Oxidative stress and DNA hypermethylation status in renal cell carcinoma arising in patients on dialysis

Journal of Pathology

Volumn 212, Issue 2, 2007, Pages 218-226

  Hori, Y ^a   Oda, Y ^a   Kiyoshima, K ^a   Yamada, Y ^b   Nakashima, Y ^b   Naito, S ^a   Tsuneyoshi, M ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b FUKUOKA RED CROSS HOSPITAL   (Japan)

Author keywords

8 OHdG; COX 2; Dialysis; iNOS; Methylation; Oxidative stress; Renal cell carcinoma

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; PROTEIN P14ARF; PROTEIN P16INK4A; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; VON HIPPEL LINDAU PROTEIN;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIALYSIS; DNA METHYLATION; FEMALE; GENE OVEREXPRESSION; HEMODIALYSIS PATIENT; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; MALE; OXIDATIVE STRESS; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ADULT; AGED; BIOLOGICAL MARKERS; CARCINOMA, RENAL CELL; CPG ISLANDS; CYCLOOXYGENASE 2; DEOXYGUANOSINE; DNA METHYLATION; FEMALE; GENES, P16; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY DISEASES; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RENAL DIALYSIS; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEINS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 34249803269     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2176     Document Type: Article

References (45)

1. Crossey PA, Richards FM, Foster K, Green JS, Prowse A, Latif F, et al.. Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype. Hum Mol Genet 1994;3:1303-1308.
2. Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, et al.. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993;260:1317-1320.
3. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, et al.. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 1994;91:9700-9704.
4. Brauch H, Weirich G, Brieger J, Glavac D, Rodl H, Eichinger M, et al.. VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot mutation. Cancer Res 2000;60:1942-1948.
5. Kawakami T, Okamoto K, Ogawa O, Okada Y. Multipoint methylation and expression analysis of tumor suppressor genes in human renal cancer cells. Urology 2003;61:226-230.
6. Kawada Y, Nakamura M, Ishida E, Shimada K, Oosterwijk E, Uemura H, et al.. Aberrations of the p14ARF and p16INK4a genes in renal cell carcinoma. Jpn J Cancer Res 2001;92:1293-1299.
7. Dulaimi E, Ibanez de Caceres I, Uzzo RG, Al-Saleem T, Greenberg RE, Polascik TJ, et al.. Promoter hypermethylation profile of kidney cancer. Clin Cancer Res 2004;10:3972-3979.
8. Battagli C, Uzzo RG, Dulaimi E, Ibanez de Caceres I, Krassenstein R, et al.. Promoter hypermethylation of tumor suppressor gene in urine from kidney cancer patients. Cancer Res 2003; 63:8695-8699.
9. Morris MR, Hesson LB, Wagner KJ, Morgan NV, Astuti D, Lees RD, et al.. Multigene methylation analysis of Wilms' tumour and adult renal cell carcinoma. Oncogene 2003;22:6794-6801.
10. Morrissey C, Martinez A, Zatyka M, Agathanggelou A, Honorio S, Astuti D, et al.. Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma. Cancer Res 2001;61:7277-7281.
11. Esteller M, Corn PG, Baylin SB, Herman JG. A gene hypermethylation profile of human cancer. Cancer Res 2001;61:3225-3229,
12. Yoon JH, Dammann R, Pfeifer GP. Hypermethylation of the CpG island of the RASSF1A gene in ovarian and renal cell carcinomas. Int J Cancer 2001;94:212-217.
13. Choyke PL. Acquired cystic kidney disease. Eur Radiol 2000; 10:1716-1721.
14. Dunnill MS, Millard PR, Oliver D. Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance haemodialysis. J Clin Pathol 1977;30:868-877.
15. Maisonneuve P, Agodoa L, Gellert R, Stewart JH, Buccianti G, Lowenfels AB, et al.. Cancer in patients on dialysis for endostage renal disease: and international collaborative study. Lancet 1999; 354:93-99.
16. Yoshida M, Yao M, Ishikawa I, Kishida T, Nagashima Y, Kondo K, et al.. Somatic von Hippel-Lindau disease gene mutation in clear-cell renal carcinomas associated with end-stage renal disease/acquired cystic disease of the kidney. Genes Chromosomes Cancer 2002; 35:359-364.
17. Davies GR, Simmonds NJ, Stevens TR, Sheaff MT, Banatvala N, Laurenson IF, et al.. Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo. Gut 1994;35:179-185.
18. Sarkar SR, Kaitwatcharachai C, Levin NW. Nitric oxide and hemodialysis. Semin Dial 2004;17:224-8.
19. Pinlaor S, Hiraku Y, Yongvanit P, Tada-Oikawa S, Ma N, Pinlaor P, et al.. iNOS-dependent DNA damage via NF-κB expression in hamsters infected with Opisthorchis viverrine and its suppression by the antihelminthic drug praziquantel. Int J Cancer 2006; 119:1067-1072.
20. Lechner M, Lirk P, Rieder J. Inducible nitric oxide synthase (iNOS) in tumor biology: the two sides of the same coin. Semin Cancer Biol 2005;15:277-289.
21. Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res 1997;384:147-163.
22. Huang XB, Ito F, Nakazawa H, Toma H. Increased expression of 8-hydroxydeoxyguanosine in acquired cystic disease of the kidney. Nephron 1999;81:458-459.
23. Miyata Y, Koga S, Kanda S, Nishikido M, Hayashi T, Kanetake H. Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. Clin Cancer Res 2003; 9:1741-1749.
24. Romanenko A, Morell-Quadreny L, Lopez-Guerrero JA, Pellin A, Nepomnyaschy V, Vozianov A, et al.. The INK4a/ARF locus: role in cell cycle control for renal cell epithelial tumor growth after the Chernobyl accident. Virchows Arch 2004;445:298-304.
25. Bretheau D, Lechevallier E, de Fromont M, Sault MC, Rampal M, Coulange C. Prognostic value of nuclear grade of renal cell carcinoma. Cancer 1995;76:2543-2549.
26. Seki S, Kitada T, Yamada T, Sakaguchi H, Nakatani K, Onoda N, et al.. Immunohistochemical detection of 8-hydroxydeoxyguanosine, a marker of oxidative DNA damage, in human chronic cholecystitis. Histopathology 2002;40:531-535.
27. Seki S, Kitada T, Sakaguchi H, Nakatani K, Wakasa K. Pathological significance of oxidative cellular damage in human alcoholic liver disease. Histopathology 2003;42:365-371.
28. Toyokuni S, Tanaka T, Hattori Y, Nishiyama Y, Yoshida A, Uchida K, et al.. Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody n45.1: its application of ferric nitrilotriacetate induced renal carcinogenesis model. Lab Invest 1997;76:365-374.
29. Ikeda H, Hirato J, Suzuki N, Kuroiwa M, Maruyama K, Tsuchida Y. Detection of hepatic oxidative DNA damage in patients with hepatoblastoma and children with non-neoplastic disease. Med Pediatr Oncol 2001;37:505-510.
30. Mohammed NA, Abd El-Aleem S, Appleton I, Maklouf MM, Said M, McMahon RF. Expression of nitric oxide synthase isoforms in human liver cirrhosis. J Pathol 2003;200:647-655.
31. Choe W, Kim S, Hwang TS, Lee SS. Expression of inducible nitric oxide synthase in thyroid neoplasms: immunohistochemical and molecular analysis. Pathol Int 2003;53:434-439.
32. Kiyoshima K, Oda Y, Kinukawa N, Naito S, Tsuneyoshi M. Overexpression of laminin-5 gamma2 chain and its prognostic significance in urothelial carcinoma of urinary bladder: association with expression of cyclooxygenase 2, epidermal growth factor, and human epidermal growth factor 2. Hum Pathol 2005;36:522-530.
33. Hashimoto Y, Kondo Y, Kimura G, Matsuzawa I, Sato S, Ishizaki M, et al.. Cyclooxygenase-2 expression and relationship to tumour progression in human renal cell carcinoma. Histopathology 2004; 44:353-359.
34. Kawaguchi K, Oda Y, Saito T, Yamamoto H, Takahira T, Kobayashi C, et al.. DNA hypermethylation status of multiple genes in soft tissue sarcomas. Mod Pathol 2006;19:106-114.
35. Oda Y, Yamamoto H, Takahira T, Kobayashi C, Kawaguchi K, Tateishi N, et al.. Frequent alteration of p16INK4Ka/p14ARF and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14ARF expression both correlate with poor prognosis. J Pathol 2005;207:410-421.
36. Xu XL, Yu J, Zhang HY, Sun MH, Gu J, Du X, et al.. Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol 2004; 10:3441-3454.
37. Ishikawa I. Renal cell carcinoma in patients on long-term hemodialysis. Contrib Nephrol 1999;128:28-44.
38. Miyake H, Hara I, Kamidono S, Eto H. Prognostic significance of oxidative DNA damage evaluated by 8-hydrocy-2′-deoxyguanosine in patients undergoing radical nephrectomy for renal cell carcinoma. Urology 2004;64:1057-1061.
39. Hara N, Bilim V, Kasahara T, Obara K, Saito K, Takahashi K, et al.. Inducible nitric oxide synthase I renal cell carcinoma: expression in tumor thrombi and induction under hypoxic conditions. Anticancer Res 2003;23:4641-4650.
40. Suschek CV, Krischel V, Bruch-Gerharz D, Berendji D, Krutmann J, Kroncke KD, et al.. Nitric oxide fully protects against UVA-induced apoptosis in tight correlation with Bcl-2 up-regulation. J Biol Chem 1999;274:6130-6137.
41. Tuna B, Yorukoglu K, Gurel D, Mungan U, Kirkali Z. Significance of COX-2 expression in human renal cell carcinoma. Urology 2004; 64:1116-1120.
42. Noh H, Kim JS, Han KH, Lee GT, Song JS, Chung SH, et al.. Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane. Kidney Int 2006; 69:2022-2028.
43. Arai E, Kanai Y, Ushijima S, Fujimoto H, Mukai K, Hirohashi S. Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues. Int J Cancer 2006;119:288-296.
44. Peng DF, Kanai Y, Sawada M, Ushijima S, Hiraoka N, Kosuge T, et al.. Increased DNA methyltransferase 1(DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas. Cancer Sci 2005;96:403-408.
45. Kitazawa S, Kitazawa R, Maeda S. Identification of methylated cytosine from archival formalin-fixed paraffin-embedded specimens. Lab Invest 2000;80:275-276.