The INK4a/ARF locus: Role in cell cycle control for renal cell epithelial tumor growth after the Chernobyl accident

Virchows Archiv

Volumn 445, Issue 3, 2004, Pages 298-304

  Romanenko, Alina ^a   Morell Quadreny, Luisa ^b   Lopez Guerrero, Jose Antonio ^c   Pellin, Antonio ^b   Nepomnyaschy, Valentin ^a   Vozianov, Alexander ^a   Llombart Bosch, Antonio ^b  

^a STATE INSTITUTION NATIONAL RESEARCH CENTER FOR RADIATION MEDICINE OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE   (Ukraine)

^b UNIVERSITY OF VALENCIA   (Spain)

^c INSTITUTO VALENCIANO DE ONCOLOGÍA   (Spain)

Author keywords

Chernobyl accident; INK4a ARF locus; p38MAPK; Renal cell carcinogenesis

Indexed keywords

CESIUM 137; CYCLIN D1; KI 67 ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; P14 ARF PROTEIN; PROTEIN; PROTEIN MDM2; UNCLASSIFIED DRUG;

ADULT; AGED; ARF GENE; ARTICLE; CELL CYCLE; CELL CYCLE REGULATION; CELL PROLIFERATION; CELL TRANSFORMATION; CHERNOBYL ACCIDENT; CHROMOSOME 9P; CONTROLLED STUDY; GENE; GENE ACTIVATION; GENE DISRUPTION; GENE LOCUS; HUMAN; HUMAN TISSUE; INK4A GENE; KIDNEY CARCINOMA; LONG TERM EXPOSURE; LOW ENERGY RADIATION; MAJOR CLINICAL STUDY; MALIGNANT TRANSFORMATION; MORBIDITY; P14 ARF GENE; P15 INK4B GENE; P16 INK4A GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION EXPOSURE; RADIOACTIVE CONTAMINATION; RADIOMETRY; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; UKRAINE; URINALYSIS;

ADULT; AGED; CARCINOMA, RENAL CELL; CELL CYCLE; CESIUM ISOTOPES; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; FEMALE; GENES, P16; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; MALE; MIDDLE AGED; MUTATION; NEOPLASMS, RADIATION-INDUCED; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P14ARF; UKRAINE;

EID: 4644301617     PISSN: 09456317     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00428-004-1056-7     Document Type: Article

References (28)

1. Adler V, Yin Z, Tew KD, Ronai Z (1999) Role of redox potential and reactive oxygen species in stress signaling. Oncogene 18:6104-6111
2. Bostwick DG, Murphy GP (1998) Diagnosis and prognosis of renal cell carcinoma: highlights from an international consensus workshop. Semin Urol Oncol 16:46-52
3. Brinda RS, Vasselli JR, Stearman R, Linehan WM, Klauser RD (2002) VH-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells. Cancer Res 62:3014-3019
4. Camero A (2000) Cell cycle and cancer, rev. Oncologia 2:12-22
5. INK4A methylation and p53 mutation status. Cancer Res 60:129-133
6. Galibert MD, Carreira S, Goding CR (2001) The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced tyrosinase expression. EMBO J 20:5022-5031
7. Gillett CE, Barnes DM (1998) Cell cycle. J Clin Pathol 51:310-316
8. Haitel A, Wiener HG, Baethge U, Marberger M, Susani M (2000) Mdm2 expression as a prognostic indicator in clear cell carcinoma: comparison with p53 overexpression and clinicopathological parameters. Clin Cancer Res 6:1840-1844
9. Johnson DG, Walker CL (1999) Cyclins and cell cycle checkpoints. Annu Rev Pharmacol Toxicol 39:295-312
10. Little JB (2000) Radiation carcinogenesis. Carcinogenesis 21:397-404
11. Lopez-Guerrero JA, Pellin A, Noguera R, Carda C, Llombart-Bosch A (2001) Molecular analysis of the 9q21 locus and p53 gene in Ewing family tumors. Lab Invest 81:803-814
12. Lundberg AS, Weinberg RA (1999) Control of the cell cycle and apoptosis. Eur J Cancer 35:531-539
13. Martin JMC, Balkenende A, Verschoor T, Lallemand F, Michalides R (1999) CyclinD1 over-expression enhances radiation-induced apoptosis and radiosensitivity in a breast tumor cell line. Cancer Res 9:1134-1140
14. Parvey S, Conroy S, Rassell T, Gabrielli B (1999) Ultraviolet radiation induces p16CDKN2a expression in human skin. Cancer Res 59:4185-4189
15. Prasad AV, Mohan N, Chandrasekar B, Meltz ML (1994) Activation of nuclear factor kB in human lymphoblastoid cells by low-dose ionizing radiation. Radiat Res 138:367-372
16. ARF. Cell 9:649-659
17. Raes F, De Cort M, Graziani G (1991) Multi-fractal nature of radioactivity deposition on soil after the Chernobyl accident. Health Phys 61:271-282
18. Richmond CR (1968) Accelerating the turnover of internally deposited radiocesium. In: Kornberg HA, Norwood WD (eds) Diagnosis and treatment of deposited radionuclides. Excerpta Medical Foundation, Richland, WA, pp 315-325
19. Rocco JW, Sidransky D (2001) p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res 264:42-55
20. IWAF1/Cip1. Jpn J Cancer Res 90:144-153
21. Romanenko A, Morell-Quadreny L, Nepomnyaschy V, Vozianov A, Llombart-Bosch A (2000) Pathology and proliferative activity of renal-cell carcinomas (RCCs) and renal oncocytomas in patients with different radiation exposure after the Chernobyl accident in Ukraine. Int J Cancer 87:880-883
22. Romanenko A, Morell-Quadreny L, Nepomnyaschy V, Vozianov A, Llombart-Bosch A (2001) Radiation sclerosing proliferative atypical nephropathy of peritumoral tissue of renal-cell carcinomas after the Chernobyl accident in Ukraine. Virchows Arch 438:146-153
23. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, pp 1-83
24. Serrano M (2000) The INK4a/ARF locus in murine tumorigenesis. Carcinogenesis 21:865-869
25. Sherr CJ, Weber JD (2000) The ARF/p53 pathway. Curr Opin Genet Dev 10:94-99
26. Suzuki K, Kodama S, Watanabe M (2001) Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells. Cancer Res 61:5396-5401
27. Wang X, Martindale IL, Liu Y, Holbrook NJ (1998) The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J 333:291-300
28. Wu LJ, Randers-Pehrson G, Xu A, Waldren CA, Geard CR, Yu ZL, Hei TK(1999) Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proc Natl Acad Sci U S A 96:4959-4964