Anterior cingulate volumes in schizophrenia: A systematic review and a meta-analysis of MRI studies

Schizophrenia Research

Volumn 93, Issue 1-3, 2007, Pages 1-12

  Baiano, M ^a   David, A ^b   Versace, A ^a,c   Churchill, R ^b   Balestrieri, M ^a   Brambilla, P ^a,d  

^a UNIVERSITY OF UDINE   (Italy)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF VERONA   (Italy)

^d SCIENTIFIC INSTITUTE   (Italy)

Author keywords

Anterior cingulate; Magnetic resonance imaging; Neuroimaging; Schizophrenia

Indexed keywords

ADULT; ARTICLE; BRAIN SIZE; CINGULATE GYRUS; DIAGNOSTIC IMAGING; EMOTION; FEMALE; HUMAN; IMAGE ANALYSIS; MALE; MEDLINE; MODEL; NUCLEAR MAGNETIC RESONANCE IMAGING; PARAMETER; PRIORITY JOURNAL; PSYCINFO; RANDOM EFFECT MODEL; REGRESSION ANALYSIS; SAMPLE SIZE; SCHIZOPHRENIA; TASK PERFORMANCE;

EMOTIONS; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE IMAGING; ORGAN SIZE; SCHIZOPHRENIA;

EID: 34249300833     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2007.02.012     Document Type: Article

References (65)

1. Bagary M.S., Symms M.R., Barker G.J., Mutsatsa S.H., Joyce E.M., and Ron M.A. Gray and white matter brain abnormalities in first-episode schizophrenia inferred from magnetization transfer imaging. Arch. Gen. Psychiatry 60 (2003) 779-788
2. Barbas H. Connections underlying the synthesis of cognitive, memory and emotion in primate prefrontal cortices. Brain Res. Bull. 52 (2000) 319-330
3. Benes F.M. Neurobiological investigations in cingulate cortex of schizophrenic brain. Schizophr. Bull. 19 (1993) 537-549
4. Benes F.M. Model generation and testing to probe neural circuitry in the cingulate cortex of postmortem schizophrenic brain. Schizophr. Bull. 24 (1998) 219-230
5. Benes F.M., Vincent S.L., Alsterberg G., Bird E.D., and SanGiovanni J.P. Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics. J. Neurosci. 12 (1992) 924-929
6. Brambilla P., Hardan A.Y., Di Nemi S.U., Perez J., Soares J.C., and Barale F. Brain anatomy and development in autism: review of structural MRI studies. Brain Res. Bull. 61 (2003) 557-569
7. Brambilla P., Hardan A.Y., Di Nemi S.U., Caverzasi E., Soares J.C., Perez J., and Barale F. The functional neuroanatomy of autism. Funct. Neurol. 19 (2004) 9-17
8. Burns J., Job D., Bastin M.E., Whalley H., Macgillivray T., Johnstone E.C., and Lawrie S.M. Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study. Br. J. Psychiatry 182 (2003) 439-443
9. Bush G., Vogt B.A., Holmes A., Dale A.M., Greve D., Jenike M.A., and Rosen B.R. Dorsal anterior cingulate cortex: a role in reward-based decision making. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 523-528
10. Choi J.S., Kang D.H., Kim J.J., Ha T.H., Roh K.S., Youn T., and Kwon J.S. Decreased caudal anterior cingulate gyrus volume and positive symptoms in schizophrenia. Psychiatry Res., Neuroimaging 139 (2005) 239-247
11. Convit A., Wolf O.T., De Leon M.J., Patalinjug M., Kandil E., Caraos C., Scherer A., Saint-Louis L.A., and Cancro R. Volumetric analysis of the pre-frontal regions: findings in aging and schizophrenia. Psychiatry Res. 107 (2001) 61-73
12. Crespo-Facorro B., Kim J.J., Andreasen N.C., O'Leary D.S., and Magnotta V. Regional frontal abnormalities in schizophrenia: a quantitative grey matter volume and cortical surface size study. Biol. Psychiatry 48 (2000) 110-119
13. Deeks J.J., Altman D.G., and Bradburn M.J. Statistical methods for examining heterogeneity and combining results from several studies in meta-analysis. In: Egger M., Smith G.D., and Altman D.G. (Eds). Systematic Reviews in Health Care: Meta-analysis in Context (1995), BMJ Publishing Group, London 290-299
14. Farrow T.F.D., Whitford T.J., Williams L.M., Gomes L., and Harris A.W.F. Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorder. Biol. Psychiatry 58 (2005) 713-723
15. Giuliani N.R., Calhoun V.D., Pearlson G.D., Francis A., and Buchanan R.W. Voxel-based morphometry versus region of interest: a comparison of two methods for analysing gray matter differences in schizophrenia. Schizophr. Res. 74 (2005) 135-147
16. Goldstein J.M., Goodman J.M., Seidman L.J., Kennedy D.N., Makris N., Lee H., Caviness Jr. V.S., Faraone S.V., and Tsuang M.T. Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Arch. Gen. Psychiatry 56 (1999) 537-547
17. Goldstein J.M., Seidman L.J., O'Brien L.M., Horton N.J., Kennedy D.N., Makris N., Caviness Jr. V.S., Faraone S.V., and Tsuang M.T. Impact of normal sexual dimorphisms on sex differences in structural brain abnormalities in schizophrenia assessed by magnetic resonance imaging. Arch. Gen. Psychiatry 59 (2002) 154-164
18. Gray J.A., Braver T.S., and Raichle M.E. Integration of emotion and cognition in the lateral prefrontal cortex. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 4115-4120
19. Ha T.H., Youn T., Ha K.S., Rho K.S., Lee J.M., Kim I.Y., Kim S.I., and Kwon J.S. Gray matter abnormalities in paranoid schizophrenia and their clinical correlations. Psychiatry Res., Neuroimaging 132 (2004) 251-260
20. Hao Y., Liu Z., Jiang T., Gong G., Liu H., Tan L., Kuang F., Xu L., Yi Y., and Zhang Z. White matter integrity of whole brain is disrupted in first-episode schizophrenia. NeuroReport 17 (2006) 23-26
21. Haznedar M.M., Buchsbaum M.S., Hazlett E.A., Shihabuddin L., New A., and Siever L.J. Cingulate gyrus volume and metabolism in the schizophrenia spectrum. Schizophr. Res. 71 (2004) 249-262
22. Heckers S., Weiss A.P., Deckersbach T., Goff D.C., Morecraft R.J., and Bush G. Anterior cingulate cortex activation during cognitive interference in schizophrenia. Am. J. Psychiatry 161 (2004) 707-715
23. Hirayasu Y., Shenton M.E., Salisbury D.F., Kwon J.S., Wible C.G., Fischer I.A., Yurgelun-Todd D., Zarate C., Kikinis R., Jolesz F.A., and McCarley R.W. Subgenual cingulate cortex volume in first-episode psychosis. Am. J. Psychiatry 156 (1999) 1091-1093
24. Hoptman M.J., Ardekani B.A., Butler P.D., Nierenberg J., Javitt D.C., and Lim K.O. DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis. NeuroReport 15 (2004) 2467-2470
25. Hubl D., Koenig T., Strik W., Federspiel A., Kreis R., Boesch C., Maier S.E., Schroth G., Lovblad K., and Dierks T. Pathways that makes voices. Arch. Gen. Psychiatry 61 (2004) 658-668
26. Job D.E., Whalley H.C., McConnell S., Glabus M., Johnstone E.C., and Lawrie S.M. Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry. NeuroImage 17 (2002) 880-889
27. Jones D.K., Catani M., Pierpaoli C., Reeves S.J.C., Shergill S.S., O'Sullivan M., Golesworthy P., McGuire P., Horsfield M.A., Simmons A., Williams S.C.R., and Howard R.J. Age effects on diffusion tensor magnetic resonance imaging tractography measures of frontal cortex connections in schizophrenia. Hum. Brain Mapp. 27 (2006) 230-238
28. Kawasaki Y., Suzuki M., Nohara S., Hagino H., Takahashi T., Matsui M., Yamashita I., Chitns X.A., McGuire P.K., Seto H., and Kurachi M. Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry. Eur. Arch. Psychiatry Clin. Neurosci. 254 (2004) 406-414
29. Keshavan M.S., Anderson S., and Pettergrew J.W. Is schizophrenia due to excessive synaptic pruning in the prefontal cortex? The Feinberg hypothesis revisited. J. Psychiatr. Res. 28 (1994) 239-265
30. Kopelman A., Andreasen N.C., and Nopoulos P. Morphology of the anterior cingulate gyrus in patients with schizophrenia: relationship to typical neuroleptic exposure. Am. J. Psychiatry 162 (2005) 1872-1878
31. Kubicki M., Shenton M.E., Salisbury D.F., Hirayasu Y., Kasai K., Kikinis R., Jolesz F.A., and McCarley R.W. Voxel-based morphometric analysis of gray matter in first episode schizophrenia. NeuroImage 17 (2002) 1711-1719
32. Kubicki M., Westin C.F., Nestor P.G., Wible C.G., Frumin M., Maier S.E., Kikins R., Jolesz F.A., Mc Carley R.W., and Shenton M.E. Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biol. Psychiatry 54 (2003) 1171-1180
33. Kubicki M., Park H., Westin C.F., Nestor P.G., Mulkern R.V., Maier S.E., Niznikiewicz M., Connor E.E., Levitt J.J., Frumin M., Kikins R., Jolesz F.A., McCarley R.W., and Shenton M.E. DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity. NeuroImage 26 (2005) 1109-1118
34. Kumra S., Ashtari M., Cervellione K.L., Henderson I., Kester H., Roofeh D., Wu J., Clarke T., Thaden E., Kane J.M., Rhinewine J., Lencz T., Diamond A., Ardekani B.A., and Szeszko P.R. White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. J. Am. Acad. Child Adolesc. Psych. 44 (2005) 934-941
35. Lane R.D., Reiman E.M., Axelrod B., Yun L.S., Holmes A., and Schwartz G.E. Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex. J. Cogn. Neurosci. 10 (1998) 525-535
36. MacLean P.D. The Triune Brain (1990), Plenum, New York
37. McDonald C., Bullmore E., Sham P., Chitnis X., Suckling J., MacCabe J., Walshe M., and Murray R.M. Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder. Br. J. Psychiatry 186 (2005) 369-377
38. McIntosh A.M., Job D.E., Moorhead W.J., Harrison L.K., Whalley H.C., Johnstone E.C., and Lawrie S.M. Genetic liability to schizophrenia or bipolar disorder and its relationship to brain structure. Am. J. Med. Genet. 141B (2006) 76-83
39. Narr K.L., Toga A.W., Szeszko P., Thompson P.M., Woods R.P., Robinson D., Sevy S., Wang Y.P., Schrock K., and Bilder R.M. Cortical thinning in cingulate and occipital cortices in first episode schizophrenia. Biol. Psychiatry 58 (2005) 32-40
40. Nestor P.G., Kubicki M., Gurrera R.J., Niznikiewicz M., Frumin M., McCarley R.W., and Shenton M.E. Neuropsychological correlates of diffusion tensor imaging in schizophrenia. Neuropsychology 4 (2004) 629-637
41. Ohnishi T., Hashimoto R., Mori T., Nemoto K., Moriguchi Y., Iida H., Noguci H., Nakabayashi T., Hori H., Ohmori M., Tsukue R., Anami K., Hirabayashi N., Harada S., Arima K., Saitoh O., and Kunugi H. The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia. Brain 129 (2006) 399-410
42. Palliere-Martinot M., Caclin A., Artiges E., Poline J.B., Joliot M., Mallet L., Recasens C., Attar-Levy D., and Martinot J.L. Cerebral gray and white matter reductions and clinical correlates in patients with early onset schizophrenia. Schizophr. Res. 50 (2001) 19-26
43. Pantelis C., Velakoulis D., McGorry P.D., Wood S.J., Suckling J., Phillips L.J., Yung A.R., Bullmore E.T., Brewer W., Soulsby B., Desmond P., and McGuire P.K. Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet 361 (2003) 281-288
44. Papez J.W. A proposed mechanism of emotion. Arch. Neurol. Psychiatry 38 (1937) 725-743
45. Park H.J., Westin C.F., Kubicki M., Maier S.E., Niznikievitz M., Baer A., Frumin M., Kikins R., Jolesz F.A., McCarley R.W., and Shenton M.E. White matter asymmetries in healthy subjects and in schizophrenia: a diffusion tensor MRI study. NeuroImage 23 (2004) 213-223
46. Salgado-Pineda P., Baeza I., Perez-Gomez M., Vendrell P., Junque C., Bargallo N., and Bernardo M. Sustained attention impairment correlates to gray matter decreases in first episode neuroleptic-naive schizophrenic patients. NeuroImage 19 (2003) 365-375
47. Salgado-Pineda P., Junque C., Vendrell P., Baeza I., Bargallo N., Falcon C., and Bernardo M. Decreased cerebral activation during CPT performance: structural and functional deficits in schizophrenic patients. NeuroImage 21 (2004) 840-847
48. Sanides F. Comparative cytoarchitectonics of the neocortex of mammals and their evolutionary interpretation. Ann. N. Y. Acad. Sci. 167 (1969) 404-423
49. Shapleske J., Rossell S.L., Chitnis X.A., Suckling J., Simmons A., Bullmore E.T., Woodruff P.W., and David A.S. A computational morphometric MRI study of schizophrenia: effects of hallucinations. Cereb. Cortex 12 (2002) 1331-1341
50. Shin Y.W., Kwon J.S., Ha T.H., Park H.J., Kim D.J., Hong S.B., Moon W.J., Lee J.M., Kim I.Y., Kim S.I., and Chung E.C. Increased water diffusivity in the frontal and temporal cortices of schizophrenic patients. NeuroImage 30 (2006) 1285-1291
51. Sigmundsson T., Suckling J., Maier M., Williams S., Bullmore E., Greenwood K., Fukuda R., Ron M., and Toone B. Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. Am. J. Psychiatry 158 (2001) 234-243
52. Sun Z., Wang F., Cui L., Breeze J., Du X., Wang X., Cong Z., Zhang H., Li B., Hong N., and Zhang D. Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study. NeuroReport 14 (2003) 1833-1836
53. Suzuki M., Nohara S., Hagino H., Kurokawa K., Yotsutsuji T., Kawasaki Y., Takahashi T., Matsui M., Watanabe N., Seto H., and Kurachi M. Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI. Schizophr. Res. 55 (2002) 41-54
54. Szeszko P.R., Bilder R.M., Lencz T., Pollack S., Alvir J.M., Ashtari M., Wu H., and Lieberman J.A. Investigation of frontal lobe subregions in first-episode schizophrenia. Psychiatry Res. 90 (1999) 1-15
55. Takahashi T., Kawasaki Y., Kurokawa K., Hagino H., Nohara S., Yamashita I., Nakamura K., Murata M., Matsui M., Suzuki M., Seto H., and Kurachi M. Lack of normal structural asymmetry of the anterior cingulate gyrus in female patients with schizophrenia: a volumetric magnetic resonance imaging study. Schizophr. Res. 55 (2002) 69-81
56. Takahashi T., Suzuki M., Kawasaki Y., Kurokawa K., Hagino H., Yamashita I., Zhou S.Y., Nohara S., Nakamura K., Seto H., and Kurachi M. Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder. Eur. Arch. Psychiatry Clin. Neurosci. 252 (2002) 268-277
57. Takahashi T., Suzuki M., Kawasaki Y., Hagino H., Yamashita I., Nohara S., Nakamura K., Seto H., and Kurachi M. Perigenual cingulate gyrus volume in patients with schizophrenia: a magnetic resonance imaging study. Biol. Psychiatry 53 (2003) 593-600
58. Takahashi T., Suzuki M., Zhou S.Y., Hagino H., Kawasaki Y., Yamashita I., Nohara S., Nakamura K., Seto H., and Kurachi M. Lack of normal gender differences of the perigenual cingulate gyrus in schizophrenia spectrum disorders. A magnetic resonance imaging study. Eur. Arch. Psychiatry Clin. Neurosci. 254 (2004) 273-280
59. Teasdale J.D., Howard R.J., Cox S.G., Ha Y., Brammer M.J., Williams S.C., and Checkley S.A. Functional MRI study of the cognitive generation of affect. Am. J. Psychiatry 156 (1999) 209-215
60. Vogt B.A., Nimchinsky E.A., Vogt L.J., and Hof P.R. Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J. Comp. Neurol. 359 (1995) 490-506
61. Vogt B.A., Berger G.R., and Derbyshire S.W. Structural and functional dichotomy of human midcingulate cortex. Eur. J. Neurosci. 18 (2003) 3134-3144
62. Wang F., Sun Z., Cui L., Du X., Wang X., Zhang H., Cong Z., and Zhang D. Anterior cingulum abnormalities in male patients with schizophrenia determined through diffusion tensor imaging. Am. J. Psychiatry 161 (2004) 573-575
63. Yakolev P.I. Motility behaviour and the brain: stereodynamic organization and neural coordinates of behaviour. J. Nerv. Ment. Dis. 107 (1948) 313-335
64. Yamasue H., Iwanami A., Hirayasu Y., Yamada H., Abe O., Kuroki N., Fukuda R., Tsujii K., Aoki S., Ohtomo K., Kato N., and Kasai K. Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: an MRI parcellation study. Psychiatry Res. 131 (2004) 195-207
65. Zhou S.Y., Suzuki M., Hagino H., Takahashi T., Kawasaki Y., Matsui M., Seto H., and Kurachi M. Volumetric analysis of sulci/gyri-defined in vivo frontal lobe regions in schizophrenia: precentral gyrus, ingulate gyrus, and prefrontal region. Psychiatry Res., Neuroimaging 139 (2005) 127-139