Anti-inflammatory effects of exogenous uridine in an animal model of lung inflammation

International Immunopharmacology

Volumn 7, Issue 8, 2007, Pages 1025-1032

  Evaldsson, C ^a,b   Ryden I ^c   Uppugunduri, S ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c KALMAR COUNTY HOSPITAL   (Sweden)

Author keywords

Asthma; Inflammation; Leukocytes; Sephadex; Tumour necrosis factor; Uridine

Indexed keywords

ADENOSINE TRIPHOSPHATE; DEXTRAN; G PROTEIN COUPLED RECEPTOR; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE TRANSPORTER; NUCLEOTIDE DERIVATIVE; PURINE P2 RECEPTOR; PURINE P2X RECEPTOR; PURINE P2Y RECEPTOR; SEPHADEX; TUMOR NECROSIS FACTOR; URIDINE; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; CELL INFILTRATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; EDEMA; EOSINOPHIL; GIANT CELL; GRANULOMA; LEUKOCYTE COUNT; LUNG LAVAGE; LUNG WEIGHT; MACROPHAGE; MALE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RAT; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BRONCHOALVEOLAR LAVAGE; DEXTRANS; DISEASE MODELS, ANIMAL; GRANULOMA; INTUBATION, INTRATRACHEAL; LEUKOCYTE COUNT; MACROPHAGES; MALE; MICROSPHERES; PNEUMONIA; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; URIDINE;

EID: 34249995227     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.03.008     Document Type: Article

References (32)

1. Rossi L., Manfredini R., Bertolini F., Ferrari D., Fogli M., Zini R., et al. The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration. Blood 109 2 (2007) 533-542
2. Anderson C.M., and Parkinson F.E. Potential signalling roles for UTP and UDP: sources, regulation and release of uracil nucleotides. Trends Pharmacol Sci 18 10 (1997) 387-392
3. Uppugunduri S., and Gautam C. Effects of uridine, isomaltitol and 4-thiouridine on in vitro cell adhesion and in vivo effects of 4-thiouridine in a lung inflammation model. Int Immunopharmacol 4 9 (2004) 1241-1248
4. Heilbronn E., Knoblauch B.H., and Muller C.E. Uridine nucleotide receptors and their ligands: structural, physiological, and pathophysiological aspects, with special emphasis on the nervous system. Neurochem Res 22 8 (1997) 1041-1050
5. Anderson J.M. Multinucleated giant cells. Curr Opin Hematol 7 1 (2000) 40-47
6. Adams D.O. The granulomatous inflammatory response. A review. Am J Pathol 84 1 (1976) 164-191
7. Al Safarjalani O.N., Zhou X.J., Naguib F.N., Shi J., Schinazi R.F., and el Kouni M.H. Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy. Cancer Chemother Pharmacol 48 5 (2001) 389-397
8. Lu H., Chen C., and Klaassen C. Tissue distribution of concentrative and equilibrative nucleoside transporters in male and female rats and mice. Drug Metab Dispos 32 12 (2004) 1455-1461
9. Van Rompay A.R., Norda A., Linden K., Johansson M., and Karlsson A. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol Pharmacol 59 5 (2001) 1181-1186
10. Ferrari D., Idzko M., Dichmann S., Purlis D., Virchow C., Norgauer J., et al. P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production. FEBS Lett 486 3 (2000) 217-224
11. Jin J., Dasari V.R., Sistare F.D., and Kunapuli S.P. Distribution of P2Y receptor subtypes on haematopoietic cells. Br J Pharmacol 123 5 (1998) 789-794
12. Yitzhaki S., Shneyvays V., Jacobson K.A., and Shainberg A. Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress. Biochem Pharmacol 69 8 (2005) 1215-1223
13. Lazarowski E.R., Paradiso A.M., Watt W.C., Harden T.K., and Boucher R.C. UDP activates a mucosal-restricted receptor on human nasal epithelial cells that is distinct from the P2Y2 receptor. Proc Natl Acad Sci U S A 94 6 (1997) 2599-2603
14. Chootip K., Gurney A.M., and Kennedy C. Multiple P2Y receptors couple to calcium-dependent, chloride channels in smooth muscle cells of the rat pulmonary artery. Respir Res 6 (2005) 124
15. Becroft D.M., Phillips L.I., Webster D.R., and Wilson J.D. Absence of immune deficiency in hereditary orotic aciduria. N Engl J Med 310 20 (1984) 1333-1334
16. Girot R., Hamet M., Perignon J.L., Guesnu M., Fox R.M., Cartier P., et al. Cellular immune deficiency in two siblings with hereditary orotic aciduria. N Engl J Med 308 12 (1983) 700-704
17. Kannan S. Neutrophil degranulation: coactivation of chemokine receptor(s) is required for extracellular nucleotide-induced neutrophil degranulation. Med Hypotheses 57 3 (2001) 306-309
18. Idzko M., Panther E., Bremer H.C., Sorichter S., Luttmann W., Virchow Jr. C.J., et al. Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br J Pharmacol 138 7 (2003) 1244-1250
19. O'Flaherty J.T., and Cordes J.F. Human neutrophil degranulation responses to nucleotides. Lab Invest 70 6 (1994) 816-821
20. Idzko M., Dichmann S., Ferrari D., Di Virgilio F., la Sala A., Girolomoni G., et al. Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood 100 3 (2002) 925-932
21. Verghese M.W., Kneisler T.B., and Boucheron J.A. P2U agonists induce chemotaxis and actin polymerization in human neutrophils and differentiated HL60 cells. J Biol Chem 271 26 (1996) 15597-15601
22. Pizzorno G., Cao D., Leffert J.J., Russell R.L., Zhang D., and Handschumacher R.E. Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochim Biophys Acta 1587 2-3 (2002) 133-144
23. Walker U.A., Venhoff N., Koch E.C., Olschewski M., Schneider J., and Setzer B. Uridine abrogates mitochondrial toxicity related to nucleoside analogue reverse transcriptase inhibitors in HepG2 cells. Antivir Ther 8 5 (2003) 463-470
24. Hou M., Moller S., Edvinsson L., and Erlinge D. Cytokines induce upregulation of vascular P2Y(2) receptors and increased mitogenic responses to UTP and ATP. Arterioscler Thromb Vasc Biol 20 9 (2000) 2064-2069
25. Sapronov N.S., Eliseev V.V., and Rodionova O.M. Effect of uridine derivatives on myocardial stunning during postischemic reperfusion of rat heart. Bull Exp Biol Med 130 10 (2000) 964-966
26. Belvisi M.G., Haddad E.B., Battram C., Birrell M., Foster M., and Webber S. Anti-inflammatory properties of ebselen in a model of sephadex-induced lung inflammation. Eur Respir J 15 3 (2000) 579-581
27. Birrell M., Hele D., McCluskie K., Webber S., Foster M., and Belvisi M.G. Effect of the p38 kinase inhibitor, SB 203580, on sephadex induced airway inflammation in the rat. Eur Respir J 16 5 (2000) 947-950
28. Finsnes F., Skjonsberg O.H., Lyberg T., and Christensen G. Endothelin-1 production is associated with eosinophilic rather than neutrophilic airway inflammation. Eur Respir J 15 4 (2000) 743-750
29. Ito A., Miyake M., Morishita M., Ito K., Torii S., and Sakamoto T. Dexamethasone reduces lung eosinophilia, and VCAM-1 and ICAM-1 expression induced by Sephadex beads in rats. Eur J Pharmacol 468 1 (2003) 59-66
30. Torii A., Miyake M., Morishita M., Ito K., Torii S., and Sakamoto T. Vitamin A reduces lung granulomatous inflammation with eosinophilic and neutrophilic infiltration in Sephadex-treated rats. Eur J Pharmacol 497 3 (2004) 335-342
31. Becroft D.M., and Phillips L.I. Hereditary orotic aciduria and megaloblastic anaemia: a second case, with response to uridine. Br Med J (1965) 547-552
32. Page T., Yu A., Fontanesi J., and Nyhan W.L. Developmental disorder associated with increased cellular nucleotidase activity. Proc Natl Acad Sci U S A 94 21 (1997) 11601-11606