Immunogenicity and in vitro protective efficacy of a polyepitope Plasmodium falciparum candidate vaccine constructed by epitope shuffling

Vaccine

Volumn 25, Issue 28, 2007, Pages 5155-5165

  Cai, Qiliang ^a   Peng, Guiying ^a   Bu, Lingyi ^a   Lin, Yahui ^a   Zhang, Lianhui ^a   Lustigmen, Sara ^b   Wang, Heng ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b NEW YORK BLOOD CENTER   (United States)

Author keywords

DNA shuffling; Immunogenicity; Malaria vaccine; Protective efficacy

Indexed keywords

EPITOPE; GAMMA INTERFERON; INTERLEUKIN 4; MALARIA RANDOM CONSTRUCTED ANTIGEN 1; MALARIA VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SYNTHESIS; IMMUNOGENICITY; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, PROTOZOAN; ANTIBODY FORMATION; ANTIGENS, PROTOZOAN; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNOGLOBULIN G; INTERFERON TYPE II; INTERLEUKIN-4; MALARIA VACCINES; MICE; MICE, INBRED BALB C; MICROSCOPY, IMMUNOELECTRON; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; RABBITS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES;

EID: 34250177601     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.04.085     Document Type: Article

References (39)

1. Breman J.G., Alilio M.S., and Mills A. Conquering the intolerable burden of malaria: what's new, what's needed: a summary. Am J Trop Med Hyg 71 2 Suppl (2004) 1-15
2. Urdaneta M., Prata A., Struchiner C.J., Tosta C.E., Tauil P., and Boulos M. Evaluation of SPf66 malaria vaccine efficacy in Brazil. Am J Trop Med Hyg 58 3 (1998) 378-385
3. Ockenhouse C.F., Sun P.F., Lanar D.E., Wellde B.T., Hall B.T., Kester K., et al. Phase I/IIa safety, immunogenicity, and efficacy trial of NYVAC-Pf7, a pox-vectored, multiantigen, multistage vaccine candidate for Plasmodium falciparum malaria. J Infect Dis 177 6 (1998) 1664-1673
4. Gilbert S.C., Plebanski M., Harris S.J., Allsopp C.E., Thomas R., Layton G.T., et al. A protein particle vaccine containing multiple malaria epitopes. Nat Biotechnol 15 12 (1997) 1280-1284
5. Shi Y.P., Hasnain S.E., Sacci J.B., Holloway B.P., Fujioka H., Kumar N., et al. Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine. Proc Natl Acad Sci USA 96 4 (1999) 1615-1620
6. Rafi-Janajreh A., Tongren J.E., Kensil C., Hackett C., Candal F., Lal A., et al. Influence of adjuvants in inducing immune responses to different epitopes included in a multiepitope, multivalent, multistage Plasmodium falciparum candidate vaccine (FALVAC-1) in outbred mice. Exp Parasitol 101 1 (2002) 3-12
7. Collins W.E., Galland G.G., Barnwell J.W., Udhayakumar V., Sullivan J.S., Nace D., et al. Preliminary observations on the efficacy of a recombinant multistage Plasmodium falciparum vaccine in Aotus nancymai monkeys. Am J Trop Med Hyg 73 4 (2005) 686-693
8. Webster D.P., Dunachie S., Vuola J.M., Berthoud T., Keating S., Laidlaw S.M., et al. Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara. Proc Natl Acad Sci USA 102 13 (2005) 4836-4841
9. Smooker P.M., Setiady Y.Y., Rainczuk A., and Spithill T.W. Expression library immunization protects mice against a challenge with virulent rodent malaria. Vaccine 18 23 (2000) 2533-2540
10. Good M.F. Towards a blood-stage vaccine for malaria: are we following all the leads?. Nat Rev Immunol 1 2 (2001) 117-125
11. Pombo D.J., Lawrence G., Hirunpetcharat C., Rzepczyk C., Bryden M., Cloonan N., et al. Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum. Lancet 360 9333 (2002) 610-617
12. Lin Chengtao J.Y., Yin B., Dong M., He X., and Wang H. Construction of malaria multivalent recombinant DNA vaccine with isocaudamer technique. Chin J Biochem Mol Biol 15 6 (1999) 974-977
13. Pan W., Huang D., Zhang Q., Qu L., Zhang D., Zhang X., et al. Fusion of two malaria vaccine candidate antigens enhances product yield, immunogenicity, and antibody-mediated inhibition of parasite growth in vitro. J Immunol 172 10 (2004) 6167-6174
14. Cai Q.L., Wei F., Lin Y.H., Shao D.D., and Wang H. Immunogenicity of polyepitope libraries assembled by epitope shuffling: an approach to the development of chimeric gene vaccination against malaria. Vaccine 23 2 (2004) 267-277
15. Sam-Yellowe T.Y., Shio H., and Perkins M.E. Secretion of Plasmodium falciparum rhoptry protein into the plasma membrane of host erythrocytes. J Cell Biol 106 5 (1988) 1507-1513
16. Leung W.H., Meng Z.Q., Hui G., and Ho W.K. Expression of an immunologically reactive merozoite surface protein (MSP-1(42)) in E. coli. Biochim Biophys Acta 1675 1-3 (2004) 62-70
17. Schlichtherle M.W.M., Perlmann H., and Scherf A. Methods in malaria research. 3rd ed. (2000), MR4/ATCC Press, Manassas, Virginia p. 28-32
18. Shi Y.P., Udhayakumar V., Oloo A.J., Nahlen B.L., and Lal A.A. Differential effect and interaction of monocytes, hyperimmune sera, and immunoglobulin G on the growth of asexual stage Plasmodium falciparum parasites. Am J Trop Med Hyg 60 1 (1999) 135-141
19. Bazhan S.I., Belavin P.A., Seregin S.V., Danilyuk N.K., Babkina I.N., Karpenko L.I., et al. Designing and engineering of DNA-vaccine construction encoding multiple CTL-epitopes of major HIV-1 antigens. Vaccine 22 13-14 (2004) 1672-1682
20. BenMohamed L., Thomas A., and Druilhe P. Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides. Infect Immun 72 8 (2004) 4376-4384
21. Baird M., Wilson R., Young L., Williman J., Young S., Wilson M., et al. Bystander help within a polyepitope DNA vaccine improves immune responses to influenza antigens. Scand J Immunol 60 4 (2004) 363-371
22. Bouche F.B., Steinmetz A., Yanagi Y., and Muller C.P. Induction of broadly neutralizing antibodies against measles virus mutants using a polyepitope vaccine strategy. Vaccine 23 17-18 (2005) 2074-2077
23. Singh S., Miura K., Zhou H., Muratova O., Keegan B., Miles A., et al. Immunity to recombinant Plasmodium falciparum merozoite surface protein 1 (MSP1): protection in Aotus nancymai monkeys strongly correlates with anti-MSP1 antibody titer and in vitro parasite-inhibitory activity. Infect Immun 74 8 (2006) 4573-4580
24. Wohlhueter R.M., Parekh K., Udhayakumar V., Fang S., and Lal A.A. Analysis of binding of monoclonal antibody to a malarial peptide by surface plasmon resonance biosensor and integrated rate equations. J Immunol 153 1 (1994) 181-189
25. Wipasa J., Elliott S., Xu H., and Good M.F. Immunity to asexual blood stage malaria and vaccine approaches. Immunol Cell Biol 80 5 (2002) 401-414
26. Hviid L. Clinical disease, immunity and protection against Plasmodium falciparum malaria in populations living in endemic areas. Expert Rev Mol Med 1998 (1998) 1-10
27. Ejov M.N., Tun T., Aung S., Lwin S., and Sein K. Hospital-based study of severe malaria and associated deaths in Myanmar. Bull World Health Organ 77 4 (1999) 310-314
28. Cheng Q., Jones G., Liu E.X., Kidson C., and Saul A. Identification of a common Plasmodium epitope (CPE) recognised by a pan-specific inhibitory monoclonal antibody. Mol Biochem Parasitol 49 1 (1991) 73-82
29. Smythe J.A., Coppel R.L., Day K.P., Martin R.K., Oduola A.M., Kemp D.J., et al. Structural diversity in the Plasmodium falciparum merozoite surface antigen 2. Proc Natl Acad Sci USA 88 5 (1991) 1751-1755
30. Chauhan V.S., Chatterjee S., and Johar P.K. Synthetic peptides based on conserved Plasmodium falciparum antigens are immunogenic and protective against Plasmodium yoelii malaria. Parasite Immunol 15 4 (1993) 239-242
31. Sim B.K., Orlandi P.A., Haynes J.D., Klotz F.W., Carter J.M., Camus D., et al. Primary structure of the 175K Plasmodium falciparum erythrocyte binding antigen and identification of a peptide which elicits antibodies that inhibit malaria merozoite invasion. J Cell Biol 111 5 Pt 1 (1990) 1877-1884
32. Sim B.K., Carter J.M., Deal C.D., Holland C., Haynes J.D., and Gross M. Plasmodium falciparum: further characterization of a functionally active region of the merozoite invasion ligand EBA-175. Exp Parasitol 78 3 (1994) 259-268
33. Kabilan L., Sharma V.P., Kaur P., Ghosh S.K., Yadav R.S., and Chauhan V.S. Cellular and humoral immune responses to well-defined blood stage antigens (major merozoite surface antigen) of Plasmodium falciparum in adults from an Indian zone where malaria is endemic. Infect Immun 62 2 (1994) 685-691
34. Joshi S.K., Bharadwaj A., Chatterjee S., and Chauhan V.S. Analysis of immune responses against T- and B-cell epitopes from Plasmodium falciparum liver-stage antigen 1 in rodent malaria models and malaria-exposed human subjects in India. Infect Immun 68 1 (2000) 141-150
35. Fidock D.A., Gras-Masse H., Lepers J.P., Brahimi K., Benmohamed L., Mellouk S., et al. Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants. J Immunol 153 1 (1994) 190-204
36. Sinigaglia F., Guttinger M., Matile H., and Pink J.R. An invariant, "universal" T-cell epitope in the P. falciparum circumsporozoite protein. Bull World Health Organ 68 Suppl (1990) 94-98
37. Egan A., Waterfall M., Pinder M., Holder A., and Riley E. Characterization of human T- and B-cell epitopes in the C terminus of Plasmodium falciparum merozoite surface protein 1. Evidence for poor T-cell recognition of polypeptides with numerous disulfide bonds. Infect Immun 65 8 (1997) 3024-3031
38. Lal A.A., Hughes M.A., Oliveira D.A., Nelson C., Bloland P.B., Oloo A.J., et al. Identification of T-cell determinants in natural immune responses to the Plasmodium falciparum apical membrane antigen (AMA-1) in an adult population exposed to malaria. Infect Immun 64 3 (1996) 1054-1059
39. Yan L, Huiliang, L., Heng, W. Cloning and characterization of a novel protective candidate antigen MAg-1, from malaria parasite Plasmodium falciparum. GenBank AF425649, 2001.