Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3458-3462

  Chitneni, Satish K ^a   Deroose, Christophe M ^a   Fonge, Humphrey ^a   Gijsbers, Rik ^a   Dyubankova, Natalia ^b   Balzarini, Jan ^b   Debyser, Zeger ^a   Mortelmans, Luc ^a   Verbruggen, Alfons M ^a   Bormans, Guy M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

BCNA; Iodine 123; Molecular imaging; Radiopharmaceutical; SPECT

Indexed keywords

BICYCLO COMPOUND; IODINE 123; NUCLEOSIDE ANALOG; NUCLEOSIDE DERIVATIVE; THYMIDINE KINASE; TRACER;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; REPORTER GENE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; VARICELLA ZOSTER VIRUS;

ANTIVIRAL AGENTS; BICYCLO COMPOUNDS; CELL LINE; GENES, REPORTER; HERPESVIRUS 3, HUMAN; HUMANS; IODINE RADIOISOTOPES; KIDNEY; MODELS, CHEMICAL; NUCLEOTIDES, CYCLIC; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; THYMIDINE KINASE;

HUMAN HERPESVIRUS 3; MUS;

EID: 34249294038     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.081     Document Type: Article

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