Expression of p53 in lesions and unaffected skin of patients with plaque-type and guttate psoriasis: A quantitative comparative study

Journal of Dermatology

Volumn 34, Issue 6, 2007, Pages 367-374

  Yazici, Ayça Cordan ^a   Karabulut, Ayşe Anil ^b   Özen, Özlem ^c   Ekşioǧlu, Meral ^b   Üstün, Hüseyin ^b  

^a MERSIN UNIVERSITY   (Turkey)

^b ANKARA TRAINING AND RESEARCH HOSPITAL   (Turkey)

^c BASKENT UNIVERSITY   (Turkey)

Author keywords

p53; Pathogenesis; Psoriasis

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; BIOPSY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MALE; PATHOGENESIS; PROTEIN EXPRESSION; PSORIASIS VULGARIS; QUANTITATIVE ANALYSIS; SCHOOL CHILD; STATISTICAL ANALYSIS; SUN EXPOSURE; ULTRAVIOLET RADIATION;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CHILD; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PSORIASIS; SEVERITY OF ILLNESS INDEX; SKIN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34249320842     PISSN: 03852407     EISSN: 13468138     Source Type: Journal    
DOI: 10.1111/j.1346-8138.2007.00290.x     Document Type: Article

References (29)

1. Tadini G, Cerri A, Crosti L, Cattoretti G, Berti T. P53 and oncogenes expression in psoriasis. Acta Derm Venerol 1989 146 : 33 35.
2. Bianchi B, Campolmi P, Mavilia L, Danesi A, Rossi R, Cappugi P. Monochromatic excimer light (308 mn): an immunohistochemical study of cutaneous T cells and apoptosis-related molecules in psoriasis. JEADV 2003 17 : 408 413.
3. Moles JP, Theillet C, Basset-Seguin N, Guilhou JJ. Mutation of the tumor suppressor gene TP53 is not detected in psoriatic skin. J Invest Dermatol 1993 101 : 100 102.
4. Barr RJ, Rohan MK, Dangaran K. Effect of orally administered antithyroid thioureylenes on PCNA and p53 expression in psoriatic lesions. Int J Dermatol 1995 34 : 280 283.
5. Healy E, Reynolds NJ, Smith MD et al. Up-regulation of p21WAF1/CIP1 in psoriasis after the application of irritants and tape stripping. J Invest Dermatol 1995 105 : 274 279.
6. Hannuksela-Svahn A, Paakko P, Autio P, Reunala T, Karvonen J, Vahakangas K. Expression of p53 protein before and after PUVA treatment in psoriasis. Acta Derm Venereol 1999 79 : 195 199.
7. Ashcroft M, Vousden KH. Regulation of p53 stability. Oncogene 1999 18 : 7637 7643.
8. Peritz AE, Gasparro FP. Psoriasis, PUVA, and skin cancer-molecular epidemiology. the curious question of T→A transversions. J Invest Dermatol Symp Proceed 1999 4 : 11 16.
9. Soini Y, Kamel D, Paakko P, Letho P, Oikarinen A, Vahakangas K. Aberrant accumulation of p53 associates with Ki67 and mitotic count in benign skin lesions. Br J Dermatol 1994 131 : 514 520.
10. May P, May E. Twenty years of p53 research: structural and functional aspects of the p53 protein. Oncogene 1999 18 : 7621 7636.
11. Lu S, Tiekso J, Hietanen S, Syrjanen K, Havu VK, Syrjanen S. Expression of cell-cycle proteins p53, p21 (WAF-1), PCNA and Ki-67 in benign, premalignant and malignant skin lesions with implicated HPV involvement. Acta Derm Venereol 1999 79 : 268 273.
12. Gasparro FP. p53 in dermatology. Arch Dermatol 1998 134 : 1029 1032.
13. McGregor JM, Yu CCW, Dublin EA, Levison DA, MacDonald DM. Aberrant expression of p53 tumour-suppressor protein in non-melanoma skin cancer. Br J Dermatol 1992 127 : 463 469.
14. Ro YS, Cooper PN, Lee JA et al. p53 protein expression in benign and malignant skin tumours. Br J Dermatol 1993 128 : 237 241.
15. Escalonilla P, Grilli R, Canamero M et al. Sebaceous carcinoma of the vulva. Am J Dermatopathol 1999 21 : 468 472.
16. Hussein MR, Al-Badaiwy ZH, Guirguis MN. Analysis of p53 and bcl-2 protein expression in the non-tumorigenic, pretumorugenic, and tumorigenic keratinocytic hyperproliferative lesions. J Cutan Pathol 2004 31 : 643 651.
17. Salvador G, Sanmarti R, Garcia-Peiro A, Rodriguez-Cros JR, Munoz-Gomez J, Canete JD. p53 expression in rheumatoid and psoriatic arthritis synovial tissue and association with joint damage. Ann Rheum Dis 2005 64 : 183 187.
18. Batinac T, Zamolo G, Jonjic N, Gruber F, Petrovecki M. p53 protein expression and cell proliferation in non-neoplastic and neoplastic proliferative skin diseases. Tumori 2004 90 : 120 127.
19. Helander SD, Peters MS, Pittelkow MR. Expression of p53 protein in benign and malignant epidermal pathologic conditions. J Am Acad Dermatol 1993 29 : 741 748.
20. Marks R, Barton SP, Shuttleworth D, Finlay AY. Assesment of disease progress in psoriasis. Arch Dermatol 1989 125 : 235 240.
21. Schmid P, Cox D, McMaster GK, Itin P. In situ hybridization analysis of cytokine, proto-oncogene and tumour suppressor gene expression in psoriasis. Arch Dermatol Res 1993 285 : 334 340.
22. Michel G, Auer H, Kemeny L, Bocking A, Ruzicka T. Antioncogene p53 and mitogenic cytokine interleukin-8 aberrantly expressed in psoriatic skin are inversely regulated by the antipsoriatic drug tacrolimus (FK506). Biochem Pharmacol 1996 51 : 1315 1320.
23. Heenen M, Laporte M, Noel JC, De Graef C. Methotrexate induces apoptotic cell death in human keratinocytes. Arch Dermatol Res 1998 290 : 240 245.
24. Harris C. P53: at the crossroads of molecular carcinogenesis and risk assessment. Science 1993 262 : 1980 1981.
25. Henseler T. Genetics of psoriasis. Arch Dermatol Res 1998 290 : 463 476.
26. Valdimarsson H, Sigmundsdottir H, Jonsdottir I. Is psoriasis induced by streptococcal superantigens and maintained by M-protein-specific T cells that cross-react with keratin? Clin Exp Immunol 1997 107 : 21 24.
27. Horrocks C, Holder JE, Jones JB, Camp RDR. Antigen independent expansion of T cells from psoriatic skin lesions. phenotypic characterization and antigen reactivity. Br J Dermatol 1997 137 : 331 338.
28. Lewis HM, Baker BS, Bokth S et al. Restricted T-cell receptor Vβ gene usage in the skin patients with guttate and chronic plaque psoriasis. Br J Dermatol 1993 129 : 514 520.
29. Qin JZ, Chaturvedi V, Denning MF et al. Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes. Oncogene 2002 21 : 2991 3002.