Autologous adult human Schwann cells genetically modified to provide alternative cellular transplants in peripheral nerve regeneration

Journal of Neurosurgery

Volumn 104, Issue 5, 2006, Pages 778-786

  Haastert, Kirsten ^a   Mauritz, Christina ^b   Matthies, Cordula ^b   Grothe, Claudia ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b NONE

Author keywords

Nerve repair; Neurotrophic factor; Peripheral nerve; Schwann cell

Indexed keywords

GROWTH FACTOR; NEUROTROPHIC FACTOR;

ARTICLE; CELL PROLIFERATION; CELL TRANSPLANTATION; DNA MODIFICATION; ELECTROPORATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOCYTOCHEMISTRY; NERVE BIOPSY; NERVE REGENERATION; PRIORITY JOURNAL; SCHWANN CELL;

ADOLESCENT; ADULT; CELL DIVISION; CELLS, CULTURED; ELECTROPORATION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MICROSURGERY; MIDDLE AGED; NERVE DEGENERATION; NERVE GROWTH FACTORS; NERVE REGENERATION; PERIPHERAL NERVES; SCHWANN CELLS; TISSUE AND ORGAN HARVESTING; TRANSFECTION;

EID: 33646479307     PISSN: 00223085     EISSN: 00223085     Source Type: Journal    
DOI: 10.3171/jns.2006.104.5.778     Document Type: Article

References (41)

1. Aebischer P, Salessiotis AN, Winn SR: Basic fibroblast growth factor released from synthetic guidance channels facilitates peripheral nerve regeneration across long nerve gaps. J Neurosci Res 23:282-289, 1989
2. Ansselin AD, Corbeil SD, Davey DF: Culture of Schwann cells from adult animals. In Vitro Cell Dev Biol Anim 31:253-254, 1995
3. Ansselin AD, Fink T, Davey DF: Peripheral nerve regeneration through nerve guides seeded with adult Schwann cells. Neuropathol Appl Neurobiol 23:387-398, 1997
4. Aviles RJ, Annex BH, Lederman RJ: Testing clinical therapeutic angiogenesis using basic fibroblast growth factor (FGF-2). Br J Pharmacol 140:637-646, 2003
5. Bunge RP: Expanding roles for the Schwann cell: ensheathment, myelination, trophism and regeneration. Curr Opin Neurobiol 3:805-809, 1993
6. Calderon-Martinez D, Garavito Z, Spinel C, Hurtado H: Schwann cell-enriched cultures from adult human peripheral nerve: a technique combining short enzymatic dissociation and treatment with cytosine arabinoside (Ara-C). J Neurosci Methods 114:1-8, 2002
7. Carvalho GA, Nikkhah G, Matthies C, Penkert G, Samii M: Diagnosis of root avulsions in traumatic brachial plexus injuries: value of computerized tomography myelography and magnetic resonance imaging. J Neurosurg 86:69-76, 1997
8. Casella GT, Bunge RP, Wood PM: Improved method for harvesting human Schwann cells from mature peripheral nerve and expansion in vitro. Glia 17:327-338, 1996
9. Claus P, Doring F, Gringel S, Muller-Ostermeyer F, Fuhlrott J, Kraft T, et al: Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein. J Biol Chem 278:479-485, 2003
10. Emery E, Li X, Brunschwig JP, Olson L, Levi AD: Assessment of the malignant potential of mitogen stimulated human Schwann cells. J Peripher Nerv Syst 4:107-116, 1999
11. Evans GR: Peripheral nerve injury: a review and approach to tissue engineered constructs. Anat Rec 263:396-404, 2001
12. Fine EG, Decosterd I, Papaloizos M, Zurn AD, Aebischer P: GDNF and NGF released by synthetic guidance channels support sciatic nerve regeneration across a long gap. Eur J Neurosci 15:589-601, 2002
13. Flores AJ, Lavernia CJ, Owens PW: Anatomy and physiology of peripheral nerve injury and repair. Am J Orthop 29:167-173, 2000
14. Fu SY, Gordon T: The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol 14:67-116, 1997
15. Guenard V, Kleitman N, Morrissey TK, Bunge RP, Aebischer P: Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration. J Neurosci 12:3310-3320, 1992
16. Haastert K, Lipokatić E, Fischer M, Timmer M, Grothe C: Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms. Neurobiol Dis 21:138-153, 2006
17. Hanemann CO, Rosenbaum C, Kupfer S, Wosch S, Stoegbauer F, Muller HW: Improved culture methods to expand Schwann cells with altered growth behavior from CMT1A patients. Glia 23:89-98, 1998
18. IJkema-Paassen J, Jansen K, Gramsbergen A, Meek MF: Transection of peripheral nerves, bridging strategies and effect evaluation. Biomaterials 25:1583-1592, 2004
19. Keilhoff G, Fansa H, Schneider W, Wolf G: In vivo predegeneration of peripheral nerves: an effective technique to obtain activated Schwann cells for nerve conduits. J Neurosci Methods 89:17-24, 1999
20. Keilhoff G, Fansa H, Smalla KH, Schneider W, Wolf G: Neuroma: a donor-age independent source of human Schwann cells for tissue engineered nerve grafts. Neuroreport 11:3805-3809, 2000
21. Levi AD: Characterization of the technique involved in isolating Schwann cells from adult human peripheral nerve. J Neurosci Methods 68:21-26, 1996
22. Levi AD, Bunge RP, Lofgren JA, Meima L, Hefti F, Nikolics K, et al: The influence of heregulins on human Schwann cell proliferation. J Neurosci 15:1329-1340, 1995
23. Mauritz C, Grothe C, Haastert K: Comparative study of cell culture and purification methods to obtain highly enriched cultures of proliferating adult rat Schwann cells. J Neurosci Res 77:453-461, 2004
24. Menei P, Montero-Menei C, Whittemore SR, Bunge RP, Bunge MB: Schwann cells genetically modified to secrete human BDNF promote enhanced axonal regrowth across transected adult rat spinal cord. Eur J Neurosci 10:607-621, 1998
25. Millesi H: Plexusverletzungen bei Erwachsenen. Orthopade 26:590-598, 1997
26. Mitsui T, Fischer I, Shumsky JS, Murray M: Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Exp Neurol 194:410-431, 2005
27. Morrissey TK, Bunge RP, Kleitman N: Human Schwann cells in vitro. I. Failure to differentiate and support neuronal health under co-culture conditions that promote full function of rodent cells. J Neurobiol 28:171-189, 1995
28. Morrissey TK, Kleitman N, Bunge RP: Human Schwann cells in vitro. II. Myelination of sensory axons following extensive purification and heregulin-induced expansion. J Neurobiol 28:190-201, 1995
29. Morrissey TK, Kleitman N, Bunge RP: Isolation and functional characterization of Schwann cells derived from adult peripheral nerve. J Neurosci 11:2433-2442, 1991
30. Mosahebi A, Fuller P, Wiberg M, Terenghi G: Effect of allogeneic Schwann cell transplantation on peripheral nerve regeneration. Exp Neurol 173:213-223, 2002
31. Mosahebi A, Simon M, Wiberg M, Terenghi G: A novel use of alginate hydrogel as Schwann cell matrix. Tissue Eng 7:525-534, 2001
32. Muller-Ostermeyer F, Claus P, Grothe C: Distinctive effects of rat fibroblast growth factor-2 isoforms on PC12 and Schwann cells. Growth Factors 19:175-191, 2001
33. Navarro X, Verdu E, Buti M: Comparison of regenerative and reinnervating capabilities of different functional types of nerve fibers. Exp Neurol 129:217-224, 1994
34. Raivich G, Kreutzberg GW: Peripheral nerve regeneration: role of growth factors and their receptors. Int J Dev Neurosci 11:311-324, 1993
35. Re F, Srinivasan R, Igarashi T, Marincola F, Childs R: Green fluorescent protein expression in dendritic cells enhances their immunogenicity and elicits specific cytotoxic T-cell responses in humans. Exp Hematol 32:210-217, 2004
36. Rutkowski JL, Kirk CJ, Lerner MA, Tennekoon GI: Purification and expansion of human Schwann cells in vitro. Nat Med 1:80-83, 1995
37. Rutkowski JL, Tennekoon GI, McGillicuddy JE: Selective culture of mitotically active human Schwann cells from adult sural nerves. Ann Neurol 31:580-586, 1992
38. Schmidt CE, Leach JB: Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng 5:293-347, 2003
39. Timmer M, Robben S, Muller-Ostermeyer F, Nikkhah G, Grothe C: Axonal regeneration across long gaps in silicone chambers filled with Schwann cells overexpressing high molecular weight FGF-2. Cell Transplant 12:265-277, 2003
40. Tohill M, Mantovani C, Wiberg M, Terenghi G: Rat bone marrow mesenchymal stem cells express glial markers and stimulate nerve regeneration. Neurosci Lett 362:200-203, 2004
41. Tuszynski MH, Weidner N, McCormack M, Miller I, Powell H, Conner J: Grafts of genetically modified Schwann cells to the spinal cord: survival, axon growth, and myelination. Cell Transplant 7:187-196, 1998