Cardioprotective effects of BMS-180448, a prototype mitoKATP channel opener, and the role of salvage kinases, in the rat model of global ischemia and reperfusion heart injury

Archives of Pharmacal Research

Volumn 30, Issue 5, 2007, Pages 634-640

  Lee, Ju Han ^a   Jung, In Sang ^a   Lee, Sung Hun ^a   Yang, Min Kyu ^a   Hwang, Ji Hye ^a   Lee, Hak Dong ^a   Cho, Yu Sun ^a   Song, Min Jin ^a   Yi, Kyu Yang ^b   Yoo, Sung Eun ^b   Kwon, Suk Hyung ^c   Kim, Bokyung ^a   Lee, Chang Soo ^a   Shin, Hwa Sup ^a  

^a Konkuk University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Rexgene Biotech Co Ltd   (South Korea)

Author keywords

BMS 180448; Cardioprotection; Ischemia; MitoKATP; Rat heart; Reperfusion

Indexed keywords

EID: 34249827872     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02977659     Document Type: Article

References (31)

1. Ahmad, N., Wang, Y., Haider, K. H., Wang, B., Pasha, Z., Uzun, O., and Ashraf, M., Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning. Am. J. Physiol. Heart. Circ. Physiol., 290, H2402-H2408 (2006).
2. Armstrong, S. C., Liu, G. S., Downey, J. M., and Ganote, C. E., Potassium channels and preconditioning of isolated rabbit cardiomyocytes: effects of glyburide and pinacidil. J. Mol. Cell Cardiol., 27, 1765-1774 (1995).
3. Coghlan, M. J., Carroll, W. A., and Gopalakrishnan, M., Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress. J. Med. Chem., 44, 1627-1653 (2001).
4. Cole, W.C., McPherson, C. D., and Sontag, D., ATP-regulated K+ channels protect the myocardium against ischemia/reperfusion damage. Circ. Res., 69, 571-581 (1991).
5. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E., Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 91, 231-241 (1997).
6. D'Alonzo, A. J., Darbenzio, R. B., Parham, C. S., and Grover, G. J., Effects of intracoronary cromakalim on postischaemic contractile function and action potential duration. Cardiovasc. Res., 26, 1046-1053 (1992).
7. Ding, C. Z., Rovnyak, G. C., Misra, R. N., Grover, G. J., Miller, A. V., Ahmed, S. Z., Kelly, Y., Normandin, D. E., Sleph, P. G., and Atwal, K. S., Cardioselective antiischemic ATP-sensitive potassium channel (K(ATP)) openers. 6. Effect of modifications at C6 of benzopyranyl cyanoguanidines. J. Med. Chem., 42, 3711-3717 (1999).
8. Fujita, E., Jinbo, A., Matuzaki, H., Konishi, H., Kikkawa, U., and Momoi, T., Akt phosphorylation site found in human caspase-9 is absent in mouse caspase-9. Biochem. Biophys. Res. Commun., 264, 550-555 (1999).
9. Gomoll, A. W., Roth, R. A., Swillo, R. E., Baird, A. J., Sargent, C. S., Behling, R. W., Malone, H. J., and Grover, G. J., Effect of timing of treatment of the glyburide-reversible cardioprotective activity of BMS-180448. J. Pharmacol. Exp. Ther., 281, 24-33 (1997).
10. Gross, G. J. and Auchampach, J. A., Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ. Res., 70, 223-233 (1992).
11. Grover, G. J., D'Alonzo, A.J., Garlid, K. D., Bajgar, R., Lodge, N. J., Sleph, P. G., Darbenzio, R. B., Hess, T. A., Smith, M. A., Paucek, P., and Atwal, K. S., Pharmacologic characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity. J. Pharmacol. Exp. Ther., 297, 1184-1192 (2001).
12. Grover, G. J., D'Alonzo, A. J., Hess, T., Sleph, P. G., and Darbenzio, R. B., Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening. Cardiovasc. Res., 30, 731-738 (1995).
13. Hausenloy, D. J. and Yellon, D. M., Survival kinases in ischemic preconditioning and postconditioning. Cardiovasc. Res., 70, 240-253 (2006).
14. Hwang, G. S., Oh, K. S., Koo, H. N., Seo, H. W., You, K. H., and Lee, B. H., Effects of KR-31378, a novel ATP-sensitive potassium channel activator, on hypertrophy of H9c2 cells and on cardiac dysfunction in rats with congestive heart failure. Eur. J. Pharmacol., 540, 131-138 (2006).
15. Juhaszova, M., Zorov, D. B., Kim, S. H., Pepe, S., Fu, Q., Fishbein, K.W., Ziman, B. D, Wang, S., Ytrehus, K., Antos, C. L., Olson, E. N., and Sollott, S. J., Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J. Clin. Invest., 113, 1535-1549 (2004).
16. Inoue, I., Nagase, H., Kishi, K., and Higuti, T., ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature, 352, 244-247 (1991).
17. Kim, K. Y., Lee, J. H., Park, J. H., Yoo, M. A., Kwak, Y. G., Kim, S. O., Yoo, S. E., and Hong, K. W., Anti-apoptotic action of (2S,3S,4R)-N″- cyano-N-(6-amino-3,4-dihydro-3-hydroxy 2-methyl-2 dimethoxymethyl-2H-benzopyran- 4-yl)-N′-benzylguanidine (KR-31378) by suppression of the phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and increased phosphorylation of casein kinase2/Akt/cyclic AMP response element binding protein via maxi-K channel opening in neuronal cells. Eur. J. Pharmacol., 497, 267-277 (2004).
18. Laude, K., Beauchamp, P., Thuillez, C., and Richard, V., Endothelial protective effects of preconditioning. Cardiovasc. Res., 55, 466-473 (2002).
19. Lee, B. H., Seo, H. W., Yoo, S. E., Kim, S. O., Lim, H., and Shin, H. S., Differential action of KR-31378, a novel potassium channel activator, on cardioprotective and hemodynamic effects, Drug Devel., Res., 54, 182-190 (2001).
20. Li, Y. and Kloner, R. A., Cardioprotective effects of ischaemic preconditioning are not mediated by prostanoids. Cardiovasc. Res., 26, 226-231 (1992).
21. Liu, Y., Sato, T., O'Rourke, B., and Marban, E., Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation, 97, 2463-2469 (1998).
22. Matsuzaki, H., Tamatani, M., Mitsuda, N., Namikawa, K., Kiyama, H., Miyake, S., and Tohyama, M., Activation of Akt kinase inhibits apoptosis and changes in Bcl-2 and Bax expression induced by nitric oxide in primary hippocampal neurons. J. Neurochem., 73, 2037-2046 (1999).
23. Mizumura, T., Nithipatikom, K., and Gross, G. J., Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs. Circulation, 92, 1236-1245 (1995).
24. Moore, P. F., The effects of diazoxide and benzothiadiazine diuretics upon phosphodiesterase. Ann. N .Y. Acad. Sci., 150, 256-260 (1968).
25. Rovnyak, G. C., Ahmed, S. Z, Ding, C. Z., Dzwonczyk, S., Ferrara, F. N., Humphreys, W. G., Grover, G. J., Santafianos, D., Atwal, K. S., Baird, A. J., McLaughlin, L. G., Normandin, D. E., Sleph, P. G., and Traeger, S. C., Cardioselective antiischemic ATP-sensitive potassium channel (KATP) openers. 5. Identification of 4-(N-aryl)-substituted benzopyran derivatives with high selectivity. J. Med. Chem., 40, 24-34 (1997).
26. Teshima, Y., Akao, M., Li, R. A., Chong, T. H., Baumgartner, W. A., Johnston, M. V., and Marban, E., Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress. Stroke, 34, 1796-1802 (2003).
27. Wang, Y., Ahmad, N., Kudo, M., and Ashraf, M., Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning. Am. J. Physiol. Heart. Circ. Physiol., 287, H1125-H1131 (2004).
28. Wang, Y., Kudo, M., Xu, M., Ayub, A., and Ashraf, M., Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. J. Mol. Cell. Cardiol., 33, 2037-2046 (2001).
29. Yao, Z. and Gross, G. J., The ATP-dependent potassium channel: an endogenous cardioprotective mechanism. J. Cardiovasc. Pharmacol., 24 (Suppl 4), S28-S34 (1994).
30. Yellon, D. M., Alkhulaif,i A. M., Browne, E. E., and Pugsley, W. B., Ischaemic preconditioning limits infarct size in the rat heart. Cardiovasc. Res., 26, 983-987 (1992).
31. Yellon, D. M., Alkhulaifi, A. M., and Pugsley, W. B., Preconditioning the human myocardium. Lancet, 342, 276-277 (1993).