ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 4, 2002, Pages 346-353

  Turner, Anthony J ^a   Tipnis, Sarah R ^a   Guy, Jodie L ^a   Rice, Gillian I ^a   Hooper, Nigel M ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

ACE2; ACEH; Angiotensin II; Carboxypeptidase; Collectrin; Metalloprotease

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN I; BACTERIAL ENZYME; BRADYKININ; CARBOXYPEPTIDASE; COLLECTRIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MEMBRANE METALLOENDOPEPTIDASE; METALLOCARBOXYPEPTIDASE; PROTEIN; PROTEIN ACE2; PROTEIN ACEH; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CHIMERA; CONFERENCE PAPER; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; KALLIKREIN KININ SYSTEM; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN METABOLISM; PROTEIN MOTIF; PROTEIN PROCESSING; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; THERMUS AQUATICUS; TISSUE INJURY;

AMINO ACID SEQUENCE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; CARBOXYPEPTIDASES; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDYL-DIPEPTIDASE A; RENIN-ANGIOTENSIN SYSTEM; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0036253032     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-021     Document Type: Conference Paper

References (50)

1. Pathways for angiotensin-(1-7) metabolism in pulmonary and renal tissue
2. Effect of the angiotensin-(1-7) peptide on nitric oxide release
3. Angiotensin-(1-7) dilates canine coronary arteries through kinins and nitric oxide
4. Angiotensin-converting enzyme inhibitors
5. Tissue renin-angiotensin system: Sites of angiotensin formation
6. Effects of neutral endopeptidase inhibition and combined angiotensin converting enzyme and neutral endopeptidase inhibition on angiotensin and bradykinin peptides in rats
7. Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function
8. 2) angiotensin receptor
9. The renin-angiotensin system and cardiovascular homeostasis
10. The structure of thermolysin: An electron density map at 2-3 Å resolution
11. N-domain-specific substrate and C-domain inhibitors of angiotensin-converting enzyme. Angiotensin-(1-7) and keto-ACE
12. Bradykinin in the heart. Friend or foe?
13. Angiotensin I-converting enzyme genotypes and angiotensin II receptors. Response to therapy
14. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
15. Effect of chronic angiotensin-converting enzyme inhibition on endothelial function in patients with chronic heart failure
16. Cell biology and genetics of angiotensin in cardiovascular disease
17. Angiotensin-converting enzyme: New concepts concerning its biological role
18. Molecular cloning of human testicular angiotensin-converting enzyme: The testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme
19. Angiotensin I converting enzyme
20. Potentiation of bradykinin by angiotensin-(1-7) on arterioles of spontaneously hypertensive rats studied in vivo
21. Counterregulatory actions of angiotensin-(1-7)
22. Characterization of angiotensin-(1-7) in the urine of normal and essential hypertensive subjects
23. The angiotensin type 1 and type 2 receptor families. Siblings or cousins?
24. Angiotensin 1-7 induces bradykinin-mediated relaxation in porcine coronary artery
25. 1) receptor
26. Membrane protein secretases
27. Potential role of mixed ACE and neutral endopeptidase inhibitor in the treatment of heart failure
28. Vasodepressor actions of angiotensin-(1-7) unmasked during combined treatment with lisinopril and losartan
29. Families of metalloendopeptidases and their relationships
30. Renin-angiotensin system: A dual tissue and hormonal system for cardiovascular control. Franz Volhard lecture
31. The coagulation-kinin pathway of human plasma
32. Male-female differences in fertility and blood pressure in ACE-deficient mice
33. Purification and characterization of a thermostable carboxypeptidase (carboxypeptidase Taq) from Thermus aquaticus YT-1
34. Carboxypeptidase Taq, a thermostable zinc enzyme, from Thermus aquaticus YT-1; molecular cloning, sequencing, and expression of the encoding gene in Escherichia coli
35. The active site of carboxypeptidase Taq possesses the active-site motif His-Glu-X-X-His of zinc-dependent endopeptidases and aminopeptidases
36. Characterization of a secretase activity which releases angiotensin-converting enzyme from the membrane
37. Angiotensin-converting enzyme secretase is inhibited by zinc metalloprotease inhibitors and requires its substrate to be inserted into a lipid bilayer
38. Plasma kinins increase after angiotensin-converting enzyme inhibition in human subjects
39. Molecular basis of human hypertension: The role of angiotensin
40. The interaction of nitric oxide, bradykinin, and the angiotensin II type 2 receptor: Lessons learned from transgenic mice
41. Angiotensin-(1-7) reduces smooth muscle growth after vascular injury
42. Bovine aortic endothelial cells contain an angiotensin-(1-7) receptor
43. Antiproliferative actions of angiotensin-(1-7) in vascular smooth muscle
44. A human homolog of angiotensin converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
45. Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation
46. Angiotensin-(1-7) attenuates vasoconstriction evoked by angiotensin II but not by noradrenaline in man
47. Metallocarboxy-peptidases and their protein inhibitors. Structure, function and biomedical properties
48. Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared to testis ACE despite cleavage at identical stalk sites
49. Converting enzyme determines plasma clearance of angiotensin-(1-7)
50. Collectrin, a collecting duct-specific transmembrane glycoprotein, is a novel homologue of ACE2 and is developmentally regulated in embryonic kidneys