A pilot study of atomoxetine in young children with attention-deficit/ hyperactivity disorder

Journal of Child and Adolescent Psychopharmacology

Volumn 17, Issue 2, 2007, Pages 175-185

  Kratochvil, Christopher J ^a,d   Vaughan, Brigette S ^a   Mayfield Jorgensen, Michelle L ^a   March, John S ^b   Kollins, Scott H ^b   Murray, Desiree W ^b   Ravi, Hima ^b   Greenhill, Laurence L ^c   Kotler, Lisa A ^c   Paykina, Natalya ^c   Biggins, Patricia ^c   Stoner, Julie ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^d NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMOXETINE; METHYLPHENIDATE;

ABDOMINAL PAIN; AGGRESSION; ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL ARTICLE; CLINICAL TRIAL; DECREASED APPETITE; DIARRHEA; DRUG EFFICACY; DRUG TOLERABILITY; FATIGUE; FEMALE; HEADACHE; HUMAN; MALE; MENTAL INSTABILITY; MOOD DISORDER; MYDRIASIS; PILOT STUDY; PRESCHOOL CHILD; SIDE EFFECT; SOMNOLENCE; THIRST; TIC; VOMITING;

EID: 34249690022     PISSN: 10445463     EISSN: None     Source Type: Journal    
DOI: 10.1089/cap.2006.0143     Document Type: Article

References (44)

1. Abidin RA: Parenting Stress Index Third Edition Professional Manual. Odessa, Psychological Assessment Resources Inc., 1995.
2. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Text Revision. Washington, DC, American Psychiatric Association, 2000.
3. Barkley RA: The effects of methylphenidate on the interactions of preschool ADHD children with their mothers. J Am Acad Child Adolesc Psychiatry 27:336-341, 1988.
4. Barkley RA, Karlsson J, Strzelecki E, Murphy JV: Effects of age and Ritalin dosage on the mother-child interactions of hyperactive children. J Consult Clin Psychol 52:750-758, 1984.
5. Bor W, Sanders MR, Markie-Dadds C: The effects of the triple p-positive parenting program on preschool children with co-occurring disruptive behavior and attentional/hyperactive difficulties. J Abnorm Child Psychol 30:571-587, 2002.
6. Chacko A, Pelham WE, Gnagy EM, Greiner A, Vallano G, Bukstein O, Rancurello M: Stimulant medication effects in a summer treatment program among young children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 44:249-257, 2005.
7. Cohen NJ, Sullivan J, Minde K, Novak C, Helwig C: Evaluation of the relative effectiveness of methylphenidate and cognitive behavior modification in the treatment of kindergarten-aged hyperactive children. J Abnorm Child Psychol 9:43-54, 1981.
8. Conners CK: Controlled trial of methylphenidate in preschool children with minimal brain dysfunction. J Mental Heath 4:61-74, 1975.
9. Conners CK, Sitarenios G, Parker JD, Epstein JN: The revised Conners' Parent Rating Scale (CPRS-R): Factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:257-268, 1998a.
10. Conners CK, Sitarenios G, Parker JD, Epstein JN: Revision and restandardization of the Conners' Teacher Rating Scale (CTRS-R): Factor structure, reliability, and criterion validity. J Abnorm Child Psychol 26:279-291, 1998b.
11. Dunn LM, Dunn LM: Peabody Picture Vocabulary Test Third Edition Form IIIA and Form IIIB. Circle Pines, American Guidance Service, 1997.
12. DuPaul GJ, Power TJ, Anastopoulos AD, Reid R: ADHD Rating Scale-IV: Checklists, Norms, and Clinical Interpretations. New York, Guilford Press, 1998.
13. DuPaul GJ, McGoey KE, Eckert TL, VanBrakle J: Preschool children with attention-deficit/hyperactivity disorder: Impairments in behavioral, social, and school functioning. J Am Acad Child Adolesc Psychiatry 40:508-515, 2001.
14. Escobar R, Soutullo CA, Hervas A, Gastaminza X, Polavieja P, Gilaberte I: Worse quality of life for children with newly diagnosed attention-deficit/ hyperactivity disorder, compared with asthmatic and healthy children. Pediatrics 116:e364-e369, 2005.
15. Firestone P, Musten LM, Pisterman S, Mercer J, Bennett S: Short-term side effects of stimulant medication are increased in preschool children with attention-deficit/hyperactivity disorder: A double-blind placebo-controlled study. J Child Adolesc Psychopharmacol 8:13-25, 1998.
16. Food and Drug Administration (1997). Modernization Act of 1997. 21 USC 321.
17. Food and Drug Administration (1997). Regulations requiring manufacturers to assess the safety and effectiveness of new drugs and biological products in pediatric patients. http://www.fda.gov/cder/guidance/pedrule.htm
18. Garfin DG, McCallon D, Cox R: Validity and reliability of the Childhood Autism Rating Scale with autistic adolescents. J Autism Dev Disord 18:367-378, 1988.
19. Greenhill LL: The use of psychotropic medication in preschoolers: Indications, safety, and efficacy. Can J Psychiatry 43:576-581, 1998.
20. Greenhill L, Kollins S, Abikoff H, McCracken J, Riddle M, Swanson J, McGough J, Wigal S, Wigal T, Vitiello B, Skrobala A, Posner K, Ghuman J, Cunningham C, Davies M, Chuang S, Cooper T: Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. J Am Acad Child Adolesc Psychiatry 45:1284-1293, 2006.
21. Guy W: ECDEU Assessment Manual for Psychopharmacology, Revised. Bethesda, US Department of Health, Education, and Welfare, 1976.
22. Handen BL, Feldman HM, Lurier A, Murray PJ: Efficacy of methylphenidate among preschool children with developmental disabilities and ADHD. J Am Acad Child Adolesc Psychiatry 38:805-812, 1999.
23. Kovacs M: Children's Depression Inventory (CDI) Technical Manual. Toronto, Multi-Health Systems Inc., 2001.
24. Lahey BB, Pelham WE, Stein MA, Loney J, Trapani C, Nugent K, Kipp H, Schmidt E, Lee S, Cale M, Gold E, Hartung CM, Willcutt E, Baumann B: Validity of DSM-IV attention-deficit/hyperactivity disorder for younger children. J Am Acad Child Adolesc Psychiatry 37:695-702, 1998.
25. Lavigne JV, Gibbons RD, Christoffel KK, Arend R, Rosenbaum D, Binns H, Dawson N, Sobel H, Isaacs C: Prevalence rates and correlates of psychiatric disorders among preschool children. J Am Acad Child Adolesc Psychiatry 35:204-214, 1996.
26. March JS, Parker JD, Sullivan K, Stallings P, Conners CK: The Multidimensional Anxiety Scale for Children (MASC): Factor structure, reliability, and validity. J Am Acad Child Adolesc Psychiatry 36:554-565, 1997.
27. Mariani MA, Barkley RA: Neuropsychological and academic functioning in preschool boys with attention deficit hyperactivity disorder. Devel Neuropsychol 13:111-129, 1997.
28. Mayes SD, Crites DL, Bixler EO, Humphrey FJ, 2nd, Mattison RE: Methylphenidate and ADHD: Influence of age, IQ and neurodevelopmental status. Dev Med Child Neurol 36:1099-1107, 1994.
29. McMahon RJ, Forehand RL: Helping the Noncompliant Child. Family-Based Treatment for Oppositional Behavior. New York, The Guilford Press, 2003.
30. Musten LM, Firestone P, Pisterman S, Bennett S, Mercer J: Effects of methylphenidate on preschool children with ADHD: Cognitive and behavioral functions. J Am Acad Child Adolesc Psychiatry 36:1407-1415, 1997.
31. National Institutes of Health (1998). NIH policy and guidelines on the inclusion of children as participants in research involving human subjects. http://www.nih.gov/grants/guide/notice-files/not98-024.html
32. Pisterman S, McGrath P, Firestone P, Goodman JT, Webster I, Mallory R: Outcome of parent-mediated treatment of preschoolers with attention-deficit disorder with hyperactivity. J Consult Clin Psychol 57:628-635, 1989.
33. Safer DJ, Zito JM: Treatment-emergent adverse events from selective serotonin reuptake inhibitors by age group: children versus adolescents. J Child Adolesc Psychopharmacol 16:159-169, 2006.
34. Schleifer M, Weiss G, Cohen N, Elman M, Cvejic H, Kruger E: Hyperactivity in preschoolers and the effect of methylphenidate. Am J Orthopsychiatry 45:38-50, 1975.
35. Shaffer D, Fisher P, Lucas CP, Dulcan MK, Schwab-Stone ME: NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): Description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39:28-38, 2000.
36. Shelton TL, Barkley RA, Crosswait C, Moorehouse M, Fletcher K, Barrett S, Jenkins L, Metevia L: Psychiatric and psychological morbidity as a function of adaptive disability in preschool children with aggressive and hyperactive-impulsive-inattentive behavior. J Abnorm Child Psychol 26:475-494, 1998.
37. Sonuga-Barke EJS, Daley D, Thompson M, Laver-Bradbury C, Weeks A: Parent-based therapies for preschool attention-deficit/hyperactivity disorder: A randomized, controlled trial with a community sample. J Am Acad Child Adolesc Psychiatry 40:402-408, 2001.
38. Spencer T, Biederman J, Wilens T, Prince J, Hatch M, Jones J, Harding M, Faraone SV, Seidman L: Effectiveness and tolerability of tomoxetine in adults with attention deficit hyperactivity disorder. Am J Psychiatry 155: 693-695, 1998.
39. Strayhorn JM, Weidman C: Reduction of attention deficit and internalizing symptoms in preschoolers through parent-child interaction training. J Am Acad Child Adolesc Psychiatry 28:888-896, 1989.
40. Van Brunt DL, Johnston JA, Ye W, Pohl GM, Sun PJ, Sterling KL, Davis ME: Predictors of selecting atomoxetine therapy for children with attention-deficit-hyperactivity disorder. Phamacotherapy 25:1541-1549, 2005.
41. Wigal T, Greenhill L, Chuang S, McGough J, Vitiello B, Skrobala A, Swanson J, Wigal S, Abikoff H, Kollins S, McCracken J, Riddle M, Posner K, Ghuman J, Davies M, Thorp B, Stehli A: Safety and tolerability of methylphenidate in preschool children with ADHD. J Am Acad Child Adolesc Psychiatry 45:1294-1303, 2006.
42. World Medical Association: Revising the Declaration of Helsinki. Bull Med Ethics 158:9-11, 2000.
43. Zito JM, Safer DJ, dosReis S, Gardner JF, Boles M, Lynch F: Trends in the prescribing of psychotropic medications to preschoolers. JAMA 283:1025-1030, 2000.
44. Zuvekas SH, Vitiello B, Norquist GS: Recent trends in stimulant medication use among U.S. children. Am J Psychiatry 163:579-585, 2006.