheral nerve regeneration. J. Neurosurg., 104: 778-786.
20. Haile, Y., Haastert, K., Cesnulevicius, K., Stummeyer, K., Timmer, M., Berski, S., Drager, G., Gerardy-Schahn, R. and Grothe, C. (2007) Culturing of glial and neuronal cells on polysialic acid. Biomaterials, 28: 1163-1173.
21. Jones, L.L., Oudega, M., Bunge, M.B. and Tuszynski, M.H. (2001) Neurotrophic factors, cellular bridges and gene therapy for spinal cord injury. J. Physiol., 533: 83-89.
22. Joung, I., Kim, H.S., Hong, J.S., Kwon, H. and Kwon, Y.K. (2000) Effective gene transfer into regenerating sciatic nerves by adenoviral vectors: potentials for gene therapy of peripheral nerve injury. Mol. Cells, 10: 540-545.
23. Kato, N., Nakanishi, K., Nemoto, K., Morishita, R., Kaneda, Y., Uenoyama, M., Ikeda, T. and Fujikawa, K. (2003) Efficient gene transfer from innervated muscle into rat peripheral and central nervous systems using a non-viral haemagglutinating virus of Japan (HVJ)-liposorne method. J. Neurochem., 85: 810-815.
24. Kato, N., Nemoto, K., Nakanishi, K., Morishita, R., Kaneda, Y., Uenoyama, M., Ikeda, T. and Fujikawa, K. (2005) Nonviral HVJ (hemagglutinating virus of Japan) liposome-mediated retrograde gene transfer of human hepatocyte growth factor into rat nervous system promotes functional and histological recovery of the crushed nerve. Neurosci. Res., 52: 299-310.
25. Li, Q., Ping, P., Jiang, H. and Liu, K. (2006) Nerve conduit filled with GDNF gene-modified Schwann cells enhances regeneration of the peripheral nerve. Microsurgery, 26: 116-121.
26. Lundborg, G. (2000) A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance. J. Hand. Surg. [Am], 25: 391-414.
27. Lundborg, G. (2004) Alternatives to autologous nerve grafts. Handchir. Mikrochir. Plast. Chir., 36: 1-7.
28. Lundborg, G., Dahlin, L.B., Danielsen, N., Gelberman, R.H., Longo, F.M., Powell, H. C. and Varon, S. (1982) Nerve regeneration in silicone chambers: influence of gap length and of distal stump components. Exp. Neurol., 76: 361-375.
29. Makwana, M. and Raivich, G. (2005) Molecular mechanisms in successful peripheral regeneration. FEBS J., 272: 2628-2638.
30. Mathieu, P., Chauveau, C., Bouchet, D., Guillot, C., Tesson, L. and Anegon, I. (2002) Genetic engineering in allotransplantation of vascularized organs. Curr. Gene Ther., 2: 9-21.
31. Mauritz, C., Grothe, C. and Haastert, K. (2004) Comparative study of cell culture and purification methods to obtain highly enriched cultures of proliferating adult rat Schwann cells. J. Neurosi. Res., 77: 453-461.
32. Mosahebi, A., Woodward, B., Wiberg, M., Martin, R. and Terenghi, G. (2001) Retroviral labeling of Schwann cells: in vitro characterization and in vivo transplantation to improve peripheral nerve regeneration. Glia, 34: 8-17.
33. O'Malley, B.W., Jr. and Ledley, F.D. (1993) Somatic gene therapy in otolaryngology-head and neck surgery. Arch. Otolaryngol. Head Neck Surg., 119: 1191-1197.
34. Palmer, J.A., Branston, R.H., Lilley, C.E., Robinson, M.J., Groutsi, F., Smith, J., Latchman, D.S. and Coffin, R.S. (2000) Development and optimization of herpes simplex virus vectors for multiple long-term gene delivery to the peripheral nervous system. J. Virol., 74: 5604-5618.
35. Perez, M.C., Hunt, S.P., Coffin, R.S. and Palmer, J.A. (2004) Comparative analysis of genomic HSV vectors for gene delivery to motor neurons following peripheral inoculation in vivo. Gene Ther., 11: 1023-1032.
36. Raivich, G. and Kreutzberg, G.W. (1993) Peripheral nerve regeneration: role of growth factors and their receptors. Int. J. Dev. Neurosci., 11: 311-324.
37. Sakamoto, T., Kawazoe, Y., Shen, J.S., Takeda, Y., Arakawa, Y., Ogawa, J., Oyanagi, K., Ohashi T., Watanabe, K., Inoue, K., Eto, Y. and Watabe, K. (2003) Adenoviral gene transfer of GDNF, BDNF and TGF beta 2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion. J. Neurosi. Res., 72: 54-64.
38. Sakamoto, T., Watabe, K., Ohashi, T., Kawazoe, Y., Oyanagi, K., Inoue, K. and Eto, Y. (2000) Adenoviral vector-mediated GDNF gene transfer prevents death of adult facial motoneurons. Neuroreport, 11: 1857-1860.
39. Schmidt, C.E. and Leach, J.B. (2003) Neural tissue engineering: strategies for repair and regeneration. Annu. Rev. Biomed. Eng., 5: 293-347.
40. Shy, M.E., Tani, M., Shi, Y.J., Whyatt, S.A., Chbihi, T., Scherer, S.S. and Kamholz, J. (1995) An adenoviral vector can transfer lacZ expression into Schwann cells in culture and in sciatic nerve. Ann. Neurol., 38: 429-436.
41. Sorensen, J., Haase, G., Krarup, C., Gilgenkrantz, H., Kahn, A. and Schmalbruch, H. (1998) Gene transfer to Schwann cells after peripheral nerve injury: a delivery system for therapeutic agents. Ann. Neurol., 43: 205-211.
42. Stoll, G., Griffin, J.W., Li, C.Y. and Trapp, B.D. (1989) Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation. J. Neurocytol., 18: 671-683.
43. Stoll, G. and Muller, H.W. (1999) Nerve injury, axonal degeneration and neural regeneration: basic insights. Brain Pathol., 9: 313-325.
44. Timmer, M., Robben, S., Muller-Ostermeyer, F., Nikkhah, G. and Grothe, C. (2003) Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2. Cell Transplant., 12: 265-277.
45. Watabe, K., Ohashi, T., Sakamoto, T., Kawazoe, Y., Takeshima, T., Oyanagi, K., Inoue, K., Eto, Y. and Kim, S.U. (2000) Rescue of lesioned adult rat spinal motoneurons by adenoviral gene transfer of glial cell line-derived neurotrophic factor. J. Neurosi. Res., 60: 511-519.
46. Watanabe, T.S., Ohtori, S., Koda, M., Aoki, Y., Doya, H., Shirasawa, H., Yamazaki, M., Moriya, H., Takahashi, K. and Yamashita, T. (2006) Adenoviral gene transfer in the peripheral nervous system. J. Orthop. Sci., 11: 64-69.
47. Zhang, N., Yan, H. and Wen, X. (2005) Tissue-engineering approaches for axonal guidance. Brain Res. Brain Res. Rev., 49: 48-64.