Sustained local delivery of chlorhexidine in the treatment of periodontitis: A multi-center study

Journal of Periodontology

Volumn 68, Issue 1, 1997, Pages 32-38

  Soskolne, W A ^a   Heasman, P A ^b   Stabholz, A ^a   Smart, G J ^c   Palmer, M ^d   Flashner, M ^d   Newman, H N ^e  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c Inst of Dental Health and Training   (United Kingdom)

^d Perio Products   (Israel)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

chlorhexidine therapeutic use; drug delivery systems; multi center studies; periodontitis drug therapy

Indexed keywords

CHLORHEXIDINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PERIODONTITIS; RANDOMIZED CONTROLLED TRIAL;

EID: 0031021027     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.1997.68.1.32     Document Type: Article

References (33)

1. Ramfjord S, Caffesse R, Morrison E, et al. Four modalities of periodontal treatment compared over 5 years. J Clin Periodontol 1987:14:445-452.
2. Ramfjord S. Surgical periodontal pocket elimination: Still a justifiable objective. J Am Dent Assoc 1987;114:37-40.
3. Claffey N, Nylund K, Kiger R, Garrett S, Egelberg J. Diagnostic predictability of scores of plaque, bleeding, suppuration and probing depth for probing attachment loss. 3.5 years of observation following initial periodontal therapy. J Clin Periodontol 1990;17:108-114.
4. Heasman PA, Benn DK, Kelly PJ, Seymour RA, Aitken D. The use of flurbiprofen as an adjunct to non-surgical management of periodontal disease. J Clin Periodontol 1993;20:457-464.
5. Genco RJ. Antibiotics in the treatment of human periodontal diseases. J Periodontol 1981;52:545-588.
6. van Palenstein Helderman WH. Is antibiotic therapy justified in the treatment of human chronic inflammatory periodontal disease? J Clin Periodontol 1986;13:932-938.
7. Greenstein G. Effects of subgingival irrigation on periodontal status. J Periodontol 1987;58:827-836.
8. Greenstein G. The role of supra- and subgingival irrigation in the treatment of periodontal diseases. Position paper published by The American Academy of Periodontology.
9. Goodson JM, Cugini MA, Kent RL, et al. Multicenter evaluation of tetracycline fiber therapy. II. Clinical response. J Periodont Res 1991:26:371-379.
10. Heijl L, Dahlen G, Sundin Y, Wenander A, Goodson JM. A 4-quadrant comparative study of periodontal treatment using tetracyclinecontaining drug delivery fibers and scaling. J Clin Periodontol 1991:18:111-116.
11. Newman MG, Kornman KS, Doherty FM. A 6-month multi-center evaluation of adjunctive tetracycline fiber therapy used in conjunction with scaling and root planing in maintenance patients: Clinical results. J Periodontol 1994;65:685-691.
12. Drisko CL, Cobb CM, Killoy WJ, et al. Evaluation of periodontal treatments using controlled-release tetracycline fibers: Clinical response. J Periodontol 1995;66:692-699.
13. van Steenberghe D, Bercy P, Kohl J, et al. Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult type periodontitis: A randomized double blind, vehicle-controlled, multicenter study. J Periodontol 1993:64:637-644.
14. Pedrazzoli V, Kilian M, Karring T. Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. J Clin Periodontol 1992;19:715-722.
15. Ainamo J, Lie T, Ellingsen BH, et al. Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. J Clin Periodontol 1992:19:723-729.
16. Klinge B, Attstrom R, Karring T, Kisch J, Lewin B, Stoltze K. 3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. J Clin Periodontol 1992;19: 708-714.
17. Stabholz A, Soskolne WA, Friedman M, Sela MN. The use of sustained release delivery of chlorhexidine for the maintenance of periodontal pockets: 2-year clinical trial. J Periodontol 1991:62:429-433.
18. Greenstein G. The role of metronidazole in the treatment of periodontal diseases. J Periodontol 1993:64:1-15.
19. Greenstein G, Berman C, Jaffin R. Chlorhexidine. An adjunct to periodontal therapy. J Periodontol 1986:57:370-377.
20. Gjermo P. Chlorhexidine in dental practice. J Clin Periodontol 1974:1:143-152.
21. Steinberg D, Friedman M, Soskolne A, Sela MN. A new degradable controlled release device for treatment of periodontal disease: In vitro release study. J Periodontol 1990;61:393-398.
22. Van der Zee E, Davies EH, Newman HN. Marking width, calibration from tip and tine diameter of periodontal probes. J Clin Periodontol 1991;18:516-520.
23. Muhlemann HR. Psychological and chemical mediators of gingival health. J Prevent Dent 1977;4:6-16.
24. Lobene RR, Weatherford T, Ross NM, Lamm RA, Menaker L. A modified gingival index for use in clinical trials. Clin Prev Dent 1986;8:3-6.
25. Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38:610-616.
26. Hill RW, Ramfjord SR Morrison EC, et al. Four types of periodontal therapy compared over two years. J Periodontol 1981;52:655-662.
27. Becker W, Becker BE, Oschenbein C, et al. A longitudinal study comparing scaling, osseous surgery and modified Widman procedures. J Periodontol 1988:59:351-365.
28. Reddy MS, Palcanis KG, Barnett ML, Haigh S, Charles CH, Jeffcoat MK. Efficacy of meclofenamate sodium (Meclomen) in the treatment of rapidly progressive periodontitis. J Clin Periodontol 1993:20:635-640.
29. Egelberg J, Claffey N. Periodontal Re-Evaluation, the Scientific Way. Copenhagen: Munksgaard; 1994:60-69.
30. Soh LL, Newman HN, Strahan JD. Effects of subgingival chlorhexidine irrigation on periodontal inflammation. J Clin Periodontol 1982;9:66-74.
31. Soskolne A, Golomb G, Friedman M, Sela MN. New sustained release dosage form of chlorhexidine for dental use II. Use in periodontal therapy. J Periodont Res 1983;18:330-336.
32. Stabholz A, Sela MN, Friedman M, Golomb G, Soskolne A. Clinical and microbiological effects of sustained release chlorhexidine in periodontal pockets. J Clin Periodontol 1986:13:783-788.
33. Goodson JM, Offenbacher S, Farr DH, Hogan PE. Periodontal disease treatment by local drug delivery. J Periodontol 1985:56:265-272.