Helicobacter pylori-induced changes in the gastric mucosa are associated with mitogen-activated protein kinase (MAPK) activation

Applied Immunohistochemistry and Molecular Morphology

Volumn 15, Issue 2, 2007, Pages 224-228

  Kacar, Furuzan ^a   Meteoǧlu, Ibrahim ^a   Yasa, Hadi ^a   Levi, E ^a,b,c,d  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Veterans Administration   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Caspase 3; Helicobacter pylori; MAPK; PCNA; Stomach

Indexed keywords

CASPASE 3; CYCLINE; MITOGEN ACTIVATED PROTEIN KINASE;

ADULT; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; STOMACH BIOPSY; STOMACH CANCER; STOMACH CARCINOGENESIS; STOMACH MUCOSA;

ADENOCARCINOMA; APOPTOSIS; CASPASE 3; CELL PROLIFERATION; ENZYME ACTIVATION; FEMALE; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; METAPLASIA; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; PROLIFERATING CELL NUCLEAR ANTIGEN; STOMACH NEOPLASMS;

EID: 34249704586     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/01.pai.0000209863.35828.dd     Document Type: Article

References (32)

1. Konturek PC, Bielanski W, Konturek SJ, et al. Helicobacter pylori associated gastric pathology. J Physiol Pharmacol. 1999;50:695-710.
2. Tatematsu M, Nozaki K, Tsukamoto T. Helicobacter pylori infection and gastric carcinogenesis in animal models. Gastric Cancer. 2003;6:1-7.
3. Peek RM Jr, Wirth HP, Moss SF, et al. Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Gastroenterology. 2000;118:48-59.
4. Peek RM Jr. Helicobacter pylori strain-specific modulation of gastric mucosal cellular turnover: implications for carcinogenesis. J Gastroenterol. 2002;37(Suppl 13):10-16.
5. Xia HH, Talley NJ. Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis. Am J Gastroenterol. 2001;96:16-26.
6. Seger R, Krebs EG. The MAPK signaling cascade. FASEB J. 1995;9:726-735.
7. Higashi H, Nakaya A, Tsutsumi R, et al. Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem. 2004;279:17205-17216.
8. Liang B, Wang S, Zhu XG, et al. Increased expression of mitogen activated protein kinase and its upstream regulating signal in human gastric cancer. World J Gastroenterol. 2005;11:623-628.
9. Mimuro H, Suzuki T, Tanaka J, et al. Grb2 is a key mediator of Helicobacter pylori CagA protein activities. Mol Cell. 2002;10:745-755.
10. Nozawa Y, Nishihara K, Peek RM, et al. Identification of a signaling cascade for interleukin-8 production by Helicobacter pylori in human gastric epithelial cells. Biochem Pharmacol. 2002;64:21-30.
11. Keates S, Sougioultzis S, Keates AC, et al. cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem. 2001;276:48127-48134.
12. Meyer-ter-Vehn T, Covacci A, Kist M, et al. Helicobacter pylori activates mitogen-activated protein kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun. J Biol Chem. 2000;275:16064-16072.
13. Keates S, Keates AC, Warny M, et al. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag - Helicobacter pylori. J Immunol. 1999;163:5552-5559.
14. Blaser MJ, Atherton JC. Helicobacter pylori persistence: biology and disease. J Clin Invest. 2004;113:321-333.
15. Hatakeyama M. Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer. 2004;4:688-694.
16. Nomura AM, Perez-Perez GI, Lee J, et al. Relation between Helicobacter pylori CagA status and risk of peptic ulcer disease. Am J Epidemiol. 2002;155:1054-1059.
17. Willhite DC, Blanke SR. Helicobacter pylori vacuolating cytotoxin enters cells, localizes to the mitochondria, and induces mitochondrial membrane permeability changes correlated to toxin channel activity. Cell Microbiol. 2004;6:143-154.
18. El-Omar EM, Rabkin CS, Gammon MD, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology. 2003; 124:1193-1201.
19. Naumann M, Crabtree JE. Helicobacter pylori-induced epithelial cell signalling in gastric carcinogenesis. Trends Microbiol. 2004;12:29-36.
20. Correa P. The Biological Model of Gastric Carcinogenesis. Lyon, France: IARC Scientific Publishers. 2004;157:301-310.
21. Scotiniotis IA, Rokkas T, Furth EE, et al. Altered gastric epithelial kinetics in Helicobacter pylori associated intestinal metaplasia: implications for gastric carcinogenesis. Int J Cancer. 2000;85:192-200.
22. Van Grieken NCT, Meijer GA, Zur Hausen A, et al. Increased apoptosis in gastric mucosa adjacent to intestinal metaplasia. J Clin Pathol. 2003;56:358-362.
23. Wambura C, Aoyama N, Shirasaka D, et al. Cell kinetic balance in gastric mucosa with intestinal metaplasia after Helicobacter pylori eradication: 2 year follow up. Dig Liver Dis. 2004;36:178-186.
24. Choi IJ, Kim JS, Kim JM, et al. Effect of inhibition of extracellular signal-regulated kinase 1 and 2 pathway on apoptosis and bcl-2 expression in Helicobacter pylori-infected AGS cells. Infect Immun. 2003;71:830-837.
25. Smalley KS. A pivotal role for ERK in the oncogenic behaviour of malignant melanoma? Int J Cancer. 2003;104:527-532.
26. Ding Q, Wang Q, Evers BM. Alterations of MAPK activities associated with intestinal cell differentiation. Biochem Biophys Res Commun. 2001;284:282-288.
27. Husain SS, Szabo IL, Pai R, et al. MAPK (ERK2) kinase - a key target for NSAIDs-induced inhibition of gastric cancer cell proliferation and growth. Life Sci. 2001;69:3045-3054.
28. Rieder G, Tessier AJ, Qiao XT, et al. Helicobacter induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. J Biol Chem. 2005;280:4906-4912.
29. Beales ILP. Effect of interleukin-1beta on proliferation of gastric epithelial cells in culture. BMC Gastroenterol. 2002;2:7.
30. Fan XM, Wong BCY, Lin MCM, et al. Interleukin-1beta induces cyclo-oxygenase-2 expression in gastric cancer cells by the p38 and p44/42MAPK signaling pathways. J Gastroenterol Hepatol. 2001;16:1098-2004.
31. Allen LF, Sebolt-Leopold J, Meyer MB. CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK). Semin Oncol. 2003;30:105-116.
32. Wang CH, Tang CW, Liu CL, et al. Inhibitory effect of octreotide on gastric cancer growth via MAPK pathway. World J Gastroenterol. 2003;9:1904-1908.