Central pressor actions of aminopeptidase-resistant angiotensin II analogs: Challenging the angiotensin III hypothesis

Hypertension

Volumn 49, Issue 6, 2007, Pages 1328-1335

  Kokje, Ranjita J ^a   Wilson, Wendy L ^b   Brown, Travis E ^b   Karamyan, Vardan T ^a   Wright, John W ^b   Speth, Robert C ^a  

^a UNIVERSITY OF MISSISSIPPI   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

Brain angiotensin receptors; Dipsogenesis; Intracerebroventricular; Metabolism

Indexed keywords

AMINOPEPTIDASE; ANGIOTENSIN II; ANGIOTENSIN II DERIVATIVE; ANGIOTENSIN III; IODINE 125;

ANIMAL EXPERIMENT; ARTICLE; BRAIN FUNCTION; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RESPONSE; COMPARATIVE STUDY; CONTROLLED STUDY; DRINKING; HYPOTHESIS; LATENT PERIOD; MALE; NONHUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; STIMULUS RESPONSE; THIRST;

AMINOPEPTIDASES; ANGIOTENSIN II; ANGIOTENSIN III; ANIMALS; BLOOD PRESSURE; DRINKING BEHAVIOR; INJECTIONS, INTRAVENTRICULAR; MALE; PRESSORECEPTORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN-ANGIOTENSIN SYSTEM;

EID: 34249336753     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.107.087130     Document Type: Article

References (48)

1. Ganten D, Minnich JL, Granger P, Hayduk K, Brecht HM, Barbeau A, Boucher R, Genest J. Angiotensin-forming enzyme in brain tissue. Science. 1971;173:64-65.
2. Phillips MI, Weyhenmeyer J, Felix D, Ganten D, Hoffman WE. Evidence for an endogenous brain renin-angiotensin system. Fed Proc. 1979;38:2260-2266.
3. Dzau VJ, Ingelfinger J, Pratt RE, Ellison KE. Identification of renin and angiotensinogen messenger RNA sequences in mouse and rat brains. Hypertension. 1986;8:544-548.
4. Veerasingham SJ, Raizada MK. Brain renin-angiotensin system dysfunction in hypertension: recent advances and perspectives. Br J Pharmacol. 2003;139:191-202.
5. de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev. 2000;52:415-472.
6. Wright JW, Harding JW. Brain angiotensin receptor subtypes AT(1), AT(2), and AT(4) and their functions. Regul Pept. 1995;59:269-295.
7. Fitzsimons JT. Angiotensin, thirst, and sodium appetite. Physiological Reviews. 1998;78:583-686.
8. Fitzsimons JT. The effect on drinking of peptide precursors and of shorter chain peptide fragments of angiotensin II injected into the rat's diencephalon. J Physiol. 1971;214:295-303.
9. Wright JW, Morseth SL, Abhold RH, Harding JW. Pressor action and dipsogenicity induced by angiotensin II and III in rats. Am J Physiol. 1985;249:R514-R521.
10. Harding JW, Felix D. The effects of the aminopeptidase inhibitors amastatin and bestatin on angiotensin-evoked neuronal activity in rat brain. Brain Res. 1987;424:299-304.
11. Sullivan MJ, Harding JW, Wright JW. Differential effects of aminopeptidase inhibitors on angiotensin- induced pressor responses. Brain Res. 1988;456:249-253.
12. Zini S, Fournie-Zaluski MC, Chauvel E, Roques BP, Corvol P, Llorens-Cortes C. Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: Predominant role of angiotensin III in the control of vasopressin release. Proc Natl Acad Sci U S A. 1996;93:11968-11973.
13. Chauvel EN, Llorens-Cortes C, Coric P, Wilk S, Roques BP, Fournie-Zaluski MC. Differential inhibition of aminopeptidase A and aminopeptidase N by new beta-amino thiols. J Med Chem. 1994;37:2950-2957.
14. Reaux A, Fournie-Zaluski MC, David C, Zini S, Roques BP, Corvol P, Llorens-Cortes C. Aminopeptidase A inhibitors as potential central antihypertensive agents. Proc Natl Acad Sci U S A. 1999;96:13415-13420.
15. Song LJ, Wilk S, Healy DP. Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin II-induced dipsogenic and pressor responses. Brain Res. 1997;744:1-6.
16. Fournie-Zaluski MC, Fassot C, Valentin B, Djordjijevic D, Reaux-Le Goazigo A, Corvol P, Roques BP, Llorens-Cortes C. Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: a potential treatment of salt-dependent hypertension. Proc Natl Acad Sci U S A. 2004;101:7775-7780.
17. Inguimbert N, Coric P, Dhotel H, Bonnard E, Llorens-Cortes C, Mota N, Fournie-Zaluski MC, Roques BP. Synthesis and in vitro activities of new non-peptidic APA inhibitors. J Pept Res. 2005;65:175-188.
18. Wright JW, Roberts KA, Cook VI, Murray CE, Sardinia MF, Harding JW. Intracerebroventricularly infused [D-Arg1]angiotensin III, is superior to [D-Asp1]angiotensin II, as a pressor agent in rats. Brain Res. 1990;514:5-10.
19. Regoli D, Rioux F, Park WK, Choi C. Role of the N-terminal amino acid for the biological activities of angiotensin and inhibitory analogues. Can J Physiol Pharmacol. 1974;52:39-49.
20. Speth RC, Harding JW. Radiolabeling of Angiotensin Peptides. In: Wang DH, ed. Angiotensin Protocols. Totowa, NJ: Humana Press;2001:275-295.
21. Jackson EK. Renin and Angiotensin. In: Brunton LL, Lazo JS, Parker KL, eds. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 11 ed. New York: McGraw-Hill;2006:789-821.
22. Karamyan VT, Speth RC Enzymatic pathways of the brain renin-angiotensin system: Unsolved problems and continuing challenges. Regul Pept. In Press.
23. Abhold RH, Hanesworth JM, Harding JW. Comparison of 125I-angiotensin III and 125I-angiotensin II binding to rat brain membranes. J Neurochem. 1988;50:831-838.
24. Lee CM, Snyder SH. Dipeptidyl-aminopeptidase III of rat brain. Selective affinity for enkephalin and angiotensin. J Biol Chem. 1982;257:12043-12050.
25. Turner AJ, Tipnis SR, Guy JL, Rice G, Hooper NM. ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors. Can J Physiol Pharmacol. 2002;80:346-353.
26. Shariat-Madar Z, Mahdi F, Schmaier AH. Assembly and activation of the plasma kallikrein/kinin system: a new interpretation. Int Immunopharmacol. 2002;2:1841-1849.
27. Dahms P, Mentlein R. Purification of the main somatostatin-degrading proteases from rat and pig brains, their action on other neuropeptides, and their identification as endopeptidases 24.15 and 24.16. Eur J Biochem. 1992;208:145-154.
28. LeDoux JE, Del BA, Tucker LW, Harshfield G, Talman WT, Reis DJ. Hierarchic organization of blood pressure responses during the expression of natural behaviors in rat: mediation by sympathetic nerves. Exp Neurol. 1982;78:121-133.
29. Camargo LLA, Menani JV, Saad WA, Saad WA. Interaction between areas of the central nervous system in the control of water intake and arterial pressure in the rats. J Physiol. 1984;350:1-8.
30. Harding JW, Yoshida MS, Dilts RP, Woods TM, Wright JW. Cerebroventricular and intravascular metabolism of [125I]angiotensins in rat. J Neurochem. 1986;46:1292-1297.
31. Brown TE, Wright JW, Speth RC. Phospholipase C inhibitor U73122 attenuates the dipsogenic response induced by angiotensin II. Proc West Pharmacol Soc. 2003;46:61-63.
32. Fregly MJ, Rowland NE. Do peripheral and cerebroventricular injections of angiotensin II act at the same site? Studies on additivity of drinking. Brain Res Bull. 1986;16:249-257.
33. Evered MD. Investigating the role of angiotensin II in thirst: interactions between arterial pressure and the control of drinking. Can J Physiol Pharmacol. 1992;70:791-797.
34. Lee RW, Gay RG, Goldman S. Atrial natriuretic peptide reverses angiotensin-induced venoconstriction in dogs. Am J Physiol. 1989;257:H1062-H1067.
35. Lee RW, Goldman S. Mechanism for decrease in cardiac output with atrial natriuretic peptide in dogs. Am J Physiol. 1989;256:H760-H765.
36. Zimmerman MC, Lazartigues E, Sharma RV, Davisson RL. Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res. 2004;95:210-216.
37. Wang G, Anrather J, Huang J, Speth RC, Pickel VM, Iadecola C. NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. J Neurosci. 2004;24:5516-5524.
38. Fujioka H, Okabe T, Yamaguchi H. Purification and characterization of angiotensin II degradation factor from porcine endothelial cells. Tohoku J Exp Med. 1995;177:183-192.
39. Kohara K, Tabuchi Y, Senanayake P, Brosnihan KB, Ferrario CM. Reassessment of plasma angiotensins measurement: effects of protease inhibitors and sample handling procedures. Peptides. 1991;12:1135-1141.
40. Karamyan VT, Speth RC. Identification of a novel non-AT1, non-AT2 angiotensin binding site in the rat brain. Brain Res. 2007;1143:83-91.
41. Whitebread S, Mele M, Kamber B, de Gasparo M. Preliminary biochemical characterization of two angiotensin II receptor subtypes. Biochem Biophys Res Commun. 1989;163:284-291.
42. Chiu AT, McCall DE, Nguyen TT, Carini DJ, Duncia JV, Herblin WF, Uyeda RT, Wong PC, Wexler RR, Johnson AL, Timmermans PBMWM. Discrimination of angiotensin II receptor subtypes by dithiothreitol. Eur J Pharmacol. 1989;170:117-118.
43. Speth RC, Rowe BP, Grove KL, Carter MR, Saylor DL. Sulfhydryl reducing agents distinguish two subtypes of angiotensin II receptors in the rat brain. Brain Res. 1991;548:1-8.
44. Fournie-Zaluski MC, Coric P, Turcaud S, Bruetschy L, Lucas E, Noble F, Roques BP. Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation. J Med Chem. 1992;35:1259-1266.
45. Shrimpton CN, Glucksman MJ, Lew RA, Tullai JW, Margulies EH, Roberts JL, Smith AI. Thiol activation of endopeptidase EC 3.4.24.15. A novel mechanism for the regulation of catalytic activity. J Biol Chem. 1997;272:17395-17399.
46. Wright JW, Tamura-Myers E, Wilson WL, Roques BP, Llorens-Cortes C, Speth RC, Harding JW. Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats. Am J Physiol Regul Integr Comp Physiol. 2003;284:R725-R733.
47. Wilson WL, Roques BP, Llorens-Cortes C, Speth RC, Harding JW, Wright JW. Roles of brain angiotensins II and III in thirst and sodium appetite. Brain Res. 2005;1060:108-117.
48. Iturrioz X, Vazeux G, Celerier J, Corvol P, Llorens-Cortes C. Histidine 450 plays a critical role in catalysis and, with Ca2-+, contributes to the substrate specificity of aminopeptidase A. Biochemistry. 2000;39:3061-3068.