Induction of apoptosis and autophagic cell death by the vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde is accompanied by the cleavage of DNA-PKcs and rapid destruction of c-Myc oncoprotein in HepG2 cells

Cancer Letters

Volumn 252, Issue 2, 2007, Pages 280-289

  Yan, Yu Qian ^a   Zhang, Bo ^a   Wang, Lin ^a   Xie, Yue Hua ^a   Peng, Tao ^a   Bai, Bei ^a   Zhou, Ping Kun ^a  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Antiproliferation; Apoptosis; Autophagy; c Myc; DNA damage; DNA PKcs; Vanillin derivative

Indexed keywords

BROMOVANIN; DOUBLE STRANDED DNA; MYC PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VANILLIN DERIVATIVE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER THERAPY; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY;

APOPTOSIS; AUTOPHAGY; BENZALDEHYDES; CELL LINE, TUMOR; COMET ASSAY; DNA DAMAGE; DNA-ACTIVATED PROTEIN KINASE; HUMANS; HYDROLYSIS; MICROSCOPY, ELECTRON, TRANSMISSION; PROTO-ONCOGENE PROTEINS C-MYC; REACTIVE OXYGEN SPECIES;

EID: 34249315081     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.01.007     Document Type: Article

References (22)

1. Andrade H.H.R., Santos J.H., Gimmler-Luz M.C., Correa M.J.F., Lehmann M., and Reguly M.L. Suppressing effect of vanillin on chromosome aberrations that occur spontaneously or are induced by mitomycin C in the germ cell line of Drsophila melanogaster. Mutat. Res. 279 (1992) 281-287
2. Ohta T. Modification of genotoxicity by naturally occurring flavorings and their derivates. Crit. Rev. Toxicol. 23 (1993) 127-146
3. Akagi K., Hirose M., Hoshiya T., Mizoguchi Y., Ito N., and Shrai T. Modulating effects of elagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model. Cancer Lett. 94 (1995) 113-121
4. Tsuda H., Uehara N., Iwahori Y., Asamoto M., Iigo M., Nagao M., Matsumoto K., Ito M., and Hirono I. Chemopreventive effects of beta-carrotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4,5-f]quinoline in the rat. Jpn. J. Cancer Res. 85 (1994) 1214-1219
5. Gustafson D.L., Franz H.R., Ueno A.M., Smith J., Doolittle D.J., and Waldren C.A. Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not 137Cs γ-radiation at the CD59 locus in human-hamster hydrid AL cells. Mutagenesis 15 (2000) 207-213
6. Lirdprapamongkol K., Sakurai H., Kawasaki N., Choo M.K., Saitoh Y., Aozukaa Y., Singhirunnusorn P., Ruchirawat S., Svasti J., and Saiki I. Vanillin suppresses in vitro invasion and in vivo metastasis of mouse breast cancer cells. Eur. J. Pharm. Sci. 25 (2005) 57-65
7. Durant S., and Karran P. Vanillins-a novel family of DNA-PK inhibitors. Nucleic Acids Res. 31 (2003) 5501-5512
8. Yaneval M., Li H., Marple T., and Hasty P. Non-homologous end joining, but not homologous recombination, enables survival for cells exposed to a histone deacetylase inhibitor. Nucleic Acids Res. 33 (2005) 5320-5330
9. Yan Y.Q., Xu Q.Z., Wang L., Sui J.L., Bai B., and Zhou P.K. Vanillin derivative 6-bromine-5-hydroxy-4- methoxybenzaldehyde-elicited apoptosis and G2/M arrest of Jurkat cells proceeds concurrently with DNA-PKcs cleavage and Akt inactivation. Int. J. Oncol. 29 (2006) 1167-1172
10. Collis S.J., Swartz M.J., Nelson W.G., and DeWeese T.L. Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by small inhibitory RNA silencing of DNA repair factors. Cancer Res. 63 (2003) 1550-1554
11. Willmore E., de Caux S., Sunter N.J., Tilby M.J., Jackson G.H., Austin C.A., and Durkacz B.W. A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood 103 (2004) 4659-4665
12. An J., Xu Q.Z., Sui J.L., Bai B., and Zhou P.K. Down-regulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cells. Int. J. Cancer 117 (2005) 531-537
13. An J., Xu Q.Z., Sui J.L., Bai B., and Zhou P.K. Silencing of DNA-PKcs alters the transcriptional profile of certain signal transduction genes related to proliferation and differentiation in HeLa cells. Int. J. Mol. Med. 16 (2005) 455-462
14. Levine B., and Yuan J. Autophagy in cell death: an innocent convict?. J. Clin. Invest. 115 (2005) 2679-2688
15. Scott R.C., Schuldiner O., and Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7 (2004) 167-178
16. Daido S., Yamamoto A., Fujiwara K., Sawaya R., Kondo S., and Kondo Y. Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy. Cancer Res. 65 (2005) 4368-4375
17. Gajewska M., Gajkowska B., and Motyl T. Apoptosis and autophagy induced by TGF-β1 in bovine mammary epithelial BME-UV1 cells. J. Physiol. Pharmacol. 56 (2005) 143-157
18. Shao Y., Gao Z., Marks P.A., and Jiang X. Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc. Nalt. Acad. Sci. USA 101 (2004) 18030-18035
19. Casciola-Rosen L.A., Anhalt G.J., and Rosen A. DNA-dependent protein kinase is one of subset of autoantigens specifically cleaved early during apoptosis. J. Exp. Med. 182 (1995) 1625-1634
20. Han Z., Malik N., Carter T., Reeves W.H., Wyche J.H., and Hendrickson E.A. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J. Biol. Chem. 271 (1996) 25035-25040
21. Welcker M., Orian A., Jin J., Grim J.E., Harper J.W., Eisenman R.N., and Clurman B.E. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl. Acad. Sci. USA 101 (2004) 9085-9090
22. Kumar S.S., Priyadarsini K.I., and Sainis K.B. Inhibition of peroxynitrite-mediated reactions by vanillin. J. Agric. Food Chem. 52 (2004) 139-145