Administration of dendritic cells modified by RNA interference prolongs cardiac allograft survival

Microsurgery

Volumn 27, Issue 4, 2007, Pages 320-323

  Xiang, Jianbin ^a   Gu, Xiaodong ^a   Zhou, Yiming ^a   Gong, Xun ^a   Qian, Shiguang ^b   Chen, Zongyou ^a  

^a FUDAN UNIVERSITY   (China)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD86 ANTIGEN; RNA; SMALL INTERFERING RNA;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; CELL MATURATION; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DENDRITIC CELL; DIAGNOSTIC VALUE; GRAFT SURVIVAL; HEART GRAFT; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE; T LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGENS, CD86; CELL DIVISION; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; FEMALE; GRAFT ENHANCEMENT, IMMUNOLOGIC; GRAFT SURVIVAL; HEART TRANSPLANTATION; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MODELS, ANIMAL; RNA INTERFERENCE; T-LYMPHOCYTES; TIME FACTORS; TRANSPLANTATION, HETEROTOPIC;

EID: 34250157411     PISSN: 07381085     EISSN: 10982752     Source Type: Journal    
DOI: 10.1002/micr.20364     Document Type: Conference Paper

References (17)

1. Kita Y, Li XK, Ohba M, Funeshima N, Enosawa S, Tamura A, Suzuki K, Amemiya H, Hayashi S, Kazui T, Suzuki S. Prolonged cardiac allograft survival in rats systemically injected adenoviral vectors containing CTLA4Ig-gene. Transplantation 1999;68:758-766.
2. Raimondi G, Thomson AW. Dendritic cells, tolerance and therapy of organ allograft rejection. Contrib Nephrol 2005;146:105-120.
3. Lang TJ, Nquven P, Peach R, Gause WC, Via CS. In vivo CD86 blockade inhibits CD4+ T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function. J Immunol 2002;168:3786-3792.
4. Judge TA, Wu Z, Zheng XG, Sharpe AH, Sayegh MH, Turka LA. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J Immunol 1999; 162:1947-1951.
5. Steinman RM, Hawiger D, Nussenzweig MC. Tolerogenic dendritic cells. Annu Rev Immunol 2003;21:685-711.
6. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K. Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-498.
7. Gu X, Xiang J, Yao Y, Chen Z. Effects of RNA interference on CD80 and CD86 expression in bone marrow-derived murine dendritic cells. Scand J Immunol 2006;64:588-594.
8. Lutz MB, Kukutsch N, Ogilvie AL, Rossner S, Koch F, Romani N, Schuler G. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 1999;223:77-92.
9. Elbashir SM, Harborth J, Weber K, Tuschl T. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002;26:199-213.
10. Lutz MB, Kukutsch NA, Menges M, Rossner S, Schuler G. Culture of bone marrow cells in GM-CSF plus high doses of lipopolysaccharide generates exclusively immature dendritic cells which induce alloantigen-specific CD4 T cell anergy in vitro. Eur J Immunol 2000;30:1048-1052.
11. Bonham CA, Peng L, Liang X, Chen Z, Wang L, Ma L, Hackstein H, Robbins PD, Thomson AW, Fung JJ, Qian S, Lu L. Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-κB oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-1g. J Immunol 2002;169:3382-3391.
12. Min WP, Gorczynski R, Huang XY, Kushida M, Kim P, Obataki M, Lei J, Suri RM, Cattral MS. Dendritic cells genetically engineered to express Fas ligand induce donor-specific hyporesponsiveness and prolong allograft survival. J Immunol 2000;164:161-167.
13. Gorczynski RM, Bransom J, Cattral M, Huang X, Lei J, Xiaorong L, Min WP, Wan Y, Gauldie J. Synergy in induction of increased renal allograft survival after portal vein infusion of dendritic cells transduced to express TGFβ and IL-10, along with administration of CHO cells expressing the regulatory molecule OX-2. Clin Immunol 2000;95:182-189.
14. Liang X, Lu L, Chen Z, Vickers T, Zhang H, Fung JJ, Qian S. Administration of dendritic cells transduced with antisense oligodeoxyribonucleotides targeting CD80 or CD86 prolongs allograft survival. Transplantation 2003;76:721-729.
15. Ichim TE, Zhong R, Min WP. Prevention of allograft rejection by in vitro generated tolerogenic dendritic cells. Transpl Immunol 2003; 11:295-306.
16. Gurney AM, Hunter E. The use of small interfering RNA to elucidate the activity and function of ion channel genes in an intact tissue. J Pharmacol Toxicol Methods 2005;51:253-262.
17. Sansom DM, Manzotti CN, Zheng Y. What's the difference between CD80 and CD86? Trends Immunol 2003;24:314-319.