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Volumn 22, Issue 4, 2007, Pages 373-378

Where are we with high-density lipoprotein raising and inhibition of cholesteryl ester transfer for heart disease risk reduction?

Author keywords

Cholesteryl ester transfer protein inhibition; Coronary heart disease; High density lipoprotein; Metabolism; Subpopulations

Indexed keywords

2 METHYLPROPANETHIOIC ACID S [2 [1 (2 ETHYLBUTYL)CYCLOHEXYLCARBOXAMIDO]PHENYL] ESTER; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN; ROSUVASTATIN; TORCETRAPIB;

EID: 34250159840     PISSN: 02684705     EISSN: None     Source Type: Journal    
DOI: 10.1097/HCO.0b013e3281fbd3c7     Document Type: Review
Times cited : (14)

References (38)
  • 1
    • 0020003095 scopus 로고
    • Plasma apolipoprotein A-I absence associated with marked reduction of high density lipoproteins and premature coronary artery disease
    • Schaefer EJ, Heaton WH, Wetzel MG, Brewer HB Jr. Plasma apolipoprotein A-I absence associated with marked reduction of high density lipoproteins and premature coronary artery disease. Arteriosclerosis 1982; 2:16-26.
    • (1982) Arteriosclerosis , vol.2 , pp. 16-26
    • Schaefer, E.J.1    Heaton, W.H.2    Wetzel, M.G.3    Brewer Jr., H.B.4
  • 3
    • 0035024968 scopus 로고    scopus 로고
    • Subpopulations of high-density lipoproteins in homozygous and heterozygous Tangier disease
    • Asztalos BF, Brousseau ME, McNamara JR, et al. Subpopulations of high-density lipoproteins in homozygous and heterozygous Tangier disease. Atherosclerosis 2001; 156:217-225.
    • (2001) Atherosclerosis , vol.156 , pp. 217-225
    • Asztalos, B.F.1    Brousseau, M.E.2    McNamara, J.R.3
  • 4
    • 0026762806 scopus 로고
    • Prevalence of familial lipoprotein disorders in patients with premature coronary artery disease
    • Genest JJ, Martin-Munley S, McNamara JR, et al. Prevalence of familial lipoprotein disorders in patients with premature coronary artery disease. Circulation 1992; 85:2025-2033.
    • (1992) Circulation , vol.85 , pp. 2025-2033
    • Genest, J.J.1    Martin-Munley, S.2    McNamara, J.R.3
  • 5
    • 0027330899 scopus 로고
    • Familial hypoalphalipoproteinemia in premature coronary artery disease
    • Genest JJ Jr, Bard JM, Fruchart JC, et al. Familial hypoalphalipoproteinemia in premature coronary artery disease. Arterioscler Thromb 1993; 13:1728-1737.
    • (1993) Arterioscler Thromb , vol.13 , pp. 1728-1737
    • Genest Jr, J.J.1    Bard, J.M.2    Fruchart, J.C.3
  • 6
    • 10744225301 scopus 로고    scopus 로고
    • Effect of intensive compared with moderate lipid lowering therapy on progression of coronary atherosclerosis in patients with acute coronary syndrome
    • Nissen SE, Tuzcu EM, Schoenhagen P, et al. Effect of intensive compared with moderate lipid lowering therapy on progression of coronary atherosclerosis in patients with acute coronary syndrome. JAMA 2004; 291:1071-1080.
    • (2004) JAMA , vol.291 , pp. 1071-1080
    • Nissen, S.E.1    Tuzcu, E.M.2    Schoenhagen, P.3
  • 7
    • 0242577955 scopus 로고    scopus 로고
    • Nissen SE, Tsunoda T, Tuzcu EM, et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndrome: a randomized controlled trial. JAMA 2003; 290:2292-2300.
    • Nissen SE, Tsunoda T, Tuzcu EM, et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndrome: a randomized controlled trial. JAMA 2003; 290:2292-2300.
  • 8
    • 33645524176 scopus 로고    scopus 로고
    • Effect of very high-intensity statin therapy on regression of coronary atherosclerosis
    • Nissen SE, Nicholls SJ, Sipahi I, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis. JAMA 2006; 295:1556-1565.
    • (2006) JAMA , vol.295 , pp. 1556-1565
    • Nissen, S.E.1    Nicholls, S.J.2    Sipahi, I.3
  • 9
    • 34247397359 scopus 로고    scopus 로고
    • Effects of reconstituted high-density-lipoprotein infusions on coronary atherosclerosis: A randomized controlled trial
    • Tardif JC, Gregoire J, L'allier PL, et al. Effects of reconstituted high-density-lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial. JAMA 2007; 297:1675-1682.
    • (2007) JAMA , vol.297 , pp. 1675-1682
    • Tardif, J.C.1    Gregoire, J.2    L'allier, P.L.3
  • 10
    • 0025104275 scopus 로고
    • Increased high density lipoprotein levels caused by a common cholesteryl-transfer protein gene mutation
    • Inazu A, Brown ML, Hesler CB, et al. Increased high density lipoprotein levels caused by a common cholesteryl-transfer protein gene mutation. N Engl J Med 1990; 323:1234-1238.
    • (1990) N Engl J Med , vol.323 , pp. 1234-1238
    • Inazu, A.1    Brown, M.L.2    Hesler, C.B.3
  • 11
    • 34447266483 scopus 로고    scopus 로고
    • Morehouse LA, Sugarman ED, Bourassa PA, et al. Inhibition of CETP activity by torcetrapib reduces susceptibility to diet induced atherosclerosis in NZW rabbits. J Lipid Res 2007 [Epub ahead of print].
    • Morehouse LA, Sugarman ED, Bourassa PA, et al. Inhibition of CETP activity by torcetrapib reduces susceptibility to diet induced atherosclerosis in NZW rabbits. J Lipid Res 2007 [Epub ahead of print].
  • 12
    • 0037035459 scopus 로고    scopus 로고
    • Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: A randomized phase II dose response study
    • De Grooth GJ, Kuivenhoven JA, Stalenhoef AF, et al. Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose response study. Circulation 2002; 105:2159-2165.
    • (2002) Circulation , vol.105 , pp. 2159-2165
    • De Grooth, G.J.1    Kuivenhoven, J.A.2    Stalenhoef, A.F.3
  • 13
    • 12144287356 scopus 로고    scopus 로고
    • Raising high-density lipoproteins in humans through inhibition of cholesteryl ester transfer protein: An initial multidose study of torcetrapib
    • Clark RW, Surfin TA, Ruggeri RB, et al. Raising high-density lipoproteins in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol 2004; 24:490-497.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 490-497
    • Clark, R.W.1    Surfin, T.A.2    Ruggeri, R.B.3
  • 14
    • 1842815777 scopus 로고    scopus 로고
    • Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
    • Brousseau ME, Schaefer EJ, Wolfe ML, et al. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med 2004; 350:1505-1515.
    • (2004) N Engl J Med , vol.350 , pp. 1505-1515
    • Brousseau, M.E.1    Schaefer, E.J.2    Wolfe, M.L.3
  • 15
    • 0033663459 scopus 로고    scopus 로고
    • Pros and cons of inhibiting cholesteryl ester transfer protein
    • Hirano K, Yameshita S, Matsuzawa Y. Pros and cons of inhibiting cholesteryl ester transfer protein. Curr Opin Lipidol 2000; 11:589-596.
    • (2000) Curr Opin Lipidol , vol.11 , pp. 589-596
    • Hirano, K.1    Yameshita, S.2    Matsuzawa, Y.3
  • 16
    • 0034712706 scopus 로고    scopus 로고
    • Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene
    • Agerholm-Larsen B, Nordestgaard BG, Steffensen R, et al. Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene. Circulation 2000; 101:1907-1912.
    • (2000) Circulation , vol.101 , pp. 1907-1912
    • Agerholm-Larsen, B.1    Nordestgaard, B.G.2    Steffensen, R.3
  • 17
    • 25444442925 scopus 로고    scopus 로고
    • Differential effects of HDL subpopulations on cellular ABCA1 and SRB1-mediated cholesterol efflux
    • Asztalos BF, De la Llera-Moya M, Dallal GE, et al. Differential effects of HDL subpopulations on cellular ABCA1 and SRB1-mediated cholesterol efflux. J Lipid Res 2005; 46:2246-2253.
    • (2005) J Lipid Res , vol.46 , pp. 2246-2253
    • Asztalos, B.F.1    De la Llera-Moya, M.2    Dallal, G.E.3
  • 18
    • 1542409274 scopus 로고    scopus 로고
    • Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency
    • Asztalos BF, Horvath KV, Kajinami K, et al. Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency. J Lipid Res 2004; 45:448-545.
    • (2004) J Lipid Res , vol.45 , pp. 448-545
    • Asztalos, B.F.1    Horvath, K.V.2    Kajinami, K.3
  • 19
    • 0034061148 scopus 로고    scopus 로고
    • Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk. The Framingham Study
    • Ordovas JM, Cupples LA, Corella D, et al. Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk. The Framingham Study. Arterioscler Thromb Vasc Biol 2000; 20:1323-1329.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1323-1329
    • Ordovas, J.M.1    Cupples, L.A.2    Corella, D.3
  • 20
    • 0036061676 scopus 로고    scopus 로고
    • Cholesteryl ester Transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease endpoints in men with HDL deficiency. Veterans Affairs HDL Cholesterol Intervention Trial
    • Brousseau ME, O'Connor JJ, Ordovas JM, et al. Cholesteryl ester Transfer protein TaqI B2B2 genotype is associated with higher HDL cholesterol levels and lower risk of coronary heart disease endpoints in men with HDL deficiency. Veterans Affairs HDL Cholesterol Intervention Trial. Arterioscler Thromb Vasc Biol 2002; 22:1148-1154.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 1148-1154
    • Brousseau, M.E.1    O'Connor, J.J.2    Ordovas, J.M.3
  • 21
    • 0142088521 scopus 로고    scopus 로고
    • Unique lipoprotein phenotype and genotype associated with exceptional longevity
    • Barzilai N, Atzmon G, Schechter C, et al. Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 2003; 290:2030-2040.
    • (2003) JAMA , vol.290 , pp. 2030-2040
    • Barzilai, N.1    Atzmon, G.2    Schechter, C.3
  • 22
    • 33947151023 scopus 로고    scopus 로고
    • Asztalos BF, Schaefer EJ, Horvath KV, et al. Role of LCAT in HDL remodeling: an investigation in LCAT deficiency states. J Lipid Res 2007; 48:592-599. Study investigating the role of lecithin:cholesterol acyl transferase on HDL remodeling. The data indicate that lack of lecithin:cholesterol acyl transferase results in the inability to form spherical HDL particles containing both apoA-I and A-II, and the accumulation of α-4 HDL that is discoidal, small and contains apoA-I without A-II. No major effect on apoE HDL was noted, except that here again the particles are likely to be discoidal rather than spherical due to the inability to esterify cholesterol and form cholesteryl ester in the core of HDL.
    • Asztalos BF, Schaefer EJ, Horvath KV, et al. Role of LCAT in HDL remodeling: an investigation in LCAT deficiency states. J Lipid Res 2007; 48:592-599. Study investigating the role of lecithin:cholesterol acyl transferase on HDL remodeling. The data indicate that lack of lecithin:cholesterol acyl transferase results in the inability to form spherical HDL particles containing both apoA-I and A-II, and the accumulation of α-4 HDL that is discoidal, small and contains apoA-I without A-II. No major effect on apoE HDL was noted, except that here again the particles are likely to be discoidal rather than spherical due to the inability to esterify cholesterol and form cholesteryl ester in the core of HDL.
  • 23
    • 8344241096 scopus 로고    scopus 로고
    • High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants in the Framingham Offspring Study
    • Asztalos BF, Cupples LA, Demissie S, et al. High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants in the Framingham Offspring Study. Arterioscler Thromb Vasc Biol 2004; 24:2181-2187.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 2181-2187
    • Asztalos, B.F.1    Cupples, L.A.2    Demissie, S.3
  • 24
    • 26244436291 scopus 로고    scopus 로고
    • Value of high density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial
    • Asztalos BF, Collins D, Cupples LA, et al. Value of high density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial. Arterioscler Thromb Vasc Biol 2005; 25:2185-2191.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2185-2191
    • Asztalos, B.F.1    Collins, D.2    Cupples, L.A.3
  • 25
    • 0038300497 scopus 로고    scopus 로고
    • Change in alpha 1 HDL concentration predicts progression in coronary artery stenosis
    • Asztalos BF, Batista M, Horvath KV, et al. Change in alpha 1 HDL concentration predicts progression in coronary artery stenosis. Arterioscler Thromb Vasc Biol 2003; 23:847-852.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 847-852
    • Asztalos, B.F.1    Batista, M.2    Horvath, K.V.3
  • 26
    • 33847008267 scopus 로고    scopus 로고
    • Asztalos BF, LeMaulf F, Dallal GE, et al. Comparison of the effects of high doses of rosuvastatin versus atorvastatin on subpopulations of high density lipoproteins. Am J Cardiol 2007; 99:681-685. This study examined the effects of rosuvastatin 40 mg/day vs. atorvastatin 8 mg/day in the STELLAR study. The data indicates that both statins lower preβ-1 HDL by about 40, suggesting more efficient reverse cholesterol transport, but that rosuvastatin is about twice as effective at raising large α-1 HDL than atorvastatin, possibly because of its longer plasma residence time and greater efficacy. Greater increases in this HDL fraction have been linked to greater benefit in promoting regression of coronary atherosclerosis. These data may explain why rosuvastatin at 40 mg/day promoted median regression of coronary atheroma while atorvastatin 80 mg/day promoted lack of progression
    • Asztalos BF, LeMaulf F, Dallal GE, et al. Comparison of the effects of high doses of rosuvastatin versus atorvastatin on subpopulations of high density lipoproteins. Am J Cardiol 2007; 99:681-685. This study examined the effects of rosuvastatin 40 mg/day vs. atorvastatin 8 mg/day in the STELLAR study. The data indicates that both statins lower preβ-1 HDL by about 40%, suggesting more efficient reverse cholesterol transport, but that rosuvastatin is about twice as effective at raising large α-1 HDL than atorvastatin, possibly because of its longer plasma residence time and greater efficacy. Greater increases in this HDL fraction have been linked to greater benefit in promoting regression of coronary atherosclerosis. These data may explain why rosuvastatin at 40 mg/day promoted median regression of coronary atheroma volume while atorvastatin 80 mg/day promoted lack of progression.
  • 27
    • 33644775588 scopus 로고    scopus 로고
    • Clark RW, Ruggieri RB, Cunningham D, Bamberger MJ. Description of the torcetrapib series of cholesteryl ester protein inhibitors, including mechanism of action. J Lipid Res 2006; 47:537-552. An important study which documented that torcetrapib and other Pfizer CETP inhibitors bind to CETP on the HDL particle. This binding process forms a nonproductive complex which may interfere with the functions of HDL, which include reverse cholesterol transport, prevention of inflammation and prevention of lipid oxidation.
    • Clark RW, Ruggieri RB, Cunningham D, Bamberger MJ. Description of the torcetrapib series of cholesteryl ester protein inhibitors, including mechanism of action. J Lipid Res 2006; 47:537-552. An important study which documented that torcetrapib and other Pfizer CETP inhibitors bind to CETP on the HDL particle. This binding process forms a nonproductive complex which may interfere with the functions of HDL, which include reverse cholesterol transport, prevention of inflammation and prevention of lipid oxidation.
  • 28
    • 33846989758 scopus 로고    scopus 로고
    • Qui X, Mistry A, Ammirati MJ, et al. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four lipid bound molecules. Nat Struct Mol Biol 2007; 14:106-113. Documentation of the crystal structure of CETP revealing a long tunnel and four lipid-bound molecules. This tunnel allows for the transfer of cholesteryl ester and triglyceride between HDL and triglyceride-rich lipoproteins in a hydrophobic manner in the plasma space. Understanding the crystal structure of CETP should allow scientists to design optimal CETP inhibitors that do not bind to HDL or interfere with any of its functions.
    • Qui X, Mistry A, Ammirati MJ, et al. Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four lipid bound molecules. Nat Struct Mol Biol 2007; 14:106-113. Documentation of the crystal structure of CETP revealing a long tunnel and four lipid-bound molecules. This tunnel allows for the transfer of cholesteryl ester and triglyceride between HDL and triglyceride-rich lipoproteins in a hydrophobic manner in the plasma space. Understanding the crystal structure of CETP should allow scientists to design optimal CETP inhibitors that do not bind to HDL or interfere with any of its functions.
  • 29
    • 27844602346 scopus 로고    scopus 로고
    • Molecular mechanism of the blockade of plasma cholesteryl ester protein by its physiologic inhibitor apolipoprotein CI
    • Dumont L, Gauthier T, De Barros JP, et al. Molecular mechanism of the blockade of plasma cholesteryl ester protein by its physiologic inhibitor apolipoprotein CI. J Biol Chem 2005; 280:38108-38116.
    • (2005) J Biol Chem , vol.280 , pp. 38108-38116
    • Dumont, L.1    Gauthier, T.2    De Barros, J.P.3
  • 30
    • 27444447838 scopus 로고    scopus 로고
    • Lack of stimulation of cholesteryl ester transfer protein by cholesterol in the presence of a high fat diet
    • Cheema SK, Agarwal-Mawal A, Murray CM, Tucker S. Lack of stimulation of cholesteryl ester transfer protein by cholesterol in the presence of a high fat diet. J Lipid Res 2005; 46:2356-2366.
    • (2005) J Lipid Res , vol.46 , pp. 2356-2366
    • Cheema, S.K.1    Agarwal-Mawal, A.2    Murray, C.M.3    Tucker, S.4
  • 31
    • 33646689775 scopus 로고    scopus 로고
    • Effect of inhibiting cholesteryl ester protein on the kinetics of high-density lipoprotein cholesteryl ester transport in plasma. In vivo studies in rabbits
    • Kee P, Cantazza D, Rye KA, et al. Effect of inhibiting cholesteryl ester protein on the kinetics of high-density lipoprotein cholesteryl ester transport in plasma. In vivo studies in rabbits. Arterioscler Vasc Thromb Biol 2006; 26:884-890.
    • (2006) Arterioscler Vasc Thromb Biol , vol.26 , pp. 884-890
    • Kee, P.1    Cantazza, D.2    Rye, K.A.3
  • 32
    • 20944437770 scopus 로고    scopus 로고
    • Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion
    • Brousseau ME, Diffenderfer MR, Millar JS, et al. Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion. Arterioscler Thromb Vasc Biol 2005; 25:1057-1064.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1057-1064
    • Brousseau, M.E.1    Diffenderfer, M.R.2    Millar, J.S.3
  • 33
    • 33644839739 scopus 로고    scopus 로고
    • Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism
    • Millar JS, Brousseau ME, Diffenderfer MR, et al. Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on apolipoprotein B100 metabolism. Arterioscler Thromb Vasc Biol 2006; 26:1350-1356.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1350-1356
    • Millar, J.S.1    Brousseau, M.E.2    Diffenderfer, M.R.3
  • 34
    • 20244371692 scopus 로고    scopus 로고
    • Cholesteryl ester protein variants have differential stability but uniform inhibition by torcetrapib
    • Lloyd DB, Lira ME, Woods LS, et al. Cholesteryl ester protein variants have differential stability but uniform inhibition by torcetrapib. J Biol Chem 2005; 280:14918-14922.
    • (2005) J Biol Chem , vol.280 , pp. 14918-14922
    • Lloyd, D.B.1    Lira, M.E.2    Woods, L.S.3
  • 35
    • 17444372760 scopus 로고    scopus 로고
    • Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia
    • Kuivenhoven JA, De Grooth GJ, Kawamura H, et al. Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia. Am J Cardiol 2005; 95:1085-1088.
    • (2005) Am J Cardiol , vol.95 , pp. 1085-1088
    • Kuivenhoven, J.A.1    De Grooth, G.J.2    Kawamura, H.3
  • 36
    • 34250207865 scopus 로고    scopus 로고
    • Pfizer. In the interests of patient safety, Pfizer stops all torcetrapib clinical trials; company has notified FDA and is in the process of notifying all clinical investigators and other regulatory authorities [news release]. New York: Pfizer 2006; http://mediaroom.pfizer.com/index.php?s= press_release&item=130.
    • Pfizer. In the interests of patient safety, Pfizer stops all torcetrapib clinical trials; company has notified FDA and is in the process of notifying all clinical investigators and other regulatory authorities [news release]. New York: Pfizer 2006; http://mediaroom.pfizer.com/index.php?s= press_release&item=130.
  • 37
    • 34047106220 scopus 로고    scopus 로고
    • Nissen SE, Tardif JC, Nicholls SJ, et al. Effects of torcetrapib on progression of coronary atherosclerosis. N Engl J Med 2007; 356:1304-1316. In a study of 910 evaluable patients with coronary atherosclerosis who underwent IVUS at baseline and at 24 months, no significant benefit of the torcetrapib-atorvastatin combination was noted vs. atorvastatin alone on the primary endpoint which was percentage change in total atheroma despite marked increases in HDL-cholesterol.
    • Nissen SE, Tardif JC, Nicholls SJ, et al. Effects of torcetrapib on progression of coronary atherosclerosis. N Engl J Med 2007; 356:1304-1316. In a study of 910 evaluable patients with coronary atherosclerosis who underwent IVUS at baseline and at 24 months, no significant benefit of the torcetrapib-atorvastatin combination was noted vs. atorvastatin alone on the primary endpoint which was percentage change in total atheroma volume, despite marked increases in HDL-cholesterol.
  • 38
    • 34247241088 scopus 로고    scopus 로고
    • Kastelein JJ, Van Leuven SI, Burgess L, et al. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med 2007; 356:1620-1630. In a study of 850 patients with familial hypercholesterolemia treated with atorvastatin plus placebo or atorvastatin plus torcetrapib over 2 years carotid intimal medial thickness was assessed by ultrasound. No significant differences in treatment groups were observed for the primary endpoint (maximal carotid intima media thickness) between groups despite dramatic differences in HDL-cholesterol level.
    • Kastelein JJ, Van Leuven SI, Burgess L, et al. Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia. N Engl J Med 2007; 356:1620-1630. In a study of 850 patients with familial hypercholesterolemia treated with atorvastatin plus placebo or atorvastatin plus torcetrapib over 2 years carotid intimal medial thickness was assessed by ultrasound. No significant differences in treatment groups were observed for the primary endpoint (maximal carotid intima media thickness) between groups despite dramatic differences in HDL-cholesterol level.


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