Targeted molecular strategies for cancer therapy based on the blockade of oncogenic pathways in human tumor cells

Yakugaku Zasshi

Volumn 127, Issue 6, 2007, Pages 983-991

  Ozaki, Kei Ichi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Akt; Extracellular signal regulated kinase; Histone deacetylase inhibitor; Molecular targeted cancer therapy; Phosphatidylinositol 3 kinase

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; HISTONE DEACETYLASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; CANCER CHEMOTHERAPY; CELL SURVIVAL; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIBIOTICS, ANTINEOPLASTIC; CELL TRANSFORMATION, NEOPLASTIC; DOXORUBICIN; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34249819070     PISSN: 00316903     EISSN: 13475231     Source Type: Journal    
DOI: 10.1248/yakushi.127.983     Document Type: Review

References (17)

1. Downward J., Nat. Rev. Cancer, 3, 11-22 (2003).
2. Sharma S. V., Gajowniczek P., Way I. P., Lee D. Y., Jiang J., Yuza Y., Classon M., Haber D. A., Settleman J., Cancer Cells, 10, 425-435 (2006).
3. Darzynkiewicz Z., Juan G., Li X., Gorczyca W., Murakami T., Traganos F., Cytometry, 27, 1-20 (1999).
4. Nagai Y., Miyazawa H., Huqun, Tanaka T., Udagawa K., Kato M., Fukuyama S., Yokote A., Kobayashi K., Kanazawa M., Hagiwara K., Cancer Res., 65, 7276-7282 (2005).
5. Davies H., Bignell G. R., Cox C., Stephens P., Edkins S., Clegg S., Teague J., Woffendin H., Garnett M. J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B. A., Cooper C., Shipley J., Hargrave D., Pritchard-Jones K., Maitland N., Chenevix-Trench G., Riggins G. J., Bigner D. D., Palmieri G., Cossu A., Flanagan A., Nicholson A., Ho J. W. C., Leung S. Y., Yuen S. T., Weber B. L., Seigler H. F., Darrow T. L., Paterson H., Marais R., Marshall C. J., Wooster R., Stratton M. R., Futreal P. A., Nature, 417, 949-954 (2002).
6. Solit D. B., Garraway L. A., Pratilas C. A., Sawai A., Getz G., Basso A., Ye Q., Lobo J. M., She Y., Osman I., Golub T. R., Sebolt-Leopold J., Sellers W. R., Rosen N., Nature, 439, 358-362 (2006).
7. Riedl S. J., Shi Y., Nat. Rev. Mol. Cell Biol., 5, 897-907 (2004).
8. Ruefli A. A., Ausserlechner M. J., Bernhard D., Sutton V. R., Tainton K. M., Kofler R., Smyth M. J., Johnstone R. W., Proc. Natl. Acad. Sci. U.S.A., 98, 10833-10838 (2001).
9. Rosato R. R., Almenara J. A., Grant S., Cancer Res., 63, 3637-3645 (2003).
10. Ozaki K., Minoda A., Kishikawa F., Kohno M., Biochem. Biophys. Res. Commun., 339, 1171-1177 (2006).
11. Vivanco I., Sawyers C. L., Nat. Rev. Cancer, 2, 489-501 (2002).
12. Fujiwara Y., Hosokawa Y., Watanabe K., Tanimura S., Ozaki K., Kohno M., Mol. Cancer Ther., 6, 1133-1142 (2007).
13. Matsumoto H., Shimura M., Omatsu T., Okaichi K., Majima H., Ohnishi T., Cancer Lett., 87, 39-46 (1994).
14. Carroll A. G., Voeller H. J., Sugars L., Gelmann E. P., Prostate, 23, 123-134 (1993).
15. Lin C. F., Chen C. L., Lin Y. S., Curr. Med. Chem., 13, 1609-1616 (2006).
16. Fujiwara Y., Kawada K., Tanimura S., Ozaki K., Kohno M., Biochem. Biophys. Res. Commun., 340, 560-566 (2006).
17. Watanabe K., Noda S., Iwashita K., Tanimura S., Ozaki K., Kohno M., Proc. Am. Assoc. Cancer Res., 43, 2891 (2002).