Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 16, 2007, Pages 6840-6845

  Welter, Marc ^a,b   Vallone, Daniela ^b,d   Samad, Tarek A ^b,e   Meziane, Hamid ^c   Usiello, Alessandro ^b,f   Borrelli, Emiliana ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^c INSTITUT CLINIQUE DE LA SOURIS   (France)

^d KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f Centro di Ingegneria Genetica e Biotecnologia Avanzate CEINGE   (Italy)

Author keywords

Behavior; c fos; Dopamine D2 receptor deficient mice; Drug abuse

Indexed keywords

COCAINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; PROTEIN C FOS; DOPAMINE 1 RECEPTOR; DOPAMINE UPTAKE INHIBITOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; GENE DELETION; MOUSE; NONHUMAN; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; BRAIN; C57BL MOUSE; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; IMMEDIATE EARLY GENE; INHIBITORY POSTSYNAPTIC POTENTIAL; INSTRUMENTAL CONDITIONING; MALE; MOTOR ACTIVITY; MOUSE MUTANT; PHYSIOLOGY;

ANIMALIA; MUS;

ANIMALS; BRAIN; COCAINE; CONDITIONING, OPERANT; DOPAMINE UPTAKE INHIBITORS; GENES, IMMEDIATE-EARLY; INHIBITORY POSTSYNAPTIC POTENTIALS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; SIGNAL TRANSDUCTION;

EID: 34249844534     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0610790104     Document Type: Article

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