Pediatric Dual-Energy X-ray Absorptiometry: Technique, Interpretation, and Clinical Applications

Seminars in Nuclear Medicine

Volumn 37, Issue 4, 2007, Pages 303-313

  Binkovitz, Larry A ^a   Henwood, Maria J ^a   Sparke, Paul ^b  

^a NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b CAPITAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CORTICOSTEROID; MEDROXYPROGESTERONE ACETATE; METHOTREXATE; ORAL CONTRACEPTIVE AGENT; VITAMIN D;

ACUTE LYMPHOCYTIC LEUKEMIA; BONE DENSITY; BONE GROWTH; BONE MINERAL; CANCER; CHRONIC KIDNEY DISEASE; CHRONIC LUNG DISEASE; DEMOGRAPHY; DIAGNOSTIC ACCURACY; DRUG EFFECT; DRUG INHIBITION; DRUG MEGADOSE; DUAL ENERGY X RAY ABSORPTIOMETRY; ENDOCRINE DISEASE; GASTROINTESTINAL DISEASE; HEMATOLOGIC DISEASE; HUMAN; OSTEOPOROSIS; RADIATION DOSE; RADIOLOGIST; REVIEW; SCORING SYSTEM;

BONE DENSITY; BONE DISEASES, METABOLIC; CHILD; DENSITOMETRY, X-RAY; HUMANS;

EID: 34249662054     PISSN: 00012998     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semnuclmed.2007.02.007     Document Type: Review

References (149)

1. Lentle B.C., and Prior J.C. Osteoporosis: What a clinician expects to learn from a patient's bone density examination. Radiology 228 (2003) 620-628
2. Bonnick S.L., Johnston Jr. C.C., Kleerekoper M., et al. Importance of precision in bone density measurements. J Clin Densitom 4 (2001) 105-110
3. The Writing Group for the ISCD. Position Development Conference; Diagnosis of osteoporosis in men, premenopausal women, and children. J Clin Densitom 7 (2004) 17-26
4. Bachrach L.K. Dual energy x-ray absorptiometry (DEXA) measurements of bone density and body composition: Promise and pitfalls. J Pediatr Endocrinol Metab 13 (2000) 983-988
5. Carter D.R., Bouxsein M.L., and Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res 7 (1992) 137-145
6. Hammami M., Koo W.W., and Hockman E.M. Technical considerations for fan-beam dual-energy x-ray absorptiometry body composition measurements in pediatric studies. J Parenter Enteral Nutr 28 (2004) 328-333
7. Leonard M.B., Feldman H.I., Zemel B.S., et al. Evaluation of low density spine software for the assessment of bone mineral density in children. J Bone Miner Res 13 (1998) 1687-1690
8. Cheng S., Nicholson P.H., Kroger H., et al. Differences in estimates of change of bone accrual and body composition in children because of scan mode selection with the prodigy densitometer. J Clin Densitom 8 (2005) 65-73
9. Simpson D.E., Dontu V.S., Stephens S.E., et al. Large variations occur in bone density measurements of children when using different software. Nucl Med Commun 26 (2005) 483-487
10. Cromer B.A., Binkovitz L., Ziegler J., et al. Reference values for bone mineral density in 12- to 18-year-old girls categorized by weight, race, and age. Pediatr Radiol 34 (2004) 787-792
11. Henderson R.C. The correlation between dual-energy x-ray absorptiometry measures of bone density in the proximal femur and lumbar spine of children. Skeletal Radiol 26 (1997) 544-547
12. Harcke H.T., Taylor A., Bachrach S., et al. Lateral femoral scan: an alternative method for assessing bone mineral density in children with cerebral palsy. Pediatr Radiol 28 (1998) 241-246
13. Henderson R.C., Lark R.K., Newman J.E., et al. Pediatric reference data for dual x-ray absorptiometric measures of normal bone density in the distal femur. AJR Am J Roentgenol 178 (2002) 439-443
14. Ellis K.J., Shypailo R.J., Hardin D.S., et al. Z score prediction model for assessment of bone mineral content in pediatric diseases. J Bone Miner Res 16 (2001) 1658-1664
15. Makitie O., Doria A.S., Henriques F., et al. Radiographic vertebral morphology: A diagnostic tool in pediatric osteoporosis. J Pediatr 146 (2005) 395-401
16. National Osteoporosis Society. A Practical Guide to Bone Densitometry in Children (2004), National Osteoporosis Society, Bath, UK
17. Wahner H.W., and Fogelman I. The Evaluation of Osteoporosis: Dual Energy X-Ray Absorptiometry in Clinical Practice (1994), Martin Dunnitz, Cambridge
18. Ho C.P., Kim R.W., Schaffler M.B., et al. Accuracy of dual-energy radiographic absorptiometry of the lumbar spine: Cadaver study. Radiology 176 (1990) 171-173
19. Margulies L., Horlick M., Thornton J.C., et al. Reproducibility of pediatric whole body bone and body composition measures by dual-energy x-ray absorptiometry using the GE lunar prodigy. J Clin Densitom 8 (2005) 298-304
20. Glastre C., Braillon P., David L., et al. Measurement of bone mineral content of the lumbar spine by dual energy x-ray absorptiometry in normal children: Correlations with growth parameters. J Clin Endocrinol Metab 70 (1990) 1330-1333
21. McCormick D.P., Ponder S.W., Fawcett H.D., et al. Spinal bone mineral density in 335 normal and obese children and adolescents: Evidence for ethnic and sex differences. J Bone Miner Res 6 (1991) 507-513
22. Bonjour J.P., Theintz G., Buchs B., et al. Critical years and stages of puberty for spinal and femoral bone mass accumulation during adolescence. J Clin Endocrinol Metab 73 (1991) 555-563
23. Faulkner R.A., Bailey D.A., Drinkwater D.T., et al. Regional and total body bone mineral content, bone mineral density, and total body tissue composition in children 8-16 years of age. Calcif Tissue Int 53 (1993) 7-12
24. Sabatier J.P., Guaydier-Souquieres G., Benmalek A., et al. Evolution of lumbar bone mineral content during adolescence and adulthood: A longitudinal study in 395 healthy females 10-24 years of age and 206 premenopausal women. Osteoporos Int 9 (1999) 476-482
25. Osteoporosis Prevention, Diagnosis, and Therapy. Available at: http://consensus.nih.gov/2000/2000Osteoporosis111html.htm. Accessed March 14, 2007
26. American College of Rheumatology. Practice guidelines. Available at: http://www.rheumatology.org/publications/guidelines/index.asp?aud=mem. Accessed March 14, 2007
27. http://www.acr.org/s acr/bin.asp?TrackID=&SID=1&DID=11796&CID=1206&VID=2 &DOC=File.PDF
28. Salle B.L., Braillon P., Glorieux F.H., et al. Lumbar bone mineral content measured by dual energy x-ray absorptiometry in newborns and infants. Acta Paediatr 81 (1992) 953-958
29. Koo W.W.K., Walters J., Bush A.J., et al. Dual-energy x-ray absorptiometry studies of bone mineral status in newborn infants. J Bone Miner Res 11 (1996) 997-1002
30. Southard R.N., Morris J.D., and Mahan J.D. Bone mass in healthy children: Measurement with quantitative DX. Radiology 179 (1991) 735-738
31. Hogler W., Briody J., Woodhead H.J., et al. Importance of lean mass in the interpretation of total body densitometry in children and adolescents. J Pediatr 143 (2003) 81-88
32. Leonard M.B., Propert K.J., Zemel B.S., et al. Discrepancies in pediatric bone mineral density reference data: potential for misdiagnosis of osteopenia. J Pediatr 135 (1999) 182-188
33. van Coeverden S.C.C.M., de Ridder C.M., Roos J.C., et al. Pubertal maturation characteristics and the rate of bone mass development longitudinally toward menarche. J Bone Miner Res 16 (2001) 774-778
34. Crabtree N.J., Kibirige M.S., Fordham J.N., et al. The relationship between lean body mass and bone mineral content in paediatric health and disease. Bone 35 (2004) 965-972
35. Ponder S.W., McCormick D.P., Fawcett H.D., et al. Spinal bone mineral density in children aged 5.00 through 11.99 years. Am J Dis Child 144 (1990) 1346-1348
36. Boot A.M., Bouquet J., de Ridder M.A.J., et al. Determinants of body composition measured by dual-energy x-ray absorptiometry in Dutch children and adolescents. Am J Clin Nutr 66 (1997) 232-238
37. van der Sluis I.M., de Ridder M.A.J., Boot A.M., et al. Reference data for bone density and body composition measured with dual energy x-ray absorptiometry in white children and young adults. Arch Dis Child 87 (2002) 341-347
38. Faulkner R.A., Bailey D.A., Drinkwater D.T., et al. The densitometry in Canadian children 8-17 years of age. Calcif Tissue Int 59 (1996) 344-351
39. Molgaard C., Thomsen B.L., and Michaelsen K.F. Influence of weight, age and puberty on bone size and bone mineral content in healthy children and adolescents. Acta Paediatr 87 (1998) 494-499
40. Rico H., Revilla L.F., Villa E.R., et al. Body composition in children and Tanner's stages: A study with dual-energy x-ray absorptiometry. Metabolism 42 (1993) 967-970
41. Leonard M.B., Propert K.J., Zemel B.S., et al. Discrepancies in pediatric bone mineral density reference data: Potential for misdiagnosis of osteopenia. J Pediatr 135 (1999) 182-188
42. Whyte M.P., Wenkert D., Clements K.L., et al. Bisphosphonate-induced osteopetrosis. N Engl J Med 349 (2003) 457-463
43. Gafni R.I., and Baron J. Overdiagnosis of osteoporosis in children due to misinterpretation of dual-energy x-ray absorptiometry (DEXA). J Pediatr 144 (2004) 253-257
44. Molgaard C., Thomsen B.L., Prentice A., et al. Whole body bone mineral content in healthy children and adolescents. Arch Dis Child 76 (1997) 9-15
45. Molgaard C., and Michaelsen K.F. Evaluation of whole body DXA scans in children. Bone 36 (2005) S73-S74
46. Binkovitz L.A., and Henwood M.J. Pediatric DXA technique and interpretation. Pediatr Radiol 37 (2007) 21-31
47. Katzman D.K., Bachrach L.K., Carter D.R., et al. Clinical and anthropometric correlates of bone mineral acquisition in healthy adolescent girls. J Clin Endocrinol Metab 73 (1991) 1332-1339
48. Kroger H., Kotaniemi A., and Vainio P. Bone densitometry of the spine and femur in children by dual-energy x-ray absorptiometry. Bone Miner 17 (1992) 75-85
49. Lu P.W., Cowell C.T., Lloyd-Jones S.A., et al. Volumetric bone mineral density in normal subjects, aged 5-27 years. J Clin Endocrinol Metab 81 (1996) 1586-1590
50. Wren T.A.L., Liu X., Pitukcheewanont P., et al. Bone acquisition in healthy children and adolescents: comparisons of dual-energy x-ray absorptiometry and computed tomography measures. J Clin Endocrinol Metab 90 (2005) 1925-1928
51. Henderson R.C., and Hayes P.R.L. Bone mineralization in children and adolescents with a milk allergy. Bone Miner 27 (1994) 1-12
52. Infante D., and Tormo R. risk of inadequate bone mineralizaton in diseases involving long-term suppression of dairy products. J Pediatr Gastroenterol Nutr 30 (2000) 310-313
53. Rockwell J.E.P., Williams S.M., Taylor R.W., et al. Two-year changes in bone and body composition in young children with a history of prolonged milk avoidance. Osteoporos Int 15 (2005) 1016-1023
54. Kalayci A.G., Kkansu A., Girgin N., et al. Bone mineral density and importance of a gluten-free diet in patients with celiac disease in childhood. Pediatrics 108 (2001) e89
55. Barera G., Beccio S., Proverbio M.C., et al. Longitudinal changes in bone metabolism and bone mineral content in children with celiac disease during consumption of a gluten-free diet. Am J Clin Nutr 79 (2004) 148-154
56. Tau C., Mautalen C., De Rosa S., et al. Bone mineral density in children with celiac disease. Effect of a Gluten-free diet. Eur J Clin Nutr 60 (2006) 358-363
57. Szathmari M., Tulassay T., Arato A., et al. Bone mineral content and density in asymptomatic children with celiac disease on a gluten-free diet. Eur J Gastroenterol Hepatol 13 (2001) 419-424
58. Boot A.M., Bouquet J., Krenning E.P., et al. Bone mineral density and nutritional status in children with chronic inflammatory bowel disease. Gut 42 (1998) 188-194
59. Ahmed S.F., Horrocks I.A., Patterson T., et al. Bone mineral assessment by dual energy x-ray absorptiometry in children with inflammatory bowel disease: Evaluation by age or bone area. J Pediatr Gastroenterol Nutr 38 (2004) 276-281
60. Burnham J.M., Shults J., Semeao E., et al. Whole body BMC in pediatric Crohn disease: Iindependent effects of altered growth, maturation, and body composition. J Bone Miner Res 19 (2004) 1961-1968
61. Walther F., Fusch C., Radke M., et al. Osteoporosis in pediatric patients suffering from chronic inflammatory bowel disease with and without steroid treatment. J Pediatr Gastroenterol Nutr 43 (2006) 42-51
62. Argao E.A., Specker B.L., and Heubi J.E. Bone mineral content in infants and children with chronic cholestatic liver disease. Pediatrics 91 (1993) 1151-1154
63. Olsen I.E., Ittenbach R.F., Rovner A.J., et al. Deficits in size-adjusted bone mass in children with Alagille Syndrome. J Pediatr Gastroenterol Nutr 40 (2005) 76-82
64. D'Antiga L., Ballan D., Luisetto G., et al. Long-term outcome of bone mineral density in children who underwent a successful liver transplantation. Transplantation 78 (2004) 899-903
65. Ahmed S.F., Russell S., Rashid R., et al. Bone mineral content, corrected for height or bone area, measured by DXA is not reduced in children with chronic renal disease or in hypoparathyroidism. Pediatr Nephrol 20 (2005) 1466-1472
66. Acott P.D., Crocker J.F.S., and Wong J.A. Decreased bone mineral density in the pediatric renal transplant population. Pediatr Transplant 7 (2003) 358-363
67. Boot A.M., Nauta J., de Jong M.C., et al. Bone mineral density, bone metabolism and body composition of children with chronic renal failure, with and without growth hormone treatment. Clin Endocrinol 49 (1998) 665-672
68. van der Sluis I.M., Boot A.M., Nauta J., et al. Bone density and body composition in chronic renal failure: Effects of growth hormone treatment. Pediatr Nephrol 15 (2000) 221-228
69. Feber J., Cochat P., Braillon P., et al. Bone mineral density after renal transplantation in children. J Pediatr 125 (1994) 870-875
70. Klaus G., Paschen C., Wuster C., et al. Weight-/height-related bone mineral density is not reduced after renal transplantation. Pediatr Nephrol 12 (1998) 343-348
71. Saggese G., Baroncelli G.I., Bertelloni S., et al. The effect of long-term growth hormone (GH) treatment on bone mineral density in children with GH deficiency. Role of GH in the attainment of peak bone mass. J Clin Endocrinol Metab 81 (1996) 3077-3083
72. Hogler W., Briody J., Moore B., et al. Effect of growth hormone therapy and puberty on bone and body composition in children with idiopathic short stature and growth hormone deficiency. Bone 37 (2005) 642-650
73. Lanes R., Gunczler P., Esaa S., et al. The effect of short- and long-term growth hormone treatment on bone mineral density and bone metabolism of prepubertal children with idiopathic short stature: A 3-year study. Clin Endocrinol 57 (2002) 725-730
74. Baroncelli G.I., Bertelloni S., Sodini F., et al. Longitudinal changes of lumbar bone mineral density (BMD) in patients with GH deficiency after discontinuation of treatment at final height; timing and peak values for lumbar BMD. Clin Endocrinol 60 (2004) 175-184
75. Baroncelli G.I., and Saggese G. Effect of GH treatment on bone mass in children with GH deficiency. J Endocrinol Invest 28 10 suppl (2005) 23-27
76. Shoepe H.A., and Snow C.M. Oral contraceptive use in young women is associated with lower bone mineral density than that of controls. Osteoporos Int 16 (2005) 1538-1544
77. Cromer B.A., Stager M., Bonny A., et al. Depot medroxyprogestrone acetate, oral contraceptives and bone mineral density in a cohort of adolescent girls. J Adolesc Health 35 (2004) 434-441
78. Cromer B.A., Blair J.M., Mahan J.D., et al. A prospective comparison of bone density in adolescent girls receiving depot medroxyprogesterone acetate (Depo-Provera), levonorgestrel (Norplant), or oral contraceptives. J Pediatr 129 (1996) 671-676
79. Banks E., Berrington A., and Casabonne D. Overview of the relationship between use of progestogen-only contraceptives and bone mineral density. BJOG 108 (2001) 1214-1221
80. Cromer B.A., Lazebnik R., Rome E., et al. Double-blinded randomized controlled trial of estrogen supplementation in adolescent girls who receive depot medroxyprogesterone acetate for contraception. Am J Obstet Gynecol 192 (2005) 42-47
81. Resch H., Newrkla S., Grampp S., et al. Ultrasound and x-ray-based bone densitometry in patients with anorexia nervosa. Calcif Tissue Int 66 (2000) 338-341
82. Soyka L.A., Misra M., Frenchman A., et al. Abnormal bone mineral accrual in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 87 (2002) 4177-4185
83. Milos G., Spindler A., Ruegsegger P., et al. Cortical and trabecular bone density and structure in anorexia nervosa. Osteoporos Int 16 (2005) 783-790
84. Seeman E., Szmukler G.I., Formica C., et al. Osteoporosis in anorexia nervosa: The influence of peak bone density, bone loss, oral contraceptive use, and exercise. J Bone Miner Res 7 (1992) 1467-1474
85. Sood M., Hambleton G., Super M., et al. Bone status in cystic fibrosis. Arch Dis Child 84 (2001) 516-520
86. Haslam R.H.M., Borovnicar D.J., Stroud D.B., et al. Correlates of prepubertal bone mineral density in cystic fibrosis. Arch Dis Child 85 (2001) 166-171
87. Hardin D.S., Arumugam R., Seilheimer D.K., et al. Normal bone mineral density in cystic fibrosis. Arch Dis Child 84 (2001) 363-368
88. Buntain H.M., Greer R.M., Schluter P.J., et al. Bone mineral density in Australian children, adolescents and adults with cystic fibrosis: a controlled cross sectional study. Thorax 59 (2004) 149-155
89. Haworth C.S., Selby P.L., Webb A.K., et al. Low bone mineral density in adults with cystic fibrosis. Thorax 54 (1999) 961-967
90. Henderson R.C., and Madsen C.D. Bone density in children and adolescents with cystic fibrosis. J Pediatr 128 (1996) 28-39
91. Haworth C.S., Selby P.L., Horrocks A.W., et al. A prospective study of change in bone mineral density over one year in adults with cystic fibrosis. Thorax 57 (2002) 719-723
92. Bhudhikanok G.S., Wang M.C., Marcus R., et al. Bone acquisition and loss in children and adults with cystic fibrosis: a longitudinal study. J Pediatr 133 (1998) 18-27
93. Aris R.M., Lester G.E., Renner J.B., et al. Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. Am J Respir Crit Care Med 162 (2000) 941-946
94. Aris R.M., Lester G.E., Caminiti M., et al. Efficacy of alendronate in adults with cystic fibrosis with low bone density. Am J Respir Crit Care Med 169 (2004) 77-82
95. Haworth C.S., Selby P.L., Adams J.E., et al. Effect of intravenous pamidronate on bone mineral density in adults with cystic fibrosis. Thorax 56 (2001) 314-316
96. Boot A.M., de Jongste J.C., Verberne A.A.P., et al. Bone mineral density and bone metabolism of prepubertal children with asthma after long-term treatment with inhaled corticosteroids. Pediatr Pulmonol 24 (1997) 379-384
97. Agertoft L., and Pedersen S. Bone mineral density in children with asthma receiving long-term treatment with inhaled budesonide. Am J Respir Crit Care Med 157 (1998) 178-183
98. Bahceciler N.N., Sezgin G., Nursoy M.A., et al. Inhaled corticosteroids and bone density of children with asthma. J Asthma 39 (2002) 151-157
99. Altzntas D.U., Karakoc G.B., Can S., et al. The effects of long term use of inhaled corticosteroids on linear growth, adrenal function and bone mineral density in children. Allergol Immunopathol 33 (2005) 204-209
100. Allen H.D.W., Thong I.G., Clifton-Bligh P., et al. Effects of high-dose inhaled corticosteroids on bone metabolism in prepubertal children with asthma. Pediatr Pulmonol 29 (2000) 188-193
101. Harris M., Hauser S., Nguyen T.V., et al. Bone mineral density in prepubertal asthmatics receiving corticosteroid treatment. J Paediatr Child Health 37 (2001) 67-71
102. Brinker M.R., Thomas K.A., Meyers S.J., et al. Bone mineral density of the lumbar spine and proximal femur is decreased in children with sickle cell anemia. Am J Orthop 27 (1998) 43-49
103. Soliman A.T., Bererhi H., Darwish A., et al. Decreased bone mineral density in prepubertal children with sickle cell disease: Correlation with growth parameters, degree of siderosis and secretion of growth factors. J Trop Pediatr 44 (1998) 194-198
104. Lal A., Fung E.B., Pakbaz Z., et al. Bone mineral density in children with sickle cell anemia. Pediatr Blood Cancer 47 (2006) 901-906
105. Buison A.M., Kawchak D.A., Schall J.I., et al. Bone area and bone mineral content deficits in children with sickle cell disease. Pediatrics 116 (2005) 943-949
106. Miller R.G., Segal J.B., Ashar B.H., et al. High prevalence and correlates of low bone mineral density in young adults with sickle cell disease. Am J Hematol 81 (2006) 236-241
107. Vogiatzi M.G., Autio K.A., Schneider R., et al. Low bone mass in prepubertal children with thalassemia major: Insights into the pathogenesis of low bone mass in thalassemia. J Pediatr Endocrinol Metab 17 (2004) 1415-1421
108. Benigno V., Bertelloni S., Baroncelli G.I., et al. Effects of thalassemia major on bone mineral density in late adolescence. J Pediatr Endocrinol Metab 16 (2003) 337-342
109. Barnes C., Wong P., Egan B., et al. Reduced bone density among children with severe hemophilia. Pediatrics 114 (2004) 177-181
110. Gallacher S.J., Deighan C., Wallace A.M., et al. Association of severe haemophilia A with osteoporosis: A densitometric and biochemical study. Q J Med 87 (1994) 181-186
111. Arikoski P., Komulainen J., Voutilainen R., et al. Reduced bone mineral density in long-term survivors of childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol 20 (1998) 234-240
112. Brennan B.M.D., Rahim A., Adams J.A., et al. Reduced bone mineral density in young adults following cure of acute lymphoblastic leukaemia in childhood. Br J Cancer 79 (1999) 1859-1863
113. van der Sluis I.M., van den Heuvel-Eibrink M.M., Hahlen K., et al. Bone mineral density, body composition, and height in long-term survivors of acute lymphoblastic leukemia in childhood. Med Pediatr Oncol 35 (2000) 415-420
114. Boot A.M., van den Heuvel-Eibrink M.M., Hahlen K., et al. Bone mineral density in children with acute lymphoblastic leukaemia. Eur J Cancer 35 (1999) 1693-1697
115. Marinovic D., Dorgeret S., Lescoeur B., et al. Improvement in bone mineral density and body composition in survivors of childhood acute lymphoblastic leukemia: A 1-year prospective study. Pediatrics 116 (2005) e102-e108
116. Jarfelt M., Fors H., Lannering B., et al. Bone mineral density and bone turnover in young adult survivors of childhood acute lymphoblastic leukaemia. Eur J Endoc 154 (2006) 303-309
117. Aisenberg J., Hsieh K., Kalaitzoglou G., et al. J Pediatr Hematol Oncol 20 (1998) 241-245
118. Vassilopoulou-Sellin R., Brosnan P., Delpassand A., et al. Osteopenia in young adult survivors of childhood cancer. Med Pediatr Oncol 32 (1999) 272-278
119. Nysom K., Holm K., Michaelsen K.F., et al. Bone mass after treatment of malignant lymphoma in childhood. Med Pediatr Oncol 37 (2001) 518-524
120. Kelly J., Damron T., Grant W., et al. Cross-sectional study of bone mineral density in adult survivors of solid pediatric cancers. J Pediatr Hematol Oncol 27 (2005) 248-253
121. Ruza E., Sierrasesumaga L., Azcona C., et al. Bone mineral density and bone metabolism in children treated for bone sarcomas. Pediatr Res 59 (2006) 866-871
122. Odame I., Duckworth J., Talsma D., et al. Osteopenia, physical activity and health-related quality of life in survivors of brain tumors treated in childhood. Pediatr Blood Cancer 46 (2006) 357-362
123. Henderson R.C., Lin P.P., and Greene W.B. Bone-mineral density in children and adolescents who have spastic cerebral palsy. J Bone Joint Surg 77-A (1995) 1671-1681
124. Henderson R.C., Lark R.K., Gurka M.J., et al. Bone density and metabolism in children and adolescents with moderate to severe cerebral palsy. Pediatrics 110 (2002) 1-10
125. Henderson R.C., Lark R.K., Kecskemethy H.H., et al. Bisphosphonates to treat osteopenia in children with quadriplegic cerebral palsy: a randomized, placego-controlled clinical trial. J Pediatr 141 (2002) 644-651
126. Bachrach S.J., Kecskemethy H.H., Harcke H.T., et al. Pamidronate treatment and posttreatment bone density in children with spastic quadriplegic cerebral palsy. J Clin Densitom 9 (2006) 167-174
127. Quan A., Adams R., Ekmark E., et al. Bone mineral density in children with myelomeningocele. Pediatrics 102 (1998) E34
128. Valtonen K.M., Goksor L.A., Jonsson O., et al. Osteoporosis in adults with meningomyelocele: An unrecognized problem at rehabilitation clinics. Arch Phys Med Rehabil 87 (2006) 376-382
129. Pepmueller P.H., Cassidy J.T., Allen S.H., et al. Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis. Arthritis Rheum 39 (1996) 746-757
130. Pereira R.M.R., Corrente J.E., Chahade W.H., et al. Evaluation by dual x-ray absorptiometry (DXA) of bone mineral density in children with juvenile chronic arthritis. Clin Exp Rheum 16 (1998) 495-501
131. Lien G., Flato B., Haugen M., et al. Frequency of osteopenia in adolescents with early-onset juvenile idiopathic arthritis. Arthritis Rheum 48 (2003) 2214-2223
132. Henderson C.J., Cawkwell G.D., Specker B.L., et al. Predictors of total body bone mineral density in non-corticosteroid-treated prepubertal children with juvenile rheumatoid arthritis. Arthritis Rheum 40 (1997) 1967-1975
133. Henderson C.J., Specker B.L., Sierra R.I., et al. Total-body bone mineral content in non-corticosteroid-treated postpubertal females with juvenile rheumatoid arthritis. Arthritis Rheum 43 (2000) 531-540
134. Mul D., van Suijlekom-Smit L.W.A., ten Cate R., et al. Bone mineral density and body composition and influencing factors in children with rheumatic diseases treated with corticosteroids. J Pediatr Endoc Metab 15 (2002) 187-192
135. Bianchi M.L., Cimaz R., Galbiati E., et al. Bone mass change during methotrexate treatment in patients with juvenile rheumatoid arthritis. Osteoporos Int 10 (1999) 20-25
136. Trapani S., Civinini R., Ermini M., et al. Osteoporosis in juvenile systemic lupus erthematosus: a longitudinal study on the effect of steroids on bone mineral density. Rheumatol Int 18 (1998) 45-49
137. Castro T.C.M., Terreri M.T., Szejnfeld V.L., et al. Bone mineral density in juvenile systemic lupus erythematosus. Braz J Med Bio Res 35 (2002) 1159-1163
138. Larson C.M., and Henderson R.C. Bone mineral density and fractures in boys with Duchenne muscular dystrophy. J Pediatr Orthop 20 (2000) 71
139. Bianchi M.L., Mazzanti A., Galbiati E., et al. Bone mineral density and bone metabolism in Duchenne muscular dystrophy. Osteoporos Int 14 (2003) 761-767
140. Hawker G.A., Ridout R., Harris V.A., et al. Alendronate in the treatment of low bone mass in steroid-treated boys with Duchenne's muscular dystrophy. Arch Phys Med Rehab 86 (2005) 284-288
141. Stewart W.A., Acott P.D., Salisbury S.R., et al. Bone mineral density in juvenile dermatomyositis. Arthritis Rheum 48 (2003) 2294-2298
142. Castro T.C.M., Terreri M.T.R., Szejnfeld V.L., et al. Bone mineral density of Brazilian girls with juvenile dermatomyositis. Braz J Med Biol Res 38 (2005) 309-313
143. Lund A.M., Molgaard C., Muller J., et al. Bone mineral content and collagen defects in osteogenesis imperfecta. Acta Paediatr 88 (1999) 1083-1088
144. Rauch F., and Glorieux F.H. Bisphosphonate treatment in osteogensis imperfecta: Which drug, for whom, for how long?. Ann Med 37 (2005) 295-302
145. Zacharin M., and Kanumakala S. Pamidronate treatment in less severe forms of osteogenesis imperfecta. J Pediatr Endocrinol Metab 17 (2004) 1511-1517
146. Gatti D., Antoniazzi F., Prizzi R., et al. Intravenous neridronate in children with osteogenesis imperfecta: A randomized controlled study. J Bone Miner Res 20 (2005) 758-763
147. Arikoski P., Silverwood B., Tillmann V., et al. Intravenous pamidronate in children with moderate to severe osteogenesis imperfecta: Assessment of indices of dual-energy X-ray absorptiometry and bone metabolic markers during the first year of therapy. Bone 34 (2004) 539-546
148. Letocha A.D., Cintas H.L., Troendle J.F., et al. Controlled trial of pamidronate in children with types III and IV osteogenesis imperfecta confirms vertebral gains but not short-term functional improvement. J Bone Miner Res 20 (2005) 977-986
149. Zeitlin L., Rauch F., Plotkin H., et al. Height and weight development during four years of therapy with cyclical intravenous pamidronate in children and adolescents with osteogenesis imperfecta types I, III, and IV. Pediatrics 111 (2003) 1030-1036