Effect of linear energy transfer (LET) on the complexity of α-particle-induced chromosome aberrations in human CD34+ cells

Radiation Research

Volumn 167, Issue 5, 2007, Pages 541-550

  Anderson, Rhona M ^a,b   Stevens, David L ^a   Sumption, Natalia D ^a   Townsend, K M Stuart ^a   Goodhead, Dudley T ^a   Hill, Mark A ^a  

^a MRC Radiation And Genome Stability Unit   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; CD34 ANTIGEN;

ALPHA RADIATION; ARTICLE; CELL CYCLE; CELL DAMAGE; CELL DIVISION; CELL STRUCTURE; CHROMOSOME ABERRATION; DOUBLE STRANDED DNA BREAK; FLUORESCENCE IN SITU HYBRIDIZATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; INTERPOSITUS NUCLEUS; LINEAR ENERGY TRANSFER; METAPHASE; MITOSIS; PREDICTION; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; APOPTOSIS; BONE MARROW CELL; CELL CULTURE; CYTOLOGY; GENETICS; HUMAN CHROMOSOME; METABOLISM; RADIATION EXPOSURE;

ALPHA PARTICLES; ANTIGENS, CD34; APOPTOSIS; BONE MARROW CELLS; CELL CYCLE; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; HUMANS;

EID: 34249943148     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR0813.1     Document Type: Article

References (35)

1. H. Nikjoo, P. O'Neill, W. E. Wilson and D. T. Goodhead, Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiat. Res. 156, 577-583 (2001).
2. H. G. Paretzke, Radiation track theory. In Kinetics of Nonhomologous Processes (G. R. Freeman, Ed.), pp. 89-169. Wiley, New York, 1987.
3. National Research Council, Committee on Health Risks of Exposure to Radon, Health Effects of Exposure to Radon (BEIR VI). National Academy Press, Washington, DC, 1998.
4. P. J. Simpson and J. R. Savage, Dose-response curves for simple and complex chromosome aberrations induced by X-rays and detected using fluorescence in situ hybridization. Int. J. Radiat. Biol. 69, 429-436 (1996).
5. R. M. Anderson, S. J. Marsden, E. G. Wright, M. A. Kadhim, D. T. Goodhead and C. S. Griffin, Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alpha-particles. Int. J. Radiat. Biol. 76, 31-42 (2000).
6. K. M. Greulich, L. Kreja, B. Heinze, A. P. Rhein, H. G. Weier, M. Bruckner, P. Fuchs and M. Molls, Rapid detection of radiation-induced chromosomal aberrations in lymphocytes and hematopoietic progenitor cells by mFISH. Mutat. Res. 452, 73-81 (2000).
7. B. D. Loucas and M. N. Cornforth, Complex chromosome exchanges induced by gamma rays in human lymphocytes: An mFISH study. Radiat. Res. 155, 660-671 (2001).
8. 238Pu alpha-particles and detected by fluorescence in situ hybridization using single chromosome-specific probes. Int. J. Radiat. Biol. 67, 431-439 (1995).
9. J. E. Moquet, J. L. Fernandez, A. A. Edwards and D. C. Lloyd, Lymphocyte chromosomal aberrations and their complexity induced in vitro by plutonium-239 alpha-particles and detected by FISH. Cell. Mol. Biol. 47, 549-556 (2001).
10. I. Testard, B. Dutrillaux and L. Sabatier, Chromosomal aberrations induced in human lymphocytes by high-LET irradiation. Int. J. Radiat. Biol. 72, 423-433 (1997).
11. M. Durante, L. Cella, Y. Furusawa, K. George, G. Gialanella, G. Grossi, M. Pugliese, M. Saito and T. C. Yang, The effect of track structure on the induction of chromosomal aberrations in murine cells. Int. J. Radiat. Biol. 73, 253-262 (1998).
12. M. Durante, K. George, H. Wu and F. A. Cucinotta, Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat. Res. 158, 581-590 (2002).
13. R. M. Anderson, D. L. Stevens and D. T. Goodhead, M-FISH analysis shows that complex chromosome aberrations induced by alpha-particle tracks are cumulative products of localized rearrangements. Proc. Natl. Acad. Sci. USA 99, 12167-12172 (2002).
14. M. P. Hande, T. V. Azizova, C. R. Geard, L. E. Burak, C. R. Mitchell, V. F. Khokhryakov, E. K. Vasilenko and D. J. Brenner, Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am. J. Hum. Genet. 72, 1162-1170 (2003).
15. R. B. Richardson, J. P. Eatough and D. L. Henshaw, Dose to red bone marrow from natural radon and thoron exposure. Br. J. Radiol. 64, 608-624 (1991).
16. D. T. Goodhead, D. A. Bance, A. Stretch and R. E. Wilkinson, A versatile Pu-238 irradiator for radiobiological studies with alpha-particles. Int. J. Radiat. Biol. 59, 195-210 (1991).
17. R. M. Anderson, V. V. Tsepenko, G. N. Gasteva, A. A. Molokanov, A. V. Sevan'kaev and D. T. Goodhead, mFISH analysis reveals complexity of chromosome aberrations in individuals occupationally exposed to internal plutonium: A pilot study to assess the relevance of complex aberrations as biomarkers of exposure to high-let alpha particles. Radiat. Res. 163, 26-35 (2005).
18. J. R. Savage and P. J. Simpson, FISH "painting" patterns resulting from complex exchanges. Mutat. Res. 312, 51-60 (1994).
19. R. K. Sachs, A. M. Chen, P. J. Simpson, L. R. Hlatky, P. Hahnfeldt and J. R. Savage, Clustering of radiation-produced breaks along chromosomes: Modelling the effects on chromosome aberrations. Int. J. Radiat. Biol. 75, 657-672 (1999).
20. M. N. Cornforth, Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting. Radiat. Res. 155, 643-659 (2001).
21. R. M. Anderson, D. G. Papworth, D. L. Stevens, N. D. Sumption and D. T. Goodhead, Increased complexity of radiation-induced chromosome aberrations consistent with a mechanism of sequential formation. Cytogenet. Genome Res. 112, 35-44 (2006).
22. J. J. Boei, S. Vermeulen and A. T. Natarajan, Detection of chromosomal aberrations by fluorescence in situ hybridization in the first three postirradiation divisions of human lymphocytes. Mutat. Res. 349, 127-135 (1996).
23. A. A. Edwards, The use of chromosomal aberrations in human lymphocytes for biological dosimetry. Radiat. Res. 148 (Suppl.), S39-S44 (1997).
24. 0. Int. J. Radiat. Biol. 78, 765-772 (2002).
25. K. George, H. Wu, V. Willingham, Y. Furusawa, T. Kawata and F. A. Cucinotta, High- and low-LET induced chromosome damage in human lymphocytes: A time-course of aberrations in metaphase and interphase. Int. J. Radiat. Biol. 77, 175-183 (2001).
26. S. Ritter, E. Nasonova, W. Kraft-Weyrather and G. Kraft, Influence of radiation quality on the expression of chromosomal damage. Int. J. Radiat. Biol. 66, 625-628 (1994).
27. M. Durante, Y. Furusawa, K. George, G. Gialanella, O. Greco, G. Grossi, N. Matsufuji, M. Pugliese and T. C. Yang, Rejoining and misrejoining of radiation-induced chromatin breaks. IV. Charged particles. Radiat. Res. 149, 446-454 (1998).
28. A. A. Edwards and J. R. Savage, Is there a simple answer to the origin of complex chromosome exchanges? Int. J. Radiat. Biol. 75, 19-22 (1999).
29. B. D. Loucas and C. R. Geard, Initial damage in human interphase chromosomes from alpha particles with linear energy transfers relevant to radon exposure. Radiat. Res. 139, 9-14 (1994).
30. C. S. Griffin, M. A. Hill, D. G. Papworth, K. M. S. Townsend, J. R. K. Savage and D. T. Goodhead, Effectiveness of 0.28 keV carbon K ultrasoft X-rays at producing simple and complex chromosome exchanges in human fibroblasts in vitro detected using FISH. Int. J. Radiat. Biol. 73, 591-598 (1998).
31. K. H. Chadwick and H. P. Leenhouts, The rejoining of DNA double-strand breaks and a model for the formation of chromosomal rearrangements. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 33, 517-529 (1978).
32. T. J. Jenner, C. M. deLara, P. O'Neill and D. L. Stevens, Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following gamma- and alpha-irradiation. Int. J. Radiat. Biol. 64, 265-273 (1993).
33. K. M. Prise, M. Pinto, H. C. Newman and B. D. Michael, A review of studies of ionizing radiation-induced double-strand break clustering. Radiat. Res. 156, 572-576 (2001).
34. S. W. Botchway, D. L. Stevens, M. A. Hill, T. J. Jenner and P. O'Neill, Induction and rejoining of DNA double-strand breaks in Chinese hamster V79-4 cells irradiated with characteristic aluminum K and copper L ultrasoft X rays. Radiat. Res. 148, 317-324 (1997).
35. H. G. Paretzke, D. T. Goodhead, I. G. Kaplan and M. Terrissol, Track structure quantities. In Atomic and Molecular Data for Radiotherapy and Radiation Research, pp. 633-721. International Atomic Energy Agency, Vienna, 1995.