Ang-2 and PDGF-BB cooperatively stimulate human peripheral blood monocyte fibrinolysis

Journal of Leukocyte Biology

Volumn 81, Issue 6, 2007, Pages 1496-1503

  Bezuidenhout, Louise ^a   Bracher, Mona ^a   Davison, Glenda ^a   Zilla, Peter ^a   Davies, Neil ^a,b  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Invasion; Matrix metalloproteinases; Proteases; Wound healing

Indexed keywords

ANGIOPOIETIN 2; FIBRIN; GELATINASE B; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; PLATELET DERIVED GROWTH FACTOR BB; SERINE PROTEINASE; UROKINASE RECEPTOR;

ARTICLE; CELL INVASION; CELL TYPE; CONTROLLED STUDY; FIBRIN CLOT; FIBRINOLYSIS; HUMAN; HUMAN CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM; WOUND; WOUND HEALING;

ANGIOPOIETIN-2; CULTURE MEDIA, SERUM-FREE; FIBRIN; FIBRINOLYSIS; HUMANS; MATRIX METALLOPROTEINASES; MONOCYTES; PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, CELL SURFACE; SERINE ENDOPEPTIDASES;

EID: 34249703445     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1106687     Document Type: Article

References (50)

1. Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., Daly, T. J., Davis, S., Sato, T. N., Yancopoulos, G. D. (1997) Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277, 55-60.
2. Fiedler, U., Scharpfenecker, M., Koidl, S., Hegen, A., Grunow, V., Schmidt, J. M., Kriz, W., Thurston, G., Augustin, H. G. (2004) The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 103, 4150-4156.
3. Kampfer, H., Pfeilschifter, J., Frank, S. (2001) Expressional regulation of angiopoietin-1 and -2 and the tie-1 and -2 receptor tyrosine kinases during cutaneous wound healing: a comparative study of normal and impaired repair. Lab. Invest. 81, 361-373.
4. Tait, C. R., Jones, P. F. (2004) Angiopoietins in tumors: the angiogenic switch. J. Pathol. 204, 1-10.
5. Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., Holash, J. (2000) Vascular-specific growth factors and blood vessel formation. Nature 407, 242-248.
6. Gale, N. W., Thurston, G., Hackett, S. F., Renard, R., Wang, Q., McClain, J., Martin, C., Witte, C., Witte, M. H., Jackson, D., Suri, C., Campochiaro, P. A., Wiegand, S. J., Yancopoulos, G. D. (2002) Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by angiopoietin-1. Dev. Cell 3, 411-423.
7. Lobov, I. B., Brooks, P. C., Lang, R. A. (2002) Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo. Proc. Natl. Acad. Sci. USA 99, 11205-11210.
8. Croll, S. D., Ransohoff, R. M., Cai, N., Zhang, Q., Martin, F. J., Wei, T., Kasselman, L. J., Kintner, J., Murphy, A. J., Yancopoulos, G. D., Wiegand, S. J. (2004) VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp. Neurol. 187, 388-402.
9. Dvorak, H. F., Brown, L. F., Detmar, M., Dvorak, A. M. (1995) Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146, 1029-1039.
10. Martin, P. (1997) Wound healing - aiming for perfect skin regeneration. Science 276, 75-81.
11. Hiraoka, N., Allen, E., Apel, I. J., Gyetko, M. R., Weiss, S. J. (1998) Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell 95, 365-377.
12. Moldovan, L., Moldovan, N. I. (2005) Role of monocytes and macrophages in angiogenesis. EXS. 2005, 127-146.
13. Jackson, J. R., Seed, M. P., Kircher, C. H., Willoughby, D. A., Winkler, J. D. (1997) The codependence of angiogenesis and chronic inflammation. FASEB J. 11, 457-465.
14. Fiedler, U., Reiss, Y., Scharpfenecker, M., Grunow, V., Koidl, S., Thurston, G., Gale, N. W., Witzenrath, M., Rosseau, S., Suttorp, N., Sobke, A., Herrmann, M., Preissner, K. T., Vajkoczy, P., Augustin, H. G. (2006) Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation. Nat. Med. 12, 235-239.
15. Rondaij, M. G., Bierings, R., Kragt, A., van Mourik, J. A., Voorberg, J. (2006) Dynamics and plasticity of Weibel-Palade bodies in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 26, 1002-1007.
16. Lemieux, C., Maliba, R., Favier, J., Theoret, J. F., Merhi, Y., Sirois, M. G. (2005) Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. Blood 105, 1523-1530.
17. Sturn, D. H., Feistritzer, C., Mosheimer, B. A., Djanani, A., Bijuklic, K., Patsch, J. R., Wiedermann, C. J. (2005) Angiopoietin affects neutrophil migration. Microcirculation 12, 393-403.
18. Hu, B., Guo, P., Fang, Q., Tao, H. Q., Wang, D., Nagane, M., Huang, H. J., Gunji, Y., Nishikawa, R., Alitalo, K., Cavenee, W. K., Cheng, S. Y. (2003) Angiopoietin-2 induces human glioma invasion through the activation of matrix metalloprotease-2. Proc. Natl. Acad. Sci. USA 100, 8904-8909.
19. Etoh, T., Inoue, H., Tanaka, S., Barnard, G. F., Kitano, S., Mori, M. (2001) Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Res. 61, 2145-2153.
20. Ernofsson, M., Siegbahn, A. (1996) Platelet-derived growth factor-BB and monocyte chemotactic protein-1 induce human peripheral blood monocytes to express tissue factor. Thromb. Res. 83, 307-320.
21. Siegbahn, A., Hammacher, A., Westermark, B., Heidin, C-H. (1990) Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes. J. Clin. Invest. 85, 916-920.
22. Maquoi, E., Noel, A., Frankenne, F., Angliker, H., Murphy, G., Foidart, J. M. (1998) Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor. FEBS Lett. 424, 262-266.
23. Atkinson, S. J., Crabbe, T., Cowell, S., Ward, R. V., Butler, M. J., Sato, H., Seiki, M., Reynolds, J. J., Murphy, G. (1995) Intermolecular autolytic cleavage can contribute to the activation of progelatinase A by cell membranes. J. Biol. Chem. 270, 30479-30485.
24. Yu, Y., Varughese, J., Brown, L. F., Mulliken, J. B., Bischoff, J. (2001) Increased Tie2 expression, enhanced response to angiopoietin-1, and dysregulated angiopoietin-2 expression in hemangioma-derived endothelial cells. Am. J. Pathol. 159, 2271-2280.
25. Huang, Y. Q., Li, J. J., Hu, L., Lee, M., Karpatkin, S. (2002) Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells. Blood 99, 1646-1650.
26. Heldin, C. H., Westermark, B. (1999) Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79, 1283-1316.
27. Frangogiannis, N. G. (2006) Targeting the inflammatory response in healing myocardial infarcts. Curr. Med. Chem. 13, 1877-1893.
28. Krettek, A., Ostergren-Lunden, G., Fager, G., Rosmond, C., Bondjers, G., Lustig, F. (2001) Expression of PDGF receptors and ligand-induced migration of partially differentiated human monocyte-derived macrophages. Influence of IFN-γ and TGF-β. Atherosclerosis 156, 267-275.
29. Gordon, S., Taylor, P. R. (2005) Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5, 953-964.
30. Ikeda, Y., Fukuda, N., Wada, M., Matsumoto, T., Satomi, A., Yokoyama, S., Saito, S., Matsumoto, K., Kanmatsuse, K., Mugishima, H. (2004) Development of angiogenic cell and gene therapy by transplantation of umbilical cord blood with vascular endothelial growth factor gene. Hypertens. Res. 27, 119-128.
31. Modarai, B., Burnand, K. G., Sawyer, B., Smith, A. (2005) Endothelial progenitor cells are recruited into resolving venous thrombi. Circulation 111, 2645-2653.
32. De Palma, M., Venneri, M. A., Galli, R., Sergi, L., Politi, L. S., Sampaolesi, M., Naldini, L. (2005) Tie-2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor cessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8, 211-226.
33. Peichev, M., Naiyer, A. J., Pereira, D., Zhu, Z., Lane, W. J., Williams, M., Oz, M. C., Hicklin, D. J., Witte, L., Moore, M. A., Rafii, S. (2000) Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood 95, 952-958.
34. Carlson, T. R., Feng, Y., Maisonpierre, P. C., Mrksich, M., Morla, A. O. (2001) Direct cell adhesion to the angiopoietins mediated by integrins. J. Biol. Chem. 276, 26516-26525.
35. Dallabrida, S. M., Ismail, N., Oberle, J. R., Himes, B. E., Rupnick, M. A. (2005) Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins. Circ. Res. 96, e8 -24.
36. Guo, P., Imanishi, Y., Cackowski, F. C., Jarzynka, M. J., Tao, H. Q., Nishikawa, R., Hirose, T., Hu, B., Cheng, S. Y. (2005) Up-regulation of angiopoietin-2, matrix metalloprotease-2, membrane type 1 metalloprotease, and laminin 5 γ 2 correlates with the invasiveness of human glioma. Am. J. Pathol. 166, 877-890.
37. Hu, B., Jarzynka, M. J., Guo, P., Imanishi, Y., Schlaepfer, D. D., Cheng, S. Y. (2006) Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the αvβ1 integrin and focal adhesion kinase signaling pathway. Cancer Res. 66, 775-783.
38. Ahlen, K., Ring, P., Tomasini-Johansson, B., Holmqvist, K., Magnusson, K. E., Rubin, K. (2004) Platelet-derived growth factor-BB modulates membrane mobility of β1 integrins. Biochem. Biophys. Res. Commun. 314, 89-96.
39. Bendeck, M. P., Irvin, C., Reidy, M., Smith, L., Mulholland, D., Horton, M., Giachelli, C. M. (2000) Smooth muscle cell matrix metalloproteinase production is stimulated via α(v)β(3) integrin. Arterioscler. Thromb. Vasc. Biol. 20, 1467-1472.
40. Ellis, V., Whawell, S. A. (1997) Vascular smooth muscle cells potentiate plasmin generation by both urokinase and tissue plasminogen activator-dependent mechanisms: evidence for a specific tissue-type plasminogen activator receptor on these cells. Blood 90, 2312-2322.
41. Estreicher, A., Muhlhauser, J., Carpentier, J. L., Orci, L., Vassalli, J. D. (1990) The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes. J. Cell Biol. 111, 783-792.
42. Matias-Roman, S., Galvez, B. G., Genis, L., Yanez-Mo, M., de la Rosa, G., Sanchez-Mateos, P., Sanchez-Madrid, F., Arroyo, A. G. (2005) Membrane type 1-matrix metalloproteinase is involved in migration of human monocytes and is regulated through their interaction with fibronectin or endothelium. Blood 105, 3956-3964.
43. Lelongt, B., Ronco, P. (2002) Role of matrix metalloproteinases in kidney development and glomerulopathy: lessons from transgenic mice. Nephrol. Dial. Transplant. 17 (Suppl. 9), 28-31.
44. Hotary, K. B., Yana, I., Sabeh, F., Li, X. Y., Holmbeck, K., Birkedal-Hansen, H., Allen, E. D., Hiraoka, N., Weiss, S. J. (2002) Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes. J. Exp. Med. 195, 295-308.
45. Bergers, G., Brekken, R., McMahon, G., Vu, T. H., Itoh, T., Tamaki, K., Tanzawa, K., Thorpe, P., Itohara, S., Werb, Z., Hanahan, D. (2000) Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat. Cell Biol. 2, 737-744.
46. Nozawa, H., Chiu, C., Hanahan, D. (2006) Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc. Natl. Acad. Sci. USA 103, 12493-12498.
47. Pierleoni, C., Castellucci, M., Kaufmann, P., Lund, L. R., Schnack Nielsen, B. (2003) Urokinase receptor is up-regulated in endothelial cells and macrophages associated with fibrinoid deposits in the human placenta. Placenta 24, 677-685.
48. Hanahan, D. (1997) Signaling vascular morphogenesis and maintenance. Science 277, 48-50.
49. Duffield, J. S., Forbes, S. J., Constandinou, C. M., Clay, S., Partolina, M., Vuthoori, S., Wu, S., Lang, R., Iredale, J. P. (2005) Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Invest. 115, 56-65.
50. Martin, P., D'Souza, D., Martin, J., Grose, R., Cooper, L., Maki, R., McKercher, S. R. (2003) Wound healing in the PU.1 null mouse - tissue repair is not dependent on inflammatory cells. Curr. Biol. 13, 1122-1128.