The effect of short- and long-term growth hormone treatment on bone mineral density and bone metabolism of prepubertal children with idiopathic short stature: A 3-year study

Clinical Endocrinology

Volumn 57, Issue 6, 2002, Pages 725-730

  Lanes, Roberto ^a,b   Gunczler, Peter ^a   Esaa, Sara ^a   Weisinger, Jose R ^a  

^a HOSPITAL UNIVERSITARIO DE CARACAS   (Venezuela)

^b M 209 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; GROWTH HORMONE; PEPTIDE; BIOLOGICAL MARKER; ICTP PEPTIDE; PEPTIDE FRAGMENT; PROCOLLAGEN; PROCOLLAGEN TYPE I CARBOXY TERMINAL PEPTIDE;

ADOLESCENT; ARTICLE; BODY HEIGHT; BONE AGE; BONE DENSITY; BONE METABOLISM; BONE MINERAL; BONE MINERALIZATION; BONE TURNOVER; CARBOXY TERMINAL SEQUENCE; CHILD; CLINICAL ARTICLE; DRUG EFFECT; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GROWTH RATE; HORMONAL THERAPY; HUMAN; IDIOPATHIC DISEASE; LUMBAR SPINE; MALE; MINERAL METABOLISM; PREPUBERTY; PRIORITY JOURNAL; SHORT STATURE; BLOOD; BONE; CASE CONTROL STUDY; COMPARATIVE STUDY; DRUG ADMINISTRATION; FEMUR NECK; GROWTH DISORDER; LUMBAR VERTEBRA; METABOLISM; PATHOPHYSIOLOGY; TIME;

BIOLOGICAL MARKERS; BODY HEIGHT; BONE AND BONES; BONE DENSITY; CASE-CONTROL STUDIES; CHILD; DRUG ADMINISTRATION SCHEDULE; FEMALE; FEMUR NECK; GROWTH DISORDERS; GROWTH HORMONE; HUMANS; LUMBAR VERTEBRAE; MALE; PEPTIDE FRAGMENTS; PROCOLLAGEN; TIME FACTORS;

EID: 0041589181     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.2002.01614.x     Document Type: Article

References (21)

1. Amato, G., Izzo, G., La Montagna, G. & Bellastella, A. (1996) Low dose recombinant human growth hormone normalizes bone metabolism and cortical bone density and improves trabecular bone density in growth hormone deficient adults without causing adverse effects. Clinical Endocrinology, 45, 27-32.
2. Antoniazzi, F., Bertoldo, F., Mottes, M., Valli, M., Sirpresi, S., Zamboni, G., Valentini, R. & Tato, L. (1996) Growth hormone treatment in osteogenesis imperfecta with quantitative defect of type 1 collagen. Journal of Pediatrics, 129, 432-439.
3. Boot, A.M., Engels, M.A.M.J., Boerma, G.J.M., Krenning, E.P. & De Muinck Keizer-Schrama, S.M.P.F. (1997) Changes in bone mineral density, body composition, and lipid metabolism during growth hormone (GH) treatment in children with GH deficiency. Journal of Clinical Endocrinology and Metabolism, 82, 2423-2428.
4. Buchlis, J.G., Irizarry, L., Crotzer, B.C., Shine, B.J., Allen, L. & Macgillivray, H. (1998) Comparison of final heights of growth hormone-treated vs untreated children with idiopathic growth failure. Journal of Clinical Endocrinology and Metabolism, 83, 1075-1079.
5. Drake, W.M., Rodriguez-Arnao, J., Weaver, J.U., James, I.T., Coyte, D., Spector, T.D., Besser, G.M. & Monson, J.P. (2001) The influence of gender on the short- and long-term effects of growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults: a 5-year study. Clinical Endocrinology, 54, 525-532.
6. Genenthec Collaborative Study Group (1989) Idiopathic short stature: results of a one-year controlled study of human growth hormone treatment. Journal of Pediatrics, 115, 713-719.
7. Greulich, W.W. & Pyle, S.I. (1969) Radiographic Atlas of Skeletal Development of the Hand and Wrist, 2nd edn. Stanford University Press, Stanford.
8. Hopwood, N.J., Hintz, R., Gertner, J.M., Attie, K.M., Johanson, A.J., Baptista, J., Kuntze, J., Blizzard, R.M., Cara, J.F., Chernausek, S.D., Kaplan, S.L., Lippe, B.M., Plotnick, L.P. & Saenger, P. (1993) Growth response of children with non-growth hormone deficiency and marked short stature during three years of growth hormone therapy. Journal of Pediatrics, 123, 215-222.
9. Kawai, M., Momoi, T., Yorifuji, T., Yamanaka, C., Sasaki, H. & Furusho, K. (1997) Unfavorable effects of growth hormone therapy on the final height of boys with short stature not caused by growth hormone deficiency. Journal of Pediatrics, 130, 205-209.
10. Lanes, R. (1995) Effects of two years of growth hormone treatment in short, slowly growing non-growth hormone deficient children. Journal of Pediatric Endocrinology and Metabolism, 8, 167-171.
11. Lanes, R., Gunczler, P., Orta, N., Bosquez, M., Scovino, R., Dominguez, L., Esaa, S. & Weisinger, J.R. (1996) Changes in bone mineral density, growth velocity and renal function of prepubertal uremic children during growth hormone treatment. Hormone Research, 46, 263-268.
12. Lanes, R., Gunczler, P., Paoli, M. & Weisinger, J.R. (1995) Bone mineral density of prepubertal age girls with Turner's syndrome while on growth hormone therapy. Hormone Research, 44, 168-171.
13. Lanes, R., Gunczler, P. & Weisinger, J.R. (1999) Decreased trabecular bone mineral density in children with idiopathic short stature. Normalization of bone density and increased bone turnover after 1 year of growth hormone treatment. Journal of Pediatrics, 135, 177-181.
14. Loche, S., Cambiaso, P., Setzu, S., Carta, D., Marini, R., Borrelli, P. & Cappa, M. (1994) Final height after growth hormone therapy in non-growth hormone-deficient children with short stature. Journal of Pediatrics, 125, 196-200.
15. Mazess, R.B., Hanson, J.A., Sorenson, J.S. & Barden, B.J. (1978) Accuracy and precision of dual photon absorptiometry. In Bone and Mineral Measurement by Photon Absorptiometry (eds J. Dequeber, P. Gensens & H. W. Wahner), p. 157. Leuven University Press, Belgium.
16. Neely, E.K., Marcus, R., Rosenfeld, R.G. & Bachrach, L.K. (1993) Turner syndrome adolescents receiving growth hormone are not osteopenic. Journal of Clinical Endocrinology and Metabolism, 76, 861-866.
17. Ogle, G.D., Rosenberg, A.R., Calligeros, D. & Kainer, G. (1994) Effects of growth hormone treatment for short stature on calcium homeostasis, bone mineralisation and body composition. Hormone Research, 41, 16-20.
18. Rekers-Mombarg, L.T.M., Massa, G.G., Wit, J.M., Matranga, A.M.C., Buckler, J.M.H., Butenandt, O., Chausain, J.L., Frisch, H., Lieberman, E., Yturriaga, R., Aarskog, D., Chatelain, P.G., Colle, M., Dacou-Voutetakis, C., Delemarre-van de Waal, H.A., Girard, F., Gosen, J.J., Irle, U., Jansen, M., Jean, R., Job, J.C., Kaar, M.L., Kolleman, F., Lenko, H.L., Muhlenberg, R., de Muinck Keizer-Schrama, S.M.P.F., Oosdik, W., Otten, B.J., Piersson, M., Preece, M.A., Price, D.A., Rayner, P.H.W., Rouwe, C., Schmitt, K., Sippell, W.G., Blumel, P., Unlsma, T. & Waelkens, J.J. (1998) Growth hormone therapy with three dosage regimens in children with idiopathic short stature. Journal of Pediatrics, 132, 455-460.
19. Saggese, G., Baroncelli, G.I., Bertelloni, S. & Barsanti, S. (1996) The effect of long term growth hormone (GH) treatment on bone mineral density in children with GH deficiency. Role of GH in the attainment of peak bone mass. Journal of Clinical Endocrinology and Metabolism, 81, 077-3083.
20. Saggese, G., Baroncelli, G.I., Bertelloni, S. & Perri, G. (1995) Long-term growth hormone treatment in children with renal hypophosphatemic rickets: effects on growth, mineral metabolism and bone density. Journal of Pediatrics, 127, 395-402.
21. Wit, J.M., Fokker, M.H., de Muinck Keizer-Schrama, M.P.F., Oostdijk, W., Gons, M., Delemarre-Van de Waal, H.A., Reeser, M. & Waelkens, J.J. (1989) Effects of two years of methionyl growth hormone therapy in two dosage regimens in prepubertal children with short stature. Journal of Pediatrics, 115, 720-725.