Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1

Nucleic Acids Research

Volumn 35, Issue 7, 2007, Pages 2269-2282

  Gupta, Pawan ^a   Park, Sung Wook ^a   Farooqui, Mariya ^a   Wei, L N ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; HISTONE ACETYLTRANSFERASE; HISTONE ACETYLTRANSFERASE PCAF; MYC PROTEIN; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR TR2; PROTEIN P300; RECEPTOR INTERACTING PROTEIN 140; RETINOIC ACID; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; NUCLEAR PROTEIN; NUCLEAR RECEPTOR SUBFAMILY 2, GROUP C, MEMBER 1; P300-CBP-ASSOCIATED FACTOR; REPRESSOR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STIMULATION; CELL STRAIN 3T3; COMPLEX FORMATION; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; DOWN REGULATION; NONHUMAN; PRIORITY JOURNAL; PROADIPOCYTE; PROMOTER REGION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BINDING SITE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; STEM CELL;

3T3-L1 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOCYTES; ANIMALS; BINDING SITES; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; HISTONE ACETYLTRANSFERASES; MICE; NUCLEAR PROTEINS; NUCLEAR RECEPTOR COACTIVATOR 2; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; RECEPTORS, THYROID HORMONE; REPRESSOR PROTEINS; STEM CELLS; TRANSCRIPTION FACTORS; TRETINOIN;

EID: 34249853762     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl1147     Document Type: Article

References (60)

1. Shyr,C.R., Collins,L.L., Mu,X.M., Platt,K.A. and Chang,C. (2002) Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2. Mol. Cell Biol., 22, 4661-4666.
2. Lin,D.L. and Chang,C. (1996) p53 is a mediator for radiation-repressed human TR2 orphan receptor expression in MCF-7 cells, a new pathway from tumor suppressor to member of the steroid receptor superfamily. J. Biol. Chem., 271, 14649-14652.
3. Mu,X., Liu,Y., Collins,L.L., Kim,E. and Chang,C. (2000) The p53/ retinoblastoma-mediated repression of testicular orphan receptor-2 in the rhesus monkey with cryptorchidism. J. Biol. Chem., 275, 23877-23883.
4. Lee,C.H. and Wei,L.N. (2000) Characterization of the mouse nuclear orphan receptor TR2-11 gene promoter and its potential role in retinoic acid-induced P19 apoptosis. Biochem. Pharmacol., 60, 127-136.
5. Park, S.W., Hu, X., Gupta, P., Lin, Y.P., Ha, S.G. and Wei, L.N. (2007) SUMOylation of Tr2 orphan receptor involves Pml and finetunes Oct4 expression in stem cells. Nat. Struct. Mol. Biol., 14, 68-75.
6. Wei,L.N. and Hsu,Y.C. (1994) Identification of a new gene expressed specifically in early mouse embryos. Dev. Growth Differ., 36 187-196.
7. Lee,C.H., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Wei,L.N. (1995) Genomic structure, promoter identification, and chromosomal mapping of a mouse nuclear orphan receptor expressed in embryos and adult testes. Genomics, 30, 46-52.
8. Lee,C.H., Chang,L. and Wei,L.N. (1997) Distinct expression patterns and biological activities of two isoforms of the mouse orphan receptor TR2. J. Endocrinol., 152, 245-255.
9. Lee,C.H. and Wei,L.N. (1999a) Characterization of an inverted repeat with a zero spacer (IR0)-type retinoic acid response element from the mouse nuclear orphan receptor TR2-11 gene. Biochemistry, 38, 8820-8825.
10. Chambon,P. (1996) A decade of molecular biology of retinoic acid receptors. FASEB J., 10, 940-954.
11. Lee,C.H., Chang,L. and Wei,L.N. (1996) Molecular cloning and characterization of a mouse nuclear orphan receptor expressed in embryos and testes. Mol. Reprod. Dev., 44, 305-314.
12. Lin,T.M., Young,W.J. and Chang,C. (1995) Multiple functions of the TR2-11 orphan receptor in modulating activation of two key cis-acting elements involved in the retinoic acid signal transduction system. J. Biol. Chem., 270, 30121-30128.
13. Hu,X., Chen,Y., Farooqui,M., Thomas,M.C., Chiang,C.M. and Wei,L.N. (2004) Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation. J. Biol. Chem., 279, 319-325.
14. Lee,C.H. and Wei,L.N. (1999b) Characterization of receptor-interacting protein 140 in retinoid receptor activities. J. Biol. Chem., 274, 31320-31326.
15. Blanco,J.C., Minucci,S., Lu,J., Yang,X.J., Walker,K.K., Chen,H., Evans,R.M., Nakatani,Y. and Ozato,K. (1998) The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev., 12, 1638-1651.
16. Wei,L.N. and Hu,X. (2004) Receptor interacting protein 140 as a thyroid hormone-dependent, negative co-regulator for the induction of cellular retinoic acid binding protein I gene. Mol. Cell Endocrinol., 218, 39-48.
17. Chen,Y., Hu,X. and Wei,L.N. (2004) Molecular interaction of retinoic acid receptors with coregulators PCAF and RIP140. Mol. Cell Endocrinol., 226, 43-50.
18. Chen,Y., Kerimo,A., Khan,S. and Wei,L.N. (2002) Real-time analysis of molecular interaction of retinoid receptors and receptor-interacting protein 140 (RIP140). Mol. Endocrinol., 16, 2528-2537.
19. Cowherd,R.M., Lyle,R.E. and McGehee,R.E.Jr (1999) Molecular regulation of adipocyte differentiation. Semin. Cell Dev. Biol., 10, 3-10.
20. Felipe,F., Mercader,J., Ribot,J., Palou,A. and Bonet,M.L. (2005) Effects of retinoic acid administration and dietary vitamin A supplementation on leptin expression in mice: Lack of correlation with changes of adipose tissue mass and food intake. Biochim. Biophys. Acta, 1740, 258-265.
21. Skillington,J., Choy,L. and Derynck,R. (2002) Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of preadipocytes. J. Cell Biol., 159, 135-146.
22. Xue,J.C., Schwarz,E.J., Chawla,A. and Lazar,M.A. (1996) Distinct stages in adipogenesis revealed by retinoid inhibition of differentiation after induction of PPARgamma. Mol. Cell Biol., 16, 1567-1575.
23. Leonardsson,G., Steel,J.H., Christian,M., Pocock,V., Milligan,S., Bell,J., So,P.W., Medina-Gomez,G., Vidal-Puig,A. et al. (2004) Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl. Acad. Sci. U.S.A., 101, 8437-8442.
24. Dilworth,F.J. and Chambon,P. (2001) Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription. Oncogene, 20, 3047-3054.
25. Xu,L., Glass,C.K. and Rosenfeld,M.G. (1999) Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev., 9, 140-147.
26. Chen,D., Ma,H., Hong,H., Koh,S.S., Huang,S.M., Schurter,B.T., Aswad,D.W. and Stallcup,M.R. (1999) Regulation of transcription by a protein methyltransferase. Science, 284, 2174-2177.
27. Safonova,I., Darimont,C., Amri,E.Z., Grimaldi,P., Ailhaud,G., Reichert,U. and Shroot,B. (1994) Retinoids are positive effectors of adipose cell differentiation. Mol. Cell Endocrinol., 104, 201-211.
28. Soukas,A., Socci,N.D., Saatkamp,B.D., Novelli,S. and Friedman,J.M. (2001) Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J. Biol. Chem., 276, 34167-34174.
29. Khan,S.A., Park,S.W., Huq,M. and Wei,L.N. (2005) Protein kinase C-mediated phosphorylation of orphan nuclear receptor TR2: Effects on receptor stability and activity. Proteomics, 5, 3885-3894.
30. Wei,L.N., Farooqui,M. and Hu,X. (2001) Ligand-dependent formation of retinoid receptors, receptor-interacting protein140 (RIP140), and histone deacetylase complex is mediated by a novel receptor-interacting motif of RIP140. J. Biol. Chem., 276 16107-16112.
31. Gupta,P., Huq,M.D., Khan,S.A., Tsai,N.P. and Wei,L.N. (2005) Regulation of co-repressive activity of and HDAC recruitment to RIP140 by site-specific phosphorylation. Mol. Cell Proteomics, 4, 1776-1784.
32. Park,S.W., Li,G., Lin,Y.P., Barrero,M.J., Ge,K., Roeder,R.G. and Wei,L.N. (2005) Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/ TRAP220. Mol. Cell, 19, 643-653.
33. Kim,J.H., Li,H. and Stallcup,M.R. (2003) CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol. Cell, 12, 1537-1549.
34. Leo,C. and Chen,J.D. (2000) The SRC family of nuclear receptor coactivators. Gene, 245, 1-11.
35. Ogawa,H., Yu,R.T., Haraguchi,T., Hitaoka,Y., Nakatani,Y., Morohashi,K. and Umesono,K. (2004) Nuclear structure-associated TIF2 recruits glucocorticoid receptor and its target DNA. Biochem. Biophys. Res. Commun., 320, 218-225.
36. Korzus,E., Torchia,J., Rose,D.W., Xu,L., Kurokawa,R., McInerney,E.M., Mullen,T.M., Glass,C.K. and Rosenfeld,M.G. (1998) Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science, 279, 703-707.
37. Wei,L.N., Hu,X., Chandra,D., Seto,E. and Farooqui,M. (2000) Receptor-interacting protein 140 directly recruits histone deacetylases for gene silencing. J. Biol. Chem., 275, 40782-40787.
38. Christian,M., Kiskinis,E., Debevec,D., Leonardsson,G., White,R. and Parker,M.G. (2005) RIP140-targeted repression of gene expression in adipocytes. Mol. Cell Biol., 25, 9383-9391.
39. Heath,V.J., Gillespie,D.A. and Crouch,D.H. (2000) Inhibition of the terminal stages of adipocyte differentiation by cMyc. Exp. Cell Res. 254, 91-98.
40. Tao,H. and Umek,R.M. (1999) Reciprocal regulation of gadd45 by C/EBP alpha and c-Myc. DNA Cell Biol., 18, 75-84.
41. Kamei,Y., Kawada,T., Mizukami,J. and Sugimoto,E. (1994) The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha. Life Sci., 55 PL307-312.
42. Kawada,T., Kamei,Y., Fujita,A., Hida,Y., Takahashi,N., Sugimoto,E. and Fushiki,T. (2000) Carotenoids and retinoids as suppressors on adipocyte differentiation via nuclear receptors. Biofactors, 13, 103-109.
43. Glass,C.K. and Rosenfeld,M.G. (2000) The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev., 14 121-141.
44. Cvoro,A., Tzagarakis-Foster,C. Tatomer,D., Paruthiyil,S., Fox,M.S. and Leitman,D.C. (2006) Distinct roles of unfiganded and liganded estrogen receptors in transcriptional repression. Mol. Cell, 21, 555-564.
45. Reily,M.M., Pantoja,C., Hu,X., Chinenov,Y. and Rogatsky I. (2006) The GRIPI:JRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J., 25, 108-117.
46. Rogatsky I., Luecke,H.F., Leitman,D.C. and Yamamoto,K.R. (2002) Alternate surfaces of transcriptional coregulator GRIPI function in different glucocorticoid receptor activation and repression contexts. Proc. Nad. Acad. Sci. U.S.A., 99 16701-16706.
47. Puustinen,R., Sarvilinna,N., Manninen,T., Tuohimaa,P. and Ylikomi T. (2001) Localization of glucocorticoid receptor interacting protein I in murine tissues using two novel polyclonal antibodies. Eur. J. Endocrinol., 145, 23-33.
48. Picard,F., Gehin,M., Annicotte,J., Rocchi,S., Champy,M.F., O'Malley,B.W., Chambon,P. and Auwerx,J. (2002) SRC-l and TIF2 control energy balance between white and brown adipose tissues. Cell, 111, 931-941.
49. Koh,S.S., Chen,D., Lee,Y.H. and Stallcup,M.R. (2001) Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities. J. Biol. Chem., 276, 1089-1098.
50. Huq,M.M., Gupta,P., Tsai,N.P., White,R., Parker,M.G. and Wei,L.N. (2006) Suppression of receptor interacting protein 140 repressive activity by protein arginine methylation. EMBO J., 25, 5094-5104.
51. Dalen,K.T., Ulven,S.M., Bamberg,K., Gustafsson, J.A. and Nebb,H.I. (2003) Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J. Biol. Chem., 278, 48283-48291.
52. Homma,H., Kurachi,H., Nishio,Y., Takeda,T., Yamamoto,T., Adachi,K., Morishige,K., Ohmichi,M., Matsuzawa,Y. and Murata,Y. (2000) Estrogen suppresses transcription of lipoprotein lipase gene. Existence of a unique estrogen response element on the lipoprotein lipase promoter. J. Biol. Chem., 275, 11404-11411.
53. Kim,J.Y., Tillison,K., Lee, J.H., Rearick,D.A. and Smas,C.M. (2006) The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-{alpha} in 3T3-LI adipocytes and is a target for transactivation by PPAR{gamma}. Am. J. Physiol. Endocrinol. Metab., 291, E115-EI27.
54. Wei,L.N. (2004) Retinoids and receptor interacting protein 140 (RIP140) in gene regulation. Curr. Med Chem., 11, 1527-1532.
55. Gregoire,F.M. (2001) Adipocyte differentiation: From fibroblast to endocrine cell. Exp. Biol. Med. (Maywood), 226, 997-1002.
56. Tao,Y., Maegawa,H., Ugi,S., Ikeda,K., Nagai,Y., Egawa,K., Nakamura, J., Tsukada,S., Nishio,Y. et al. (2006) The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-LI adipocytes. Endocrinology, 147, 1685-1696.
57. Brandebourg,T.D. and Hu,C.Y. (2005) Regulation of differentiating pig preadipocytes by retinoic acid. J. Anim. Sci., 83, 98-107.
58. Stone,R.L. and Bernlohr,D.A. (1990) The molecular basis for inhibition of adipose conversion of murine 3T3-LI cells by retinoic acid. Differentiation, 45, 119-127.
59. Suryawan,A. and Hu,C.Y. (1997) Effect of retinoic acid on differentiation of cultured pig preadipocytes. J. Anim. Sci., 75, 112-117.
60. Villarroya,F., Iglesias,R. and Giralt,M. (2004) Retinoids and retinoid receptors in the control of energy balance: Novel pharmacological strategies in obesity and diabetes. Curr. Med Chem., 11, 795-805.