Pros and cons of inhibiting cholesteryl ester transfer protein

Current Opinion in Lipidology

Volumn 11, Issue 6, 2000, Pages 589-596

  Hirano, Ken Ichi ^a,b   Yamashita, Shizuya ^a   Matsuzawa, Yuji ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ATHEROSCLEROSIS; CHOLESTEROL TRANSPORT; GENE MUTATION; GENETIC POLYMORPHISM; HUMAN; JAPAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RABBIT; REVIEW;

ANIMALS; ARTERIOSCLEROSIS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; GLYCOPROTEINS; HUMANS; MODELS, BIOLOGICAL; MUTATION; POLYMORPHISM, GENETIC; RABBITS;

ORYCTOLAGUS CUNICULUS;

EID: 0033663459     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200012000-00004     Document Type: Review

References (41)

1. Cholesteryl ester transfer protein: Friend or foe?
2. Cholesteryl ester transfer protein deficiency: Virtue or vice?
3. Plasma cholesteryl ester transfer protein and high density liporoteins: New insights from molecular genetic studies
4. Molecular genetics of plasma cholesteryl ester transfer protein
5. Genetic cholesteryl ester transfer protein deficiency is extremely frequent in Omagari area of Japan: Marked hyperalphalipoproteinemia caused by cholesteryl ester transfer protein gene mutation is not a longevity syndrome
6. Atherosclerotic disease in marked hyperalphalipoproteinemia: Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase
7. Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels
8. A low prevalence of coronary heart disease among subjects with increased high density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency
9. Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein
10. Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene
11. Changes in plasma lipoprotein cholesterol levels by antisense oligodeoxynucleotides against cholesteryl ester transfer protein in cholesterol-fed rabbits
12. Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits
13. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits
14. Marked hyper HDL2-cholesterolemia associated with premature corneal opacity: A case report
15. Molecular basis of lipid transfer protein deficieny in a family with increased high density lipoprotein
16. Accumulation of apolipoprotein E-rich high density lipoproteins in hyperalphalipoproteinemic human subjects with plasma cholesteryl ester transfer protein deficiency
17. Unravelling high density lipoprotein-apolipoprotein metabolism in human mutants and animal models
18. Detection of two species of low density lipoprotein particles in cholesteryl ester trasnsfer protein deficiency
19. Decreased affinity of low density lipoprotein (LDL) particles for LDL receptors in patients with cholesteryl ester transfer protein deficiency
20. Large and cholesteryl ester-rich high density lipoproteins in cholesteryl ester transfer protein deficiency can not prevent macrophages from cholesterol accumulation induced by acetylated low density lipoproteins
21. Very high density lipoproteins induced by plasma cholesteryl ester transfer protein (CETP) have a potent antiatherogenic function
22. Frequency of intron 14 splicing defect of cholesteryl ester transfer protein gene in the Japanese general population
23. Frequency of exon 15 missense mutation (442D: G) in cholesteryl ester transfer protein gene in hyperalphalipoproteinemic Japanese subjects
24. New functional promoter polymorphism, CETP/-629, in cholesteryl ester transfer protein (CETP) gene related to CETP mass and high density lipoprotein cholesterol levels. Role of Sp1/Sp3 in transcriptional regulation
25. A novel molecular basis for genetic cholesteryl ester transfer protein deficiency: G to A mutation in consensus ETS binding site at the promoter region of CETP gene
26. Marked hyperalphalipoproteinemia is not a longevity syndrome: Insights from a cohort study in a city where CETP deficiency accumulates
27. Cholesteryl ester transfer protein deficiency is substantially atherogenic: Measurement of pulse wave velocity and quantification of carotid and aortic plaques
28. Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertrigyceridemia
29. Elevated HDL cholesterol is a risk factor for ischemic heart disease in white women when caused by a common mutation in the cholesteryl ester transfer protein gene
30. The role of a common variant of the cholesteryl ester protein gene the of transfer in progression coronary atherosclerosis
31. Association of cholesteryl ester transfer protein-TaqlB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: The Framingham study
32. Polydisperse low-density lipoproteins in hyperalpha-lipoproteinemic chronic alcohol drinkers in association with marked reduction of cholesteryl ester transfer protein activity
33. Cholesteryl ester transfer protein gene polymorphisms are associated with carotid atherosclerosis in men
34. Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency
35. Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and atherosclerotic lesions
36. Identification of a GPI-anchored type HDL-binding protein on human macrophages
37. Involvement of decreased expression of a member of RhoGTPases, Cdc42Hs, in the pathophysiology of Tangier disease
38. Cholesteryl ester transfer protein deficiency caused by a nonsense mutation detected in the patient's macrophages mRNA
39. The role of the high-density lipoprotein receptor SR-BI in cholesterol metabolism
40. Remodeling of HDL by CETP in vivo and by CETP and hepatic lipase in vitro results in enhanced uptake of HDL-CE by cells expressing scavenger receptor B-I
41. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element