Cell type-specific quantitative predictions of radiation-induced chromosome aberrations: A computer model approach

Radiation Research

Volumn 167, Issue 5, 2007, Pages 515-525

  Kreth, G ^a   Pazhanisamy, S K ^a   Hausmann, M ^a   Cremer, C ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALGORITHM; ARTICLE; CALCULATION; CELL NUCLEUS MEMBRANE; CELL TYPE; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; COMPUTER MODEL; DICENTRIC CHROMOSOME; EXPERIMENTAL STUDY; KARYOTYPE; LYMPHOCYTE; PREDICTION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; SIMULATION; STATISTICAL SIGNIFICANCE; VIRTUAL REALITY; ANTIBODY SPECIFICITY; COMPUTER SIMULATION; GENETICS; HUMAN; METABOLISM; MONTE CARLO METHOD;

DNA;

CHROMOSOME ABERRATIONS; COMPUTER SIMULATION; DNA; HUMANS; LYMPHOCYTES; MONTE CARLO METHOD; ORGAN SPECIFICITY;

EID: 34249945361     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR0691.1     Document Type: Article

References (32)

1. T. Cremer and C. Cremer, Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat. Rev. Genet. 2, 292-301 (2001).
2. M. Dundr and T. Misteli, Functional architecture in the cell nucleus. Biochem. J. 356, 297-310 (2001).
3. T. P. O'Brien, C. J. Bult, C. Cremer, M. Grunze, B. B. Knowles, J. Langowski, J. McNally, T. Pederson, J. C. Politz and R. van Driel, Genome function and nuclear architecture: From gene expression to nanoscience. Genome Res. 13, 1029-1041 (2003).
4. S. Kozubek, E. Lukasova, A. Mareckova, M. Skalnikova, M. Kozubek, E. Bartova, V. Kroha, E. Krahulcova and J. Slotova, The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias. Chromosoma 108, 426-435 (1999).
5. M. N. Cornforth, K. M. Greulich-Bode, B. D. Loucas, J. Arsuaga, M. Vazquez, R. K. Sachs, M. Bruckner, M. Molls, P. Hahnfeldt and D. J. Brenner, Chromosomes are predominantly located randomly with respect to each other in interphase human cells. J. Cell Biol. 159, 237-244 (2002).
6. J. J. Roix, P. G. McQueen, P. J. Munson, L. A. Parada and T. Misteli, Spatial proximity of translocation-prone gene loci in human lymphomas. Nat. Genet. 34, 287-291 (2003).
7. J. Arsuaga, K. M. Greulich-Bode, M. Vazquez, M. Bruckner, P. Hahnfeldt, D. J. Brenner, R. Sachs and L. Hlatky, Chromosome spatial clustering inferred from radiogenic aberrations. Int. J. Radiat. Biol. 80, 507-515 (2004).
8. L. A. Parada, S. Sotiriou and T. Misteli, Spatial genome organization. Exp. Cell Res. 296, 64-70 (2004).
9. H. Tanabe, S. Müller, M. Neusser, J. von Hase, E. Calcagno, M. Cremer, I. Solovei, C. Cremer and T. Cremer, Evolutionary conservation of chromosome territory arrangements in cell nuclei from higher primates. Proc. Natl. Acad. Sci. USA 99, 4424-4429 (2002).
10. S. Boyle, S. Gilchrist, J. M. Bridger, N. L. Mahy, J. A. Ellis and W. A. Bickmore, The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells. Hum. Mol. Genet. 10, 211-219 (2001).
11. M. Cremer, J. von Hase, T. Volm, A. Brero, G. Kreth, J. Walter, C. Fischer, I. Solovei, C. Cremer and T. Cremer, Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells. Chrom. Res. 9, 541-567 (2001).
12. H. B. Sun, J. Shen and H. Yokota, Size-dependent positioning of human chromosomes in interphase nuclei. Biophys. J. 79, 184-190 (2000).
13. A. Bolzer, G. Kreth, I. Solovei, D. Koehler, K. Saracoglu, Ch. Fauth, S. Müller, R. Eils, C. Cremer and T. Cremer, Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes. PLOS Biol. 3, e157 (2005).
14. R. K. Sachs, A. M. Chen and D. J. Brenner, Proximity effects in the production of chromosome aberrations by ionizing radiation. Int. J. Radiat. Biol. 71, 1-19 (1997).
15. R. K. Sachs, D. Levy, A. M. Chen, P. J. Simpson, M. N. Cornforth, E. Ingerman, P. Hahnfeldt and L. R. Hlatky, Random breakage-and-reunion chromosome aberration formation model: An interaction-distance implementation based on chromatin geometry. Int. J. Radiat. Biol. 76, 1579-1588 (2000).
16. W. R. Holley, I. S. Mian, S. J. Park, B. Rydberg and A. Chatterjee, A model for interphase chromosomes and evaluation of radiation-induced aberrations. Radiat. Res. 158, 568-580 (2002).
17. F. Ballarini, M. Biaggi and A. Ottolenghi, Nuclear architecture and radiation induced chromosome aberrations: models and simulations. Radiat. Prot. Dosim. 99, 175-182 (2002).
18. G. Kreth, J. Finsterle, J. von Hase, M. Cremer and C. Cremer, Radial arrangement of chromosome territories in human cell nuclei: A computer model approach based on gene-density indicates a probabilistic global positioning code. Biophys. J. 86, 2803-2812 (2004).
19. G. Kreth, J. Finsterle and C. Cremer, Virtual radiation biophysics: Implications of nuclear structure. Cytogenet. Genome Res. 104, 157-161 (2004).
20. T. Cremer, G. Kreth, H. Koester, R. H. A. Fink, R. Heintzmann, M. Cremer, I. Solovei, D. Zink and C. Cremer, Chromosome territories, interchromatin domain compartment and nuclear matrix: An integrated view of the functional nuclear architecture. Crit. Rev. Eukaryot. Gene Expr. 10, 179-212 (2000).
21. P. J. Johnston, P. L. Olive and P. E. Bryant, Higher-order chromatin structure-dependent repair of DNA double-strand breaks: Modeling the elution of DNA from nucleoids. Radiat. Res. 148, 561-567 (1997).
22. B. D. Loucas and M. N. Cornforth, Complex chromosome exchanges induced by gamma rays in human lymphocytes: An mFISH study. Radiat. Res. 155, 660-671 (2001).
23. A. A. Edwards, The use of chromosomal aberrations in human lymphocytes for biological dosimetry. Radiat. Res. 148, 539-544 (1997).
24. D. C. Lloyd, R. J. Purrott, G. W. Dolphin, D. Bolton, A. A. Edwards and M. J. Corp, The relationship between chromosome aberrations and low LET radiation dose to human lymphocytes. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 28, 75-90 (1975).
25. D. C. Lloyd, A. A. Edwards and J. S. Prosser, Chromosome aberrations induced in human lymphocytes by in vitro acute X and gamma radiation. Radiat. Prot. Dosim. 15, 83-88 (1986).
26. E. Schmid, H. Braselmann and U. Nahrstedt, Comparison of gamma-ray induced dicentric yields in human lymphocytes measured by conventional analysis and FISH. Mutat. Res. 348, 125-130 (1995).
27. C. Lindholm, S. Luomahaara, A. Koivistoinen, T. Ilus, A. A. Edwards and S. Salomaa, Comparison of dose-response curves for chromosomal aberrations established by chromosome painting and conventional analysis. Int. J. Radiat. Biol. 74, 27-34 (1998).
28. A. A. Edwards, V. V. Moiseenko and H. Nikjoo, Modelling of DNA breaks and the formation of chromosome aberrations. Int. J. Radiat. Biol. 66, 633-637 (1994).
29. G. Kreth, C. Münkel, J. Langowski, T. Cremer and C. Cremer, Chromatin structure and chromosome aberrations: Modelling of damage induced by isotropic and localized irradiation. Mutat. Res. 404, 77-88 (1998).
30. R. J. Simpson and J. R. K. Savage, Dose-response curves for simple and complex chromosome aberrations induced by x-rays and detected using fluorescence in situ hybridization. Int. J. Radiat. Biol. 69, 429-436 (1996).
31. M. R. Branco and A. Pombo, Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations. PLOS Biol. 4, e138 (2006).
32. L. S. Shopland, C. R. Lynch, K. A. Peterson, K. Thornton, N. Kepper, J. Hase, S. Stein, S. Vincent, K. R. Molloy and T. P. O'Brien, Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence. J. Cell Biol. 174, 27-38 (2006).