Repair of diaphyseal bone defects with calcitriol-loaded PLGA scaffolds and marrow stromal cells

Tissue Engineering

Volumn 13, Issue 5, 2007, Pages 1125-1133

  Sun, Jung Yoon ^a   Ki, Suk Park ^a   Moon, Suk Kim ^b   Rhee, John M ^a   Khang, Gilson ^a,b   Hai, Bang Lee ^b  

^a Chonbuk National University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CALCIUM; CASTING; COMPUTERIZED TOMOGRAPHY; DEFECTS; DRUG PRODUCTS; ENZYMES; LEACHING; POROUS MATERIALS; SPECTROPHOTOMETERS;

SALT LEACHING; SOLVENT CASTING; SULFORHODAMINE B (SRB);

CELLS;

ALKALINE PHOSPHATASE; BIOMATERIAL; CALCITRIOL; COLLAGEN TYPE 1; MESSENGER RNA; OSTEONECTIN; POLYGLACTIN; SULFORHODAMINE B;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE DEVELOPMENT; BONE MARROW CELL; CALCIFICATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; CORTICAL BONE; DIAPHYSIS; FEMUR; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPECTROPHOTOMETER; THREE DIMENSIONAL IMAGING;

ABSORBABLE IMPLANTS; ANIMALS; ANTIGENS, DIFFERENTIATION; BONE MARROW CELLS; BONE REGENERATION; BONE SUBSTITUTES; CALCIFICATION, PHYSIOLOGIC; CALCITRIOL; DELAYED-ACTION PREPARATIONS; DIAPHYSES; DRUG IMPLANTS; FEMUR; LACTIC ACID; POLYGLYCOLIC ACID; POLYMERS; RABBITS; STROMAL CELLS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

ORYCTOLAGUS CUNICULUS;

EID: 34249873763     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2006.0287     Document Type: Article

References (28)

1. Khang, G., Lee, S.G., Kim, M.S., and Lee, H.B. Biomaterials: tissue-engineering and scaffolds. In: Webster, S., ed. Encyclopedia of Medical Devices and Instrumentation, 2nd ed. New York: John & Wiley Press, 2006, pp. 366-383.
2. Khang, G., Kim, S.H., Kim, M.S., and Lee, H.B. Hybrid, composite, and complex biomaterials for scaffolds. In: Atala, A., Lanza, R., Thomson, J.A., and Nerem, R.M., eds. Principles of Regenerative Medicine. San Diego: Elsevier, 2007, in press.
3. Hoogendoorn, H.A., Renooij, W., Akkermanns, L.M.A., Visser, D.D.S., and Wittebol, P. Long-term study of large ceramic implants in dog femora. Clin. Orthop. 187, 281, 1984.
4. Masahiro, Y., Hidetomi, T., and Yuuki, I. Repair of intercalated long bone defect with a synthetic biodegradable bone-inducing implant. Biomaterials 26, 5145, 2005.
5. Khang, G., and Lee, H.B. Cell-synthetic surface interaction: physicochemical surface modification, Section II. Methods for cell delivery vehicles. In: Atala, A., and Lanza, R., eds. Methods of Tissue Engineering. New York: Academic Press, 2001, pp. 771-780.
6. Frazza, E.J., and Schmitt, E.E. A new absorbable suture. J. Biomed. Mater. Res. 5, 43, 1971.
7. Bostman, O. Absorbable implants for the fixation of fractures. J. Bone Joint Surg. Am. 73, 148, 1991.
8. Dong, J., Kojima, H., Uemura, T., Kikuchi, M., Tateishi, T., and Tanaka, J. In vivo evaluation of a novel porous hydroxyapatites to sustain osteogenesis of transplanted bone marrow-derived osteoblastic cell. J. Biomed. Mater. Res. 57, 208, 2001.
9. Lieberman, J.R., Daluiski, A., and Einhorn, T.A. The role of growth factors in the repair of bone. Biology and clinical application. J. Bone Joint Surg. Am. 84, 1032, 2002.
10. Baltzer, A.W., Lattermann, C., Whalen, J.D., Wooley, P., Weiss, K., Grimm, M., Ghivizzani, S.C., Robbins, P.D., and Evans, C.H. Genetic enhancement of fracture repair: healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene. Gene Ther. 7, 743, 2000.
11. Cho, J.C., Khang, G., Rhee, J.M., Kim, Y.S., Lee, J.S., and Lee, H.B. Preparation and characterization of gentamicin sulfate loaded poly(L-lactide-co-glycolide) microspheres for the treatment of osteomyelitis. Polymer (Korea) 7, 79, 1999.
12. Jang, J.W., Lee, B., Han, CW., Lee, I.W., Lee, H.B., and Khang, G. Preparation and characterization of ipriflavone-loaded PLGA scaffolds for tissue engineered bone. Polymer (Korea) 27, 226, 2003.
13. Kim, S.H., Park, K.S., Kim, S.H., Jang, J.W., Han, C.H., Kim, M.S., Khang, G., and Lee, H.B. Effects of SIS/PLGA porous scaffolds and muscle-derived stem cell on the formation of tissue engineered bone. Polymer (Korea) 30, 14, 2006.
14. Kim, M.S., Hong, K.D., Shin, H.W., Kim, S.H., Kim, S.H., Lee, M.S., Jang, W.Y., Khang, G., and Lee, H.B. Preparation of porcine small intestinal submucosa sponge and their application as a wound dressing in full-thickness skin defect of rat. Int. J. Biol. Macromol. 36, 54, 2005.
15. Carl, A.G., Darwin, J.P., and Jeffrey, L.S. Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Exp. Cell Res. 306, 330, 2005.
16. Lee, S.J., Choi, J.S., Park, K.S., Khang, G., Lee, Y.M., and Lee, H.B. Surface roughness on MG63 osteoblast-like cells to the polycarbonate membrane surfaces with different micropore sizes. Biomaterials 25, 4699, 2004.
17. Hicok, K.C., Thomas, T., Gori, F., Rickard, D.J., Spelsberg, T.C., and Riggs, B.L. Development and characterization of conditionally immortalized osteoblast precursor cell lines from human bone marrow stroma. J. Bone Miner. Res. 13, 205, 1998.
18. Lohmann, C.H., Bonewald, L.F., Sisk, M.A., Sylvia, V.L., Cochran, D.L., Dean, D.D., Boyan, B.D., and Schwartz, Z. Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3. J. Bone Miner. Res. 25, 1169, 2000.
19. Jorgensen, N.R., Henriksen, Z., Sorensen, O.H., and Civitelli, R. Dexamethasone, BMP-2 and 1,25-dihydroxyvitamin D enhance a more differentiated osteoblast phenotype. Steroids 69, 219, 2004.
20. Vehof, J.W., Mahmood, J., Takita, H., van't Hof, M.A., Kuboki, Y., Spauwen, P.H., and Jansen, J.A. Ectopic bone formation in titanium mesh loaded with bone morphogenetic protein and coated with calcium phosphate. Plast. Reconstr. Surg. 108, 434, 2001.
21. 3 on proliferation and osteogenic differentiation of cultured human bone marrow stromal cells. J. Korean Soc. Endocrinol. 17, 206, 2002.
22. 3 loaded the biodegradable PLGA scaffolds for tissue engineered bone. Macromol. Chem. Symp. 15, 201, 2002.
23. Bruder, S.P., Horowitz, M.C., Mosca, J.D., and Haynesworth, S.E. Monoclonal antibodies reactive with human osteogenic cell surface antigens. Bone 21, 225, 1997.
24. Bruder, S.P., Jaiswal, N., Ricalton, N.S., Mosca, J.D., Kraus, K.H., and Kadiyala, S. Mesenchymal stem cells in osteobiology and applied bone regeneration. Clin. Orthop. Relat. Res. 355(Suppl), S247, 1998.
25. Lian, J.B., and Stein, G.S. Concepts of osteoblast growth and differentiation: basis for modulation of bone cell development and tissue formation. Crit. Rev. Oral Biol. Med. 3, 269, 1992.
26. Al-Khaldi, A., Eliopoulos, N., Martineau, D., Lejeune, L., Lachapelle, K., and Galipeau, J. Postnatal bone marrow stromal cells elicit a potent VEGF-dependent neoangiogenic response in vivo. Gene Ther. 10, 621, 2003.
27. Kinnaird, T., Stabile, E., Burnett, M.S., Shou, M., Lee, C.W., Barr, S., Fuchs, S., and Epstein, S.E., Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 109, 1543, 2004.
28. Tatebe, M., Nakamura, R., Kagami, H., Okada, K., and Ueda, M. Differentiation of transplanted mesenchymal stem cells in a large osteochondral defect in rabbit. Cytotherapy 7, 520, 2005.