Levels of three distinct p75 neurotrophin receptor forms found in human plasma are altered in type 2 diabetic patients

Diabetologia

Volumn 50, Issue 7, 2007, Pages 1517-1522

  Humpert, P M ^a   Kopf, S ^a   Djuric, Z ^a   Laine, K ^a   Korosoglou, G ^a   Rudofsky Jr , G ^a   Hamann, A ^a   Morcos, M ^a   Von Eynatten, M ^b   Nawroth, P P ^a   Bierhaus, A ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cardiovascular autonomic neuropathy; Diabetic polyneuropathy; p75 neurotrophin receptor; Peripheral neuropathy; Type 2 diabetes

Indexed keywords

INSULIN; NEUROTROPHIN RECEPTOR; PROTEIN P75;

ADULT; AGED; ARTICLE; AUTONOMIC NEUROPATHY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HEART RATE VARIABILITY; HUMAN; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIPHERAL NEUROPATHY; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SCORING SYSTEM; WESTERN BLOTTING;

AGED; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; DIABETIC NEUROPATHIES; EPITOPES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MALE; MIDDLE AGED; NEURONS; PERIPHERAL NERVOUS SYSTEM; RECEPTOR, NERVE GROWTH FACTOR;

EID: 34249938900     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0683-3     Document Type: Article

References (21)

1. Chilton L, Middlemas A, Gardiner N, Tomlinson DR (2004) The p75 neurotrophin receptor appears in plasma in diabetic rats-characterisation of a potential early test for neuropathy. Diabetologia 47:1924-1930
2. Barker PA (2004) p75NTR is positively promiscuous: novel partners and new insights. Neuron 42:529-533
3. Barker PA, Shooter EM (1994) Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron 13:203-215
4. Cusick M, Meleth AD, Agron E et al (2005) Associations of mortality and diabetes complications in patients with type 1 and type 2 diabetes: early treatment diabetic retinopathy study report no. 27. Diabetes Care 28:617-625
5. Maser RE, Mitchell BD, Vinik AI, Freeman R (2003) The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis. Diabetes Care 26:1895-1901
6. Bierhaus A, Schiekofer S, Schwaninger M et al (2001) Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes 50:2792-2808
7. Roose SP, Laghrissi-Thode F, Kennedy JS et al (1998) Comparison of paroxetine and nortriptyline in depressed patients with ischemic heart disease. JAMA 279:287-291
8. Sampson MJ, Drury PL (1992) Accurate estimation of glomerular filtration rate in diabetic nephropathy from age, body weight, and serum creatinine. Diabetes Care 15:609-612
9. Young MJ, Boulton AJ, MacLeod AF, Williams DR, Sonksen PH (1993) A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population. Diabetologia 36:150-154
10. Ziegler D, Siekierka-Kleiser E, Meyer B, Schweers M (2005) Validation of a novel screening device (NeuroQuick) for quantitative assessment of small nerve fiber dysfunction as an early feature of diabetic polyneuropathy. Diabetes Care 28:1169-1174
11. Zampieri N, Xu CF, Neubert TA, Chao MV (2005) Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains. J Biol Chem 280:14563-14571
12. Lee KF, Bachman K, Landis S, Jaenisch R (1994) Dependence on p75 for innervation of some sympathetic targets. Science 263:1447-1449
13. Lee KF, Li E, Huber LJ et al (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69:737-749
14. Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology (1996) Assessment: clinical autonomic testing report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 46:873-880
15. Sorensen B, Tandrup T, Koltzenburg M, Jakobsen J (2003) No further loss of dorsal root ganglion cells after axotomy in p75 neurotrophin receptor knockout mice. J Comp Neurol 459:242-250
16. Kanning KC, Hudson M, Amieux PS, Wiley JC, Bothwell M, Schecterson LC (2003) Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J Neurosci 23:5425-5436
17. Schiekofer S, Andrassy M, Chen J et al (2003) Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs. Diabetes 52:621-633
18. Bierhaus A, Haslbeck KM, Humpert PM et al (2004) Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J Clin Invest 114:1741-1751
19. Schor NF (2005) The p75 neurotrophin receptor in human development and disease. Prog Neurobiol 77:201-214
20. Vinik AI, Maser RE, Mitchell BD, Freeman R (2003) Diabetic autonomic neuropathy. Diabetes Care 26:1553-1579
21. Yang B, Slonimsky JD, Birren SJ (2002) A rapid switch in sympathetic neurotransmitter release properties mediated by the p75 receptor. Nat Neurosci 5:539-545