Cholesterol synthesis prevails over absorption in metabolic syndrome

Translational Research

Volumn 149, Issue 6, 2007, Pages 310-316

  Gylling, Helena ^a   Hallikainen, Maarit ^a   Kolehmainen, Marjukka ^a   Toppinen, Leena ^a   Pihlajamäki, Jussi ^a   Mykkänen, Hannu ^a   Ågren, Jyrki J ^a   Rauramaa, Rainer ^a   Laakso, Markku ^a   Miettinen, Tatu A ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; INSULIN; PHYTOSTEROL; SQUALENE; TRIACYLGLYCEROL;

ABDOMINAL OBESITY; ADULT; AGED; ARTICLE; BODY MASS; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GAS LIQUID CHROMATOGRAPHY; GENETIC REGULATION; GLUCOSE METABOLISM; HUMAN; LIPID ABSORPTION; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; PREVALENCE; PRIORITY JOURNAL;

EID: 34249308484     PISSN: 19315244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trsl.2006.11.012     Document Type: Article

References (29)

1. Kesäniemi Y.A., and Miettinen T.A. Cholesterol absorption efficiency regulates plasma cholesterol level in the Finnish population. Eur J Clin Invest 17 (1987) 391-395
2. Miettinen T.A., and Kesäniemi Y.A. Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels. Am J Clin Nutr 49 (1989) 629-635
3. Miettinen T.A., Gylling H., Strandberg T., Sarna S., and Finnish 4S Investigators. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survival study. BMJ 316 (1998) 1127-1130
4. Miettinen T.A., Strandberg T.E., Gylling H., and Finnish Investigators of the Scandinavian Simvastatin Survival Study Group. Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients. Relation to basal serum cholestanol. Arterioscler Thromb Vasc Biol 20 (2000) 1340-1346
5. Miettinen T.A., and Gylling H. Cholesterol absorption efficiency with sterol metabolism in obesity. Atherosclerosis 153 (2000) 241-248
6. Strandberg T.E., Salomaa V., Vanhanen H., and Miettinen T.A. Associations of fasting blood glucose with cholesterol absorption and synthesis in nondiabetic middle-aged men. Diabetes 45 (1996) 755-761
7. Pihlajamäki J., Gylling H., Miettinen T.A., and Laakso M. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. J Lipid Res 45 (2004) 507-512
8. Simonen P., Gylling H., Howard A.N., and Miettinen T.A. Introducing a new component of the metabolic syndrome: low cholesterol absorption. Am J Clin Nutr 72 (2000) 82-88
9. Simonen P.P., Gylling H.K., and Miettinen T.A. Diabetes contributes to cholesterol metabolism regardless of obesity. Diabet Care 25 (2002) 1511-1515
10. Gylling H., Hallikainen M., Pihlajamäki J., Ågren J., Laakso M., Rajaratnam R.A., et al. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. J Lipid Res 45 (2004) 1660-1665
11. Chan D.C., Watts G.F., Barrett P.H.R., O'Neill F.H., Redgrave T.G., and Thompson G.R. Relationships between cholesterol homeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome. Clin Sci 104 (2003) 383-388
12. Miettinen T.A., Tilvis R.S., and Kesäniemi Y.A. Serum cholestanol and plant sterol levels in relation to cholesterol metabolism in middle-aged men. Metabolism 38 (1989) 136-140
13. Gylling H., and Miettinen T.A. Serum noncholesterol sterols related to cholesterol metabolism in familial hypercholesterolemia. Clin Chim Acta 178 (1988) 41-50
14. Miettinen T.A., Tilvis R.S., and Kesäniemi Y.A. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population. Am J Epidemiol 131 (1990) 20-31
15. National Cholesterol Education Program. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285 (2001) 2486-2497
16. Rastas M., Seppänen R., Knuts L.R., Karvetti R.L., and Varo P. Nutrient composition of foods (1993), Publications of the Social Insurance Institution, Helsinki, Finland
17. Friedewald W.T., Levy R.I., and Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18 (1972) 499-502
18. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 (1985) 412-419
19. Miettinen T.A. Cholesterol metabolism during ketoconazole treatment in man. J Lipid Res 29 (1988) 43-51
20. Berge K.E., von Bergmann K., Lutjohann D., Guerra R., Grundy S.M., Hobbs H.H., et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. J Lipid Res 43 (2002) 486-494
21. Yu L., Li-Hawkins J., Hammer R.E., Berge K.E., Horton J.D., Cohen J.C., et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest 110 (2002) 671-680
22. Peltola P., Pihlajamäki J., Koutnikova H., Ruotsalainen E., Salmenniemi U., Vauhkonen I., et al. Visceral obesity is associated with high levels of serum squalene. Obesity 14 (2006) 1155-1163
23. Salmenniemi U., Ruotsalainen E., Pihlajamäki J., Vauhkonen I., Kainulainen S., Punnonen K., et al. Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation 110 (2004) 3842-3848
24. Goodman D.S. Squalene in human and rat blood plasma. J Clin Invest 43 (1964) 1480-1485
25. Liu G.C.K., Ahrens Jr. E.H., Schreibman P.H., Samuel P., McNamara D.J., and Crouse J.R. Measurement of cholesterol synthesis in man by isotope kinetics of squalene. Proc Natl Acad Sci USA 72 (1975) 4612-4616
26. Miettinen T.A. Serum squalene and methyl sterols as indicators of cholesterol synthesis in vivo. Life Sci 8 (1969) 713-721
27. Simonen P.P., Gylling H., and Miettinen T.A. Body weight modulates cholesterol metabolism in non-insulin dependent type 2 diabetics. Obes Res 10 (2002) 328-335
28. Rajaratnam R.A., Gylling H., and Miettinen T.A. Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. J Am Coll Cardiol 35 (2000) 1185-1191
29. Gylling H., and Miettinen T.A. Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption. J Lipid Res 43 (2002) 1472-1476