Proteomic co-expression of cyclin-dependent kinases 1 and 4 in human cancer cells

European Journal of Cancer

Volumn 43, Issue 9, 2007, Pages 1483-1492

  Seabra, Laurence ^a,b   Warenius, Hilmar ^a,b,c  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b KEELE UNIVERSITY   (United Kingdom)

^c Theryte Ltd   (United Kingdom)

Author keywords

Cancer; Cdk1; Cdk4; Cell lines; Cyclin dependent kinase; Human; Western blotting

Indexed keywords

ANTINEOPLASTIC AGENT; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 4;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL CYCLE REGULATION; CONTROLLED STUDY; DNA SYNTHESIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; MELANOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; SKIN FIBROBLAST; WESTERN BLOTTING;

BLOTTING, WESTERN; CDC2 PROTEIN KINASE; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE 4; FIBROBLASTS; HALF-LIFE; HUMANS; KERATINOCYTES; MELANOMA; NEOPLASM PROTEINS; NEOPLASMS; PROTEOME; TRANSFECTION;

EID: 34249888738     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2007.03.014     Document Type: Article

References (30)

1. Hartwell L., and Weinert T. Checkpoints: controls that ensure the order in cell cycle events. Science (Washington, DC) 246 (1989) 629-634
2. Murray A. Creative blocks: cell cycle checkpoints and feedback controls. Nature (London) 359 (1992) 599-604
3. Norbury C., and Nurse P. Animal cell cycles and their controls. Annu Rev Biochem 61 (1992) 441-470
4. Ando K., and Griffin J. Cdk4 integrates growth stimulatory and inhibitory signals during G1 phase of hematopoietic cells. Oncogene 10 (1995) 751-755
5. Grana X., and Reddy E. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11 (1995) 211-219
6. Harbor J., Luo R., Dei Santi A., Postigo A., and Dean D. Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1. Cell 98 (1999) 859-869
7. Classon M., and Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer 2 (2002) 910-917
8. Kamb A. Cell cycle regulators and cancer. Trends Genet 11 (1995) 136-140
9. Strauss M., Lukas J., and Bartek J. Unrestricted cell cycle and cancer. Nature Med 1 (1995) 1245-1246
10. Cordon-Cardo C. Mutation of the cell cycle regulators: biological and clinical implications for human neoplasia. Am J Pathol 147 (1995) 545-560
11. Sherr C., and Roberts J.M. Living with or without cyclins and cyclin-dependent kinases. Genes Dev 18 (2006) 2699-2711
12. Deshpande A., Sicinski P., and Hinds P. Cyclins and cdks in development and cancer: a perspective. Oncogene 24 (2005) 2909-2915
13. Rodriguez-Puebla M., Miliani de Marval P., LaCava M., Moons D., Kiyokawa H., and Conti C. Cdk4 deficiency inhibits skin tumour development but does not affect normal keratinocyte proliferation. Am J Pathol 161 (2002) 405-411
14. Zou X., Ray D., Aziyu A., et al. Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation leading to Arf/p53-independent senescence. Genes Dev 16 (2002) 2923-2934
15. Matsuura I., Denissova N., Wang G., He D., Long J., and Liu F. Cyclin-dependent kinases regulate the anti-proliferative function of Smads. Nature 430 (2004) 226-231
16. Sherr C., and Roberts J. CDK inhibitors: positive and negative regulators of G-1 phase progression. Genes Dev 13 (1999) 1501-1512
17. II250 to regulate Sp-1 mediated transcription. Oncogene 18 (1999) 239-247
18. Coqueret O. Linking cyclins to transcriptional control. Gene 299 (2002) 35-55
19. Tang L., Li G., Tron V., Trotter M., and Ho V. Expression of cell cycle regulators in human cutaneous malignant melanoma. Melanoma Res 9 (1999) 148-154
20. +) neutrons than 4 MeV photons. Int J Rad Oncol Biol Phys 28 (1994) 913-920
21. Warenius H., Browning P., Britten R., Peacock J., and Rapp U. C-raf-1 proto-oncogene expression relates to radiosensitivity rather than radioresistance. Eur J Cancer 30A (1994) 369-375
22. Warenius H., Jones M., Gorman T., et al. Combined RAF1 protein expression and p53 mutational status provides a strong predictor of cellular radiosensitivity. Brit J Cancer 83 (2000) 1084-1095
23. Warenius H., Seabra A., and Maw P. Sensitivity to cis-diamminedichloroplatinum in human cancer cells is related to expression of cyclin D1 but not c-raf-1 protein. Int J Cancer 67 (1996) 224-231
24. Zhang S., Wang G., Liu D., et al. The c-terminal region of S100A4 is important for its metastasis-inducing properties. Oncogene 24 (2005) 4401-4411
25. Welch P., and Wang J. Coordinated synthesis and degradation of cdc2 in the mammalian cell cycle. Proc Natl Acad Sci USA 89 (1992) 3093-3097
26. Bockstaele L., Coulonval K., Kooken H., Paternot S., and Roger P. Regulation of CDK4. Cell Division 1 (2006) 25
27. Warenius H. Are critical normal gene products in cancer cells the real therapeutic targets?. Anticancer Res 22 (2002) 2651-2656
28. Nevins J. The Rb/E2F pathway and cancer. Hum Mol Genet 10 (2001) 699-703
29. Evan G., and Vousden K. Proliferation, cell cycle and apoptosis in cancer. Nature 411 (2001) 342-348
30. Vassilev L., Tovar C., Chen S., et al. Selective small molecule inhibitor reveals critical mitotic functions of human CDK1. Proc Natl Acad Sci USA 103 (2006) 10660-10665