Dose-response curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridization

International Journal of Radiation Biology

Volumn 69, Issue 4, 1996, Pages 429-436

  Simpson, P J ^a   Savage, J R K ^a  

^a Chromosome Damage Group   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DOSE RESPONSE; FIBROBLAST CULTURE; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; X IRRADIATION;

CELL LINE; CHROMOSOME ABERRATIONS; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; X-RAYS;

EID: 0029938407     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530096145724     Document Type: Article

References (25)

1. BENDER, M. A., GRIGGS, H. S. and BEDFORD, J. S., 1974, Mechanisms of chromosomal aberration production. III. Chemicals and ionizing radiation. Mutation Research, 23, 387-402.
2. BROWN, J. M. and KOVACS, M. S., 1993, Visualisation of nonreciprocal chromosome exchanges in irradiated human fibroblasts by fluorescent in situ hybridisation. Radiation Research, 136, 71-70.
3. CHADWICK, K. H. and LEENHOUTS, H. P., 1978, The rejoining of DNA double-strand breaks and a model for the formation of chromosomal rearrangements. International Journal of Radiation Biology, 33, 517-529.
4. CHADWICK, K. H. and LEENHOUTS, H. P., 1981, The Molecular Theory of Radiation Biology (Springer, Berlin).
5. GOODHEAD, D. T., 1994, Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. International Journal of Radiation Biology, 65, 7-17.
6. GOODHEAD, D. T. and NIKJOO, H., 1989, Track-structure analysis of ultra-soft X-rays compared to high- and low-LET radiations. International Journal of Radiation Biology, 55, 513-529.
7. GOODHEAD, D. T., THACKER, J. and COX, R., 1993, Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. International Journal of Radiation Biology, 63, 543-550.
8. LEA, D. E. and CATCHESIDE, D. G., 1942, The mecanisms of the induction by radiation of chromosome aberrations in Tradescantia. Journal of Genetics, 44, 216-245.
9. LLOYD, D. C., PURROTT, R. J., DOLPHIN G. W., BOLTON, D. and EDWARDS, A. A., 1975, The relationship between chromosome aberrations and low LET radiation dose to human lymphocytes. International Journal of Radiation Biology, 28, 75-90.
10. NORMAN, A. and SASAKI, M. S., 1966, Chromosome-exchange aberrations in human lymphocytes. International Journal of Radiation Biology, 11, 321-328.
11. RESNICK, M. A., 1976, The repair of double-strand breaks in DNA: a model involving recombination. Journal of Theoretical Biology, 59, 97-106.
12. SAVAGE, J. R. K., 1975, Radiation-induced chromosomal aberrations in the plant Tradescantia: dose-response curves. Radiation Botany, 15, 87-140.
13. SAVAGE, J. R. K., 1995a, The transmission of FISH-painted patterns derived from complex chromosome exchanges. Mutation Research, 347, 87-95.
14. SAVAGE, J. R. K., 1995b, Insights into sites, Mutation Research (in press).
15. SAVAGE, J. R. K., and SIMPSON, P. J., 1994a, FISH 'painting' patterns resulting from complex exchanges. Mutation Research, 312, 51-60.
16. SAVAGE, J. R. K. and SIMPSON, P. J., 1994b, On the scoring of FISH-'painted' chromosome-type exchange aberrations. Mutation Research, 307, 345-353.
17. SAX, K., 1940, An analysis of X-ray induced chromosomal aberrations in Tradescantia. Genetics, 25, 11-68.
18. SIMPSON, P. J. and SAVAGE, J. R. K., 1994, Identification of X-ray-induced complex aberrations using fluorescence in situ hybridization: a comparison at two doses. International Journal of Radiation Biology, 66, 629-632.
19. SIMPSON, P. J. and SAVAGE, J. R. K., 1995a, estimating the true frequency of X-ray-induced complex chromosome exchanges using fluorescence in situ hybridization. International Journal of Radiation Biology, 67, 37-45.
20. SIMPSON, P. J. and SAVAGE, J. R. K., 1995b, Detecting 'hidden' exchange events within X-ray induce 1 aberrations using multicolour chromosome paints. Chromosome Research, 3, 69-72.
21. POWELL, S. and MCMILLAN, T. J., 1990, DNA damage and repair following treatment with ionising radiation. Radiation and Oncology, 19, 95-108.
22. TAYLOR, A. M. R., 1978, Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations. Mutation Research, 50, 407-41S.
23. THACKER, J. T., COX, R. and GOODHEAD, D. T., 1980, Do carbon soft X-rays induce exchange aberrations in cultured mammalian cells? International Journal of Radiation Biology, 38, 469-472.
24. THACKER, J. T., WILKINSON, R. E. and GOODHEAD, D. T., 1986, The induction of chromosome exchange abrerrations by carbon ultrasoft X-rays in V79 hamster cells. International Journal of Radiation Biology, 49, 645-656.
25. TUCKER, J. D., RAMSFY, M. J. and MINKLER, J. L., 1993, Validation of chromosome painting as a biodosimeter in human peripheral lymphocytes following acute exposure to ionizing radiation in vitro. International Journal of Radiation Biology, 64, 27-37.