Three novel ABCC5 splice variants in human retina and their role as regulators of ABCC5 gene expression

BMC Molecular Biology

Volumn 8, Issue , 2007, Pages

  Stojic, Jelena ^a,b   Stöhr, Heidi ^b   Weber, Bernhard H F ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER C5; ISOPROTEIN; MESSENGER RNA; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ABCC5 PROTEIN, HUMAN; MULTIDRUG RESISTANCE PROTEIN;

3' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; EXON; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE SILENCING; GENETIC CONSERVATION; GENETIC STABILITY; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INTRON; NUCLEOTIDE SEQUENCE; PIGMENT EPITHELIUM; PROTEIN FUNCTION; RETINA; RETINA BLOOD VESSEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA DEGRADATION; RNA TRANSLATION; STOP CODON; ANIMAL; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MOLECULAR CLONING; MOUSE; RNA INTERFERENCE; RNA SPLICING;

ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; EXONS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INTRONS; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN ISOFORMS; RETINA; RNA INTERFERENCE; RNA SPLICE SITES; RNA SPLICING; TRANSCRIPTION, GENETIC;

EID: 34250183824     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-8-42     Document Type: Article

References (32)

1. Dean M Allikmets R Complete characterization of the human ABC gene family J Bioenerg Biomembr 2001 33 475-479 10.1023/A:1012823120935 11804189
2. Borst P Elferink RO Mammalian ABC transporters in health and disease Annu Rev Biochem 2002 71 537-592 10.1146/ annurev.biochem.71.102301.093055 12045106
3. Jedlitschky G Burchell B Keppler D The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides J Biol Chem 2000 275 30069-30074 10.1074/jbc.M005463200 10893247
4. Reid G Wielinga P Zelcer N De Haas M Van Deemter L Wijnholds J Balzarini J Borst P Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5 Mol Pharmacol 2003 63 1094-103 10.1124/mol.63.5.1094 12695538
5. Pratt S Shepard RL Kandasamy RA Johnston PA Perry W 3rd Dantzig AH The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites Mol Cancer Ther 2005 4 855-863 10.1158/1535-7163.MCT-04-0291 15897250
6. McAleer MA Breen MA White NL Matthews N pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells J Biol Chem 1999 274 23541-23548 10.1074/jbc.274.33.23541 10438534
7. Wijnholds J Mol CA van Deemter L de Haas M Scheffer GL Baas F Beijnen JH Scheper RJ Hatse S De Clercq E Balzarini J Borst P Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs Proc Natl Acad Sci USA 2000 97 7476-7481 16570 10840050 10.1073/pnas.120159197
8. Belinsky MG Bain LJ Balsara BB Testa JR Kruh GD Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins J Natl Cancer Inst 1998 90 1735-1741 10.1093/jnci/90.22.1735 9827529
9. Grant CE Kurz EU Cole SP Deeley RG Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA Genomics 1997 45 368-378 10.1006/ geno.1997.4950 9344662
10. Lamba JK Adachi M Sun D Tammur J Schuetz EG Allikmets R Schuetz JD Nonsense mediated decay downregulates conserved alternatively spliced ABCC4 transcripts bearing nonsense codons Hum Mol Gene 2003 12 99-109 10.1093/hmg/ddg011
11. Suzuki T Nishio K Sasaki H Kurokawa H Saito-Ohara F Ikeuchi T Tanabe S Terada M Saijo N cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line Biochem Biophys Res Commun 1997 238 790-794 10.1006/bbrc.1997.7346 9325169
12. Suzuki T Sasaki H Kuh HJ Agui M Tatsumi Y Tanabe S Terada M Saijo N Nishio K Detailed structural analysis on both human MRP5 and mouse mrp5 transcripts Gene 2000 242 167-173 10.1016/S0378-1119(99)00529-6 10721709
13. Schulz HL Rahman FA Fadl El Moula FM Stojic J Gehrig A Weber BH Identifying differentially expressed genes in the mammalian retina and the retinal pigment epithelium by suppression subtractive hybridization Cytogenet Genome Res 2004 106 74-81 10.1159/000078564 15218245
14. National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool 2004 http://www.ncbi.nlm.nih.gov/BLAST
15. Hentze MW Kulozik AE A perfect message: RNA surveillance and nonsense-mediated decay Cell 1999 96 307-310 10.1016/ S0092-8674(00)80542-5 10025395
16. Noensie EN Dietz HC A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition Nat Biotechnol 2001 19 434-439 10.1038/88099 11329012
17. Allikmets R Singh N Sun H Shroyer NF Hutchinson A Chidambaram A Gerrard B Baird L Stauffer D Peiffer A Rattner A Smallwood P Li Y Anderson KL Lewis RA Nathans J Leppert M Dean M Lupski JR A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy Nat Genet 1997 15 236-246 10.1038/ ng0397-236 9054934
18. Bergen AA Plomp AS Schuurman EJ Terry S Breuning M Dauwerse H Swart J Kool M van Soest S Baas F ten Brink JB de Jong PT Mutations in ABCC6 cause pseudoxanthoma elasticum Nat Genet 2000 25 228-231 10.1038/76109 10835643
19. Le Saux O Urban Z Tschuch C Csiszar K Bacchelli B Quaglino D Pasquali-Ronchetti I Pope FM Richards A Terry S Bercovitch L de Paepe A Boyd CD Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum Nat Genet 2000 25 223-227 10.1038/76102 10835642
20. Modrek B Lee C A genomic view of alternative splicing Nat Genet 2002 30 13-19 10.1038/ng0102-13 11753382
21. Zavolan M Kondo S Schonbach C Adachi J Hume DA Hayashizaki Y Gaasterland T RIKEN GER Group, GSL members Impact of alternative initiation, splicing, and termination on the diversity of the mRNA transcripts encoded by the mouse transcriptome Genome Res 2003 13 1290-1300 403716 12819126 10.1101/gr.1017303
22. Yeo G Holste D Kreiman G Burge CB Variation in alternative splicing across human tissues Genome Biol 2004 5 R74 545594 15461793 10.1186/ gb-2004-5-10-r74
23. Wistow G Bernstein SL Wyatt MK Ray S Behal A Touchman JW Bouffard G Smith D Peterson K Expressed sequence tag analysis of human retina for the NEIBank Project: Retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts Mol Vis 2002 8 196-204 12107411
24. Hong DH Li T Complex expression pattern of RPGR reveals a role for purine-rich exonic splicing enhancers Invest Ophthalmol Vis Sci 2002 43 3373-3382 12407146
25. Bowne SJ Liu Q Sullivan LS Zhu J Spellicy CJ Rickman CB Pierce EA Daiger SP Why do mutations in the ubiquitously expressed housekeeping gene IMPDH1 cause retina-specific photoreceptor degeneration? Invest Ophthalmol Vis Sci 2006 47 3754-3765 10.1167/iovs.06-0207 16936083
26. Lareau LF Green RE Bhatnagar RS Brenner SE The evolving roles of alternative splicing Curr Opin Struct Biol 2004 14 273-282 10.1016/ j.sbi.2004.05.002 15193306
27. Maquat LE Carmichael GG Quality control of mRNA function Cell 2001 104 173-176 10.1016/S0092-8674(01)00202-1 11207359
28. Lewis BP Green RE Brenner SE Evidence fort he wide spread coupling of alternative splicing and nonsense-mediated mRNA decay in humans Proc Natl Acad Sci USA 2003 100 189-192 140922 12502788 10.1073/ pnas.0136770100
29. Yabuuchi H Shimizu H Takayanagi S Ishikawa T Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12 Biochem Biophys Res Commun 2001 288 933-939 10.1006/bbrc.2001.5865 11688999
30. Nies AT Spring H Thon WF Keppler D Jedlitschky G Immunolocalization of multidrug resistance protein 5 in the human genitourinary system J Urol 2002 167 2271-2275 10.1016/S0022-5347(05)65141-5 11956491
31. Dazert P Meissner K Vogelgesang S Heydrich B Eckel L Bohm M Warzok R Kerb R Brinkmann U Schaeffeler E Schwab M Cascorbi I Jedlitschky G Kroemer HK Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart Am J Pathol 2003 163 1567-1577 14507663
32. Nies AT Jedlitschky G Konig J Herold-Mende C Steiner HH Schmitt HP Keppler D Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain Neuroscience 2004 129 349-360 10.1016/j.neuroscience.2004.07.051 15501592