Hypothermia

Seminars in Fetal and Neonatal Medicine

Volumn 12, Issue 4, 2007, Pages 303-310

  Azzopardi, D ^a   Edwards, A D ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Asphyxia; Disabilities; Hypothermia; Hypoxia ischaemia; Meta analyses; Neuroprotection

Indexed keywords

ANTIINFLAMMATORY AGENT; CALCIUM CHANNEL BLOCKING AGENT; GLUTAMATE RECEPTOR ANTAGONIST; GROWTH FACTOR; SCAVENGER;

BODY TEMPERATURE; BRAIN DISEASE; BRAIN FUNCTION; BRAIN HYPOXIA; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN PROTECTION; CLINICAL STUDY; CLINICAL TRIAL; COLD TREATMENT; CONTROLLED CLINICAL TRIAL; CRYOTHERAPY; ELECTROENCEPHALOGRAM; ENERGY METABOLISM; FOLLOW UP; HUMAN; META ANALYSIS; METABOLIC REGULATION; NEWBORN MORTALITY; NONHUMAN; PERINATAL ASPHYXIA; PERINATAL CARE; RANDOMIZED CONTROLLED TRIAL; REVIEW; SURVIVAL RATE; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME;

ANIMALS; ASPHYXIA NEONATORUM; BODY TEMPERATURE; HUMANS; HYPOTHERMIA, INDUCED; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; RANDOMIZED CONTROLLED TRIALS; TREATMENT OUTCOME;

EID: 34249913163     PISSN: 1744165X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.siny.2007.01.022     Document Type: Review

References (71)

1. Siesjo B.K., Katsura K., and Kristian T. The biochemical basis of cerebral ischemic damage. J Neurosurg Anesthesiol 7 (1995) 47-52
2. Siesjo B.K. Cell damage in the brain: a speculative synthesis. Acta Psychiatr Scand Suppl 313 (1984) 57-91
3. Blumberg R.M., Cady E.B., Wigglesworth J.S., McKenzie J.E., and Edwards A.D. Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain. Exp Brain Res 113 (1997) 130-137
4. Amess P.N., Penrice J., Wylezinska M., Lorek A., and Townsend J. Wyatt JS et al. Early brain proton magnetic resonance spectroscopy and neonatal neurology related to neurodevelopmental outcome at 1 year in term infants after presumed hypoxic-ischaemic brain injury. Dev Med Child Neurol 41 (1999) 436-445
5. Lorek A., Takei Y., Cady E.B., Wyatt J.S., Penrice J., Edwards A.D., et al. Delayed ('secondary') cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: continuous 48-hour studies by phosphorus magnetic resonance spectroscopy. Pediatr Res 36 (1994) 699-706
6. Edwards A.D., and Azzopardi D.V. Perinatal hypoxia-ischemia and brain injury. Pediatr Res 47 (2000) 431-432
7. Azzopardi D., Wyatt J.S., Cady E.B., Delpy D.T., Baudin J., Stewart A.L., et al. Prognosis of newborn infants with hypoxic-ischemic brain injury assessed by phosphorus magnetic resonance spectroscopy. Pediatr Res 25 (1989) 445-451
8. Robertson N.J., Cox I.J., Cowan F.M., Counsell S.J., Azzopardi D., and Edwards A.D. Cerebral intracellular lactic alkalosis persisting months after neonatal encephalopathy measured by magnetic resonance spectroscopy. Pediatr Res 46 (1999) 287-296
9. Roth S.C., Edwards A.D., Cady E.B., Delpy D.T., Wyatt J.S., Azzopardi D., et al. Relation between cerebral oxidative metabolism following birth asphyxia, and neurodevelopmental outcome and brain growth at one year. Dev Med Child Neurol 34 (1992) 285-295
10. Siesjo B.K., Elmer E., Janelidze S., Keep M., Kristian T., Ouyang Y.B., et al. Role and mechanisms of secondary mitochondrial failure. Acta Neurochir Suppl (Wien) 73 (1999) 7-13
11. Siesjo B.K., Katsura K., Zhao Q., Folbergrova J., Pahlmark K., Siesjo P., et al. Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis. J Neurotrauma 12 (1995) 943-956
12. Taylor D.L., Edwards A.D., and Mehmet H. Oxidative metabolism, apoptosis and perinatal brain injury. Brain Pathol 9 (1999) 93-117
13. Northington F.J., Ferriero D.M., Graham E.M., Traystman R.J., and Martin L.J. Early neurodegeneration after hypoxia-ischemia in neonatal rat is necrosis while delayed neuronal death is apoptosis. Neurobiol Dis 8 (2001) 207-219
14. Smith S.L., and Hall E.D. Mild pre- and posttraumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat. J Neurotrauma 13 (1996) 1-9
15. Busto R., Globus M.Y., Dietrich W.D., Martinez E., Valdes I., and Ginsberg M.D. Effect of mild hypothermia on ischemia-induced release of neurotransmitters and free fatty acids in rat brain. Stroke 20 (1989) 904-910
16. Nakashima K., and Todd M.M. Effects of hypothermia on the rate of excitatory amino acid release after ischemic depolarization. Stroke 27 (1996) 913-918
17. Globus M.Y., Alonso O., Dietrich W.D., Busto R., and Ginsberg M.D. Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurochem 65 (1995) 1704-1711
18. Akisu M., Huseyinov A., Yalaz M., Cetin H., and Kultursay N. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. Prostaglandins Leukotrienes Essent Fatty Acids 69 (2003) 45-50
19. Qing M., Nimmesgern A., Heinrich P.C., Schumacher K., Vazquez-Jimenez J.F., Hess J., et al. Intrahepatic synthesis of tumor necrosis factor-alpha related to cardiac surgery is inhibited by interleukin-10 via the Janus kinase (Jak)/signal transducers and activator of transcription (STAT) pathway. Crit Care Med 31 (2003) 2769-2775
20. Erecinska M., Thoresen M., and Silver I.A. Effects of hypothermia on energy metabolism in Mammalian central nervous system. J Cereb Blood Flow Metab 23 (2003) 513-530
21. Amess P.N., Penrice J., Cady E.B., Lorek A., Wylezinska M., Cooper C.E., et al. Mild hypothermia after severe transient hypoxia-ischemia reduces the delayed rise in cerebral lactate in the newborn piglet. Pediatr Res 41 (1997) 803-808
22. Bona E., Hagberg H., Loberg E.M., Bagenholm R., and Thoresen M. Protective effects of moderate hypothermia after neonatal hypoxia-ischemia: short- and long-term outcome. Pediatr Res 43 (1998) 738-745
23. Gunn A.J., Gunn T.R., Gunning M.I., Williams C.E., and Gluckman P.D. Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep. Pediatrics 102 (1998) 1098-1106
24. Edwards A.D., Yue X., Squier M.V., Thoresen M., Cady E.B., Penrice J., et al. Specific inhibition of apoptosis after cerebral hypoxia-ischaemia by moderate post-insult hypothermia. Biochem Biophys Res Commun 217 (1995) 1193-1199
25. Xu L., Yenari M.A., Steinberg G.K., and Giffard R.G. Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade. J Cereb Blood Flow Metab 22 (2002) 21-28
26. Zhu C., Wang X., Cheng X., Qiu L., Xu F., Simbruner G., et al. Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia. Brain Res 996 (2004) 67-75
27. Zhang Z., Sobel R.A., Cheng D., Steinberg G.K., and Yenari M.A. Mild hypothermia increases Bcl-2 protein expression following global cerebral ischemia. Brain Res Mol Brain Res 95 (2001) 75-85
28. Tomimatsu T., Fukuda H., Endoh M., Mu J., Kanagawa T., Hosono T., et al. Long-term neuroprotective effects of hypothermia on neonatal hypoxic-ischemic brain injury in rats, assessed by auditory brainstem response. Pediatr Res 53 (2003) 57-61
29. Colbourne F., Corbett D., Zhao Z., Yang J., and Buchan A.M. Prolonged but delayed postischemic hypothermia: a long-term outcome study in the rat middle cerebral artery occlusion model. J Cereb Blood Flow Metab 20 (2000) 1702-1708
30. MacLellan C.L., Girgis J., and Colbourne F. Delayed onset of prolonged hypothermia improves outcome after intracerebral hemorrhage in rats. J Cereb Blood Flow Metab 24 (2004) 432-440
31. Taylor D.L., Mehmet H., Cady E.B., and Edwards A.D. Improved neuroprotection with hypothermia delayed by 6 h following cerebral hypoxia-ischemia in the 14-day-old rat. Pediatr Res 51 (2002) 13-19
32. Tooley J.R., Satas S., Porter H., Silver I.A., and Thoresen M. Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective. Ann Neurol 53 (2003) 65-72
33. Gunn A.J., Bennet L., Gunning M.I., Gluckman P.D., and Gunn T.R. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr Res 46 (1999) 274-280
34. Thoresen M., Satas S., Loberg E.M., Whitelaw A., Acolet D., Lindgren C., et al. Twenty-four hours of mild hypothermia in unsedated newborn pigs starting after a severe global hypoxic-ischemic insult is not neuroprotective. Pediatr Res 50 (2001) 405-411
35. Clifton G.L., Choi S.C., Miller E.R., Levin H.S., Smith Jr. K.R., Muizelaar J.P., et al. Intercenter variance in clinical trials of head trauma-experience of the National Acute Brain Injury Study: Hypothermia. J Neurosurg 95 (2001) 751-755
36. Henderson W.R., Dhingra V.K., Chittock D.R., Fenwick J.C., and Ronco J.J. Hypothermia in the management of traumatic brain injury. A systematic review and meta-analysis. Intensive Care Med 29 (2003) 1637-1644
37. McIntyre L.A., Fergusson D.A., Hebert P.C., Moher D., and Hutchison J.S. Prolonged therapeutic hypothermia after traumatic brain injury in adults: a systematic review. JAMA 289 (2003) 2992-2999
38. Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 346 (2002) 549-556
39. Bernard S.A., Gray T.W., Buist M.D., Jones B.M., Silvester W., Gutteridge G., et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 346 (2002) 557-563
40. Nolan J.P., Morley P.T., Hoek T.L., and Hickey R.W. Therapeutic hypothermia after cardiac arrest. An advisory statement by the Advancement Life support Task Force of the International Liaison committee on Resuscitation. Resus 57 (2003) 231-235
41. Speer M., and Perlman J.M. Modest hypothermia as a neuroprotective strategy in high-risk term infants. Clin Perinatol 33 (2006) 169-182 [ix]
42. Edwards A.D., and Azzopardi D.V. Therapeutic hypothermia following perinatal asphyxia. Arch Dis Child Fetal Neonatal 91 (2006) F127-F131
43. Higgins R.D., Raju T.N., Perlman J., Azzopardi D.V., Blackmon L.R., Clark R.H., et al. Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop. J Pediatr 148 (2006) 170-175
44. Higgins R.D. Hypoxic ischemic encephalopathy and hypothermia: a critical look. Obstet Gynecol 106 (2005) 1385-1387
45. Gunn A.J., Battin M., Gluckman P.D., Gunn T.R., and Bennet L. Therapeutic hypothermia: from lab to NICU. J Perinat Med 33 (2005) 340-346
46. Thoresen M., and Whitelaw A. Therapeutic hypothermia for hypoxic-ischaemic encephalopathy in the newborn infant. Curr Opin Neurol 18 (2005) 111-116
47. Wyatt J.S., and Robertson N.J. Time for a cool head-neuroprotection becomes a reality. Early Hum Dev 81 (2005) 5-11
48. Barks J. Neonatal hypothermia: What are we waiting for? Online. Available at: http://www.nicuniversity.org/lectures.asp [last accessed 2005].
49. Thoresen M., Simmonds M., Satas S., Tooley J., and Silver I.A. Effective selective head cooling during posthypoxic hypothermia in newborn piglets. Pediatr Res 49 (2001) 594-599
50. Van Leeuwen G.M., Hand J.W., Lagendijk J.J., Azzopardi D.V., and Edwards A.D. Numerical modeling of temperature distributions within the neonatal head. Pediatr Res 48 (2000) 351-356
51. Azzopardi D., Robertson N.J., Cowan F.M., Rutherford M.A., Rampling M., and Edwards A.D. Pilot study of treatment with whole body hypothermia for neonatal encephalopathy. Pediatrics 106 (2000) 684-694
52. Thoresen M., and Whitelaw A. Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy. Pediatrics 106 (2000) 92-99
53. Zhou W.H., Shao X.M., Cao Y., Chen C., and Zhang X. Safety study of hypothermia for the treatmnet of hypoxic-ischaemic brain damage in term neonates. Acta Pharmacol Sin 23 (October, 2002) 64-68
54. Eicher D.J., Wagner C.L., Katikaneni L.P., Hulsey T.C., Bass W.T., Kaufman D.A., et al. Moderate hypothermia in neonatal encephalopathy: Safety outcomes. Pediatr Neurol 32 (2005) 18-24
55. Gunn T.R., Wilson N.J., Aftimos S., and Gunn A.J. Brain hypothermia and QT interval. Pediatrics 103 (1999) 1079
56. Horan M, Edwards AD, Firmin RK, Ablett T, Rawson H, Field D. The effect of temperature on the QTc interval in the newborn infant receiving extracorporeal membrane oxygenation (ECMO). Early Hum Dev 2006 July 10 [Epub ahead of print].
57. Rutherford M.A., Azzopardi D., Whitelaw A., Cowan F., Renowden S., Edwards A.D., et al. Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy. Pediatrics 116 (2005) 1001-1006
58. Inder T.E., Hunt R.W., Morley C.J., Coleman L., Stewart M., Doyle L.W., et al. Randomized trial of systemic hypothermia selectively protects the cortex on MRI in term hypoxic-ischemic encephalopathy. J Pediatr 145 (2004) 835-837
59. Eicher D.J., Wagner C.L., Katikaneni L.P., Hulsey T.C., Bass W.T., Kaufman D.A., et al. Moderate hypothermia in neonatal encephalopathy: efficacy outcomes. Pediatr Neurol 32 (2005) 11-17
60. Gunn A.J., Gluckman P.D., and Gunn T.R. Selective head cooling in newborn infants after perinatal asphyxia: a safety study. Pediatrics 102 (1998) 885-892
61. Lin Z.L., Yu H.M., Lin J., Chen S.Q., Liang Z.Q., and Zhang Z.Y. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit. J Perinatol 26 (2006) 180-184
62. Gluckman P.D., Wyatt J.S., Azzopardi D., Ballard R., Edwards A.D., Ferriero D.M., et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial. Lancet 365 (2005) 663-670
63. Shankaran S., Laptook A.R., Ehrenkranz R.A., Tyson J.E., McDonald S.A., Donovan E.F., et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 353 (2005) 1574-1584
64. Gluckman P., Wyatt J.S., Azzopardi D., Ballard R., Edwards A.D., Ferriero D.M., et al. Selective head cooling after neonatal encephalopathy. Lancet 365 (2005) 1619-1620
65. Shankaran S., Laptook A., Ehrenkranz R.A., Tyson J.E., McDonald J.S., and Donovan E.F. Reduction in death or moderate/severe disability by whole body hypothermia for hypoxic-ischemic encephalopathy (HIE). Pediatr Res 57 (2005) 1548A
66. Wyatt JS, Gluckman PD, Liu PL, Azzopardi D, Edwards AD, Ferriero DM, et al. The determinants of outcome after head cooling for neonatal encephalopathy. Pediatrics; in press
67. Ambalavanan N., Carlo W.A., Shankaran S., Bann C.M., Emrich S.L., Higgins R.D., et al. Predicting outcomes of neonates diagnosed with hypoxemic-ischemic encephalopathy. Pediatrics 118 (2006) 2084-2093
68. The TOBY study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy. Online. Available at: http://www.npeu.ox.ac.uk/Toby [last accessed 1 October 2006].
69. neo.nEuro.network. HYPOTHERMIA trial. Online. Available at: http://www.neonatal-research [last accessed 20 September 2005].
70. Evans K., Rigby A.S., Hamilton P., Titchiner N., and Hall D.M. The relationships between neonatal encephalopathy and cerebral palsy: a cohort study. J Obstet Gynaecol 21 (2001) 114-120
71. Lawn J., Shibuya K., and Stein C. No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths. Bull World Health Organ 83 (2005) 409-417