Role of extracellular charged amino acids in the yeast α-factor receptor

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1773, Issue 6, 2007, Pages 707-717

  Bajaj, Anshika ^a   Connelly, Sara M ^a   Gehret, Austin U ^a   Naider, Fred ^b   Dumont, Mark E ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

factor; Electrostatic; G protein coupled receptor; Ligand binding; Pheromone; Pheromone receptor; Saccharomyces cerevisiae; STE2; Yeast

Indexed keywords

ALANINE; AMINO ACID DERIVATIVE; ASPARAGINE; G PROTEIN COUPLED RECEPTOR; MATING HORMONE ALPHA FACTOR RECEPTOR; PHEROMONE; PHEROMONE RECEPTOR; PHEROMONE RECEPTOR STE2P; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; HORMONE BINDING; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; YEAST;

AMINO ACID SUBSTITUTION; AMINO ACIDS, BASIC; ASPARTIC ACID; MUTATION, MISSENSE; PEPTIDES; PROTEIN BINDING; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, MATING FACTOR; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 34249712001     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2007.02.002     Document Type: Article

References (44)

1. Spiegel A.M. Mutations in G proteins and G protein-coupled receptors in endocrine disease. J. Clin. Endocrinol. Metab. 81 (1996) 2434-2442
2. Spiegel A.M., and Weinstein L.S. Inherited diseases involving g proteins and g protein-coupled receptors. Annu. Rev. Med. 55 (2004) 27-39
3. Schoneberg T., Schulz A., Biebermann H., Hermsdorf T., Rompler H., and Sangkuhl K. Mutant G-protein-coupled receptors as a cause of human diseases. Pharmacol. Ther. 104 (2004) 173-206
4. Strader C.D., Fong T.M., Tota M.R., Underwood D., and Dixon R.A. Structure and function of G protein-coupled receptors. Annu. Rev. Biochem. 63 (1994) 101-132
5. Ji T.H., Grossmann M., and Ji I. G protein-coupled receptors: I. Diversity of receptor-ligand interactions. J. Biol. Chem. 273 (1998) 17299-17302
6. Strader C.D., Fong T.M., Graziano M.P., and Tota M.R. The family of G-protein-coupled receptors. FASEB J. 9 (1995) 745-754
7. Flower D.R. Modelling G-protein-coupled receptors for drug design. Biochim. Biophys. Acta 1422 (1999) 207-234
8. Palczewski K., Kumasaka T., Hori T., Behnke C.A., Motoshima H., Fox B.A., Le Trong I., Teller D.C., Okada T., Stenkamp R.E., Yamamoto M., and Miyano M. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289 (2000) 739-745
9. Fan Q.R., and Hendrickson W.A. Structure of human follicle-stimulating hormone in complex with its receptor. Nature 433 (2005) 269-277
10. Kunishima N., Shimada Y., Tsuji Y., Sato T., Yamamoto M., Kumasaka T., Nakanishi S., Jingami H., and Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407 (2000) 971-977
11. Gantz I., DelValle J., Wang L.D., Tashiro T., Munzert G., Guo Y.J., Konda Y., and Yamada T. Molecular basis for the interaction of histamine with the histamine H2 receptor. J. Biol. Chem. 267 (1992) 20840-20843
12. Fraser C.M., Wang C.D., Robinson D.A., Gocayne J.D., and Venter J.C. Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function. Mol. Pharmacol. 36 (1989) 840-847
13. Wang C.D., Buck M.A., and Fraser C.M. Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists. Mol. Pharmacol. 40 (1991) 168-179
14. Strnad J., and Hadcock J.R. Identification of a critical aspartate residue in transmembrane domain three necessary for the binding of somatostatin to the somatostatin receptor SSTR2. Biochem. Biophys. Res. Commun. 216 (1995) 913-921
15. Macdonald D., Murgolo N., Zhang R., Durkin J.P., Yao X., Strader C.D., and Graziano M.P. Molecular characterization of the melanin-concentrating hormone/receptor complex: identification of critical residues involved in binding and activation. Mol. Pharmacol. 58 (2000) 217-225
16. Feng Y.H., Noda K., Saad Y., Liu X.P., Husain A., and Karnik S.S. The docking of Arg2 of angiotensin II with Asp281 of AT1 receptor is essential for full agonism. J. Biol. Chem. 270 (1995) 12846-12850
17. Ji I., Zeng H., and Ji T.H. Receptor activation of and signal generation by the lutropin/choriogonadotropin receptor. Cooperation of Asp397 of the receptor and alpha Lys91 of the hormone. J. Biol. Chem. 268 (1993) 22971-22974
18. Erickson J.R., Wu J.J., Goddard J.G., Tigyi G., Kawanishi K., Tomei L.D., and Kiefer M.C. Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J. Biol. Chem. 273 (1998) 1506-1510
19. Price L.A., Kajkowski E.M., Hadcock J.R., Ozenberger B.A., and Pausch M.H. Functional coupling of a mammalian somatostatin receptor to the yeast pheromone response pathway. Mol. Cell. Biol. 15 (1995) 6188-6195
20. Zhang Y.L., Lu H.F., Becker J.M., and Naider F. Position one analogs of the Saccharomyces cerevisiae tridecapeptide pheromone. J. Pept. Res. 50 (1997) 319-328
21. Blumer K.J., and Thorner J. Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling. Proc. Natl. Acad. Sci. U. S. A. 87 (1990) 4363-4367
22. Abel M.G., Zhang Y.L., Lu H.F., Naider F., and Becker J.M. Structure-function analysis of the Saccharomyces cerevisiae tridecapeptide pheromone using alanine-scanned analogs. J. Pept. Res. 52 (1998) 95-106
23. Raths S.K., Naider F., and Becker J.M. Peptide analogues compete with the binding of alpha-factor to its receptor in Saccharomyces cerevisiae. J. Biol. Chem. 263 (1988) 17333-17341
24. Ding F.X., Lee B.K., Hauser M., Davenport L., Becker J.M., and Naider F. Probing the binding domain of the Saccharomyces cerevisiae alpha-mating factor receptor with fluorescent ligands. Biochemistry 40 (2001) 1102-1108
25. Henry L.K., Khare S., Son C., Babu V.V., Naider F., and Becker J.M. Identification of a contact region between the tridecapeptide alpha-factor mating pheromone of Saccharomyces cerevisiae and its G protein-coupled receptor by photoaffinity labeling. Biochemistry 41 (2002) 6128-6139
26. Levin Y., Khare R.K., Abel G., Hill D., Eriotou-Bargiota E., Becker J.M., and Naider F. Histidine2 of the alpha-factor of Saccharomyces cerevisiae is not essential for binding to its receptor or for biological activity. Biochemistry 32 (1993) 8199-8206
27. Sommers C.M., and Dumont M.E. Genetic interactions among the transmembrane segments of the G protein coupled receptor encoded by the yeast STE2 gene. J. Mol. Biol. 266 (1997) 559-575
28. Leavitt L.M., Macaluso C.R., Kim K.S., Martin N.P., and Dumont M.E. Dominant negative mutations in the alpha-factor receptor, a G protein-coupled receptor encoded by the STE2 gene of the yeast Saccharomyces cerevisiae. Mol. Gen. Genet. 261 (1999) 917-932
29. Chen D.C., Yang B.C., and Kuo T.T. One-step transformation of yeast in stationary phase. Curr. Genet. 21 (1992) 83-84
30. Rose M.D., Winston F., and Hieter P. Methods in Yeast Genetics (1990), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
31. Martin N.P., Celic A., and Dumont M.E. Mutagenic mapping of helical structures in the transmembrane segments of the yeast alpha-factor receptor. J. Mol. Biol. 317 (2002) 765-788
32. Sprague Jr. G.F. Assay of yeast mating reaction. Methods Enzymol. 194 (1991) 77-93
33. Bajaj A., Celic A., Ding F.X., Naider F., Becker J.M., and Dumont M.E. A fluorescent alpha-factor analogue exhibits multiple steps on binding to its G protein coupled receptor in yeast. Biochemistry 43 (2004) 13564-13578
34. Shah A., and Marsh L. Role of Sst2 in modulating G protein-coupled receptor signaling. Biochem. Biophys. Res. Commun. 226 (1996) 242-246
35. Akal-Strader A., Khare S., Xu D., Naider F., and Becker J.M. Residues in the first extracellular loop of a G protein-coupled receptor play a role in signal transduction. J. Biol. Chem. 277 (2002) 30581-30590
36. Lee B.K., Lee Y.H., Hauser M., Son C.D., Khare S., Naider F., and Becker J.M. Tyr266 in the sixth transmembrane domain of the yeast alpha-factor receptor plays key roles in receptor activation and ligand specificity. Biochemistry 41 (2002) 13681-13689
37. Lin J.C., Parrish W., Eilers M., Smith S.O., and Konopka J.B. Aromatic residues at the extracellular ends of transmembrane domains 5 and 6 promote ligand activation of the G protein-coupled alpha-factor receptor. Biochemistry 42 (2003) 293-301
38. Naider F., and Becker J.M. The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors. Peptides 25 (2004) 1441-1463
39. Yi T.M., Kitano H., and Simon M.I. A quantitative characterization of the yeast heterotrimeric G protein cycle. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 10764-10769
40. Lin J.C., Duell K., and Konopka J.B. A microdomain formed by the extracellular ends of the transmembrane domains promotes activation of the G protein-coupled alpha-factor receptor. Mol. Cell. Biol. 24 (2004) 2041-2051
41. Marsh L. Substitutions in the hydrophobic core of the alpha-factor receptor of Saccharomyces cerevisiae permit response to Saccharomyces kluyveri alpha-factor and to antagonist. Mol. Cell. Biol. 12 (1992) 3959-3966
42. Dosil M., Giot L., Davis C., and Konopka J.B. Dominant-negative mutations in the G-protein-coupled alpha-factor receptor map to the extracellular ends of the transmembrane segments. Mol. Cell. Biol. 18 (1998) 5981-5991
43. Lee Y.H., Naider F., and Becker J.M. Interacting residues in an activated state of a G protein-coupled receptor. J. Biol. Chem. 281 (2006) 2263-2272
44. Celic A., Martin N.P., Son C.D., Becker J.M., Naider F., and Dumont M.E. Sequences in the intracellular loops of the yeast pheromone receptor Ste2p required for G protein activation. Biochemistry 42 (2003) 3004-3017