Efficacy of Alendronate in Adults with Cystic Fibrosis with Low Bone Density

American Journal of Respiratory and Critical Care Medicine

Volumn 169, Issue 1, 2004, Pages 77-82

  Aris, Robert M ^a   Lester, Gayle E ^b   Caminiti, Melissa ^b   Blackwood, A Denene ^b   Hensler, Margaret ^b   Lark, Robert K ^b   Hecker, Travis M ^b   Renner, Jordan B ^b   Guillen, Ursula ^b   Brown, Sue A ^b   Neuringer, Isabel P ^b   Chalermskulrat, Worakij ^b   Ontjes, David A ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b NONE

Author keywords

Alendronate; Bisphosphonates; Bone metabolism; Cystic fibrosis; Osteoporosis

Indexed keywords

ALENDRONIC ACID; AMINO TERMINAL TELOPEPTIDE; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM CARBONATE; COLECALCIFEROL; PLACEBO;

ABDOMINAL CRAMP; ADULT; ANOREXIA; ARTICLE; BODY MASS; BONE DENSITY; BONE MINERAL; BONE PAIN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTIC FIBROSIS; DIARRHEA; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; DRUG FEVER; DYSPHAGIA; FEMALE; FEMUR; GASTROESOPHAGEAL REFLUX; GENE MUTATION; HUMAN; KIDNEY FUNCTION; MALE; NEPHROLITHIASIS; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SIDE EFFECT; SPINE; SYSTEMIC DISEASE; TREATMENT OUTCOME; URINALYSIS; WEIGHT REDUCTION;

EID: 10744230137     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200307-1049oc     Document Type: Article

References (35)

1. Cystic Fibrosis Foundation. Patient Registry 2001: Annual Report. Bethesda, MD: Cystic Fibrosis Foundation: 2002.
2. Mischler EH, Chesney PJ, Chesney RW, Mazess RB. Demineralization in cystic fibrosis detected by direct photon absorptiometry. Am J Dis Child 1979;133:632-635.
3. Aris RM, Merkel P, and the Cystic Fibrosis Foundation Consensus Committee. Guide to Bone Health in Cystic Fibrosis. Bethesda. MD: Cystic Fibrosis Foundation. (In press)
4. Aris RM, Neuringer IP, Weiner MA, Egan TM, Ontjes DA. Severe osteoporosis before and after lung transplantation. Chest 1996;109:1176-1183.
5. Shane E, Silverberg SJ, Donovan D, Papadopoulos A, Staron RB, Addesso V, Jorgesen B, McGregor C, Schulman L. Osteoporosis in lung transplantation candidates with end-stage pulmonary disease. Am J Med 1996;101:262-269.
6. Bachrach LK, Loutit CW, Moss RB, Marcus R. Osteopenia in adults with cystic fibrosis. Am J Med 1994;96:27-32.
7. Henderson RC, Madsen CD. Bone density in children and adolescents with cystic fibrosis. J Pediatr 1996;128;28-34.
8. Baroncelli G, De Luca F, Magazzu G, Arrigo T, Sferlazzas C, Catena C, Bertelloni S, Saggese G. Bone demineralization in CF: evidence of imbalance between bone formation and degradation. Pediatr Res 1997;41:397-403.
9. Aris RM, Lester G, Dingman S, Ontjes DA. Altered calcium homeostasis in adults with cystic fibrosis. Osteoporos Int 1999;10:102-108.
10. Haworth CS, Selby PL, Webb AK, Dodd ME, Musson H, McL Niven R, Economou G, Horrocks AW, Freemont AJ, Mawer EB, et al. Low bone mineral density in adults with cystic fibrosis. Thorax 1999;54:961-967.
11. Aris RM, Stevens A, Ontjes DA, Blackwood AD, Lark RK, Hensler M, Neuringer IP, Lester GE. Adverse alterations in bone metabolism are associated with lung infection in adults with cystic fibrosis. Am J Respir Crit Care Med 2000;162:1674-1678.
12. Elkin SL, Vedi S, Bord S, Garrahan NJ, Hodson ME, Compston JE. Histomorphometric analysis of bone biopsies from the iliac crest of adults with cystic fibrosis. Am J Respir Crit Care Med 2002;166:1470-1474.
13. Lark RK, Lester GE, Ontjes DA, Blackwood AD, Hollis BW, Hensler M, Aris RM. Diminished and erratic absorption of ergocalciferol in adult cystic fibrosis patients. Am J Clin Nutr 2001;73:602-606.
14. The American Society for Transplant Physicians (ASTP)/American Thoracic Society(ATS)/European Respiratory Society(ERS)/International Society for Heart and Lung Transplantation(ISHLT). International guidelines for the selection of lung transplant candidates. Am J Respir Crit Care Med 1998;158:335-339.
15. Bhudhikanok GS, Wang MC, Marcus R, Harkins A, Moss RB, Bachrach LK. Bone acquisition and loss in children and adults with cystic fibrosis: a longitudinal study. J Pediatr 1998;133:18-27.
16. Haworth CS, Selby PL, Horrocks AW, Mawer EB, Adams JE, Webb AK. A prospective study of change in bone mineral density over one year in adults with cystic fibrosis. Thorax 2002;57:719-723.
17. Aris RM, Renner JB, Winders AD, Riggs DB, Buell H, Lester G, Ontjes DA. Increased fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann Intern Med 1998;128:186-193.
18. Henderson RC, Spekter BB. Kyphosis and fractures in children and young adults with cystic fibrosis. J Pediatr 1994;125:208-212.
19. Liberman UA, Weiss SR, Broll J, Minne HW, Quan H, Bell NH, Rodriguez-Portales J, Down Downs Jr RW, Dequeker J, Favus M. Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis: The Alendronate Phase III Osteoporosis Treatment Study Group. N Engl J Med 1995;333:1437-1443.
20. Orwoll E, Ettinger M, Weiss S, Miller P, Kendler D, Graham J, Adami S, Weber K, Lorenc R, Pietschmann P, et al. Alendronate for the treatment of osteoporosis in men. N Engl J Med 2000;343:604-610.
21. Saag KG, Emkey R, Schnitzer TJ, Brown JP, Hawkins F, Goemaere S, Thamsborg G, Liberman UA, Delmas PD, Malice MP, et al. Alendronate for the prevention and treatment of glucocorticoid-induced osteoporosis: Glucocorticoid-Induced Osteoporosis Intervention Study Group. N Engl J Med 1998;339:292-299.
22. Aris RM, Ontjes DA, Buell HE, Blackwood AD, Lark RK, Caminiti M, Hensler M, Neuringer IP, Lester GE. Abnormal bone turnover in cystic fibrosis adults. Osteoporos Int 2002;13:151-157.
23. Aris RM, Lester GE, Renner JB, Winders A, Blackwood AD, Lark RK, Ontjes DA. Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. Am J Respir Crit Care Med 2000;162:941-946.
24. Cobb JR. Outline for the study of scoliosis. Instr Course Lect 1948;5:261-268.
25. Melton LJ III, Kan SH, Frye MA, Wahner HW, O'Fallon WM, Riggs BL. Epidemiology of vertebral fractures in women. Am J Epidemiol 1989;129:1000-1011.
26. Garnero P, Grimaux M, Demaux B, Preaudat C, Seguin P, Delmas PD. Measurement of serum osteocalcin with a human-specific two-site immunoradiometric assay. J Bone Miner Res 1992;7:1389-1398.
27. Garnero P, Delmas PD. Assessment of the serum levels of bone alkaline phosphatase with a new immunoradiometric assay in patients with metabolic bone disease. J Clin Endocrinol Metab 1993;77:1046-1053.
28. Koch G, Stokes ME, Davis CS. Categorical data analysis using the SAS system. Cary, NC: SAS Institute; 1995.
29. Marshall D, Johnell OJ, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 1996;312:1254-1259.
30. Melton LJ, Atkinson EJ, O'Connor MK, O'Fallon WM, Riggs BL. Bone density and fracture risk in men. J Bone Miner Res 1998;13:1915-1923.
31. Haworth CS, Selby PL, Webb AK, Mawer EB, Adams JE, Freemont TJ. Severe bone pain after intravenous pamidronate in adult patients with cystic fibrosis. Lancet 1998;352:1753-1754.
32. Haworth CS, Selby PL, Adams JE, Mawer EB, Horrocks AW, Webb AK. Effect of intravenous pamidronate on bone mineral density in adults with cystic fibrosis. Thorax 2001;56:314-316.
33. Haworth CS, Selby PL, Webb AK, Adams JE, Freemont TJ. Oral corticosteroids and bone pain after alendronate in adults with cystic fibrosis. Lancet 1999;353:1886.
34. Conway SP, Morton AM, Oldroyd B, Truscott JG, Smith AH. Follow-up DEXA scans in adult patients: an assessment of the efficacy of bisphosphonate therapy. Ped Pulmonol 2000;(Suppl 20):320.
35. Greenspan SL, Bone G 3rd, Schnitzer TJ, Watts NB, Adami S, Foldes AJ. Two-year results of once-weekly administration of alendronate 70 mg for the treatment of postmenopausal osteoporosis. J Bone Miner Res 2002;17:1988-1996.