메뉴 건너뛰기




Volumn 4, Issue 2, 2007, Pages 157-169

Influence of CYP2C9 genotype on warfarin dose among African-Americans and European-Americans

Author keywords

African American; CYP2C9; European American; Pyrosequencing; Warfarin dose

Indexed keywords

CYTOCHROME P450 2C9; VITAMIN K GROUP; WARFARIN;

EID: 34249823331     PISSN: 17410541     EISSN: 1744828X     Source Type: Journal    
DOI: 10.2217/17410541.4.2.157     Document Type: Article
Times cited : (49)

References (50)
  • 1
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: A status report summarizing their reactions. substrates, inducers, and inhibitors
    • Rendic S, Di Carlo FJ: Human cytochrome P450 enzymes: a status report summarizing their reactions. substrates, inducers, and inhibitors. Drug Metab. Rev. 29, 413-580 (1997).
    • (1997) Drug Metab. Rev , vol.29 , pp. 413-580
    • Rendic, S.1    Di Carlo, F.J.2
  • 2
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE, Relling MV: Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487-491 (1999).
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 3
    • 0036223336 scopus 로고    scopus 로고
    • Introductory remarks on human CYPs
    • Nelson DR: Introductory remarks on human CYPs. Drug Metab. Rev. 34, 1-5 (2002).
    • (2002) Drug Metab. Rev , vol.34 , pp. 1-5
    • Nelson, D.R.1
  • 4
    • 13944274619 scopus 로고    scopus 로고
    • Clinical and toxicological relevance of CYP2C9. drug-drug interactions and pharmacogenetics
    • Rettie AE. Jones JP: Clinical and toxicological relevance of CYP2C9. drug-drug interactions and pharmacogenetics. Annu. Rev. Pharmacol. Toxicol. 45, 477-494 (2005).
    • (2005) Annu. Rev. Pharmacol. Toxicol , vol.45 , pp. 477-494
    • Rettie, A.E.1    Jones, J.P.2
  • 5
    • 0031856787 scopus 로고    scopus 로고
    • Lasker JM, Wester MR, Aramsombatdee E. Raucy JL: Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch. Biochem. Biophys. 353, 16-28 (1998).
    • Lasker JM, Wester MR, Aramsombatdee E. Raucy JL: Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations. Arch. Biochem. Biophys. 353, 16-28 (1998).
  • 6
    • 0031841377 scopus 로고    scopus 로고
    • Cytochrome P4502C9: An enzyme of major importance in human drug metabolism
    • Miners JO. Birkett DJ: Cytochrome P4502C9: an enzyme of major importance in human drug metabolism. Br. J. Clin. Pharmacol. 45, 525-538 (1998).
    • (1998) Br. J. Clin. Pharmacol , vol.45 , pp. 525-538
    • Miners, J.O.1    Birkett, D.J.2
  • 7
    • 0141791128 scopus 로고    scopus 로고
    • Cytochrome P450 enzyme polymorphisms and adverse drug reactions
    • Pirmohamed M, Park BK: Cytochrome P450 enzyme polymorphisms and adverse drug reactions. Toxicology 192, 23-32 (2003).
    • (2003) Toxicology , vol.192 , pp. 23-32
    • Pirmohamed, M.1    Park, B.K.2
  • 8
    • 0035369825 scopus 로고    scopus 로고
    • Genetic susceptibility to adverse drug reactions
    • Pirmohamed M, Park BK: Genetic susceptibility to adverse drug reactions. Trends Pharmacol. Sci. 22, 298-305 (2001).
    • (2001) Trends Pharmacol. Sci , vol.22 , pp. 298-305
    • Pirmohamed, M.1    Park, B.K.2
  • 9
    • 0037131892 scopus 로고    scopus 로고
    • CYP2C9 allelic variants: Ethnic distribution and functional significance
    • Xie HG, Prasad HC, Kim RB, Stein CM: CYP2C9 allelic variants: ethnic distribution and functional significance. Adv. Drug Deliv. Rev. 54, 1257-1270 (2002).
    • (2002) Adv. Drug Deliv. Rev , vol.54 , pp. 1257-1270
    • Xie, H.G.1    Prasad, H.C.2    Kim, R.B.3    Stein, C.M.4
  • 10
    • 11844304376 scopus 로고    scopus 로고
    • Clinical consequences of cytochrome P450 2C9 polymorphisms
    • Kirchheiner J, Brockmoller J: Clinical consequences of cytochrome P450 2C9 polymorphisms. Clin. Pharmacol. Ther. 77, 1-16 (2005).
    • (2005) Clin. Pharmacol. Ther , vol.77 , pp. 1-16
    • Kirchheiner, J.1    Brockmoller, J.2
  • 11
    • 11844287412 scopus 로고    scopus 로고
    • Influence of CYP2C9 polymorphisms, demographic factors and concomitant drug therapy on warfarin metabolism and maintenance dose
    • Herman D. Locatelli I, Grabnar I et al.: Influence of CYP2C9 polymorphisms, demographic factors and concomitant drug therapy on warfarin metabolism and maintenance dose. Pharmacogenomics J. 5, 193-202 (2005).
    • (2005) Pharmacogenomics J , vol.5 , pp. 193-202
    • Herman, D.1    Locatelli, I.2    Grabnar, I.3
  • 12
    • 0037012465 scopus 로고    scopus 로고
    • Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy
    • Higashi MK, Veenstra DL. Kondo LM et al.: Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA 287, 1690-1698 (2002).
    • (2002) JAMA , vol.287 , pp. 1690-1698
    • Higashi, M.K.1    Veenstra, D.L.2    Kondo, L.M.3
  • 13
    • 0033694203 scopus 로고    scopus 로고
    • Genetic modulation of oral anticoagulation with warfarin
    • Margaglione M, Colaizzo D, D'Andrea G et al.: Genetic modulation of oral anticoagulation with warfarin. Thromb. Haemost. 84, 775-778 (2000).
    • (2000) Thromb. Haemost , vol.84 , pp. 775-778
    • Margaglione, M.1    Colaizzo, D.2    D'Andrea, G.3
  • 14
    • 33745411452 scopus 로고    scopus 로고
    • Schalekamp T, Brasse BP. Roijers JF et al.: VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects overanticoagulation. Clin. Pharmacol. Ther. 80, 13-22 (2006).
    • Schalekamp T, Brasse BP. Roijers JF et al.: VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects overanticoagulation. Clin. Pharmacol. Ther. 80, 13-22 (2006).
  • 15
    • 33846578240 scopus 로고    scopus 로고
    • VKORC1 and CYP2C9 genotypes and phenprocoumon anticoagulation status: Interaction between both genotypes affects dose requirement
    • Schalekamp T, Brasse BP, Roijers JF et al.: VKORC1 and CYP2C9 genotypes and phenprocoumon anticoagulation status: interaction between both genotypes affects dose requirement. Clin. Pharmacol. Ther. 81, 185-193 (2007).
    • (2007) Clin. Pharmacol. Ther , vol.81 , pp. 185-193
    • Schalekamp, T.1    Brasse, B.P.2    Roijers, J.F.3
  • 16
    • 0036854237 scopus 로고    scopus 로고
    • Pharmacogenetics of acenocoumarol: Cytochrome P450 CYP2C9 polymorphisms influence dose requirements and stability of anticoagulation
    • Tassies D, Freire C, Pijoan J et al.: Pharmacogenetics of acenocoumarol: cytochrome P450 CYP2C9 polymorphisms influence dose requirements and stability of anticoagulation. Haematologica 87, 1185-1191 (2002).
    • (2002) Haematologica , vol.87 , pp. 1185-1191
    • Tassies, D.1    Freire, C.2    Pijoan, J.3
  • 17
    • 0034283762 scopus 로고    scopus 로고
    • Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment
    • Taube J, Halsall D, Baglin T. Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment. Blood 96, 1816-1819 (2000).
    • (2000) Blood , vol.96 , pp. 1816-1819
    • Taube, J.1    Halsall, D.2    Baglin, T.3
  • 18
    • 19144373497 scopus 로고    scopus 로고
    • CYP2C9 haplotype structure in European-American warfarin patients and association with clinical outcomes
    • Veenstra DL, Blough DK, Higashi MK et al.: CYP2C9 haplotype structure in European-American warfarin patients and association with clinical outcomes. Clin. Pharmacol. Ther. 77, 353-364 (2005).
    • (2005) Clin. Pharmacol. Ther , vol.77 , pp. 353-364
    • Veenstra, D.L.1    Blough, D.K.2    Higashi, M.K.3
  • 19
    • 13644260557 scopus 로고    scopus 로고
    • Enhanced antithrombotic effect of warfarin associated with low-dose alcohol consumption
    • Havrda DE, Mai T, Chonlahan J: Enhanced antithrombotic effect of warfarin associated with low-dose alcohol consumption. Pharmacotherapy 25, 303-307 (2005).
    • (2005) Pharmacotherapy , vol.25 , pp. 303-307
    • Havrda, D.E.1    Mai, T.2    Chonlahan, J.3
  • 20
    • 28544449207 scopus 로고    scopus 로고
    • Search for predictors of nontherapeutic INR results with warfarin therapy
    • McGriff-Lee NJ, Csako G, Chen JT et al.: Search for predictors of nontherapeutic INR results with warfarin therapy. Ann. Pharmacotherapy 39, 1996-2002 (2005).
    • (2005) Ann. Pharmacotherapy , vol.39 , pp. 1996-2002
    • McGriff-Lee, N.J.1    Csako, G.2    Chen, J.T.3
  • 21
    • 4644332692 scopus 로고    scopus 로고
    • Frequency and causes of overanticoagulation and underanticoagulation in patients treated with warfarin
    • Wittkowsky AK, Devine EB: Frequency and causes of overanticoagulation and underanticoagulation in patients treated with warfarin. Pharmacotherapy 24, 1311-1336 (2004).
    • (2004) Pharmacotherapy , vol.24 , pp. 1311-1336
    • Wittkowsky, A.K.1    Devine, E.B.2
  • 22
    • 2542441843 scopus 로고    scopus 로고
    • Potential interactions between exercise and drug therapy
    • Lenz TL, Lenz NJ, Faulkner MA: Potential interactions between exercise and drug therapy. Sports Med. 34, 293-306 (2004).
    • (2004) Sports Med , vol.34 , pp. 293-306
    • Lenz, T.L.1    Lenz, N.J.2    Faulkner, M.A.3
  • 25
    • 3543006619 scopus 로고    scopus 로고
    • Functional impact of CYP2C95. CYP2C96, CYP2C98, and CYP2C911 in vivo among black Africans
    • Allabi AC, Gala JL, Horsmans Y et al.: Functional impact of CYP2C95. CYP2C96, CYP2C98, and CYP2C911 in vivo among black Africans. Clin. Pharmacol. Ther. 76(2). 113-118 (2004).
    • (2004) Clin. Pharmacol. Ther , vol.76 , Issue.2 , pp. 113-118
    • Allabi, A.C.1    Gala, J.L.2    Horsmans, Y.3
  • 26
    • 4243052841 scopus 로고    scopus 로고
    • Discovery of new potentially defective alleles of human CYP2C9
    • Blaisdell J, Jorge-Nebert LF, Coulter S et al.: Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics 14, 527-537 (2004).
    • (2004) Pharmacogenetics , vol.14 , pp. 527-537
    • Blaisdell, J.1    Jorge-Nebert, L.F.2    Coulter, S.3
  • 27
    • 0029658591 scopus 로고    scopus 로고
    • The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism
    • Sullivan-Klose TH, Ghanayem BI, Bell DA et al.: The role of the CYP2C9-Leu359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics 6, 341-349 (1996).
    • (1996) Pharmacogenetics , vol.6 , pp. 341-349
    • Sullivan-Klose, T.H.1    Ghanayem, B.I.2    Bell, D.A.3
  • 28
    • 0026689178 scopus 로고
    • Performing the exact test of Hardy-Weinberg proportion for multiple alleles
    • Guo SW, Thompson EA: Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 48, 361-372 (1992).
    • (1992) Biometrics , vol.48 , pp. 361-372
    • Guo, S.W.1    Thompson, E.A.2
  • 29
    • 33748860865 scopus 로고    scopus 로고
    • Racial differences in the prevalence of factor V Leiden mutation among patients on chronic warfarin therapy
    • Limdi NA, Beasley TM, Allison DB, Rivers CA, Acton RT: Racial differences in the prevalence of factor V Leiden mutation among patients on chronic warfarin therapy. Blood Cells Mol. Dis. 37, 100-106 (2006).
    • (2006) Blood Cells Mol. Dis , vol.37 , pp. 100-106
    • Limdi, N.A.1    Beasley, T.M.2    Allison, D.B.3    Rivers, C.A.4    Acton, R.T.5
  • 30
    • 33947587270 scopus 로고    scopus 로고
    • Warfarin and cytochrome P450 2C9 genotype: Possible ethnic variation in warfarin sensitivity
    • Kealey C, Chen Z, Christie J et al.: Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity. Pharmacogenomics 8, 217-225 (2007).
    • (2007) Pharmacogenomics , vol.8 , pp. 217-225
    • Kealey, C.1    Chen, Z.2    Christie, J.3
  • 31
  • 33
    • 0034921210 scopus 로고    scopus 로고
    • Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans
    • Dickmann LJ, Rettie AE, Kneller MB et al.: Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans. Mol. Pharmacol. 60, 382-387 (2001).
    • (2001) Mol. Pharmacol , vol.60 , pp. 382-387
    • Dickmann, L.J.1    Rettie, A.E.2    Kneller, M.B.3
  • 34
    • 0037782102 scopus 로고    scopus 로고
    • HLA class II and TNF genes in African-Americans from the southeastern United States: Regional differences in allele frequencies
    • Kuffner T, Whitworth W, Jairam M, McNicholl J: HLA class II and TNF genes in African-Americans from the southeastern United States: regional differences in allele frequencies. Hum. Immunol. 64, 639-647 (2003).
    • (2003) Hum. Immunol , vol.64 , pp. 639-647
    • Kuffner, T.1    Whitworth, W.2    Jairam, M.3    McNicholl, J.4
  • 35
    • 0014687735 scopus 로고
    • Caucasian genes In American Negroes
    • Reed TE: Caucasian genes In American Negroes. Science 165, 762-768 (1969).
    • (1969) Science , vol.165 , pp. 762-768
    • Reed, T.E.1
  • 36
    • 0020030559 scopus 로고
    • Evidence for genetic admixture as a determinant in the occurrence of insulin-dependent diabetes mellitus in U.S. blacks
    • Reitnauer PJ, Go RC, Acton RT et al.: Evidence for genetic admixture as a determinant in the occurrence of insulin-dependent diabetes mellitus in U.S. blacks. Diabetes 31, 532-537 (1982).
    • (1982) Diabetes , vol.31 , pp. 532-537
    • Reitnauer, P.J.1    Go, R.C.2    Acton, R.T.3
  • 37
    • 0035217171 scopus 로고    scopus 로고
    • Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin
    • Kidd RS, Curry TB, Gallagher S, Edeki T, Blaisdell J, Goldstein JA: Identification of a null allele of CYP2C9 in an African-American exhibiting toxicity to phenytoin. Pharmacogenetics 11, 803-808 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 803-808
    • Kidd, R.S.1    Curry, T.B.2    Gallagher, S.3    Edeki, T.4    Blaisdell, J.5    Goldstein, J.A.6
  • 38
    • 22544431989 scopus 로고    scopus 로고
    • In vitro and in vivo effects of the CYP2C9*11 polymorphism on warfarin metabolism and dose
    • Tai G, Farin F, Rieder MJ et al.: In vitro and in vivo effects of the CYP2C9*11 polymorphism on warfarin metabolism and dose. Pharmacogenet. Genomics 15, 475-481 (2005).
    • (2005) Pharmacogenet. Genomics , vol.15 , pp. 475-481
    • Tai, G.1    Farin, F.2    Rieder, M.J.3
  • 39
    • 0026542989 scopus 로고
    • Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences
    • Gotoh O: Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J. Biol. Chem. 267, 83-90 (1992).
    • (1992) J. Biol. Chem , vol.267 , pp. 83-90
    • Gotoh, O.1
  • 40
    • 0034892729 scopus 로고    scopus 로고
    • Genetic polymorphisms and functional characterization of the 5′-flanking region of the human CYP2C9 gene: In vitro and in vivo studies
    • Shintani M, Ieiri I, Inoue K et al.: Genetic polymorphisms and functional characterization of the 5′-flanking region of the human CYP2C9 gene: in vitro and in vivo studies. Clin. Pharmacol. Ther. 70, 175-182 (2001).
    • (2001) Clin. Pharmacol. Ther , vol.70 , pp. 175-182
    • Shintani, M.1    Ieiri, I.2    Inoue, K.3
  • 41
    • 0034051119 scopus 로고    scopus 로고
    • Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: Genetic analysis of the CYP2C9 locus
    • Imai J, Ieiri I, Mamiya K et al.: Polymorphism of the cytochrome P450 (CYP) 2C9 gene in Japanese epileptic patients: genetic analysis of the CYP2C9 locus. Pharmacogenetics 10, 85-89 (2000).
    • (2000) Pharmacogenetics , vol.10 , pp. 85-89
    • Imai, J.1    Ieiri, I.2    Mamiya, K.3
  • 43
    • 33744803155 scopus 로고    scopus 로고
    • Multiple molecular dynamics simulations of human p450 monooxygenase CYP2C9: The molecular basis of substrate binding and regioselectivity toward warfarin
    • Seifert A, Tatzel S, Schmid RD, Pleiss J: Multiple molecular dynamics simulations of human p450 monooxygenase CYP2C9: the molecular basis of substrate binding and regioselectivity toward warfarin. Proteins 64, 147-155 (2006).
    • (2006) Proteins , vol.64 , pp. 147-155
    • Seifert, A.1    Tatzel, S.2    Schmid, R.D.3    Pleiss, J.4
  • 44
    • 33947227273 scopus 로고    scopus 로고
    • Association of warfarin dose with genes involved in its action and metabolism
    • Wadelius M, Chen LY, Eriksson N et al.: Association of warfarin dose with genes involved in its action and metabolism. Hum. Genet. 121, 23-34 (2007).
    • (2007) Hum. Genet , vol.121 , pp. 23-34
    • Wadelius, M.1    Chen, L.Y.2    Eriksson, N.3
  • 45
    • 1342332251 scopus 로고    scopus 로고
    • Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors
    • Wadelius M, Sorlin K, Wallerman O et al.: Warfarin sensitivity related to CYP2C9, CYP3A5, ABCB1 (MDR1) and other factors. Pharmacogenomics J. 4, 40-48 (2004).
    • (2004) Pharmacogenomics J , vol.4 , pp. 40-48
    • Wadelius, M.1    Sorlin, K.2    Wallerman, O.3
  • 46
    • 34248514013 scopus 로고    scopus 로고
    • Apolipoprotein E genotype and warfarin dosing among Caucasians and African-Americans
    • Kimmel SE, Christie J, Kealey C et al.: Apolipoprotein E genotype and warfarin dosing among Caucasians and African-Americans. Pharmacogenomics J. (2007).
    • (2007) Pharmacogenomics J
    • Kimmel, S.E.1    Christie, J.2    Kealey, C.3
  • 47
    • 22044433685 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 ( CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity
    • Bodin L, Verstuyft C, Tregouet DA et al.: Cytochrome P450 2C9 ( CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Blood 106, 135-140 (2005).
    • (2005) Blood , vol.106 , pp. 135-140
    • Bodin, L.1    Verstuyft, C.2    Tregouet, D.A.3
  • 48
    • 23044440450 scopus 로고    scopus 로고
    • The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: Proposal for a new dosing regimen
    • Sconce EA, Khan TI, Wynne HA et al.: The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimen. Blood 106, 2329-2333 (2005).
    • (2005) Blood , vol.106 , pp. 2329-2333
    • Sconce, E.A.1    Khan, T.I.2    Wynne, H.A.3
  • 49
    • 34247215617 scopus 로고    scopus 로고
    • Warfarin response and vitamin K epoxide reductase complex 1 in African-Americans and Caucasians
    • Epub ahead of print
    • Schelleman H, Chen Z, Kealey C et al.: Warfarin response and vitamin K epoxide reductase complex 1 in African-Americans and Caucasians. Clin. Pharmacol. Ther. (2007) (Epub ahead of print).
    • (2007) Clin. Pharmacol. Ther
    • Schelleman, H.1    Chen, Z.2    Kealey, C.3
  • 50
    • 33644849222 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2006 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Thom T, Haase N, Rosamond W et al.: Heart disease and stroke statistics - 2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 113, E85-E151 (2006).
    • (2006) Circulation , vol.113
    • Thom, T.1    Haase, N.2    Rosamond, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.