Nanohydroxyapatite microspheres as delivery system for antibiotics: Release kinetics, antimicrobial activity, and interaction with osteoblasts

Journal of Biomedical Materials Research - Part A

Volumn 81, Issue 4, 2007, Pages 994-1004

  Ferraz, M P ^a,b   Mateus, A Y ^a,c   Sousa, J C ^b   Monteiro, F J ^a,c  

^a INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^b UNIVERSIDADE FERNANDO PESSOA   (Portugal)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Antibacterial; Cytotoxicity; Drug release; Hydroxyapatite; Microsphere; Nanoparticles

Indexed keywords

ANTIBIOTICS ADMINISTRATION; DRUG DELIVERY SYSTEMS; DRUG RELEASE; OPTICAL MICROSCOPE ANALYSIS;

BACTERIA; CYTOTOXICITY; HYDROXYAPATITE; MICROSPHERES; NANOPARTICLES; OSTEOBLASTS; X RAY DIFFRACTION;

DRUG DELIVERY;

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; CLINDAMYCIN; ERYTHROMYCIN; HYDROXYAPATITE; METRONIDAZOLE; MICROSPHERE; MINOCYCLINE; NANOHYDROXYAPATITE; NANOPARTICLE; TETRACYCLINE; UNCLASSIFIED DRUG;

ALVEOLAR BONE; ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; CELL GROWTH; CELL KINETICS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; PERIODONTITIS; POROSITY; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; X RAY DIFFRACTION;

ANTI-BACTERIAL AGENTS; CELL COMMUNICATION; CELL DEATH; CELL LINE; CELL PROLIFERATION; DRUG DELIVERY SYSTEMS; DURAPATITE; ESCHERICHIA COLI; HUMANS; KINETICS; MATERIALS TESTING; MICROBIAL SENSITIVITY TESTS; MICROSPHERES; OSTEOBLASTS; STAPHYLOCOCCUS AUREUS;

EID: 34249689569     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31151     Document Type: Article

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