Peroxisome proliferator-activated receptor α is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro

Cell Biology International

Volumn 31, Issue 9, 2007, Pages 1002-1009

  Ding, Ling ^a   Liang, Xingguang ^a   Zhu, Danyan ^a   Lou, Yijia ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Cardiomyocytes; Differentiation; Embryonic stem cells; PGC 1 ; PPAR

Indexed keywords

ALPHA ACTININ; GW 6471; LIPID; MAJOR HISTOCOMPATIBILITY ANTIGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ANTAGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PIRINIXIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR MEF2C; TRANSCRIPTION FACTOR NKX2.5; TROPONIN T; UNCLASSIFIED DRUG;

ALPHA MHC GENE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CORRELATION ANALYSIS; EMBRYO; EMBRYONIC STEM CELL; ENERGY METABOLISM; GENE; GENE EXPRESSION; HEART MUSCLE CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; INHIBITION KINETICS; MLC2V GENE; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOMERE; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MYOCYTES, CARDIAC; PPAR ALPHA; PYRIMIDINES; TRANS-ACTIVATORS; TROPONIN T;

MAMMALIA; MURINAE;

EID: 34249318044     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2007.03.013     Document Type: Article

References (41)

1. Aoyama T., Peters J.M., Iritani N., Nakajima T., Furihata K., Hashimoto T., et al. Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha). J Biol Chem 273 (1998) 5678-5684
2. Braissant O., and Wahli W. Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 139 (1998) 2748-2754
3. Brandt J.M., Djouadi F., and Kelly D.P. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha. J Biol Chem 273 (1998) 23786-23792
4. Chen J., Kubalak S.W., Minamisawa S., Price R.L., Becker K.D., Hickey R., et al. Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem 273 (1998) 1252-1256
5. Dell'Era P., Ronca R., Coco L., Nicoli S., Metra M., and Presta M. Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development. Circ Res 93 (2003) 414-420
6. Depre C., Shipley G.L., Chen W., Han Q., Doenst T., Moore M.L., et al. Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med 4 (1998) 1269-1275
7. Desvergne B., and Wahli W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20 (1999) 649-688
8. Djouadi F., Brandt J.M., Weinheimer C.J., Leone T.C., Gonzalez F.J., and Kelly D.P. The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism. Prostaglandins Leukot Essent Fatty Acids 60 (1999) 339-343
9. Gulick T., Cresci S., Caira T., Moore D.D., and Kelly D.P. The peroxisome proliferator-activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci U S A 91 (1994) 11012-11016
10. Herzberg N.H., Middelkoop E., Adorf M., Dekker H.L., Van Galen M.J., Van den Berg M., et al. Mitochondria in cultured human muscle cells depleted of mitochondrial DNA. Eur J Cell Biol 61 (1993) 400-408
11. Hescheler J., Fleischmann B.K., Lentini S., Maltsev V.A., Rohwedel J., Wobus A.M., et al. Embryonic stem cells: a model to study structural and functional properties in cardiomyogenesis. Cardiovasc Res 36 (1997) 149-162
12. Jiang Y.J., Lu B., Xu F.Y., Gartshore J., Taylor W.A., Halayko A.J., et al. Stimulation of cardiac cardiolipin biosynthesis by PPARalpha activation. J Lipid Res 45 (2004) 244-252
13. Kliewer S.A., Forman B.M., Blumberg B., Ong E.S., Borgmeyer U., Mangelsdorf D.J., et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci U S A 91 (1994) 7355-7359
14. Kraft C.S., LeMoine C.M., Lyons C.N., Michaud D., Mueller C.R., and Moyes C.D. Control of mitochondrial biogenesis during myogenesis. Am J Physiol Cell Physiol 290 (2006) C1119-C1127
15. Lee S.S., Pineau T., Drago J., Lee E.J., Owens J.W., Kroetz D.L., et al. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15 (1995) 3012-3022
16. Lehman J.J., Barger P.M., Kovacs A., Saffitz J.E., Medeiros D.M., and Kelly D.P. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106 (2000) 847-856
17. Leone T.C., Weinheimer C.J., and Kelly D.P. A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc Natl Acad Sci U S A 96 (1999) 7473-7478
18. Li J., Puceat M., Perez-Terzic C., Mery A., Nakamura K., Michalak M., et al. Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis. J Cell Biol 158 (2002) 103-113
19. Liu Z.P., Nakagawa O., Nakagawa M., Yanagisawa H., Passier R., Richardson J.A., et al. CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev Biol 234 (2001) 497-509
20. Makinde A.O., Kantor P.F., and Lopaschuk G.D. Maturation of fatty acid and carbohydrate metabolism in the newborn heart. Mol Cell Biochem 188 (1998) 49-56
21. Marin-Garcia J., Ananthakrishnan R., Agrawal N., and Goldenthal M.J. Mitochondrial gene expression during bovine cardiac growth and development. J Mol Cell Cardiol 26 (1994) 1029-1036
22. Marin-Garcia J., Ananthakrishnan R., and Goldenthal M.J. Heart mitochondrial DNA and enzyme changes during early human development. Mol Cell Biochem 210 (2000) 47-52
23. Mascaro C., Acosta E., Ortiz J.A., Marrero P.F., Hegardt F.G., and Haro D. Control of human muscle-type carnitine palmitoyltransferase I gene transcription by peroxisome proliferator-activated receptor. J Biol Chem 273 (1998) 8560-8563
24. Metzger J.M., Lin W.I., Johnston R.A., Westfall M.V., and Samuelson L.C. Myosin heavy chain expression in contracting myocytes isolated during embryonic stem cell cardiogenesis. Circ Res 76 (1995) 710-719
25. Metzger J.M., Lin W.I., and Samuelson L.C. Vital staining of cardiac myocytes during embryonic stem cell cardiogenesis in vitro. Circ Res 78 (1996) 547-552
26. Meyer N., Jaconi M., Landopoulou A., Fort P., and Puceat M. A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells. FEBS Lett 478 (2000) 151-158
27. Mueller E., Sarraf P., Tontonoz P., Evans R.M., Martin K.J., Zhang M., et al. Terminal differentiation of human breast cancer through PPAR gamma. Mol Cell 1 (1998) 465-470
28. Park K.S., Lee R.D., Kang S.K., Han S.Y., Park K.L., Yang K.H., et al. Neuronal differentiation of embryonic midbrain cells by upregulation of peroxisome proliferator-activated receptor-gamma via the JNK-dependent pathway. Exp Cell Res 297 (2004) 424-433
29. Rosen E.D., Sarraf P., Troy A.E., Bradwin G., Moore K., Milstone D.S., et al. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 4 (1999) 611-617
30. Sack M.N., Rader T.A., Park S., Bastin J., McCune S.A., and Kelly D.P. Fatty acid oxidation enzyme gene expression is downregulated in the failing heart. Circulation 94 (1996) 2837-2842
31. Sack M.N., Disch D.L., Rockman H.A., and Kelly D.P. A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. Proc Natl Acad Sci U S A 94 (1997) 6438-6443
32. Sauer H., Rahimi G., Hescheler J., and Wartenberg M. Effects of electrical fields on cardiomyocyte differentiation of embryonic stem cells. J Cell Biochem 75 (1999) 710-723
33. Srivastava D., and Olson E.N. A genetic blueprint for cardiac development. Nature 407 (2000) 221-226
34. Steinmetz M., Quentin T., Poppe A., Paul T., and Jux C. Changes in expression levels of genes involved in fatty acid metabolism: upregulation of all three members of the PPAR family (alpha, gamma, delta) and the newly described adiponectin receptor 2, but not adiponectin receptor 1 during neonatal cardiac development of the rat. Basic Res Cardiol 100 (2005) 263-269
35. Vega R.B., Huss J.M., and Kelly D.P. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 20 (2000) 1868-1876
36. Watanabe K., Fujii H., Takahashi T., Kodama M., Aizawa Y., Ohta Y., et al. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. J Biol Chem 275 (2000) 22293-22299
37. Wobus A.M., Wallukat G., and Hescheler J. Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers. Differentiation 48 (1991) 173-182
38. Wobus A.M., Kaomei G., Shan J., Wellner M.C., Rohwedel J., Ji G., et al. Retinoic acid accelerates embryonic stem cell-derived cardiac differentiation and enhances development of ventricular cardiomyocytes. J Mol Cell Cardiol 29 (1997) 1525-1539
39. Xu C., Liguori G., Adamson E.D., and Persico M.G. Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. Dev Biol 196 (1998) 237-247
40. Xu H.E., Stanley T.B., Montana V.G., Lambert M.H., Shearer B.G., Cobb J.E., et al. Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature 415 (2002) 813-817
41. Yu G.S., Lu Y.C., and Gulick T. Co-regulation of tissue-specific alternative human carnitine palmitoyltransferase Ibeta gene promoters by fatty acid enzyme substrate. J Biol Chem 273 (1998) 32901-32909